Page last updated: 2024-08-21

alpha-aminopyridine and Innate Inflammatory Response

alpha-aminopyridine has been researched along with Innate Inflammatory Response in 102 studies

Research

Studies (102)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (19.61)29.6817
2010's50 (49.02)24.3611
2020's32 (31.37)2.80

Authors

AuthorsStudies
Bufton, JC; Bullock, AN; Cuny, GD; Dai, B; Degterev, A; Duddupudi, AL; Gyrd-Hansen, M; Hu, M; Li, L; Pinkas, DM; Schlicher, L; Suebsuwong, C1
Lea, S; Mathioudakis, AG; Singh, D1
Al-Abbasi, FA; Almalki, WH; Fuloria, NK; Fuloria, S; Gupta, G; Joshi, N; Kazmi, I; Rajput, SS; Singh, Y; Subramaniyan, V1
Cao, Z; Chen, Y; Guo, W; Hu, H; Li, B; Liu, J; Pang, J; Song, M; Song, X; Wang, C; Wang, J; Wang, M; Xing, Y; Yang, H; Yang, J; Yang, P; Zhang, T; Zhang, Z1
Appel, D; Hummel, R; Klein, M; Li, S; Ritter, K; Schäfer, MKE; Strehle, J; Tegeder, I; Wang, Y; Wernersbach, I1
Cao, Z; Chen, C; Chen, G; Chen, J; Hu, H; Li, W; Li, X; Liao, X; Lin, Y; Liu, F; Liu, K; Liu, Z; Lu, H; Sun, S; Xiong, G; Yang, D; Zhang, L1
Kim, B; Kim, JW; Lim, CW; Qi, J; Zhao, J; Zhou, Z1
Crapser, JD; Green, KN; Ochaba, J; Reidling, JC; Soni, N; Thompson, LM1
Bentham, RB; Bianchi, K; Carter, E; Dalli, J; Godinho, SA; Grose, R; Hodivala-Dilke, K; Holdsworth, J; Ironside, A; Jones, L; Jones, W; Mataloni, I; Moreno Béjar, R; Szabadkai, G; Uhlik, L; Wilcz-Villega, E; Xu, R1
Coleman, LG; Crews, FT; Zou, J1
Fujikawa, K; Fujikawa, M; Ikeda, F; Kanayama, S; Kitano, T; Matsumoto, T; Mori, S; Nakamura, A; Okamoto, K; Tabara, K; Tamura, R; Uratsuji, H1
Brazina, S; Clark, D; Hsieh, CL; Hu, D; Marcucio, R; Miclau, T; Nakamura, MC; Niemi, EC; Yang, F1
Clifton, I; Etherington, C; Holbrook, J; Jarosz-Griffiths, HH; Lara-Reyna, S; Martinon, F; McDermott, MF; Mehta, A; Peckham, D; Savic, S; Scambler, T; Spoletini, G; Whitaker, P; Wong, CH1
Doull, I1
Hu, B; Jiang, H; Liao, L; Tan, M; Xu, X1
Cai, R; Gao, Y; Han, Y; Hou, R; Li, X; Liu, H; Qi, R; Qi, Y; Zhang, X1
Beaufils, F; Bui, S; Burgel, PR; Delhaes, L; Enaud, R; Fayon, M; Lamireau, T; Mas, E; Maumus, P; Mittaine, M; Tétard, C1
Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; Bai, Z; Baisch, PRM; Balkissou, AD; Baltzopoulos, V; Banaszewski, M; Banerjee, S; Bao, Y; Baradwan, A; Barandika, JF; Barger, PM; Barion, MRL; Barrett, CD; Basudan, AM; Baur, LE; Baz-Rodríguez, SA; Beamer, P; Beaulant, A; Becker, DF; Beckers, C; Bedel, J; Bedlack, R; Bermúdez de Castro, JM; Berry, JD; Berthier, C; Bhattacharya, D; Biadgo, B; Bianco, G; Bianco, M; Bibi, S; Bigliardi, AP; Billheimer, D; Birnie, DH; Biswas, K; Blair, HC; Bognetti, P; Bolan, PJ; Bolla, JR; Bolze, A; Bonnaillie, P; Borlimi, R; Bórquez, J; Bottari, NB; Boulleys-Nana, JR; Brighetti, G; Brodeur, GM; Budnyak, T; Budnyk, S; Bukirwa, VD; Bulman, DM; Burm, R; Busman-Sahay, K; Butcher, TW; Cai, C; Cai, H; Cai, L; Cairati, M; Calvano, CD; Camacho-Ordóñez, A; Camela, E; Cameron, T; Campbell, BS; Cansian, RL; Cao, Y; Caporale, AS; Carciofi, AC; Cardozo, V; Carè, J; Carlos, AF; Carozza, R; Carroll, CJW; Carsetti, A; Carubelli, V; Casarotta, E; Casas, M; Caselli, G; Castillo-Lora, J; Cataldi, TRI; Cavalcante, ELB; Cavaleiro, A; Cayci, Z; Cebrián-Tarancón, C; Cedrone, E; Cella, D; Cereda, C; Ceretti, A; Ceroni, M; Cha, YH; Chai, X; Chang, EF; Chang, TS; Chanteux, H; Chao, M; Chaplin, BP; Chaturvedi, S; Chaturvedi, V; Chaudhary, DK; Chen, A; Chen, C; Chen, HY; Chen, J; Chen, JJ; Chen, K; Chen, L; Chen, Q; Chen, R; Chen, SY; Chen, TY; Chen, WM; Chen, X; Chen, Y; Cheng, G; Cheng, GJ; Cheng, J; Cheng, YH; Cheon, HG; Chew, KW; Chhoker, S; Chiu, WN; Choi, ES; Choi, MJ; Choi, SD; Chokshi, S; Chorny, M; Chu, KI; Chu, WJ; Church, AL; Cirrincione, A; Clamp, AR; Cleff, MB; Cohen, M; Coleman, RL; Collins, SL; Colombo, N; Conduit, N; Cong, WL; Connelly, MA; Connor, J; Cooley, K; Correa Ramos Leal, I; Cose, S; Costantino, C; Cottrell, M; Cui, L; Cundall, J; Cutaia, C; Cutler, CW; Cuypers, ML; da Silva Júnior, FMR; Dahal, RH; Damiani, E; Damtie, D; Dan-Li, W; Dang, Z; Dasa, SSK; Davin, A; Davis, DR; de Andrade, CM; de Jong, PL; de Oliveira, D; de Paula Dorigam, JC; Dean, A; Deepa, M; Delatour, C; Dell'Aiera, S; Delley, MF; den Boer, RB; Deng, L; Deng, Q; Depner, RM; Derdau, V; Derici, U; DeSantis, AJ; Desmarini, D; Diffo-Sonkoue, L; Divizia, M; Djenabou, A; Djordjevic, JT; Dobrovolskaia, MA; Domizi, R; Donati, A; Dong, Y; Dos Santos, M; Dos Santos, MP; Douglas, RG; Duarte, PF; Dullaart, RPF; Duscha, BD; Edwards, LA; Edwards, TE; Eichenwald, EC; El-Baba, TJ; Elashiry, M; Elashiry, MM; Elashry, SH; Elliott, A; Elsayed, R; Emerson, MS; Emmanuel, YO; Emory, TH; Endale-Mangamba, LM; Enten, GA; Estefanía-Fernández, K; Estes, JD; Estrada-Mena, FJ; Evans, S; Ezra, L; Faria de, RO; Farraj, AK; Favre, C; Feng, B; Feng, J; Feng, L; Feng, W; Feng, X; Feng, Z; Fernandes, CLF; Fernández-Cuadros, ME; Fernie, AR; Ferrari, D; Florindo, PR; Fong, PC; Fontes, EPB; Fontinha, D; Fornari, VJ; Fox, NP; Fu, Q; Fujitaka, Y; Fukuhara, K; Fumeaux, T; Fuqua, C; Fustinoni, S; Gabbanelli, V; Gaikwad, S; Gall, ET; Galli, A; Gancedo, MA; Gandhi, MM; Gao, D; Gao, K; Gao, M; Gao, Q; Gao, X; Gao, Y; Gaponenko, V; Garber, A; Garcia, EM; García-Campos, C; García-Donas, J; García-Pérez, AL; Gasparri, F; Ge, C; Ge, D; Ge, JB; Ge, X; George, I; George, LA; Germani, G; Ghassemi Tabrizi, S; Gibon, Y; Gillent, E; Gillies, RS; Gilmour, MI; Goble, S; Goh, JC; Goiri, F; Goldfinger, LE; Golian, M; Gómez, MA; Gonçalves, J; Góngora-García, OR; Gonul, I; González, MA; Govers, TM; Grant, PC; Gray, EH; Gray, JE; Green, MS; Greenwald, I; Gregory, MJ; Gretzke, D; Griffin-Nolan, RJ; Griffith, DC; Gruppen, EG; Guaita, A; Guan, P; Guan, X; Guerci, P; Guerrero, DT; Guo, M; Guo, P; Guo, R; Guo, X; Gupta, J; Guz, G; Hajizadeh, N; Hamada, H; Haman-Wabi, AB; Han, TT; Hannan, N; Hao, S; Harjola, VP; Harmon, M; Hartmann, MSM; Hartwig, JF; Hasani, M; Hawthorne, WJ; Haykal-Coates, N; Hazari, MS; He, DL; He, P; He, SG; Héau, C; Hebbar