alpha-chymotrypsin and Genital-Neoplasms--Female

The immunologic reactivity of glycoprotein antigens extractable from individual, histologically different ovarian and uterine cancers was studied taking into account their relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), alpha-feto-protein (AFP), and alpha-1-antichymotrypsin. All studies were performed using specific immune sera against perchloric acid (PCA) extracts of ovarian mucinous cystadenocarcinoma (anti-PCA-CaOm) and cervical squamous cell carcinoma (anti-PCA-CaCx), and antisera against the reference antigens mentioned above. A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and often cross-reacting, but not identical with respective antigens of uterine body and cervical carcinomas; 4) an antigen reacting with anti-alpha-1-anti-chymotrypsin serum; and 5) an antigen reacting with anti-AFP serum.

Topics: Adenocarcinoma; alpha 1-Antichymotrypsin; alpha-Fetoproteins; Antigens, Neoplasm; Carcinoembryonic Antigen; Carcinoma, Squamous Cell; Cell Adhesion Molecules; Chymotrypsin; Cross Reactions; Cystadenocarcinoma; Female; Genital Neoplasms, Female; Glycoproteins; Humans; Immune Sera; Immunologic Techniques; Ovarian Neoplasms; Tissue Extracts; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Balsams; Chymotrypsin; Endometritis; Episiotomy; Female; Genital Neoplasms, Female; Gynecology; Humans; Mastitis; Obstetrics; Pelvic Inflammatory Disease; Pregnancy; Trypsin