alpha-chymotrypsin and Failure-to-Thrive

Direct measurement of pancreatic enzymes is the gold standard in the evaluation of exocrine pancreatic function. The purpose of our study was to evaluate the use of cholecystokinin as a single-agent secretagogue for pancreatic drainage studies. Twenty pediatric patients received cholecystokinin (group 1) and 40 patients received either secretin plus placebo (group 2) or secretin plus cholecystokinin (group 3). Duodenal fluid was collected for measurement of lipase, amylase, trypsin, chymotrypsin. The mean lipase and amylase activities were higher in group 3 and the mean trypsin and chymotrypsin activities were higher in group 1, but none of these observations were statistically significant. Group 3 had more patients with all four enzymes being normal (75%) compared to groups 1 (60%) and 2 (50%) (P = 0.262). Patients in all three groups had at least one normal enzyme. Cholecystokinin is useful as a single agent for direct pancreatic enzyme measurements in the absence of commercially available secretin.

Topics: Adolescent; Amylases; Child; Child, Preschool; Cholecystokinin; Chymotrypsin; Diagnosis, Differential; Drug Synergism; Failure to Thrive; Female; Humans; Infant; Lipase; Malabsorption Syndromes; Male; Pancreatic Function Tests; Pancreatic Juice; Pilot Projects; Prospective Studies; Secretin; Trypsin