Kannur, K; Helvaci, O; Heuberger, DM; Hidalgo, F; Hilty, MP; Hirata, K; Hirsch, A; Hoffman, AM; Hoffmann, JF; Holloway, RW; Holmes, RK; Hong, S; Hongisto, M; Hopf, NB; Hörlein, R; Hoshino, N; Hou, Y; Hoven, NF; Hsieh, YY; Hsu, CT; Hu, CW; Hu, JH; Hu, MY; Hu, Y; Hu, Z; Huang, C; Huang, D; Huang, DQ; Huang, L; Huang, Q; Huang, R; Huang, S; Huang, SC; Huang, W; Huang, Y; Huffman, KM; Hung, CH; Hung, CT; Huurman, R; Hwang, SM; Hyun, S; Ibrahim, AM; Iddi-Faical, A; Immordino, P; Isla, MI; Jacquemond, V; Jacques, T; Jankowska, E; Jansen, JA; Jäntti, T; Jaque-Fernandez, F; Jarvis, GA; Jatt, LP; Jeon, JW; Jeong, SH; Jhunjhunwala, R; Ji, F; Jia, X; Jia, Y; Jian-Bo, Z; Jiang, GD; Jiang, L; Jiang, W; Jiang, WD; Jiang, Z; Jiménez-Hoyos, CA; Jin, S; Jobling, MG; John, CM; John, T; Johnson, CB; Jones, KI; Jones, WS; Joseph, OO; Ju, C; Judeinstein, P; Junges, A; Junnarkar, M; Jurkko, R; Kaleka, CC; Kamath, AV; Kang, X; Kantsadi, AL; Kapoor, M; Karim, Z; Kashuba, ADM; Kassa, E; Kasztura, M; Kataja, A; Katoh, T; Kaufman, JS; Kaupp, M; Kehinde, O; Kehrenberg, C; Kemper, N; Kerr, CW; Khan, AU; Khan, MF; Khan, ZUH; Khojasteh, SC; Kilburn, S; Kim, CG; Kim, DU; Kim, DY; Kim, HJ; Kim, J; Kim, OH; Kim, YH; King, C; Klein, A; Klingler, L; Knapp, AK; Ko, TK; Kodavanti, UP; Kolla, V; Kong, L; Kong, RY; Kong, X; Kore, S; Kortz, U; Korucu, B; Kovacs, A; Krahnert, I; Kraus, WE; Kuang, SY; Kuehn-Hajder, JE; Kurz, M; Kuśtrowski, P; Kwak, YD; Kyttaris, VC; Laga, SM; Laguerre, A; Laloo, A; Langaro, MC; Langham, MC; Lao, X; Larocca, MC; Lassus, J; Lattimer, TA; Lazar, S; Le, MH; Leal, DB; Leal, M; Leary, A; Ledermann, JA; Lee, JF; Lee, MV; Lee, NH; Leeds, CM; Leeds, JS; Lefrandt, JD; Leicht, AS; Leonard, M; Lev, S; Levy, K; Li, B; Li, C; Li, CM; Li, DH; Li, H; Li, J; Li, L; Li, LJ; Li, N; Li, P; Li, T; Li, X; Li, XH; Li, XQ; Li, XX; Li, Y; Li, Z; Li, ZY; Liao, YF; Lin, CC; Lin, MH; Lin, Y; Ling, Y; Links, TP; Lira-Romero, E; Liu, C; Liu, D; Liu, H; Liu, J; Liu, L; Liu, LP; Liu, M; Liu, T; Liu, W; Liu, X; Liu, XH; Liu, Y; Liuwantara, D; Ljumanovic, N; Lobo, L; Lokhande, K; Lopes, A; Lopes, RMRM; López-Gutiérrez, JC; López-Muñoz, MJ; López-Santamaría, M; Lorenzo, C; Lorusso, D; Losito, I; Lu, C; Lu, H; Lu, HZ; Lu, SH; Lu, SN; Lu, Y; Lu, ZY; Luboga, F; Luo, JJ; Luo, KL; Luo, Y; Lutomski, CA; Lv, W; M Piedade, MF; Ma, J; Ma, JQ; Ma, JX; Ma, N; Ma, P; Ma, S; Maciel, M; Madureira, M; Maganaris, C; Maginn, EJ; Mahnashi, MH; Maierhofer, M; Majetschak, M; Malla, TR; Maloney, L; Mann, DL; Mansuri, A; Marelli, E; Margulis, CJ; Marrella, A; Martin, BL; Martín-Francés, L; Martínez de Pinillos, M; Martínez-Navarro, EM; Martinez-Quintanilla Jimenez, D; Martínez-Velasco, A; Martínez-Villaseñor, L; Martinón-Torres, M; Martins, BA; Massongo, M; Mathew, AP; Mathews, D; Matsui, J; Matsumoto, KI; Mau, T; Maves, RC; Mayclin, SJ; Mayer, JM; Maynard, ND; Mayr, T; Mboowa, MG; McEvoy, MP; McIntyre, RC; McKay, JA; McPhail, MJW; McVeigh, AL; Mebazaa, A; Medici, V; Medina, DN; Mehmood, T; Mei-Li, C; Melku, M; Meloncelli, S; Mendes, GC; Mendoza-Velásquez, C; Mercadante, R; Mercado, MI; Merenda, MEZ; Meunier, J; Mi, SL; Michels, M; Mijatovic, V; Mikhailov, V; Milheiro, SA; Miller, DC; Ming, F; Mitsuishi, M; Miyashita, T; Mo, J; Mo, S; Modesto-Mata, M; Moeller, S; Monte, A; Monteiro, L; Montomoli, J; Moore, EE; Moore, HB; Moore, PK; Mor, MK; Moratalla-López, N; Moratilla