alpha-chymotrypsin and Edema

To evaluate changes on cutaneous microangiopathy in chronic venous disorder (CVD) after use of Cirkan [venotonic drug containing Ruscus aculeatus (plant extract), hesperidine methylchalcone (flavonoid) and vitamin C], elastic compression stockings (ECS) or no treatment for four weeks.. Fifty-five female patients (85 legs), 25 to 57 years, with at least one limb classified as C2,s or C2,3,s (CEAP classification), were allocated consecutively, according to entrance order, in these three groups. Ten healthy women age-matched were also investigated. Using orthogonal polarization spectral technique (noninvasive method), measurements of functional capillary density (FCD, number of capillaries with flowing red blood cells/mm(2)), capillary morphology (CM, % of abnormal capillaries/mm(2)) and diameters (mum) of dermal papilla (DDP), capillary bulk (DCB) and capillary limb (CD) were obtained on the medial perimalleolar region and later analyzed using CapImage software.. CVD patients showed significant changes on CD and CM compared to healthy subjects in agreement with our previous findings (J Vasc Surg 43:1037-1044, 2006). On Cirkan-treated patients, after 4 weeks, CD decreased on both limbs and CM improved on the left one, suggesting an amelioration of the chronic venous hypertension. No significant changes could be detected on other patient groups. These results confirm the existence of microcirculatory dysfunction in early stages of CVD, probably due to post-capillary hypertension, and further support the venotonic action of Cirkan.

Topics: Adult; Ascorbic Acid; Capillaries; Chymotrypsin; Combined Modality Therapy; Drug Combinations; Edema; Female; Hesperidin; Humans; Leg; Microcirculation; Middle Aged; Phytosterols; Plant Extracts; Stockings, Compression; Treatment Outcome; Trypsin; Venous Insufficiency; Venous Thrombosis

During the surgical extraction of 102 impacted lower wisdom teeth the following factors were studied: the amount of trauma applied during tooth removal; the duration of the operation; post-operative swelling; post-operative trismus; sex differences; the relationship between swelling and trismus; the pattern of development and subsidence of swelling and trismus. This study was combined with a clinical 'double-blind' trial of the drug Chymoral.

Topics: Chymotrypsin; Clinical Trials as Topic; Dental Equipment; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Male; Molar; Pericoronitis; Photogrammetry; Postoperative Complications; Tooth Extraction; Tooth, Impacted; Trismus; Trypsin

A double-blind trial was carried out on 50 patients with soft-tissue ankle injuries. The treated group was given proteolytic enzymes (Chymoral) by mouth while the untreated group was given enteric-coated lactose tablets. Both groups received identical supportive therapy for their injuries. No statistically significant difference in swelling, bruising and function between the 2 groups in the measurements of volume and allied parameters was found. No side effects were noted. The results suggest that the use of Chymoral in this type of injury is not indicated.

Topics: Adolescent; Adult; Ankle Injuries; Bandages; Chymotrypsin; Contusions; Edema; Female; Humans; Male; Movement; Sprains and Strains; Trypsin

Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Chymotrypsin; Clinical Trials as Topic; Edema; Hand; Humans; Methods; Middle Aged; Placebos; Postoperative Care; Postoperative Complications; Tablets; Time Factors; Trypsin

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Hand; Humans; Peptide Hydrolases; Placebos; Postoperative Complications; Time Factors; Trypsin

Topics: Adolescent; Adult; Athletic Injuries; Child; Chymotrypsin; Clinical Trials as Topic; Contusions; Edema; Humans; Placebos; Trypsin

Topics: Administration, Oral; Athletic Injuries; Chymotrypsin; Clinical Trials as Topic; Edema; Hematoma; Humans; Male; Placebos; Sprains and Strains; Trypsin

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Humans; Hydrolases; Placebos; Postoperative Complications

Topics: Chymotrypsin; Edema; Foot Diseases; Humans; Postoperative Complications; Tablets; Trypsin

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Fractures, Bone; Hand Injuries; Humans; Placebos; Trypsin

Topics: Adolescent; Adult; Chymotrypsin; Edema; Female; Hand; Humans; Male; Postoperative Care; Trypsin

