Page last updated: 2024-08-21

alpha-aminopyridine and Seizures

alpha-aminopyridine has been researched along with Seizures in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (57.14)	18.7374
1990's	2 (7.14)	18.2507
2000's	4 (14.29)	29.6817
2010's	3 (10.71)	24.3611
2020's	3 (10.71)	2.80

Authors

Authors	Studies
Tulsawani, R; Vohora, D; Vyas, P	1
Medina-Ceja, L; Nuñez-Ibarra, BH; Ventura-Mejía, C	1
Busquet, N; Diaz, MJ; Gonzalez, MI; Lam, PM; Laoprasert, M; Raol, YH; Sampath, D; White, AM	1
Raol, YH; Sampath, D; Valdez, R; White, AM	1
Bennet, L; Davidson, JO; Drury, PP; Gunn, AJ; Ji, H; Mathai, S; Silverman, RB; Tan, S; van den Heuij, LG	1
Raol, YH; Sampath, D; Shmueli, D; White, AM	1
Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH	1
Dixit, T; Kadaba, PK	1
Egert, M; Gommert, LR; Hoffmann, O	1
Adrian, R; Koob, GF; Solbrig, MV; Wechsler, SL	1
Aleman, V; de Muñoz, DM	1
Joó, F; Mihály, A; Szente, M	1
Fehér, O; Gyuris, T; Szente, M	1
Lamiable, D; Lechat, P; Lemeignan, M; Millart, H; Molgo, J	1
Mihály, A	1
Arzate, ME; Pasantes-Morales, H	1
Pongrácz, F; Szente, M	1
Boda, B; Szente, M	2
Baranyi, A; Fehér, O	1
Conner, CS; Hooper, RG; Rumack, BH	1
Bidard, JN; Gandolfo, G; Gottesmann, C; Lazdunski, M	1
Lobbestael, SJ; Pavia, MR; Taylor, CP	1
Arzate, ME; Huxtable, RJ; Pasantes-Morales, H; Quesada, O	1
Kaji, R; Sumner, AJ	1
Joó, F; Mihály, A; Szente, M; Tóth, G	1
Albus, H; Voskuyl, RA	1
Baranyi, A; Szente, M	1

Reviews

2 review(s) available for alpha-aminopyridine and Seizures

Article	Year
An update of 4‑aminopyride as a useful model of generalized seizures for testing antiseizure drugs: in vitro and in vivo studies. Acta neurobiologiae experimentalis, 2023, Volume: 83, Issue:1 Topics: Aminopyridines; Glutamic Acid; Hippocampus; Humans; Neurons; Neurotransmitter Agents; Potassium Channels; Seizures	2023
Aminoalkylpyridines (AAPs), triazoline metabolite analogues, as anticonvulsants highly effective in the MES test. Current medicinal chemistry, 2003, Volume: 10, Issue:20 Topics: Aminopyridines; Animals; Anticonvulsants; Brain Ischemia; Humans; Receptors, sigma; Seizures; Sigma-1 Receptor; Structure-Activity Relationship	2003

