alpha-chymotrypsin and Flavivirus-Infections

alpha-chymotrypsin has been researched along with Flavivirus-Infections* in 1 studies

Other Studies

1 other study(ies) available for alpha-chymotrypsin and Flavivirus-Infections

ArticleYear
A human-blood-derived microRNA facilitates flavivirus infection in fed mosquitoes.
    Cell reports, 2021, 12-14, Volume: 37, Issue:11

    Hematophagous arthropods, such as mosquitoes, naturally carry and transmit hundreds of arboviruses to humans. Blood meal is a predominant physical interface that shapes cross-species communications among humans, bloodsuckers, and arboviruses. Here, we identify a human-blood-derived microRNA, hsa-miR-150-5p, that interferes with a mosquito antiviral system to facilitate flavivirus infection and transmission. hsa-miR-150-5p is acquired with a blood meal into the mosquito hemocoel and persists for a prolonged time there. The agomir of hsa-miR-150-5p enhances, whereas the antagomir represses flaviviral infection in mosquitoes and transmission from mice to mosquitoes. Mechanistic studies indicate that hsa-miR-150-5p hijacks the mosquito Argonaute-1-mediated RNA interference system to suppress the expression of some chymotrypsins with potent virucidal activity. Mosquito chymotrypsins are essential for resisting systemic flavivirus infection in hemocoel tissues. Chymotrypsin homologs potentially targeted by miR-150-5p are also found in other hematophagous arthropods, demonstrating a conserved miR-150-5p-mediated cross-species RNAi mechanism that might determine flaviviral transmissibility in nature.

    Topics: Aedes; Animals; Chymotrypsin; Female; Flavivirus; Flavivirus Infections; Genome, Viral; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Mosquito Vectors; Virus Replication

2021