Page last updated: 2024-08-21

alpha-aminopyridine and Substance Withdrawal Syndrome

alpha-aminopyridine has been researched along with Substance Withdrawal Syndrome in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's0 (0.00)18.2507
2000's6 (46.15)29.6817
2010's4 (30.77)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clepce, M; Kornhuber, J; Reich, K; Thuerauf, N; Wielopolski, J1
Hennings, JM; Ising, M; Klengel, T; Knop, M; Rosenhagen, MC1
Dong, L; Jiang, Q; Liu, H; Pang, G; Stackman, RW; Tao, X; Wu, X; Zhang, G; Zhang, YM1
Bleich, S; Heberlein, A; Hillemacher, T; Kornhuber, J; Stoessel, C1
Breese, GR; Knapp, DJ; Moy, SS; Overstreet, DH2
Chevrette, J; Harrison, AA; Hoyer, D; Markou, A1
Adrian, R; Koob, GF; Solbrig, MV; Wechsler, SL1
Breese, GR; Knapp, DJ; Overstreet, DH1
Bashore, TM; Evans, JR; Huss, P; Leier, CV; Pacht, K; Unverferth, DV1
Agoston, S; Houwertjes, MC; Ket, JM; Maestrone, E; Uges, DR; van Hezik, EJ1
Harrison, AA; Liem, YT; Markou, A1
Aigner, M; Herrmann, WM; Kern, U1

Trials

2 trial(s) available for alpha-aminopyridine and Substance Withdrawal Syndrome

ArticleYear
Chronic oral amrinone therapy in congestive heart failure: a double-blind placebo-controlled withdrawal study.
    International journal of clinical pharmacology research, 1984, Volume: 4, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aminopyridines; Amrinone; Cardiotonic Agents; Clinical Trials as Topic; Double-Blind Method; Exercise Test; Female; Heart Failure; Humans; Male; Middle Aged; Platelet Count; Substance Withdrawal Syndrome

1984
On the adverse reactions and efficacy of long-term treatment with flupirtine: preliminary results of an ongoing twelve-month study with 200 patients suffering from chronic pain states in arthrosis or arthritis.
    Postgraduate medical journal, 1987, Volume: 63 Suppl 3

    Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Arthritis, Rheumatoid; Chronic Disease; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Long-Term Care; Male; Middle Aged; Palliative Care; Substance Withdrawal Syndrome; Substance-Related Disorders

1987

Other Studies

11 other study(ies) available for alpha-aminopyridine and Substance Withdrawal Syndrome

ArticleYear
Long-term use of flupirtine leads to withdrawal symptoms and is associated with dependency.
    Pharmacopsychiatry, 2013, Volume: 46, Issue:7

    Topics: Adult; Aminopyridines; Analgesics; Butyrophenones; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders

2013
Hypothalamic-pituitary-adrenocortical axis activity as a potential predictor for withdrawal symptoms in addiction to flupirtine, a nonopiate analgesic.
    Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:6

    Topics: Aminopyridines; Analgesics; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Pituitary-Adrenal System; Predictive Value of Tests; Substance Withdrawal Syndrome

2014
Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
    Neuropharmacology, 2016, Volume: 101

    Topics: Aminopyridines; Analgesics, Opioid; Animals; Benzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Reaction Time; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Substance Withdrawal Syndrome; Time Factors

2016
Positive reinforcing effects of flupirtine--two case reports.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, Aug-16, Volume: 34, Issue:6

    Topics: Adult; Aminopyridines; Analgesics; Humans; Low Back Pain; Male; Middle Aged; Pleasure; Substance Withdrawal Syndrome

2010
A 5-HT1A agonist and a 5-HT2c antagonist reduce social interaction deficit induced by multiple ethanol withdrawals in rats.
    Psychopharmacology, 2003, Volume: 167, Issue:4

    Topics: Aminopyridines; Animals; Anxiety; Buspirone; Dose-Response Relationship, Drug; Ethanol; Ethylamines; Indoles; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Substance Withdrawal Syndrome

2003
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats.
    Alcohol (Fayetteville, N.Y.), 2004, Volume: 32, Issue:2

    Topics: Alcohol Drinking; Aminopyridines; Animals; Anxiety; Ethanol; Flumazenil; Indoles; Male; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2004
Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats.
    Psychopharmacology, 2005, Volume: 178, Issue:2-3

    Topics: Affective Symptoms; Aminopyridines; Amphetamine; Animals; Brain; Drug Synergism; Hypothalamus, Posterior; Male; Motivation; Norepinephrine; Paroxetine; Piperazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors; Self Stimulation; Serotonin 5-HT1 Receptor Antagonists; Substance Withdrawal Syndrome

2005
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
    European journal of pharmacology, 2007, Jan-19, Volume: 555, Issue:1

    Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Borna Disease; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Male; Naloxone; Naltrexone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome

2007
Drug challenges reveal differences in mediation of stress facilitation of voluntary alcohol drinking and withdrawal-induced anxiety in alcohol-preferring P rats.
    Alcoholism, clinical and experimental research, 2007, Volume: 31, Issue:9

    Topics: Alcohol Drinking; Aminopyridines; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Buspirone; Dopamine Antagonists; Ethanol; Flumazenil; GABA Modulators; Haloperidol; Indoles; Naloxone; Narcotic Antagonists; Olanzapine; Rats; Rats, Inbred Strains; Restraint, Physical; Serotonin Receptor Agonists; Stress, Physiological; Substance Withdrawal Syndrome

2007
Effective treatment of verapamil intoxication with 4-aminopyridine in the cat.
    The Journal of clinical investigation, 1984, Volume: 73, Issue:5

    Topics: 4-Aminopyridine; Aminopyridines; Animals; Antidotes; Blood Pressure; Cats; Heart Rate; Humans; Substance Withdrawal Syndrome; Verapamil

1984
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:1

    Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; Disease Models, Animal; Drug Combinations; Electric Stimulation; Fluoxetine; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder

2001