Topics: Adult; Chymotrypsin; Clinical Trials as Topic; Edema; Humans; Male; Oral Hemorrhage; Periodontal Diseases; Tablets; Trypsin; Wound Healing

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Episiotomy; Female; Hematoma; Humans; Inflammation; Pain; Placebos; Postoperative Complications; Pregnancy; Tablets, Enteric-Coated; Wound Healing

Topics: Administration, Oral; Adult; Chymotrypsin; Clinical Trials as Topic; Double-Blind Method; Edema; Female; Humans; Male; Middle Aged; Postoperative Complications

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Episiotomy; Female; Humans; Pain; Placebos; Postoperative Complications; Pregnancy

Topics: Chymotrypsin; Clinical Trials as Topic; Edema; Humans; Polysaccharides; Postoperative Complications; Surgery, Oral

Chalcones and Mannich bases have been reported to present antiinflammatory activities as well as inhibitory activities on several factors implicated in inflammation disorders. A series of chalcones and some related Mannich bases were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehyde. Mannich bases were derived from chalcones, with formaldehyde and the corresponding amine. The compounds were tested in vitro for their ability to inhibit various enzymes involved in the arachidonic acid cascade, for their antioxidant behaviour and in vivo for anti-inflammatory activity. Some chalcones and Mannich bases present strong anti-inflammatory and antioxidant activities. Almost all the tested compounds present high inhibitory activity on lipid peroxidation. Some compounds showed potent inhibitory effect on superoxide anion formation. Among the tested compounds 5 and 6 showed the highest lipoxygenase (LO) inhibitory activity. All the tested compounds inhibit both the proteolytic and esteratic activities of trypsin and chymotrypsin. The results indicated that the anti-inflammatory effects of the compounds were partially mediated, through their antioxidant activity. Attempts to correlate quantitatively structure with activity revealed that lipophilicity and molar refractivity influence the biological response.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Chalcones; Chymotrypsin; Edema; Esterases; Free Radical Scavengers; Glutathione; Heme; Indicators and Reagents; Lipids; Magnetic Resonance Spectroscopy; Mannich Bases; Picrates; Reactive Oxygen Species; Spectroscopy, Fourier Transform Infrared; Superoxides

The objective of this study was to examine the in vivo and in vitro gonadotropin-inhibiting potencies, edematogenic activities and the receptor binding affinities of the D-Cit6, D,L-Cit6 and L-Cit6 forms of the LH-RH antagonist Cetrorelix (SB-75) [Ac-D-Nal(2)1,D-Phe(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH- RH. In order to demonstrate the suppressive effects of two different diastereomers of SB-75 and their racemic mixture on LH and FSH release, [D-Cit6] SB-75 was injected subcutaneously in doses of 2.5 and 10 micrograms/rat, [D,L-Cit6]-SB-75 in doses of 5 and 20 micrograms/rat and [L-Cit6] SB-75 in doses of 12.5 and 50 micrograms/rat to castrated male rats. Two hours after administration, there was no difference in LH levels between rats injected with the L-form and control animals, indicating a low activity and/or a rapid enzymatic degradation of this peptide. The (1:1) diastereomeric mixture was only about half as potent in suppression of LH release compared to [D-Cit6] SB-75. Serum FSH levels were suppressed significantly (p < 0.01) for more than 48 h after the administration of 10 micrograms [D-Cit6] SB-75 and 20 micrograms of [D,L-Cit6] SB-75, respectively. [D-Cit6] SB-75 administered at a dose of 2 micrograms/rat induced 100% inhibition of ovulation, while 4 micrograms/rat of the D,L-Cit6 peptide were necessary to produce the same effect.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Anaphylaxis; Animals; Chromatography, High Pressure Liquid; Chymotrypsin; Citrulline; Edema; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; Luteinizing Hormone; Male; Ovulation; Pronase; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Hormone; Structure-Activity Relationship; Subtilisins

This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or saline. Rats were killed 6 h after the first injection. Misoprostol treatment significantly reduced interstitial edema and acinar cell lesions induced by hyperstimulation. Pancreatic amylase and chymotrypsin contents were increased by cerulein and returned towards control levels in the misoprostol-treated group. The lysosomal volume density and the pancreatic beta-D-glucuronidase activity were significantly increased after hyperstimulation. The two parameters were significantly reduced by misoprostol. A protective effect of misoprostol against lesions induced by cerulein hyperstimulation would be a consequence of a lysosomal stabilizating effect.

