alpha-aminopyridine has been researched along with Obesity in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bentham, RB; Bianchi, K; Carter, E; Dalli, J; Godinho, SA; Grose, R; Hodivala-Dilke, K; Holdsworth, J; Ironside, A; Jones, L; Jones, W; Mataloni, I; Moreno Béjar, R; Szabadkai, G; Uhlik, L; Wilcz-Villega, E; Xu, R | 1 |
| Ameye, L; Awada, A; Azambuja, E; Brandão, M; Caparica, R; De Angelis, C; Desmedt, C; Di Cosimo, S; Eiger, D; Franzoi, MA; Kotecki, N; Lambertini, M; Piccart, M; Ponde, N | 1 |
| Xiao, J; Xu, W; Zhang, J | 1 |
| Shen, Q; Zhang, G | 1 |
| Ahmadian, M; Ajluni, N; Butz, L; Chenevert, TL; Downes, M; Evans, RM; Gomez, AV; Hench, R; Horowitz, JF; Jain, M; Korytnaya, E; Lehmann, K; Liddle, C; Meral, R; Neidert, AH; Oral, EA; Poirier, B; Reilly, SM; Rus, D; Saltiel, AR; Yu, R; Zhao, P | 1 |
| Ding, H; Dong, L; He, X; Li, N; Liu, B; Liu, Y | 1 |
| Arner, EN; Brekken, RA; Cruz, VH; Scherer, PE; Wynne, KW | 1 |
| Chua, S; Iqbal, NJ; Liu, SM; Lu, Z; Schwartz, GJ; Zhu, L | 1 |
| Adams, SE; Brooks, AES; Jaiswal, JK; Jamieson, SMF; Masson, SW; Merry, TL; Shepherd, PR | 1 |
| Calay, ES; Hotamisligil, GS | 1 |
| Chang, L; Chiang, SH; Leto, D; Mowers, J; Reilly, SM; Saltiel, AR; Simon, J; Uhm, M | 1 |
| Alford, T; Anderson, DA; Baer, BR; Bandyopadhyay, G; Chicarelli, MJ; Conn, M; Coward, P; Dewolf, WE; Lagakos, W; Li, P; Lu, M; McVean, M; Véniant, MM; Williams, L | 1 |
| Janez, A; Jensterle, M; Kocjan, T | 1 |
| Janez, A; Jensterle, M; Kocjan, T; Salamun, V; Vrtacnik Bokal, E | 1 |
| Han, H; Lee, JH; Park, HJ; Park, JW; Park, KH; Park, YH; Sim, da W | 1 |
| Black, SC; Briscoe, CP; Chen, P; Cho, H; Fraser, J; Kelly-Sullivan, D; Looper, D; McDonnell, SR; Ogilvie, KM; Shi, M; Siegel, K; Timofeevski, S; Yie, J; Yu, XH | 1 |
| Corkey, B; Farb, MG; Gokce, N; Johnston-Cox, H; Koupenova, M; LeBrasseur, N; Ravid, K; Yang, D | 1 |
| Chang, L; Chiang, SH; Decker, SJ; Downes, M; Evans, RM; Hochberg, I; Larsen, MJ; Li, P; Liddle, C; Mowers, J; Oh, D; Olefsky, JM; Reilly, SM; Rubin, JR; Saltiel, AR; Uhm, M; White, NM; Yu, RT | 1 |
| Hayashi, A; Kimura, Y; Miyata, K; Sasamata, M; Sonoda, R; Suzuki, M; Takasu, T | 1 |
| Al-Shamma, H; Behan, D; Chalmers, D; Chen, W; Espitia, S; Grottick, AJ; Martin, M; Menzaghi, F; Morgan, M; Reyes-Saldana, H; Smith, B; Thomsen, WJ; Whelan, K; Yuskin, D | 1 |
4 trial(s) available for alpha-aminopyridine and Obesity
| Article | Year |
|---|---|
Clinical Implications of Body Mass Index in Metastatic Breast Cancer Patients Treated With Abemaciclib and Endocrine Therapy.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Benzimidazoles; Body Mass Index; Breast Neoplasms; Confidence Intervals; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Female; Fulvestrant; Humans; Middle Aged; Neutropenia; Obesity; Odds Ratio; Overweight; Placebos; Progression-Free Survival; Thinness; Weight Loss | 2021 |
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Topics: Aged; Aminopyridines; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Energy Metabolism; Female; Glycated Hemoglobin; Humans; I-kappa B Kinase; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2017 |
Phosphodiesterase 4 inhibition as a potential new therapeutic target in obese women with polycystic ovary syndrome.
Topics: Adult; Aminopyridines; Benzamides; Body Weight; Cyclopropanes; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Insulin; Menstrual Cycle; Metformin; Molecular Targeted Therapy; Obesity; Phosphodiesterase 4 Inhibitors; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Testosterone | 2014 |
Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study.