Lapeña, L; Moreira, R; Moreno, MA; Mörk, AC; Morton, M; Mosier, JM; Mou, LH; Mougharbel, AS; Muccillo-Baisch, AL; Muñoz-Serrano, AJ; Mustafa, B; Nair, GM; Nakanishi, I; Nakanjako, D; Naraparaju, K; Nawani, N; Neffati, R; Neil, EC; Neilipovitz, D; Neira-Borrajo, I; Nelson, MT; Nery, PB; Nese, M; Nguyen, F; Nguyen, MH; Niazy, AA; Nicolaï, J; Nogueira, F; Norbäck, D; Novaretti, JV; O'Donnell, T; O'Dowd, A; O'Malley, DM; Oaknin, A; Ogata, K; Ohkubo, K; Ojha, M; Olaleye, MT; Olawande, B; Olomo, EJ; Ong, EWY; Ono, A; Onwumere, J; Ortiz Bibriesca, DM; Ou, X; Oza, AM; Ozturk, K; Özütemiz, C; Palacio-Pastrana, C; Palaparthi, A; Palevsky, PM; Pan, K; Pantanetti, S; Papachristou, DJ; Pariani, A; Parikh, CR; Parissis, J; Paroul, N; Parry, S; Patel, N; Patel, SM; Patel, VC; Pawar, S; Pefura-Yone, EW; Peixoto Andrade, BCO; Pelepenko, LE; Peña-Lora, D; Peng, S; Pérez-Moro, OS; Perez-Ortiz, AC; Perry, LM; Peter, CM; Phillips, NJ; Phillips, P; Pia Tek, J; Piner, LW; Pinto, EA; Pinto, SN; Piyachaturawat, P; Poka-Mayap, V; Polledri, E; Poloni, TE; Ponessa, G; Poole, ST; Post, AK; Potter, TM; Pressly, BB; Prouty, MG; Prudêncio, M; Pulkki, K; Pupier, C; Qian, H; Qian, ZP; Qiu, Y; Qu, G; Rahimi, S; Rahman, AU; Ramadan, H; Ramanna, S; Ramirez, I; Randolph, GJ; Rasheed, A; Rault, J; Raviprakash, V; Reale, E; Redpath, C; Rema, V; Remucal, CK; Remy, D; Ren, T; Ribeiro, LB; Riboli, G; Richards, J; Rieger, V; Rieusset, J; Riva, A; Rivabella Maknis, T; Robbins, JL; Robinson, CV; Roche-Campo, F; Rodriguez, R; Rodríguez-de-Cía, J; Rollenhagen, JE; Rosen, EP; Rub, D; Rubin, N; Rubin, NT; Ruurda, JP; Saad, O; Sabell, T; Saber, SE; Sabet, M; Sadek, MM; Saejio, A; Salinas, RM; Saliu, IO; Sande, D; Sang, D; Sangenito, LS; Santos, ALSD; Sarmiento Caldas, MC; Sassaroli, S; Sassi, V; Sato, J; Sauaia, A; Saunders, K; Saunders, PR; Savarino, SJ; Scambia, G; Scanlon, N; Schetinger, MR; Schinkel, AFL; Schladweiler, MC; Schofield, CJ; Schuepbach, RA; Schulz, J; Schwartz, N; Scorcella, C; Seeley, J; Seemann, F; Seinige, D; Sengoku, T; Seravalli, J; Sgromo, B; Shaheen, MY; Shan, L; Shanmugam, S; Shao, H; Sharma, S; Shaw, KJ; Shen, BQ; Shen, CH; Shen, P; Shen, S; Shen, Y; Shen, Z; Shi, J; Shi-Li, L; Shimoda, K; Shoji, Y; Shun, C; Silva, MA; Silva-Cardoso, J; Simas, NK; Simirgiotis, MJ; Sincock, SA; Singh, MP; Sionis, A; Siu, J; Sivieri, EM; Sjerps, MJ; Skoczen, SL; Slabon, A; Slette, IJ; Smith, MD; Smith, S; Smith, TG; Snapp, KS; Snow, SJ; Soares, MCF; Soberman, D; Solares, MD; Soliman, I; Song, J; Sorooshian, A; Sorrell, TC; Spinar, J; Staudt, A; Steinhart, C; Stern, ST; Stevens, DM; Stiers, KM; Stimming, U; Su, YG; Subbian, V; Suga, H; Sukhija-Cohen, A; Suksamrarn, A; Suksen, K; Sun, J; Sun, M; Sun, P; Sun, W; Sun, XF; Sun, Y; Sundell, J; Susan, LF; Sutjarit, N; Swamy, KV; Swisher, EM; Sykes, C; Takahashi, JA; Talmor, DS; Tan, B; Tan, ZK; Tang, L; Tang, S; Tanner, JJ; Tanwar, M; Tarazi, Z; Tarvasmäki, T; Tay, FR; Teketel, A; Temitayo, GI; Thersleff, T; Thiessen Philbrook, H; Thompson, LC; Thongon, N; Tian, B; Tian, F; Tian, Q; Timothy, AT; Tingle, MD; Titze, IR; Tolppanen, H; Tong, W; Toyoda, H; Tronconi, L; Tseng, CH; Tu, H; Tu, YJ; Tung, SY; Turpault, S; Tuynman, JB; Uemoto, AT; Ugurlu, M; Ullah, S; Underwood, RS; Ungell, AL; Usandizaga-Elio, I; Vakonakis, I; van