Topics: Acid Phosphatase; Acute Disease; Alprostadil; Amylases; Animals; Ceruletide; Chymotrypsin; Edema; Glucuronidase; Male; Microscopy, Electron; Misoprostol; Organ Size; Pancreatic Diseases; Pancreatitis; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains

Topics: Chymotrypsin; Double-Blind Method; Edema; Humans; Molar, Third; Postoperative Complications; Tooth Extraction; Tooth, Impacted; Trismus; Trypsin

The etiology of aortitis syndrome (Takayasu's arteritis) is unknown. This study was designed to show whether aortic and pulmonary artery lesions might be induced by a small dose of protease in the circulating blood of rabbits. Serum trypsin activity was increased transiently but significantly by an intravenous infusion of the enzyme at the rate of 1000 IU/min for 100 min. The aortic wall was significantly thickened. Marked edema and focal tears were seen in the intima and media and a mild inflammatory reaction in the adventitia of rabbits sacrificed 2 weeks following trypsin infusion. The lesions were also present in rabbits sacrificed at 6 weeks. They were observed in 7 of 8 rabbits given the same dose of chymotrypsin-A4, but not in control rabbits infused with saline alone. The lesions were observed frequently in the ascending aorta and arch, but were rare in the descending aorta. The main pulmonary artery showed similar lesions in about half of the studied rabbits. These results show evidence that a diffuse lesion of the aorta and pulmonary artery may be induced by a small dose of serine protease in the circulating blood.

Topics: Animals; Aorta; Aortitis; Chymotrypsin; Edema; Infusions, Parenteral; Pulmonary Artery; Rabbits; Sodium Chloride; Trypsin

Topics: Adolescent; Adult; Chymotrypsin; Drug Therapy, Combination; Edema; Hand; Hand Injuries; Humans; Middle Aged; Postoperative Complications; Trypsin

Due to its fibrinolytic activity, alpha-chymotrypsin should be applied, even in doses of 5 and 10 mg (as indicated in the List of Drugs) only for postoperative oedema and haematoma prophylaxis, with due regard to the simultaneous effect on haemostasis. The maximum of fibrinolytic activity was observed 6 to 9 hours after intramuscular injection. These findings are consistent with clinical observation. The authors dissuade from uncontrolled use because, in spite of many separate experimental studies and clinical trials, there are still numerous questions that must be considered unsettled.

Topics: Adult; Chymotrypsin; Edema; Fibrinolysis; Hematoma; Hemostasis; Humans; Thrombelastography

Topics: Animals; Ascorbic Acid; Chymotrypsin; Drug Combinations; Edema; Flavonoids; Male; Peptide Hydrolases; Phytosterols; Rats; Trypsin

Topics: Administration, Oral; Adult; Chymotrypsin; Edema; Female; Foot; Humans; Male; Middle Aged; Osteotomy; Postoperative Complications

In some cases we observed after-bleeding subsequent to the postoperative prescription of alpha-chymotrypsin. In contrast to this, several authors have pointed out that haemostasis is not affected by therapeutical doses. In vitro studies on 10 individuals (test methods: hirudin tolerance test and euglobulin lysis estimation) showed increased fibrinolytic activity. It is, therefore, dissuaded from administering alpha-chymotrypsin to outpatients for the prevention of postoperative oedema and haematoma formation.

Topics: Chymotrypsin; Edema; Fibrinolysis; Hematoma; Hemostasis; Humans; Molar; Tooth Extraction

An experimental oedema of the bladder wall was produced by electric coagulation current in 130 rats. The amount of oedema was calculated by determination of the difference between the weight of the freshly excised wet bladder and that after drying to constant weight. Thus, oedema of a fairly constant and reproducible amount could be produced. The effect of three different drugs on such oedema was tested (Na-Aescinat, 6-methylprednisolone, alpha-Chymotrase). After the application of Na-Aescinat and 6-methylprednisolone no significant oedema could be measured after 48 h. Using alpha-Chymotrase, there was no measurable influence on the oedema.

