Compounds > alpha-aminopyridine
Page last updated: 2024-08-21

alpha-aminopyridine and Liver Neoplasms

alpha-aminopyridine has been researched along with Liver Neoplasms in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199011 (26.83)18.7374
1990's1 (2.44)18.2507
2000's1 (2.44)29.6817
2010's18 (43.90)24.3611
2020's10 (24.39)2.80

Authors

AuthorsStudies
Gu, J; Jiang, S; Shen, Z; Zhou, D1
Fang, JC; Liu, J; Zhong, L1
Chow, EK; Hooi, L; Lim, JJ; Rashid, MBMA; Toh, TB1
Cong, L; Dong, J; Ke, M; Li, Y; Lv, Y; Wang, X; Zhang, Z; Zhao, S; Zhu, Y1
Cheng, W; Fang, S; Gong, YF; Guan, XY; Hu, L; Jiang, LX; Kong, FE; Li, HL; Li, L; Li, MM; Li, Y; Lin, G; Liu, M; Loong, JH; Ma, NF; Ma, S; Mo, JQ; Nam, Y; Ouyang, Q; Sun, Y; Tang, YQ; Wang, JG; Yan, Q; Yang, XD; Yuan, YF; Zhang, Y1
Gao, J; Jiang, X; Liu, F; Qian, Y; Wang, Y; Wu, X1
Huynh, H; Le, TBU; Prawira, A; Vu, TC1
Decaens, T; Lerat, H; Macek Jílková, Z; Marche, PN; Mroweh, M; Roth, G1
Chen, X; Duan, Y; Huang, H; Jiang, Y; Jin, Z; Li, C; Wang, Q; Wu, D; Xu, T; Zhu, Q1
Ajioka, I; Harada, K; Horike, SI; Inoue, H; Kitajima, S; Kohno, S; Kumar, S; Linn, P; Matsuda, F; Nagatani, N; Okada, N; Okahashi, N; Sheng, J; Shimizu, H; Takahashi, C; Teranishi, K; Yamamura, M; Yano, S1
He, X; Ji, X; Jiang, C; Shen, Z; Yin, L; Zhou, H; Zhu, X1
Feng, S; Huang, H; Ling, Q; Rui, T; Sun, J; Tu, Z; Zhang, C; Zhang, X; Zheng, S1
Alisi, A; Artuso, S; Balsano, C; Carcarino, E; Ceccarelli, S; Chierici, M; Crudele, A; D'Oria, V; De Stefanis, C; Ferrari, K; Furlanello, C; Giorda, E; Gnani, D; Leonetti, C; Locatelli, F; Miele, L; Nobili, V; Panera, N; Pasini, D; Porru, M; Romito, I; Rota, R; Villa, E1
Ao, JY; Cai, H; Chai, ZT; Kong, LQ; Ma, DN; Sun, HC; Ye, BG; Zhang, KZ; Zhang, N; Zhang, YY; Zhu, XD1
Arteaga, CL; Blackwell, KL; Burris, HA; Cameron, DA; Campone, M; Conte, P; Elmeliegy, M; Germa, C; Hortobagyi, GN; Janni, W; Miller, M; Mondal, S; O'Shaughnessy, J; Paluch-Shimon, S; Petrakova, K; Sonke, GS; Stemmer, SM; Su, F; Verma, S; Winer, EP; Yap, YS1
Fang, D; Hou, JZ; Li, W; Liang, C; Niu, J; Sun, H; Wang, X; Xi, ZQ; Xie, SQ1