Topics: Adult; Aminopyridines; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Female; Glucagon-Like Peptide-1 Receptor; Humans; Liraglutide; Metformin; Obesity; Phosphodiesterase 4 Inhibitors; Polycystic Ovary Syndrome; Weight Loss | 2015 |
16 other study(ies) available for alpha-aminopyridine and Obesity
| Article | Year |
|---|---|
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
Topics: Aminopyridines; Animals; Breast Neoplasms; Culture Media, Conditioned; Epithelial Cells; Female; Humans; I-kappa B Kinase; Inflammation; Macrophages; Mammary Glands, Human; Mice; Obesity; Protein Serine-Threonine Kinases; Serine | 2020 |
Roflumilast Suppresses Adipogenic Differentiation
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Aminopyridines; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Benzamides; Cell Differentiation; Cyclopropanes; Diet, High-Fat; Gene Expression Regulation, Enzymologic; Lipolysis; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphodiesterase 4 Inhibitors | 2021 |
Depletion of microglia mitigates cerebrovascular dysfunction in diet-induced obesity mice.
Topics: Aminopyridines; Animals; Basilar Artery; Cerebrovascular Disorders; Encephalitis; Male; Mice, Inbred C57BL; Microglia; Obesity; Pyrroles | 2021 |
Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast.
Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Dietary Fats; Female; Gene Expression; Interleukin-1beta; Interleukin-6; Muscle, Smooth; NF-kappa B; Obesity; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Urinary Bladder; Urinary Bladder, Overactive; Urodynamics | 2017 |
Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.
Topics: Aminopyridines; Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty Liver; I-kappa B Kinase; Insulin; Insulin Resistance; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Weight Loss | 2018 |
Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity.
Topics: Aminopyridines; Animals; Benzimidazoles; Cyclin-Dependent Kinase 4; Diet, High-Fat; Disease Models, Animal; Drug Approval; Energy Metabolism; Hypothalamus; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Retinoblastoma Protein; United States; United States Food and Drug Administration | 2018 |
The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice.
Topics: Adipose Tissue; Aminopyridines; Animals; Diet, High-Fat; Glucose; Homeostasis; Insulin Resistance; Macrophages; Mice; Obesity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2020 |
Turning off the inflammatory, but not the metabolic, flames.
Topics: Aminopyridines; Animals; Anti-Obesity Agents; Energy Metabolism; I-kappa B Kinase; Insulin Resistance; Male; Obesity; Protein Serine-Threonine Kinases | 2013 |
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; Adrenergic beta-3 Receptor Agonists; Aminopyridines; Animals; Catecholamines; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dioxoles; Disease Models, Animal; Energy Metabolism; Enzyme Activation; HEK293 Cells; Humans; I-kappa B Kinase; Inflammation; Ion Channels; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Phosphorylation; Poly I-C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Sterol Esterase; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Uncoupling Protein 1 | 2013 |
Characterization of a novel glucokinase activator in rat and mouse models.
Topics: Aminopyridines; Animals; Area Under Curve; Blood Glucose; Catalysis; Diabetes Mellitus, Experimental; Enzyme Activators; Glucokinase; Glucose; Glucose Tolerance Test; Hepatocytes; Homeostasis; Insulin; Insulin Secretion; Insulin-Secreting Cells; Kinetics; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Rats; Rats, Sprague-Dawley; Thiadiazoles | 2014 |
Roflumilast Ameliorates Airway Hyperresponsiveness Caused by Diet-Induced Obesity in a Murine Model.
Topics: Adiponectin; Aminopyridines; Animals; Benzamides; Cell Proliferation; Cyclopropanes; Cytokines; Diet; Disease Models, Animal; Leptin; Mice, Inbred C57BL; Models, Biological; Obesity; Ovalbumin; Pulmonary Fibrosis; Reactive Oxygen Species; Respiratory Hypersensitivity; T-Lymphocytes | 2016 |
Pharmacological characterization of a small molecule inhibitor of c-Jun kinase.
Topics: 3T3-L1 Cells; Adipose Tissue, White; Aminopyridines; Animals; Blood Glucose; Body Weight; Cytokines; Dietary Fats; Eating; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 8; Obesity; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Tumor Necrosis Factor-alpha; U937 Cells | 2008 |
The A2b adenosine receptor modulates glucose homeostasis and obesity.
Topics: Adenosine A2 Receptor Agonists; Adult; Aminopyridines; Animals; Cholesterol; Diabetes Mellitus, Type 2; Dietary Fats; Female; Gene Expression Regulation; Glucose; Homeostasis; Humans; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Male; Mice; Mice, Knockout; Middle Aged; Obesity; Receptor, Adenosine A2B; Sterol Regulatory Element Binding Protein 1 | 2012 |
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.
Topics: Aminopyridines; Animals; Anti-Allergic Agents; Anti-Obesity Agents; Cell Line; Diet, High-Fat; Energy Metabolism; Enzyme Activation; Fatty Liver; Glucose Metabolism Disorders; I-kappa B Kinase; Insulin Resistance; Intra-Abdominal Fat; Male; Mice; Mice, Inbred C57BL; Mice, Obese; NF-kappa B; Obesity; Oxygen Consumption; Protein Serine-Threonine Kinases; Weight Loss | 2013 |
Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats.
Topics: Aminopyridines; Animals; Anti-Obesity Agents; Blood Glucose; Body Temperature; Body Weight; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Eating; Energy Intake; Indazoles; Indoles; Insulin; Lipids; Male; Obesity; Rats; Rats, Zucker; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists; Time Factors; Weight Gain | 2004 |
Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.
Topics: Aminopyridines; Animals; Behavior, Animal; Benzazepines; Body Weight; Brain; Cell Line; Dopamine; Eating; Fluorobenzenes; Humans; Indoles; Male; Norepinephrine; Obesity; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Recombinant Proteins; Serotonin; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Transfection | 2008 |