Topics: Animals; Chymotrypsin; Edema; Electrocoagulation; Escin; Male; Methylprednisolone; Organ Size; Postoperative Complications; Rats; Urinary Bladder; Urinary Bladder Diseases

Postoperative bleeding was observed in 2 patients for whom alpha-chymotrypsin had been prescribed to prevent haematoma or oedema formation. In vitro experiments with citrated blood added with alpha-chymotrypsin evidenced (thrombelastogram, hirudin tolerance test, euglobulin-lysis time) an action on haemostasis. As compared to blanks, the application of an alpha-chymotrypsin dose which was 100-fold higher than those currently used in therapy resulted in a significant shortening of the r-time (thrombelastogram), delayed blood clotting (hirudin tolerance test) and a shortening of the euglobulin-lysis time. In vivo experiments are needed for further elucidation.

Topics: Chymotrypsin; Edema; Hemorrhage; Hemostasis; Humans; Postoperative Complications

Topics: Administration, Topical; Anti-Inflammatory Agents; Chymotrypsin; Edema; Humans; Ointments; Reflex Sympathetic Dystrophy

The experiments reported here indicate that, when exposed to insulin, viable lymphocytes rapidly released into the incubation medium a factor capable of increasing the dextran-induced anaphylactoid reaction, but having no effect on the inflammatory response evoked by 5-HT. This pro-inflammatory factor was shown to be elaborated by cell suspensions derived from lymph nodes of rats, rabbits, pigs or calves as well as from human tonsils. Thymus cells showed no such activity. The pro-inflammatory factor was termed as anaphylactoid-inflammation-promoting factor (AIPF). Its production depended upon the dose of insulin, and the time of exposure. AIPF was found to have an elution pattern in Sephadex G-100 gels similar to that of BSA (67,000 daltons). The activity was abolished by heat or incubation with DNase or a-chymotrypsin, but was not influenced by RNase. AIPF by itself did not induce increased vascular permeability, and proved to be distinct from the permeability factors present in the lysate of lymph node cells.

Topics: Adrenalectomy; Anaphylaxis; Animals; Capillary Permeability; Cattle; Cell-Free System; Chromatography; Chromatography, Gel; Chymotrypsin; Creatinine; Deoxyribonucleases; Dextrans; Edema; Hindlimb; Insulin; Lymph Nodes; Lymphocytes; Lymphokines; Palatine Tonsil; Rabbits; Rats; Ribonucleases; Serotonin; Species Specificity; Swine; Thymus Gland

Topics: Administration, Oral; Administration, Topical; Animals; Aprotinin; Chymotrypsin; Edema; Glycosaminoglycans; Hindlimb; Injections, Intravenous; Male; Oxyphenbutazone; Phytotherapy; Plants, Medicinal; Rats; Wounds and Injuries

Topics: Chymotrypsin; Edema; Humans; Hyaluronoglucosaminidase; Microbial Collagenase; Microcirculation; Postural Balance; Pronase; Serum Albumin, Bovine; Time Factors; Umbilicus

Topics: Aged; Aqueous Humor; Cataract Extraction; Chymotrypsin; Cornea; Edema; Eye Movements; Glaucoma; Humans; Intraocular Pressure; Lenses; Middle Aged; Pain, Postoperative; Prostheses and Implants; Time Factors; Tonometry, Ocular

Topics: Athletic Injuries; Chymotrypsin; Edema; Hematoma; Humans; Indomethacin; Male; Physical Therapy Modalities; Placebos

Topics: Chymotrypsin; Drainage; Edema; Humans; Hypospadias; Male; Postoperative Care; Postoperative Complications; Urinary Catheterization; Urinary Diversion

Topics: Adult; Anti-Inflammatory Agents; Chymotrypsin; Edema; Female; Fluphenazine; Humans; Indomethacin; Injections, Intramuscular; Male; Pregnancy; Tooth Extraction