Boxel, GI; van den Beucken, JJJP; van der Boom, T; van Slegtenhorst, MA; Vanni, JR; Vaquera, A; Vasconcellos, RS; Velayos, M; Vena, R; Ventura, G; Verso, MG; Vincent, RP; Vitale, F; Vitali, S; Vlek, SL; Vleugels, MPH; Volkmann, N; Vukelic, M; Wagner Mackenzie, B; Wairagala, P; Waller, SB; Wan, J; Wan, MT; Wan, Y; Wang, CC; Wang, H; Wang, J; Wang, JF; Wang, K; Wang, L; Wang, M; Wang, S; Wang, WM; Wang, X; Wang, Y; Wang, YD; Wang, YF; Wang, Z; Wang, ZG; Warriner, K; Weberpals, JI; Weerachayaphorn, J; Wehrli, FW; Wei, J; Wei, KL; Weinheimer, CJ; Weisbord, SD; Wen, S; Wendel Garcia, PD; Williams, JW; Williams, R; Winkler, C; Wirman, AP; Wong, S; Woods, CM; Wu, B; Wu, C; Wu, F; Wu, P; Wu, S; Wu, Y; Wu, YN; Wu, ZH; Wurtzel, JGT; Xia, L; Xia, Z; Xia, ZZ; Xiao, H; Xie, C; Xin, ZM; Xing, Y; Xing, Z; Xu, S; Xu, SB; Xu, T; Xu, X; Xu, Y; Xue, L; Xun, J; Yaffe, MB; Yalew, A; Yamamoto, S; Yan, D; Yan, H; Yan, S; Yan, X; Yang, AD; Yang, E; Yang, H; Yang, J; Yang, JL; Yang, K; Yang, M; Yang, P; Yang, Q; Yang, S; Yang, W; Yang, X; Yang, Y; Yao, JC; Yao, WL; Yao, Y; Yaqub, TB; Ye, J; Ye, W; Yen, CW; Yeter, HH; Yin, C; Yip, V; Yong-Yi, J; Yu, HJ; Yu, MF; Yu, S; Yu, W; Yu, WW; Yu, X; Yuan, P; Yuan, Q; Yue, XY; Zaia, AA; Zakhary, SY; Zalwango, F; Zamalloa, A; Zamparo, P; Zampini, IC; Zani, JL; Zeitoun, R; Zeng, N; Zenteno, JC; Zepeda-Palacio, C; Zhai, C; Zhang, B; Zhang, G; Zhang, J; Zhang, K; Zhang, Q; Zhang, R; Zhang, T; Zhang, X; Zhang, Y; Zhang, YY; Zhao, B; Zhao, D; Zhao, G; Zhao, H; Zhao, Q; Zhao, R; Zhao, S; Zhao, T; Zhao, X; Zhao, XA; Zhao, Y; Zhao, Z; Zheng, Z; Zhi-Min, G; Zhou, CL; Zhou, HD; Zhou, J; Zhou, W; Zhou, XQ; Zhou, Z; Zhu, C; Zhu, H; Zhu, L; Zhu, Y; Zitzmann, N; Zou, L; Zou, Y1
Anyaegbu, G; Bentley, H; Bulusu, VR; Hatcher, H; Horan, G; Watkins, J; Wong, HH1
Duan, L; Jiang, J; Liu, Y; Wang, R; Zhao, J1
Bode-Lesniewska, B; Fritz, C; John, H; Pless, M; Reinhart, S; Trachsel, Y; Wagner, U1
Shah, CA1
Dayang, EZ; Kuiper, T; Luxen, M; Molema, G; Moser, J; Rangarajan, S; van Meurs, M; Yan, R1
Dosanjh, A; Won, CY1
Du, Y; Liu, J; Wu, P; Yang, Z; Zhang, S1
Akhtar, A; Bansal, Y; Bishnoi, M; Kuhad, A; Sah, SP; Saroj, P; Singh, R; Sodhi, RK1
Franceschelli, S; Pascale, M; Pecoraro, M1
Eubler, K; Heikelä, H; Köhn, FM; Kunz, L; Mayerhofer, A; Missel, A; Mundt, N; Pickl, U; Popper, B; Poutanen, M; Spehr, M; Strauss, L; Trottmann, M; Walenta, L1
Chen, D; Chen, K; Chen, Z; Huang, B; Liu, Q; Sun, Y1
Crider, A; Lodholz, E; Polina, J; Sandoval, K; Schober, J; Scott, N; Walters, F; Witt, K1
Harwood, KH; Jarnicki, A; McQuade, RM; Schneider-Futschik, EK1
Ambarkhane, A; Bellenie, BR; Bracher, M; Bruce, I; Chinn, C; Coote, J; Cullen, E; Culshaw, A; Hall, E; Hollingworth, GJ; Lal, A; Marshall, S; McDonald, S; Neef, J; Nicklin, P; Rosner, E; Spendiff, M; Tessier, C; Thomas, M; Wallis, G; Wuersch, K1
Kong, J; Li, H; Mao, L; Qi, L; Sun, B; Wang, J; Wu, Q; Xie, R; Yang, M; Yang, X; Zhang, Z1
Albrecht, W; Bauer, SM; Laufer, SA; Unger, A1
Chen, J; Cheng, Y; Feng, H; Wang, H; Xu, J; Zhong, Q; Zou, Z1