Dong, QZ; Gao, XM; Hsu, JL; Hung, MC; Jia, HL; Li, CW; Li, JH; Lim, SO; Lu, L; Luo, Q; Qin, LX; Sheng, YY; Xu, D; Yang, J; Zhang, Y; Zhang, Z; Zhao, Y; Zheng, Y; Zhu, Y1
Cheng, Y; Cristofanilli, M; Cui, S; Feng, J; Gao, J; Geng, C; Gu, K; Hu, X; Jiang, Z; Li, W; Liu, T; Lu, X; Ning, Z; Ouyang, Q; Ouyang, T; Pan, Y; Sun, T; Sun, Y; Tong, Z; Wang, H; Wang, S; Wang, X; Yin, Y; Zhang, Q1
De Toni, EN; Denk, G; Gerbes, AL; Hohenester, S; Itzel, T; Mayerle, J; Munker, S; Ofner, A; Reiter, FP; Schiergens, TS; Spampatti, M; Teufel, A; Wimmer, R; Ye, L; Ziesch, A1
Coleman, N; Popat, S; Wotherspoon, A; Yousaf, N1
Higo, H; Hotta, K; Ichihara, E; Kano, H; Kayatani, H; Kiura, K; Kubo, T; Maeda, Y; Makimoto, G; Matsubara, T; Ninomiya, K; Ninomiya, T; Nishii, K; Ohashi, K; Rai, K; Sato, A; Tabata, M; Takata, M; Tomida, S; Toyooka, S; Watanabe, H1
de Gramont, A; Dos Santos, C; Faivre, S; Raymond, E; Riveiro, ME; Serova, M; Slimane, K; Tijeras-Raballand, A1
Boukouris, AE; Buitrago-Molina, LE; Hegermann, J; Kirstein, MM; Kühnel, F; Manns, MP; Marhenke, S; Orlik, J; Pothiraju, D; Schütt, J; Vogel, A1
Huang, YH; Lin, HC1
Cheng, AL; Cheng, JC; Gao, M; Hsu, FM; Liu, WL; Tsai, CL; Tzen, KY1
Dou, H; Feng, K; Jiang, X; Li, Z; Wang, T; Zhang, Y; Zhou, F1
Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN1
Bergqvist, S; Brooun, A; Burke, BJ; Dardaei, L; Deng, YL; Engelman, JA; Frias, RL; Friboulet, L; Gainor, JF; Getz, G; Iafrate, AJ; James, LP; Johnson, TW; Katayama, R; Le, L; Leshchiner, I; Liu, W; Logan, J; McTigue, M; Schultz, KR; Shaw, AT; Smeal, T; Timofeevski, S1
Fu, M; Guo, Y; Liang, X; Lin, C; Qian, H; Wang, H; Wang, R; Zhang, X1
Gao, CX; Hayashi, N; Honke, K; Hori, M; Ihara, H; Kasahara, A; Miyoshi, E; Nakahara, S; Noda, K; Sasaki, Y; Taniguchi, N; Yanagidani, S1
Altmannsberger, M; Fischer, G; Katz, N; Schauer, A1
Casciano, DA; Schol, HM1
Lijinsky, W1
Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM1
Furuya, K; Williams, GM1
Brennan, LM; Creasia, DA1
Lijinsky, W; Reznik-Schüller, HM1
Kovatch, RM; Lijinsky, W1
Katyal, SL; Perera, MI; Shinozuka, H1
Kammerer, RC; Kloc, K; Lampe, MA; Schmitz, DA1
Eisenbrand, G; Habs, M; Shubik, P1