Topics: Animals; Anti-Inflammatory Agents; Chymotrypsin; Edema; Methods; Rats

Topics: Adult; Age Factors; Aged; Cataract Extraction; Chymotrypsin; Cornea; Edema; Eye Diseases; Female; Humans; Iris; Macula Lutea; Male; Middle Aged; Postoperative Complications; Prednisone; Retinal Diseases; Syndrome; Vitreous Body

Topics: Animals; Chymotrypsin; Cricetinae; Edema; Hemorrhage; Injections, Intramuscular; Male; Tongue; Wound Healing

Topics: Acetates; Animals; Anti-Inflammatory Agents; Antifungal Agents; Arthritis; Carrageenan; Chymotrypsin; Dextrans; Edema; Fatty Acids; Formaldehyde; Hindlimb; Irritants; Kaolin; Lactones; Male; Mustard Plant; Plants, Medicinal; Rats; Yeasts

Topics: Adult; Chymotrypsin; Edema; Episiotomy; Female; Genital Diseases, Female; Humans; Peptide Hydrolases; Pregnancy; Puerperal Disorders; Thrombophlebitis; Trypsin

Topics: Animals; Anti-Inflammatory Agents; Aprotinin; Chymotrypsin; Corticosterone; Depression, Chemical; Dimethyl Sulfoxide; Disease Models, Animal; Edema; Heparin; Heparinoids; Histamine H1 Antagonists; Humans; Male; Methysergide; Ointments; Phenylbutazone; Rats; Stimulation, Chemical; Tibial Fractures; Time Factors; Wounds and Injuries

Topics: Animals; Biomechanical Phenomena; Chymotrypsin; Edema; Rabbits; Time Factors; Water; Wound Healing; Wounds and Injuries

Topics: Actinomycetales; Animals; Anti-Bacterial Agents; Carrageenan; Chymotrypsin; Edema; Infrared Rays; Male; Protease Inhibitors; Rats; Spectrophotometry; Ultraviolet Rays

Topics: Anti-Inflammatory Agents; Chymotrypsin; Drug Synergism; Edema; Humans; Phenylbutazone; Postoperative Care; Wound Healing; Wounds and Injuries

Topics: Chymotrypsin; Edema; Humans; Maxillary Sinus; Nasal Septum; Postoperative Complications; Tonsillectomy

Topics: Amylases; Carboxypeptidases; Chromatography; Chromatography, Gel; Chymotrypsin; Diarrhea, Infantile; Duodenum; Edema; Endopeptidases; Female; Growth Disorders; Humans; Hypoproteinemia; Infant, Newborn; Intestinal Secretions; Lipase; Metabolism, Inborn Errors; Trypsin

Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Aspirin; Bromelains; Carrageenan; Chymotrypsin; Edema; Enzyme Activation; Female; Flufenamic Acid; Granuloma; Guinea Pigs; Histamine Release; Hot Temperature; Hydrocortisone; Immune Sera; Indomethacin; Injections, Intramuscular; Kaolin; Male; Peptide Hydrolases; Phenylbutazone; Rats; Serotonin; Serratia; Time Factors

Topics: Accidents, Occupational; Adult; Blood Circulation; Capillaries; Chymotrypsin; Edema; Foot; Foot Injuries; Humans; Male; Middle Aged; Vasodilator Agents

Topics: Amylases; Anemia; Body Weight; Carboxypeptidases; Child, Preschool; Chronic Disease; Chymotrypsin; Diet Therapy; Duodenum; Edema; Exocrine Glands; Feces; Female; Growth Disorders; Humans; Hypoproteinemia; Intestinal Secretions; Lipase; Lipid Metabolism, Inborn Errors; Lipids; Metabolism, Inborn Errors; Nitrogen; Pancreas; Pancreatin; Psychomotor Disorders; Trypsin

Topics: Chymotrypsin; Edema; Female; Humans; Male; Trypsin; Varicose Veins; Vascular Diseases

Topics: Acid Phosphatase; Aminocaproates; Animals; Antifibrinolytic Agents; Aprotinin; Carbon Tetrachloride Poisoning; Chymotrypsin; Cyclohexanecarboxylic Acids; Edema; Female; Fibrinolysin; Guinea Pigs; Inflammation; Kallikreins; Microbial Collagenase; Pancreatic Elastase; Peptides; Protease Inhibitors; Rats; Ribonucleases; Trypsin