Amenduni, M; Fabris, L; Fiorotto, R; Mariotti, V; Spirli, C; Strazzabosco, M1
Canter, RG; Dominique, MA; Fang, TC; Khan, T; Lee, VM; Miller, KR; Ransohoff, RM; Restrepo, CR; Roberts, CJ; Spiller, KJ; Trojanowski, JQ1
Ames, L; Axford, L; Blank, J; Casson, N; Custeau, D; Deng, L; Hamann, LG; Harrison, TJ; Hollis-Symynkywicz, M; Honda, T; Lee, L; Loi, S; Marcinkeviciene, J; Marro, ML; Papillon, JPN; Patnaik, A; Patterson, AW; Regard, JB; Ren, X; Reynolds, A; Zhang, L1
Beyett, TS; Chang, L; Gan, X; Gomez, AV; Reilly, SM; Saltiel, AR; Showalter, HD; Tesmer, JJG1
McAdoo, S; Tam, FWK1
Aki, A; Baba, D; Fukuda, T; Hashimoto, M; Ishiyama, T; Katagiri, T; Muramatsu, S; Tanaka, N; Ueda, K; Watanabe, K1
Boyles, SE; Cholon, DM; Gentzsch, M; Martino, MEB; Quinney, NL; Ribeiro, CMP1
Lee, BC; Li, JD; Susuki-Miyata, S; Yan, C1
Ding, H; Li, N; Liu, Y; Wang, P; Zhang, P1
Berve, K; Groh, J; Klein, D; Martini, R; West, BL1
Al-Sajee, D; Gauvreau, GM; Yin, X1
Ducruet, AF; Lawton, MT; Qiu, S; Sheth, KN; Shi, E; Shi, K1
Artis, DR; Bollag, G; Bremer, R; Burton, EA; Carias, H; Habets, G; Hirth, P; Hurt, CR; Ibrahim, PN; Lin, P; Marimuthu, A; Matusow, B; Nespi, M; Nguyen, H; Nolop, K; Oh, A; Powell, B; Shellooe, R; Spevak, W; Tesch, GH; Tsang, G; West, BL; Wu, G; Zhang, C; Zhang, J; Zhang, KY; Zhang, Y1
Csóka, B; Eltzschig, HK; Haskó, G; Koscsó, B; Németh, ZH; Pacher, P; Trepakov, A1
Giembycz, MA; Greer, S; Joshi, T; Newton, R; Page, CW; Yan, D1
Chang, L; Chiang, SH; Leto, D; Mowers, J; Reilly, SM; Saltiel, AR; Simon, J; Uhm, M1
Arban, R; Cavallini, P; Davies, CH; Davis, TG; Gray, FA; Montanari, D; Negri, M; Poffe, A; Rutter, AR; Schneck, J; Vicentini, E; Wren, PB1
Song, SD; Tang, HF1
Ahmadian, M; Chang, L; Downes, M; Evans, RM; Korytnaya, E; Krause, DM; Liddle, C; Lumeng, CN; Neidert, A; Oral, EA; Peng, X; Poirier, B; Reilly, SM; Saltiel, AR; Uhm, M; Yu, RT; Zamarron, BF1
Kai, H; Lee, BC; Li, JD; Miyata, M; Susuki-Miyata, S; Xu, H; Yan, C1
Chai, Z; Feng, L; Li, YH; Liu, JC; Ma, CG; Xiao, BG; Xin, YL; Yu, JZ; Zhang, GX; Zhang, HZ1
Bailey, WC; Bhatt, SP; Blalock, JE; Dransfield, MT; Gaggar, A; Gautney, J; Handley, G; Jackson, PL; King, RW; Viera, L; Wells, JM; Xu, X1
Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN1
Chan, HC; Chen, J; Chen, Y; Dong, ZW; Peng, YZ; Ruan, YC; Tsang, LL; Zhou, T1
Aouadi, M; Bhattacharya, SK; Buckbinder, L; Cooper, MP; Cortes, C; Czech, MP; Danai, LV; Fitzgibbons, TP; Hagan, N; Matevossian, A; Menendez, LG; Roth Flach, RJ; Skoura, A; Vangala, P; Yawe, JC; Zheng, W1
Al-Sawalha, N; Bond, RA; Forkuo, GS; Gonnella, PA; Joshi, R; Kim, H; Knoll, BJ; Parra, S; Penn, RB; Pera, T; Thanawala, VJ; Valdez, D; Walker, JK1
Baier, F; Bise, T; de Preux Charles, AS; Jaźwińska, A; Marro, J1
Lopez-Garcia, JA; Rivera-Arconada, I; Vicente-Baz, J1
Eckle, T; Eltzschig, HK; Grenz, A; Klingel, K; Osswald, H; Ravid, K; Tran, ZV; Yang, D; Zhang, H1
Bähr, M; Diem, R; Neusch, C; Otto, M; Pehlke, JR; Sättler, MB; Williams, SK1
Aberg, A; Andersson, G; Andrews, G; Arvai, AS; Cheshire, DR; Connolly, S; Crane, BR; Garcin, ED; Gensmantel, NP; Getzoff, ED; Hamley, PJ; Kroeger, MD; Mallinder, PR; Mete, A; Nicholls, DJ; Rosenfeld, RJ; St-Gallay, SA; Stuehr, DJ; Tainer, JA; Tinker, AC; Wallace, AV1