Reviews

2 review(s) available for alpha-aminopyridine and Liver Neoplasms

ArticleYear
Effective treatment with programmed cell death protein-1 antibody, chidamide and conventional chemotherapy for hepatosplenic γδ T-cell lymphoma: A case report and literature review.
    Journal of digestive diseases, 2022, Volume: 23, Issue:1

    Topics: Aminopyridines; Apoptosis Regulatory Proteins; Benzamides; Humans; Liver Neoplasms; Lymphoma, T-Cell; Receptors, Antigen, T-Cell, gamma-delta

2022
Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment.
    International journal of molecular sciences, 2021, Feb-11, Volume: 22, Issue:4

    Topics: Aminopyridines; Carcinoma, Hepatocellular; Drug Delivery Systems; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Liver Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Tumor Microenvironment

2021

Trials

3 trial(s) available for alpha-aminopyridine and Liver Neoplasms

ArticleYear
Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 07-01, Volume: 29, Issue:7

    Topics: Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Follow-Up Studies; Humans; Letrozole; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Neoplasm Recurrence, Local; Prognosis; Purines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Rate

2018
Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial.
    The Lancet. Oncology, 2019, Volume: 20, Issue:6

    Topics: Aminopyridines; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Neoplasms; Breast Neoplasms; Double-Blind Method; Female; Follow-Up Studies; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Salvage Therapy; Survival Rate; Treatment Outcome

2019
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.
    The New England journal of medicine, 2016, Jan-07, Volume: 374, Issue:1

    Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Binding Sites; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; Female; Humans; Lactams; Lactams, Macrocyclic; Liver Failure; Liver Neoplasms; Lung Neoplasms; Middle Aged; Molecular Structure; Mutation; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones

2016

Other Studies

36 other study(ies) available for alpha-aminopyridine and Liver Neoplasms

ArticleYear
Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface beta-1,4-galactosyltransferase.
    The Biochemical journal, 1996, Dec-01, Volume: 320 ( Pt 2)

    Topics: Aminopyridines; Carbohydrate Conformation; Carbohydrate Sequence; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Humans; Kinetics; Liver Neoplasms; Molecular Sequence Data; N-Acetyllactosamine Synthase; Oligosaccharides; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured

1996
Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinoma.
    Journal of hepatology, 2020, Volume: 72, Issue:1

    Topics: Aminopyridines; Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Dimethyl Sulfoxide; Female; Humans; Hyaluronan Receptors; Janus Kinases; Liver Neoplasms; Male; Mice; Mice, Transgenic; Neoplastic Stem Cells; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Signal Transduction; STAT Transcription Factors; Sulfonamides; Transfection; Transplantation, Homologous; Tumor Burden

2020
MicroRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120

    Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasms, Experimental; Pyrroles; Signal Transduction

2019
A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 03-17, Volume: 117, Issue:11

    Topics: Aminopyridines; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cohort Studies; Disease-Free Survival; E2F1 Transcription Factor; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Hepatectomy; Hepatocytes; Human Embryonic Stem Cells; Humans; Hydroxyquinolines; Isoquinolines; Kaplan-Meier Estimate; Liver; Liver Neoplasms; Male; Mice; Middle Aged; Prognosis; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Xenograft Model Antitumor Assays

2020
PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor.
    Cell death & disease, 2020, 06-08, Volume: 11, Issue:6

    Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplastic Stem Cells; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Random Allocation; Transfection; Triazines; Xenograft Model Antitumor Assays

2020
Ribociclib enhances infigratinib-induced cancer cell differentiation and delays resistance in FGFR-driven hepatocellular carcinoma.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:3

    Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Male; Mice; Mice, SCID; Phenylurea Compounds; Purines; Pyrimidines; Xenograft Model Antitumor Assays

2021
Clinical features and treatment outcomes of 14 patients with hepatosplenic γ δ T-cell lymphoma.
    Journal of cancer research and clinical oncology, 2021, Volume: 147, Issue:11

    Topics: Adolescent; Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bortezomib; Cyclophosphamide; Doxorubicin; Hematopoietic Stem Cell Transplantation; Humans; Intraepithelial Lymphocytes; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Middle Aged; Prednisolone; Retrospective Studies; Splenic Neoplasms; Treatment Outcome; Vincristine; Young Adult

2021
Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy.
    Hepatology (Baltimore, Md.), 2021, Volume: 74, Issue:4

    Topics: Aminopyridines; Animals; Benzimidazoles; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Hep G2 Cells; Humans; In Vitro Techniques; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Neoplasm Transplantation; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Retinoblastoma Protein; Tumor Suppressor Protein p53; Xenopus Proteins

2021
Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.
    Cellular oncology (Dordrecht), 2021, Volume: 44, Issue:5

    Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aurora Kinase A; Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; Hep G2 Cells; Humans; Indazoles; Kaplan-Meier Estimate; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Pyrazoles; RNA Interference; Xenograft Model Antitumor Assays

2021
Sarcomatoid hepatocellular carcinoma: From clinical features to cancer genome.
    Cancer medicine, 2021, Volume: 10, Issue:18

