alpha-chymotrypsin has been researched along with Central-Nervous-System-Diseases* in 2 studies
2 other study(ies) available for alpha-chymotrypsin and Central-Nervous-System-Diseases
| Article | Year |
|---|---|
Alpha-2-macroglobulin, albumin, and chymotrypsin inhibitory capacity in cerebrospinal fluid as indices of blood-cerebrospinal fluid barrier.
Concentration of alpha-2-macroglobulin, albumin, and chymotrypsin inhibitory capacity representing mainly alpha-1-proteinase inhibitor were estimated in cerebrospinal fluid in disorders of the central nervous system. While chymotrypsin inhibitory capacity was elevated in all cases with derangement of the blood-cerebrospinal fluid barrier, in 30% of the cases alpha-2-macroglobulin levels were in the normal range. The difference can be attributed to the much larger size of the latter. Better correlation between albumin concentration and chymotrypsin inhibitory capacity (r = 0.84) than between albumin and alpha-2-macroglobulin (r = 0.62) supports the view that the rate of entry of proteins from blood into cerebrospinal fluid is inversely related to their size. Topics: Albumins; alpha-Macroglobulins; Blood-Brain Barrier; Central Nervous System Diseases; Chymotrypsin; Encephalitis; Humans; Meningitis | 1986 |
Comparison of methods to identify microglial cells and macrophages in the human central nervous system.
The macrophage markers non-specific esterase, alpha 1-antitrypsin, alpha 1-antichymotrypsin, and lysozyme were compared with conventional microglial and macrophage stains in the human central nervous system. In a series of specimens from cases of head trauma, conventionally fixed and embedded, the modified Weil-Davenport stain was unequivocally best for demonstrating reactive microglia. alpha 1-antichymotrypsin, however, was the most effective for showing macrophages in a series of specimens from patients with other conditions, which included inflammatory, neoplastic, and non-inflammatory diseases. The non-specific esterase reaction was unsatisfactory in tissues fixed in neutral formalin but was successful in fresh frozen tissue. In a series of specimens from cases of multiple sclerosis, non-specific esterase showed demyelination clearly and stained neuronal cytoplasm. It also stained macrophages but was less satisfactory for lipid-bearing phagocytes in multiple sclerosis than oil red 0. Topics: alpha 1-Antichymotrypsin; alpha 1-Antitrypsin; Brain Injuries; Carboxylesterase; Carboxylic Ester Hydrolases; Central Nervous System; Central Nervous System Diseases; Chymotrypsin; Histocytochemistry; Humans; Macrophages; Muramidase; Neuroglia; Palatine Tonsil; Staining and Labeling | 1984 |