Eltzschig, HK; Hart, ML; Henn, M; Jacobi, B; Schittenhelm, J1
Gavaldà, A; Lehner, MD; Pagès, L1
Adnot, S; Beume, R; Hatzelmann, A; Lungarella, G; Morcillo, EJ; Sanjar, S; Schudt, C; Tenor, H1
Colbatzky, F; Göggel, R; Nickolaus, P; Peter, D1
Akbari, P; Bryant, J; Gibson, G; Holsworth, D; Kolte, D; Shariat-Madar, Z; Wang, J1
Cortijo Gimeno, J1
Martínez, FJ1
Berman, BM; Lao, L; Li, A; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y1
Bode, C; Buchner, M; Colberg, C; Eisele, S; Hilgendorf, I; Hoppe, N; Lozhkin, A; Ortiz-Rodriguez, A; Remer, I; Schmitz, J; Stachon, P; von zur Muhlen, C; Willecke, F; Wolf, D; Zeschky, K; Zirlik, A; Zirlik, K; zur Hausen, A1
Şenyiğit, A; Sezgi, C1
Gamper, N; Huang, D; Linley, JE; Pettinger, L1
Haran, AC; Mansfield, CN; Salmon, M; Sorensen, EA; Tannheimer, SL; Wright, CD1
Del Pino-Montes, J; Gómez-Castro, S; Hidalgo, C; López, R; Montilla Morales, C; Sánchez, M1
Salmon, M; Tannheimer, SL; Wright, CD1
Germer, CT; Roewer, N; Schick, MA; Schlegel, N; Waschke, J; Wollborn, J; Wunder, C1
Blasco, LM1
Corkey, B; Farb, MG; Gokce, N; Johnston-Cox, H; Koupenova, M; LeBrasseur, N; Ravid, K; Yang, D1
Bleyer, M; Braun, A; Fieguth, HG; Förster, C; Fuchs, E; Hohlfeld, JM; Kaup, FJ; Knauf, S; Lauenstein, HD; Neuhaus, V; Pfennig, O; Schlumbohm, C; Seehase, S; Sewald, K; Switalla, S1
Diener, M; Steidle, J; Würner, L1
Broadley, KJ; Evans, RL; Ford, WR; Kidd, EJ; Knowles, RG; Nials, AT1
Adamec, J; Baldridge, LA; Dudhgaonkar, S; Jedinak, A; Jiang, J; Lamb, JG; Loganathan, J; Sandusky, GE; Sliva, D; Terry, C1
Arndt, PG; Avdi, NJ; Henson, PM; Lieber, JG; Malcolm, KC; Nick, JA; Poch, KR; Suratt, BT; Taube, C; Worthen, GS; Young, SK1
Beume, R; Foster, PS; Herbert, C; Kumar, RK; Thomas, PS; Webb, DC; Wollin, L; Yang, M1
Bock, MG; Boyce, S; Chang, RS; Feng, DM; Freidinger, RM; Harrell, CM; Ivarsson, M; Kuduk, SD; Mason, G; Murphy, KL; Ng, C; Pettibone, DJ; Prueksaritanont, T; Ransom, RW; Reiss, D; Tang, C; Wai, JM1
Hanania, NA; Soto, FJ1
Morice, AH1
Burnet, M; Guse, JH; Gutke, HJ; Khobzaoui, M; Renukappa-Gutke, T1
Husfeld, C; Ji, YH; Klein, U; Linnevers, C; McCluskie, K; Thomas, GR; Yang, A1
Hasegawa, K; Kaneko, S; Kishimoto, K; Ohmori, K; Tamura, T1
Banquerigo, ML; Brahn, E; Chang, B; Grossbard, EB; Lau, A; Payan, DG; Pine, PR; Schoettler, N; Wang, S; Zhao, F1
Foster, PS; Herbert, C; Hettiaratchi, A; Kumar, RK; Thomas, PS; Webb, DC1
Bredenbroeker, D; Hermann, R; Hohlfeld, JM; Krug, N; Lavae-Mokhtari, M; Mueller, M; Schaumann, F; Schoenfeld, K1
Douglas, GJ; Evans, SM; Fidock, MD; Hincks, JS; Lamb, DJ; Perros-Huguet, C; Sreckovic, S; Ulrich, K; Walsh, R; Wetterstrand, EM; Yeadon, M1
Blackburn, MR; Ebisuno, Y; Joachims, ML; Krahn, T; Maeda, E; McEver, RP; McGee, ST; Miyasaka, M; Murakami, S; Oohara, H; Qu, D; Takedachi, M; Tanaka, T; Thompson, LF1
Boichot, E; Cayron-Elizondo, V; Gillon, JY; Guénon, I; Lagente, V; Le Quément, C; Valença, S1
Arndt, PG; Avdi, NJ; Brown, KK; Henson, PM; Janes, MS; Nick, JA; Suratt, BT; Worthen, GS; Young, SK1