Topics: Chymotrypsin; Edema; Face; Hematoma; Humans; Rutin; Surgery, Plastic

Topics: Adult; Aged; Carbon Dioxide; Cataract Extraction; Chymotrypsin; Cornea; Cryosurgery; Edema; Humans; Methods; Middle Aged; Postoperative Complications; Sterilization; Vitreous Body

Topics: Aged; Child; Chymotrypsin; Edema; Eye Diseases; Female; Hemorrhage; Humans; Male; Middle Aged

Topics: Adrenalectomy; Animals; Bradykinin; Chymotrypsin; Deoxyribonucleases; Edema; Fibrinolysin; Granuloma; Inflammation; Male; Muramidase; Pancreatin; Peptide Hydrolases; Rats; Serratia; Trypsin

Topics: Chymotrypsin; Edema; Glycosaminoglycans; Humans; Neuraminidase; Postoperative Complications; Surgery, Oral

Topics: Amylases; Chymotrypsin; Edema; Glycosaminoglycans; Humans; Tooth Extraction

Topics: Child; Child, Preschool; Chymotrypsin; Edema; Glycosaminoglycans; Humans; Surgery, Plastic

Topics: Anaphylaxis; Chymotrypsin; Edema; Glycosaminoglycans; Humans; Hydrolases; Injections, Intramuscular

Topics: Adolescent; Adult; Amylases; Chymotrypsin; Edema; Female; Humans; Hydrolases; Male; Middle Aged; Orthopedics; Postoperative Complications; Wounds and Injuries

Topics: Adult; Animals; Burns; Chymotrypsin; Contusions; Edema; Fracture Fixation; Fractures, Bone; Hemarthrosis; Hematoma; Humans; Joint Dislocations; Methocarbamol; Phenylbutazone; Rats; Skin Transplantation; Wound Healing; Wounds and Injuries

Topics: Adult; Chymotrypsin; Edema; Hematoma; Humans; Inflammation; Ligaments; Male; Mandibular Fractures; Trypsin

Topics: Amylases; Carbamoyl-Phosphate Synthase I Deficiency Disease; Carboxypeptidases; Chymotrypsin; Clinical Enzyme Tests; Diagnosis; Diet; Diet Therapy; Edema; Genetics, Medical; Growth; Humans; Hypoproteinemia; Infant; Infant, Newborn; Intestinal Secretions; Lipase; Metabolism; Metabolism, Inborn Errors; Nitrogen; Pancreatic Juice; Proteins; Trypsin; Trypsinogen

Topics: Chymotrypsin; Deoxyribonuclease I; Drug Therapy; Edema; Enzyme Therapy; Hematologic Tests; Humans; Hyaluronoglucosaminidase; Streptodornase and Streptokinase; Streptokinase; Surgery, Oral; Trypsin

Topics: Chymotrypsin; Dermatologic Agents; Diuretics; Drug Therapy; Edema; Extremities; Humans; Neoplasms; Peptide Hydrolases

Topics: Chymotrypsin; Edema; Glycoside Hydrolases; Hematologic Tests; Humans; Surgical Procedures, Operative

Topics: Chymotrypsin; Edema; Episiotomy; Female; Hematologic Tests; Humans; Labor, Obstetric; Lacerations; Pain; Pregnancy; Sutures; Trypsin

Topics: Adult; Aged; Chymotrypsin; Edema; Female; Glycosaminoglycans; Humans; Male; Middle Aged; Postoperative Complications

Topics: Animals; Anti-Inflammatory Agents; Chymotrypsin; Edema; Enzymes; Fibrinolysin; Lymph; Manometry; Rats; Thoracic Duct; Trypsin

Topics: Adolescent; Child; Chymotrypsin; Edema; Glycosaminoglycans; Humans; Orthopedics; Pediatrics; Postoperative Complications

Topics: Chymotrypsin; Edema; Eyelids; Postoperative Complications; Surgery, Plastic

