alpha-chymotrypsin and Duodenal-Ulcer

Topics: Animals; Cattle; Chymotrypsin; Duodenal Ulcer; Enzyme Activation; Gastric Juice; Gastric Mucosa; Glycyrrhiza; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Osmolar Concentration; Papain; Pepsin A; Pepsinogens; Peptic Ulcer; Plants, Medicinal; Pronase; Streptomyces griseus; Succinates; Swine; Temperature; Time Factors; Triterpenes; Trypsin Inhibitors

Topics: Adult; Aged; Breast Neoplasms; Carcinoma; Cholecystitis; Chymotrypsin; Colorimetry; Duodenal Ulcer; Female; Hepatitis; Humans; Intestinal Diseases; Liver Cirrhosis; Lung Diseases; Lung Diseases, Obstructive; Male; Middle Aged; Neoplasm Metastasis; Pancreatitis; Pregnancy; Respiratory Tract Infections; Trypsin Inhibitors

The interrelationships of proteolytic enzymes and amylase have been studied in the duodenal aspirate obtained from subjects with normal and abnormal pancreatic function during stimulation with secretin and pancreozymin. While the relationship of trypsin to chymotrypsin was independent of stimulus and presence of pancreatic disease the ratio of proteolytic enzymes to amylase rose when the degree of stimulation of the pancreas was increased. Patients with recent acute pancreatitis and with chronic pancreatitis tended to have more severe impairment of secretion of proteolytic enzymes than of amylase. In routine tests of pancreatic function both proteolytic and non-proteolytic enzymes should be measured, both because an abnormal ratio may be of diagnostic significance and because the two different groups of enzymes provide mutual checks of the secretory capacity of pancreatic enzymes.

Topics: Amylases; Cholecystokinin; Chymotrypsin; Duodenal Ulcer; Duodenum; Humans; Pancreas; Pancreatic Neoplasms; Pancreatitis; Peptide Hydrolases; Secretin; Trypsin

Topics: Aged; Anti-Bacterial Agents; Chymotrypsin; Duodenal Ulcer; Gastric Juice; Humans; Injections, Intramuscular; Methods; Peptic Ulcer; Stomach Ulcer

This study comprises 39 patients with duodenal ulcer, 113 patients with partial gastrectomy, 9 with total gastrectomy and 6 patients with gastroenterostomy. After ingestion of a standard meal the intestinal contents were collected during 4 subsequent periods of 20 minutes each. The volume, pH, and the concentrations of alpha-amylase, trypsin, chymotrypsin, and lipase in the collections were determined. The pH was not below normal in patients with duodenal ulcer. The results indicated an admixture of salivary to pancreatic amylase in the intestine of patients with gastrojejunostomy, especially by concomitant hypochlorhydria. In all groups of patients, secretions of trypsin and chymotrypsin were closely related. In patients with partial or total gastrectomy, the secretion of lipase was more markedly reduced than the secretion of the other enzymes. The mean concentration of lipase in the efferent loop in Billroth II patients was found to be closely related to the fat absorption. Depending on the enzyme concerned, 10-20 per cent of the patients with duodenal ulcer, and 21-50 per cent of the patients subjected to Billroth II gastrectomy had abnormally low concentrations of enzymes in all collections. In these groups of patients, the mean concentration of the four enzymes was significantly reduced in all collections. In patients exposed to Billroth I gastrectomy, gastroenterostomy, or total gastrectomy, mean concentrations of the enzymes were below normal levels in collection I only.

Topics: Amylases; Chymotrypsin; Digestion; Duodenal Ulcer; Duodenum; Female; Gastrectomy; Gastroenterostomy; Humans; Hydrogen-Ion Concentration; Intestinal Secretions; Lipase; Male; Pancreas; Sex Factors; Trypsin

Topics: Chymotrypsin; Duodenal Ulcer; Enzyme Inhibitors; Fibrinolysis; Gastroenterostomy; Humans; Pancreas; Postoperative Complications; Postoperative Period; Trypsin