alpha-chymotrypsin and Candidiasis

To explore the management of fungal pyelonephritis in infants.. Data from 5 cases with fungal pyelonephritis, including the clinical situation, laboratory examination, feature of imaging, and treatment were analyzed.. All the 5 cases were preterm and low birth weight infants. In 3 cases the disease was unilateral, in 2 cases were bilateral, and acute renal failure occurred. Fungus balls presented on imaging. Urine culture was positive of Candida albicans. Treatment with percutaneous nephrostomy, irrigation and antifungal agent were associated with good prognosis. Only 1 case died. The surviving patients were followed up for 10 - 20 months and the results showed normal growth and development. B-mode ultrasound examination did not show any malformation of the urinary system.. Fungal pyelonephritis was commom in preterm infants. Candida albicans was the major pathogenic microorganism. Percutaneous nephrostomy and drainage were effective in patients with urinary obstruction in relief of obstruction, early diagnosis and control of infection.

Topics: Acute Kidney Injury; Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis; Chymotrypsin; Female; Humans; Infant; Infant, Newborn; Infant, Premature; Male; Nephrostomy, Percutaneous; Pyelonephritis; Treatment Outcome; Ultrasonography, Doppler, Color; Ureteral Obstruction; Urine