alpha-chymotrypsin and Epididymitis

Twenty eight patients aged 18 to 40 years with urogenital infections complicated by orchiepididymitis were examined immunologically. The use of specific monoclonal antibodies OKT-4+ and OKT-8 revealed lower contents of T-helper cells (Thc) (23.33 +/- 9.7%) and higher contents of T-suppressor cells (Tsc) (41.17 +/- 13.41%) in them as compared to those in healthy volunteers (18 persons) and patients with noncomplicated urogenital infections (19 persons). There was a significant decrease in the immunoregulatory index (IRI): Thc/Tsc (0.68 +/- 0.33) reached in some patients the ratio observed in persons infected with the HIV (0.6 +/- 0.2) and an increase in the contents of circulating immune complexes (CIC) (28.5 +/- 2.0 arbitrary units against the normal of 10.0 +/- 0.7). Enzyme therapy including the use of chymotrypsin and trypsin manufactured in the USSR in doses of 10 mg each administered intramuscularly once a day or in doses of 5 mg each administered intramuscularly twice a day for 10 days promoted normalization of the impaired immunity indices (Thc 44.0 +/- 10.51%, Tsc 31.5 +/- 11.26%, IRI 1.53 +/- 0.33 and CIC 12.1 +/- 0.74 arbitrary units). Therefore, the enzymes had an immunomodulating effect. It is likely that they will be useful in treatment of infectious inflammatory processes accompanied by analogous immune disorders which makes the enzyme immunocorrection more applicable in treatment of various pathological processes.

Topics: Adolescent; Adult; Chymotrypsin; Drug Administration Schedule; Epididymitis; Humans; Injections, Intramuscular; Lymphopenia; Male; Orchitis; T-Lymphocytes; Trypsin

A method for the treatment of acute inflammatory diseases of the scrotal organs by means of puncture scrotostomy, which consists in passing the indwelling micro-irrigator into a cavity of the serous sheath of the testis and epididymis and administration via this route of antibacterial and resolving preparations for 4-5 days, is suggested. A method approved in treatment of 45 patients permits to avoid surgical intervention, and is highly effective.

Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Infective Agents; Catheterization; Chymotrypsin; Epididymitis; Humans; Male; Middle Aged; Orchitis; Penicillins; Punctures; Quinoxalines; Scrotum; Therapeutic Irrigation; Trypsin

Chymotrypsin, a proteolytic enzyme included in combined therapy of 27 patients with gonorrhea complicated by the scrotal organs inflammation, has normalized the functions of the hypophyseo-gonadal and hypophyseo-adrenal systems, i.e. hypophyseal luteotropic function, adrenocortical gluco- and mineralocorticoid functions, and testicular androgenopoiesis. Hyperprolactin- and hyperprogesteronemia persisted after therapy, hyperestrogenism and follitropic hypofunction of the hypophysis have developed, that may become the reason of stable pathospermia and disordered fertility after therapy of complicated gonorrhea.

Topics: Adrenal Cortex; Chymotrypsin; Combined Modality Therapy; Epididymitis; Gonorrhea; Humans; Male; Orchitis; Pituitary Gland; Spermatozoa; Testis; Time Factors

Topics: Chymotrypsin; Drug Combinations; Epididymitis; Humans; Male; Oxytetracycline; Trypsin