Topics: Chymotrypsin; Edema; Facial Neoplasms; Head and Neck Neoplasms; Humans; Laryngeal Neoplasms; Laryngectomy; Lymph Node Excision; Neoplasms; Postoperative Complications; Radiosurgery

Topics: Chymotrypsin; Edema; Gastroenterostomy; Humans; Japan; Postoperative Complications; Radiography; Statistics as Topic

Topics: Chymotrypsin; Edema; Glucuronidase; Glycoside Hydrolases; Inflammation; Lyases; Pharmacology; Rats; Research

Topics: Adolescent; Child; Chymotrypsin; Ear; Edema; Geriatrics; Humans; Injections, Intramuscular; Laryngitis; Otitis Media; Otolaryngology; Pharyngitis; Sinusitis; Stomatitis

Topics: Chymotrypsin; Drug Combinations; Edema; Hematoma; Humans; Surgical Procedures, Operative; Traumatology; Trypsin; Wounds and Injuries

Topics: Ammonium Compounds; Anti-Bacterial Agents; Anti-Infective Agents, Local; Cataract; Cataract Extraction; Chymotrypsin; Cocaine; Cornea; Corneal Dystrophies, Hereditary; Corneal Ulcer; Drug Hypersensitivity; Drug Therapy; Edema; Epinephrine; Humans; Hypersensitivity; Keratitis; Keratoconjunctivitis; Mercury Compounds; Postoperative Complications; Quaternary Ammonium Compounds; Sutures; Tissue Adhesions; Toxicology

Topics: Chymotrypsin; Edema; Hematologic Tests; Hematoma; Humans; Wounds and Injuries

Topics: Chymotrypsin; Edema; Hematologic Tests; Humans; Specialties, Surgical

Topics: Chymotrypsin; Edema; Face; Humans; Plastic Surgery Procedures; Postoperative Care; Postoperative Period; Rhinoplasty; Surgery, Plastic; Trypsin

Topics: Chymotrypsin; Edema; Face; Hematoma; Humans; Postoperative Care; Surgery, Plastic; Trypsin; Wound Healing

Topics: Chymotrypsin; Edema; Humans; Oral Medicine; Postoperative Period; Surgery, Oral; Trypsin

Topics: Biomedical Research; Chymotrypsin; Edema; Postoperative Complications; Rats; Research; Wound Healing

Topics: Accidents; Accidents, Occupational; Chymotrypsin; Ecchymosis; Edema; Humans; Inflammation; Occupational Medicine; Wounds and Injuries

Topics: Chymotrypsin; Edema; Eyelids; Face; Facial Injuries; Humans; Plastics; Postoperative Complications; Rhinoplasty; Surgery, Plastic; Wound Healing

Topics: Body Weight; Body Weights and Measures; Chymotrypsin; Edema; Egg White; Peptide Hydrolases; Pharmacology; Rats; Research

Topics: Chymotrypsin; Edema; Humans; Inflammation; Postoperative Complications; Rifamycins; Suppuration; Surgical Wound Infection; Thrombophlebitis; Trypsin

Topics: Chymotrypsin; Contusions; Edema; Edetic Acid; Hematologic Tests; Humans; Postoperative Care; Postoperative Period

Topics: Chymotrypsin; Edema; Edetic Acid; Extremities; Musculoskeletal Diseases

Topics: Chymotrypsin; Edema; Edetic Acid; Fractures, Bone; Hematoma; Orthopedic Procedures; Orthopedics; Trypsin

Topics: Chymotrypsin; Dermatologic Agents; Edema; Episiotomy; Female; Humans; Pain; Peptide Hydrolases; Pregnancy

Topics: Chymotrypsin; Edema; Edetic Acid; Hematologic Tests; Hydrolases; Peptide Hydrolases; Wounds and Injuries

Topics: Chymotrypsin; Edema; Hand; Hematologic Tests; Humans; Postoperative Period

Topics: Chymotrypsin; Edema; Humans; Plastic Surgery Procedures; Plastics; Postoperative Period; Surgery, Plastic

Topics: Chymotrypsin; Dermatologic Surgical Procedures; Edema

Topics: Acridines; Chymotrypsin; Edema; Hematologic Tests; Inflammation; Ointments; Trypsin