    Topics: Aged; Aminopyridines; Benzimidazoles; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Cyclin-Dependent Kinase Inhibitor p16; Disease-Free Survival; DNA Helicases; Female; Follow-Up Studies; Hepatectomy; Humans; Liver; Liver Neoplasms; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mutation Rate; Neoplasm Recurrence, Local; Prognosis; Receptor, EphA5; Risk Factors; Tumor Burden

2021
Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.
    Cell death and differentiation, 2017, Volume: 24, Issue:5

    Topics: Aminopyridines; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; E2F2 Transcription Factor; E2F3 Transcription Factor; Enhancer of Zeste Homolog 2 Protein; Focal Adhesion Kinase 1; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Receptor, Notch2; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Protein p53

2017
Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma.
    Molecular cancer therapeutics, 2017, Volume: 16, Issue:8

    Topics: Aminopyridines; Animals; Biomarkers, Tumor; Bone Marrow Cells; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Monocytes; Phenotype; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Microenvironment

2017
Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy.
    Oncology reports, 2019, Volume: 41, Issue:3

    Topics: Adult; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Heterocyclic Compounds, 3-Ring; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Xenograft Model Antitumor Assays

2019
Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade.
    Gut, 2019, Volume: 68, Issue:9

    Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chemotaxis; Cytokines; Gene Deletion; Humans; Liver Neoplasms; Lymphocytes, Tumor-Infiltrating; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice, Knockout; Molecular Targeted Therapy; Osteopontin; Prognosis; Pyrroles; Tumor Cells, Cultured; Tumor Escape; Tumor Microenvironment

2019
Predictors of ribociclib-mediated antitumour effects in native and sorafenib-resistant human hepatocellular carcinoma cells.
    Cellular oncology (Dordrecht), 2019, Volume: 42, Issue:5

    Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Drug Resistance, Neoplasm; G1 Phase Cell Cycle Checkpoints; Hepatocytes; Humans; Liver Neoplasms; Purines; Retinoblastoma Protein; RNA, Small Interfering; Sorafenib

2019
Transformation to neuroendocrine carcinoma as a resistance mechanism to lorlatinib.
    Lung cancer (Amsterdam, Netherlands), 2019, Volume: 134

    Topics: Adult; Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Gene Rearrangement; Humans; Lactams; Lactams, Macrocyclic; Liver Neoplasms; Lung Neoplasms; Male; Molecular Targeted Therapy; Mutation; Neoplasm Metastasis; Neoplasm Staging; Pyrazoles; Tomography, X-Ray Computed

2019
Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2019, Volume: 14, Issue:11

    Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazoles; Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Kidney Neoplasms; Lactams; Lactams, Macrocyclic; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Middle Aged; Mutation; Piperidines; Pyrazoles; Xenograft Model Antitumor Assays

2019
Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib.
    Cancer chemotherapy and pharmacology, 2013, Volume: 71, Issue:5

    Topics: Aminopyridines; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Everolimus; Humans; Imidazoles; Indoles; Kidney Neoplasms; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Niacinamide; Phenylurea Compounds; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolines; Signal Transduction; Sirolimus; Sorafenib; Sunitinib; TOR Serine-Threonine Kinases

2013
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:5

    Topics: Aminopyridines; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line; Cell Respiration; Cisplatin; Doxorubicin; Everolimus; Humans; Imidazoles; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Sirolimus; TOR Serine-Threonine Kinases

2013
The role of mTOR inhibitors in the treatment of hepatocellular carcinoma.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:8

    Topics: Aminopyridines; Carcinoma, Hepatocellular; Humans; Imidazoles; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Sirolimus; TOR Serine-Threonine Kinases

2013
Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma.
    Oncotarget, 2014, Jun-15, Volume: 5, Issue:11

    Topics: Aminopyridines; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Random Allocation

2014
Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma.
    Oncotarget, 2015, May-20, Volume: 6, Issue:14

    Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoxazoles; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Liver Neoplasms; Mice; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Real-Time Polymerase Chain Reaction; Sorafenib; Transfection; Xenograft Model Antitumor Assays

2015
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
    Neoplasia (New York, N.Y.), 2015, Volume: 17, Issue:7

    Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides; Disease Models, Animal; Enzyme Activation; Humans; Inflammation; Interleukin-6; Janus Kinases; Liver; Liver Neoplasms; Morpholines; Niclosamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; STAT3 Transcription Factor; Zebrafish; Zebrafish Proteins

2015
Antitumor activity of Chidamide in hepatocellular carcinoma cell lines.
    Molecular medicine reports, 2012, Volume: 5, Issue:6

    Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms; Pyridines; Up-Regulation

2012
An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography.
    Analytical biochemistry, 2002, Nov-01, Volume: 310, Issue:1

    Topics: Aminopyridines; Animals; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Fluorescent Dyes; Fucosyltransferases; Guanosine Diphosphate Fucose; Humans; Liver; Liver Neoplasms; Microsomes; Molecular Sequence Data; Oligosaccharides; Rats; Spectrometry, Fluorescence; Time Factors; Tumor Cells, Cultured

2002
Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride.
    Journal of cancer research and clinical oncology, 1983, Volume: 106, Issue:1

    Topics: Adenosine Triphosphatases; Administration, Oral; Aminopyridines; Animals; Female; gamma-Glutamyltransferase; Liver Neoplasms; Methapyrilene; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains

1983
Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.
    Cancer letters, 1984, Volume: 21, Issue:3

    Topics: Aminopyridines; Animals; Cricetinae; Cricetulus; Female; Hypoxanthine Phosphoribosyltransferase; Liver Neoplasms; Male; Methapyrilene; Mutagenicity Tests; Mutagens; Ovary; Rats; Rats, Inbred Strains

1984
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1984, Volume: 22, Issue:1

    Topics: Aminopyridines; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Male; Methapyrilene; Pyrilamine; Rats; Rats, Inbred F344; Structure-Activity Relationship; Time Factors

1984
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
    Journal of the National Cancer Institute, 1984, Volume: 72, Issue:3

    Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methapyrilene; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors

1984
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.
    Toxicology and applied pharmacology, 1984, Jun-15, Volume: 74, Issue:1

    Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neoplasms; Male; Methapyrilene; Rats; Rats, Inbred F344

1984
The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.
    Toxicology and applied pharmacology, 1982, Volume: 66, Issue:2

    Topics: Aminopyridines; Animals; Enzyme Induction; Female; Liver; Liver Neoplasms; Male; Methapyrilene; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pentobarbital; Rats; Rats, Inbred F344; Sleep

1982
Morphology of early changes in liver carcinogenesis induced by methapyrilene.
    Archives of toxicology, 1981, Volume: 49, Issue:1

    Topics: Aminopyridines; Animals; Female; Liver; Liver Neoplasms; Methapyrilene; Microscopy, Electron; Rats; Rats, Inbred F344; Subcellular Fractions

1981
Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats.
    Journal of cancer research and clinical oncology, 1986, Volume: 112, Issue:1

    Topics: Aminopyridines; Animals; Female; Histamine H1 Antagonists; Liver Neoplasms; Male; Methapyrilene; Pyridines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Structure-Activity Relationship

1986
Choline deficient diet enhances the initiating and promoting effects of methapyrilene hydrochloride in rat liver as assayed by the induction of gamma-glutamyltranspeptidase-positive hepatocyte foci.
    British journal of cancer, 1987, Volume: 56, Issue:6

    Topics: Aminopyridines; Animals; Choline Deficiency; Enzyme Activation; gamma-Glutamyltransferase; Lipid Peroxides; Liver; Liver Neoplasms; Male; Membrane Lipids; Methapyrilene; Microsomes, Liver; Rats; Rats, Inbred Strains

1987
The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:7

    Topics: Aminopyridines; Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Liver Neoplasms; Male; Methapyrilene; Molecular Structure; Rats; Rats, Inbred Strains

1988
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
    Journal of cancer research and clinical oncology, 1986, Volume: 111, Issue:1

    Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methapyrilene; Neoplasms, Experimental; Pyridines; Pyrilamine; Rats; Structure-Activity Relationship; Tripelennamine

1986