Other Studies

26 other study(ies) available for alpha-aminopyridine and Seizures

Article	Year
Dual Targeting by Inhibition of Phosphoinositide-3-Kinase and Mammalian Target of Rapamycin Attenuates the Neuroinflammatory Responses in Murine Hippocampal Cells and Seizures in C57BL/6 Mice. Frontiers in immunology, 2021, Volume: 12 Topics: Aminopyridines; Animals; Apoptosis; Cell Line; Cytokines; Hippocampus; Imidazoles; Immunosuppressive Agents; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Morpholines; Neuroinflammatory Diseases; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Seizures; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2021
Effects of a potassium channel opener on brain injury and neurologic outcomes in an animal model of neonatal hypoxic-ischemic injury. Pediatric research, 2020, Volume: 88, Issue:2 Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Injuries; Carotid Arteries; Cognition; Disease Models, Animal; Hand Strength; Hypoxia; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Skills; Nervous System Diseases; Neuroprotection; Neuroprotective Agents; Potassium Channels; Quality of Life; Rats; Seizures	2020
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy. Neuropharmacology, 2017, Sep-01, Volume: 123 Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease Progression; Electrocorticography; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Phenobarbital; Random Allocation; Rats, Sprague-Dawley; Seizures; Time Factors	2017
nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep. Neuropharmacology, 2014, Volume: 83 Topics: Aminopyridines; Animals; Asphyxia; Corpus Striatum; Enzyme Inhibitors; Female; Fetal Hypoxia; Fetus; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Phenotype; Pregnancy; Premature Birth; Seizures; Sheep	2014
Flupirtine effectively prevents development of acute neonatal seizures in an animal model of global hypoxia. Neuroscience letters, 2015, Oct-21, Volume: 607 Topics: Acute Disease; Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Female; Hypoxia; KCNQ Potassium Channels; Male; Rats, Sprague-Dawley; Seizures	2015
A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Annals of neurology, 2009, Volume: 65, Issue:3 Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors	2009
Paradoxical cerebral cortical hyperexcitability following flupirtine overdose. Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:6 Topics: Adult; Aminopyridines; Analgesics; Anticonvulsants; Benzodiazepines; Cerebral Cortex; Electroencephalography; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Phenytoin; Potassium Channels, Inwardly Rectifying; Seizures	2004
Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. European journal of pharmacology, 2007, Jan-19, Volume: 555, Issue:1 Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Borna Disease; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Male; Naloxone; Naltrexone; Narcotic Antagonists; Potassium; Rats; Rats, Inbred Lew; Receptors, Opioid, delta; Seizures; Substance Withdrawal Syndrome	2007
Effect of different convulsant drugs on some seizure parameters in morphine-dependent mice. Experimental neurology, 1983, Volume: 80, Issue:2 Topics: 3-Mercaptopropionic Acid; 4-Aminopyridine; Aminopyridines; Animals; Bicuculline; Brain; Convulsants; Humans; Mice; Morphine Dependence; Pentylenetetrazole; Receptors, Opioid; Seizures; Strychnine	1983
Neuropathological alterations in the neocortex of rats subjected to focal aminopyridine seizures. Acta neuropathologica, 1983, Volume: 61, Issue:2 Topics: Aminopyridines; Animals; Astrocytes; Cerebral Cortex; Epilepsies, Partial; Microscopy, Electron; Neuroglia; Neurons; Rats; Seizures; Synaptic Vesicles	1983
The effects of aminopyridines on the cortical evoked potentials. Acta physiologica Hungarica, 1984, Volume: 63, Issue:3-4 Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Cats; Cerebral Cortex; Evoked Potentials, Somatosensory; Female; Male; Seizures	1984
Evaluation of 4-aminopyridine and 3,4-diaminopyridine penetrability into cerebrospinal fluid in anesthetized rats. Brain research, 1984, Jun-18, Volume: 304, Issue:1 Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Injections, Intravenous; Injections, Intraventricular; Male; Rats; Rats, Inbred Strains; Seizures	1984
