alpha-aminopyridine has been researched along with Leukemia, Lymphocytic, Chronic, B-Cell in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 12 (80.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Aloyz, R; Amrein, L; Assouline, S; Banerji, V; Caplan, S; Chen, BE; Hagerman, L; Hasegawa, W; Hay, AE; Owen, C; Panasci, L; Peters, A; Prica, A; Robinson, S; Rodriguez, L; Shivakumar, S; Skamene, T | 1 |
| Fan, L; Kong, YL; Li, JY; Liang, JH; Pan, BH; Wang, L; Wu, JZ; Xia, Y; Xu, W; Zhu, HY | 1 |
| Aymerich, M; Campo, E; Colomer, D; López-Guerra, M; Montraveta, A; Pérez-Galán, P; Rosich, L; Roué, G; Saborit-Villarroya, I; Villamor, N; Xargay-Torrent, S | 1 |
| Fan, L; Han, TT; Li, JY; Xu, W | 1 |
| Niemann, CU | 1 |
| Pettitt, AR; Slupsky, JR; Till, KJ | 1 |
| Bravo, Y; Cabrera, G; Chen, A; Chiorazzi, N; Correa, L; Jacintho, J; Lorrain, D; Lorrain, K; Messmer, D; Prasit, P; Spaner, D; Stebbins, K; Stock, N; Yan, XJ | 1 |
| Cripe, LD; De Vos, S; Friedberg, JW; Gregory, SA; Johnston, PB; Lacasce, A; Leonard, JP; Levy, R; Lowe, AM; Schaefer-Cutillo, J; Sharman, J; Shipp, MA; Sinha, R; Sterba, MP; Sweetenham, J; Vose, JM | 1 |
| Bennardo, S; Efremov, DG; Laurenti, L; Leone, G; Longo, PG; Perlas, E; Suljagic, M | 1 |
| Burger, JA | 1 |
| Wiestner, A | 2 |
| Aloyz, R; Amrein, L; Grenier, J; Panasci, L; Shawi, M | 1 |
| Barr, PM; Friedberg, JW; Herman, SE; Liu, D; McAuley, EM; Wiestner, A | 1 |
| Chaves, J; Lerner, A; Makkinje, A; Meyers, JA; Taverna, J | 1 |
5 review(s) available for alpha-aminopyridine and Leukemia, Lymphocytic, Chronic, B-Cell
| Article | Year |
|---|---|
Role of chemokines and their receptors in chronic lymphocytic leukemia: function in microenvironment and targeted therapy.
Topics: Aminopyridines; Antineoplastic Agents; Benzylamines; Chemokine CXCL12; Clinical Trials as Topic; Cyclams; Dasatinib; Heterocyclic Compounds; Humans; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Molecular Targeted Therapy; Morpholines; Niacinamide; Oxazines; Phenylurea Compounds; Protein Kinase Inhibitors; Purines; Pyridines; Pyrimidines; Quinazolinones; Receptors, CXCR4; Sorafenib; Thalidomide; Thiazoles; Tumor Microenvironment | 2014 |
[Targeted treatment of chronic lymphocytic leukaemia].
Topics: Adenine; Aminopyridines; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Oxazines; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Signal Transduction; Sulfonamides | 2014 |
Inhibiting B-cell receptor signaling pathways in chronic lymphocytic leukemia.
Topics: Adenine; Aminopyridines; Antineoplastic Agents; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Oxazines; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Risk Factors; Signal Transduction | 2012 |
Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.
Topics: Adenine; Aminopyridines; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Models, Biological; Morpholines; Oxazines; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction | 2012 |
Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.
Topics: Adenine; Aminopyridines; Antineoplastic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Count; Medical Oncology; Morpholines; Mutation; NF-kappa B; Oxazines; Phosphatidylinositol 3-Kinases; Piperidines; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases | 2012 |
2 trial(s) available for alpha-aminopyridine and Leukemia, Lymphocytic, Chronic, B-Cell
| Article | Year |
|---|---|
IND.216: a phase II study of buparlisib and associated biomarkers, raptor and p70S6K, in patients with relapsed and refractory chronic lymphocytic leukemia.
Topics: Aminopyridines; Biomarkers; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Regulatory-Associated Protein of mTOR; Ribosomal Protein S6 Kinases, 70-kDa | 2020 |
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Agents; Cohort Studies; Diarrhea; Disease-Free Survival; Female; Hematologic Diseases; Humans; Hypertension; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Morpholines; Neoplasm Proteins; Oxazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Salvage Therapy; Syk Kinase; Treatment Outcome | 2010 |
8 other study(ies) available for alpha-aminopyridine and Leukemia, Lymphocytic, Chronic, B-Cell
| Article | Year |
|---|---|
Chidamide, a histone deacetylase inhibitor, inhibits autophagy and exhibits therapeutic implication in chronic lymphocytic leukemia.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Proteins; Benzamides; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Phosphatidylinositol 3-Kinase; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells.
Topics: Aged; Aged, 80 and over; Aminopyridines; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Movement; Coculture Techniques; Drug Resistance, Neoplasm; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Proteins; Middle Aged; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Tumor Microenvironment | 2013 |
Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Aminopyridines; Antineoplastic Agents; B-Lymphocytes; Case-Control Studies; Cell Movement; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation, Leukemic; Germinal Center; Human Umbilical Vein Endothelial Cells; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Lysophospholipids; Morpholines; Oxazines; Piperidines; Primary Cell Culture; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Purines; Pyrazoles; Pyridines; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Syk Kinase | 2015 |
A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo.
Topics: Aminopyridines; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fatty Acids; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; PPAR alpha; Sulfonamides; Transcriptional Activation | 2015 |
The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Topics: Adoptive Transfer; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Separation; Disease Models, Animal; Flow Cytometry; Immunophenotyping; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Transgenic; Morpholines; Oxazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction; Syk Kinase | 2010 |
The phosphatidylinositol-3 kinase I inhibitor BKM120 induces cell death in B-chronic lymphocytic leukemia cells in vitro.
Topics: Adult; Aged; Aminopyridines; Antineoplastic Agents; Apoptosis; Blotting, Western; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Treatment Outcome; Tumor Cells, Cultured | 2013 |
Fostamatinib inhibits B-cell receptor signaling, cellular activation and tumor proliferation in patients with relapsed and refractory chronic lymphocytic leukemia.
Topics: Aminopyridines; Antineoplastic Agents; Cell Proliferation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Morpholines; Oxazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction | 2013 |
Phosphodiesterase 4 inhibitors augment levels of glucocorticoid receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Apoptosis; Benzamides; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Dexamethasone; Gene Expression Regulation, Leukemic; Hematopoietic System; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Nitriles; Phosphodiesterase Inhibitors; Receptors, Glucocorticoid; Rolipram | 2007 |