alpha-chymotrypsin and Hematoma

Topics: Administration, Oral; Chymotrypsin; Clinical Trials as Topic; Female; Hematoma; Humans; Male; Middle Aged; Placebos; Postoperative Complications; Tablets, Enteric-Coated; Trypsin; Varicose Veins

Topics: Administration, Oral; Athletic Injuries; Chymotrypsin; Clinical Trials as Topic; Edema; Hematoma; Humans; Male; Placebos; Sprains and Strains; Trypsin

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Episiotomy; Female; Hematoma; Humans; Inflammation; Pain; Placebos; Postoperative Complications; Pregnancy; Tablets, Enteric-Coated; Wound Healing

Due to its fibrinolytic activity, alpha-chymotrypsin should be applied, even in doses of 5 and 10 mg (as indicated in the List of Drugs) only for postoperative oedema and haematoma prophylaxis, with due regard to the simultaneous effect on haemostasis. The maximum of fibrinolytic activity was observed 6 to 9 hours after intramuscular injection. These findings are consistent with clinical observation. The authors dissuade from uncontrolled use because, in spite of many separate experimental studies and clinical trials, there are still numerous questions that must be considered unsettled.

Topics: Adult; Chymotrypsin; Edema; Fibrinolysis; Hematoma; Hemostasis; Humans; Thrombelastography

In some cases we observed after-bleeding subsequent to the postoperative prescription of alpha-chymotrypsin. In contrast to this, several authors have pointed out that haemostasis is not affected by therapeutical doses. In vitro studies on 10 individuals (test methods: hirudin tolerance test and euglobulin lysis estimation) showed increased fibrinolytic activity. It is, therefore, dissuaded from administering alpha-chymotrypsin to outpatients for the prevention of postoperative oedema and haematoma formation.

Topics: Chymotrypsin; Edema; Fibrinolysis; Hematoma; Hemostasis; Humans; Molar; Tooth Extraction

Topics: Biological Transport; Brachial Plexus; Carpal Tunnel Syndrome; Chymotrypsin; Dermatan Sulfate; Dupuytren Contracture; Electric Stimulation Therapy; Electrodes; Electrolysis; Electrolytes; Enzymes; Facial Paralysis; Glycosaminoglycans; Hematoma; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Hyaluronic Acid; Hydrolases; Salts; Scleroderma, Systemic

Topics: Athletic Injuries; Chymotrypsin; Edema; Hematoma; Humans; Indomethacin; Male; Physical Therapy Modalities; Placebos

Topics: Chymotrypsin; Edema; Face; Hematoma; Humans; Rutin; Surgery, Plastic

Topics: Chymotrypsin; Cystoscopy; Dextrans; Erectile Dysfunction; Hematoma; Hematuria; Heparin; Humans; Kidney Calculi; Leeches; Lidocaine; Male; Methods; Middle Aged; Penis; Priapism; Streptokinase

Topics: Adolescent; Adult; Chymotrypsin; Contusions; Female; Hematoma; Humans; Male; Middle Aged; Oxyphenbutazone; Sprains and Strains; Streptodornase and Streptokinase; Tablets; Trypsin

Topics: Adult; Chymotrypsin; Female; Fractures, Bone; Goiter; Hematoma; Hemorrhoids; Humans; Male; Middle Aged; Scrotum; Surgical Wound Dehiscence; Testicular Hydrocele

Topics: Adult; Animals; Burns; Chymotrypsin; Contusions; Edema; Fracture Fixation; Fractures, Bone; Hemarthrosis; Hematoma; Humans; Joint Dislocations; Methocarbamol; Phenylbutazone; Rats; Skin Transplantation; Wound Healing; Wounds and Injuries

Topics: Adolescent; Cholesterol; Chymotrypsin; Deafness; Female; Granuloma; Hematoma; Humans; Otitis Media; Suppuration; Tympanic Membrane

Topics: Adult; Chymotrypsin; Edema; Hematoma; Humans; Inflammation; Ligaments; Male; Mandibular Fractures; Trypsin

Topics: Adolescent; Adult; Brain Concussion; Brain Edema; Chymotrypsin; Female; Fracture Fixation; Hemarthrosis; Hematoma; Humans; Joint Diseases; Male; Middle Aged; Wounds and Injuries

Topics: Chymotrypsin; Drug Combinations; Edema; Hematoma; Humans; Surgical Procedures, Operative; Traumatology; Trypsin; Wounds and Injuries

Topics: Chymotrypsin; Edema; Hematologic Tests; Hematoma; Humans; Wounds and Injuries

Topics: Chymotrypsin; Edema; Face; Hematoma; Humans; Postoperative Care; Surgery, Plastic; Trypsin; Wound Healing

Topics: Chymotrypsin; Edema; Edetic Acid; Fractures, Bone; Hematoma; Orthopedic Procedures; Orthopedics; Trypsin