Early ultrastructural changes in the cerebral cortex of albino rats subjected to 3-aminopyridine seizures. Experientia, 1981, Volume: 37, Issue:8 Topics: Aminopyridines; Animals; Astrocytes; Cerebral Cortex; Convulsants; Dendrites; Female; Male; Microscopy, Electron; Pyramidal Tracts; Rats; Seizures; Synapses	1981
Effect of taurine on seizures induced by 4-aminopyridine. Journal of neuroscience research, 1981, Volume: 6, Issue:4 Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mice; Seizures; Synaptosomes; Taurine	1981
Aminopyridine--induced seizure activity. Monographs in neural sciences, 1980, Volume: 5 Topics: Aminopyridines; Animals; Calcium; Cats; Cerebellum; Electroencephalography; Penicillins; Potassium; Seizures	1980
Nitric oxide synthase inhibitor facilitates focal seizures induced by aminopyridine in rat. Neuroscience letters, 1996, May-03, Volume: 209, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Aminopyridines; Animals; Arginine; Cerebral Ventricles; Drug Synergism; Enzyme Inhibitors; Epilepsies, Partial; Functional Laterality; Injections, Intraventricular; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures	1996
Nitric oxide synthase inhibitor facilitates aminopyridine induced neocortical seizure. Neurobiology (Budapest, Hungary), 1996, Volume: 4, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Aminopyridines; Animals; Cerebral Cortex; Electroencephalography; Nitric Oxide Synthase; Nitroarginine; Rats; Seizures	1996
Convulsive effects of 3-aminopyridine on cortical neurones. Electroencephalography and clinical neurophysiology, 1979, Volume: 47, Issue:6 Topics: Administration, Topical; Aminopyridines; Animals; Cats; Electroencephalography; Evoked Potentials; Injections, Intravenous; Membrane Potentials; Motor Cortex; Seizures; Time Factors	1979
Acute poisoning from over-the-counter sleep preparations. JACEP, 1979, Volume: 8, Issue:3 Topics: Adolescent; Adult; Aminopyridines; Arrhythmias, Cardiac; Child; Child, Preschool; Coma; Hallucinations; Humans; Hypertension; Infant; Methapyrilene; Nonprescription Drugs; Physostigmine; Retrospective Studies; Salicylamides; Scopolamine; Seizures	1979
Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures. Brain research, 1989, Aug-21, Volume: 495, Issue:1 Topics: 4-Aminopyridine; Aminopyridines; Animals; Elapid Venoms; Injections, Intraventricular; Male; Neurotoxins; Peptides; Potassium Channels; Rats; Rats, Inbred Strains; Seizures	1989
6-Alkyl-N,N-disubstituted-2-pyridinamines as anticonvulsant agents. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Aminopyridines; Animals; Ataxia; Blepharoptosis; Chemical Phenomena; Chemistry; Electroshock; Kindling, Neurologic; Male; Mice; Molecular Structure; Motor Activity; Rats; Seizures; Structure-Activity Relationship	1989
Higher susceptibility of taurine-deficient rats to seizures induced by 4-aminopyridine. Neuropharmacology, 1987, Volume: 26, Issue:12 Topics: 4-Aminopyridine; Aminopyridines; Animals; Cerebral Cortex; Rats; Seizures; Taurine	1987
Effects of 4-aminopyridine in experimental CNS demyelination. Neurology, 1988, Volume: 38, Issue:12 Topics: 4-Aminopyridine; Aminopyridines; Animals; Central Nervous System Diseases; Demyelinating Diseases; Dose-Response Relationship, Drug; Electric Stimulation; Male; Neural Conduction; Rats; Rats, Inbred Strains; Seizures	1988
Neocortical cytopathology in focal aminopyridine seizures as related to the intracortical diffusion of [3H] 4-aminopyridine. Electrophysiologic and light-microscopic studies. Acta neuropathologica, 1985, Volume: 66, Issue:2 Topics: 4-Aminopyridine; Aminopyridines; Animals; Autoradiography; Blood-Brain Barrier; Capillary Permeability; Cats; Cerebral Cortex; Diffusion; Electroencephalography; Electrophysiology; Histocytochemistry; Immunochemistry; Rats; Rats, Inbred Strains; Seizures; Tritium	1985
Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridine. Brain research, 1985, Sep-02, Volume: 342, Issue:1 Topics: 4-Aminopyridine; Aminopyridines; Animals; Female; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Seizures	1985
Mechanism of aminopyridine-induced ictal seizure activity in the cat neocortex. Brain research, 1987, Jun-16, Volume: 413, Issue:2 Topics: Action Potentials; Aminopyridines; Animals; Cats; Membrane Potentials; Motor Cortex; Seizures	1987