Reviews

16 review(s) available for alpha-aminopyridine and Innate Inflammatory Response

ArticleYear
Inhaled Phosphodiesterase Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease.
    Drugs, 2021, Volume: 81, Issue:16

    Topics: Administration, Inhalation; Aminopyridines; Animals; Benzamides; Cyclic AMP; Cyclopropanes; Humans; Inflammation; Isoquinolines; para-Aminobenzoates; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrimidinones; Sulfonamides

2021
Cystic fibrosis 2019: Year in review.
    Paediatric respiratory reviews, 2020, Volume: 35

    Topics: Administration, Inhalation; Aminophenols; Aminopyridines; Anti-Bacterial Agents; Azithromycin; Benzodioxoles; Carrier State; Chloride Channel Agonists; Cystic Fibrosis; Drug Combinations; Exercise; Health Services Accessibility; Healthcare Disparities; Humans; Indoles; Inflammation; Physical Therapy Modalities; Pseudomonas Infections; Pyrazoles; Pyridines; Quinolines; Quinolones; Saline Solution, Hypertonic

2020
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea

2022
Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease.
    The Yale journal of biology and medicine, 2020, Volume: 93, Issue:5

    Topics: Aminopyridines; Animals; Anti-Allergic Agents; Asthma; Humans; Hypersensitivity, Immediate; Inflammation; Japan; Signal Transduction

2020
Anti-Inflammatory Influences of Cystic Fibrosis Transmembrane Conductance Regulator Drugs on Lung Inflammation in Cystic Fibrosis.
    International journal of molecular sciences, 2021, Jul-16, Volume: 22, Issue:14

    Topics: Aminophenols; Aminopyridines; Anti-Inflammatory Agents; Benzodioxoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Indoles; Inflammation; Ion Transport; Lung; Macrophages; Pneumonia; Quinolones; Signal Transduction

2021
Role of the Spleen Tyrosine Kinase Pathway in Driving Inflammation in IgA Nephropathy.
    Seminars in nephrology, 2018, Volume: 38, Issue:5

    Topics: Aminopyridines; B-Lymphocytes; Capillaries; Cell Proliferation; Cytokines; Glomerulonephritis, IGA; Humans; Inflammation; Mesangial Cells; Molecular Targeted Therapy; Morpholines; Oxazines; Pyridines; Pyrimidines; Receptors, Fc; Signal Transduction; Syk Kinase

2018
An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma.
    Expert opinion on pharmacotherapy, 2019, Volume: 20, Issue:5

    Topics: Aminopyridines; Asthma; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Humans; Inflammation; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive

2019
[Progress in PDE4 targeted therapy for inflammatory diseases].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2014, Volume: 43, Issue:3

    Topics: Aminopyridines; Aminoquinolines; Arthritis; Asthma; Benzamides; Cyclopropanes; Dermatitis; Humans; Inflammation; Inflammatory Bowel Diseases; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Sulfones; Thalidomide; Thiazoles

2014
PDE4 inhibitors: a review of current developments (2005 - 2009).
    Expert opinion on therapeutic patents, 2009, Volume: 19, Issue:11

    Topics: Aminopyridines; Animals; Benzamides; Clinical Trials as Topic; Cyclopropanes; Drug Design; Humans; Inflammation; Nervous System Diseases; Patents as Topic; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors

2009
The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.
    Pulmonary pharmacology & therapeutics, 2010, Volume: 23, Issue:4

    Topics: Administration, Oral; Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Cyclopropanes; Drug Evaluation, Preclinical; Humans; Inflammation; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive

2010
[Phosphodiesterase 4 inhibitors: a new pharmacologic group in the treatment of chronic inflammation of the airways].
    Archivos de bronconeumologia, 2010, Volume: 46 Suppl 9

    Topics: Aminopyridines; Anti-Inflammatory Agents; Benzamides; Cilia; Cyclic AMP; Cyclic GMP; Cyclopropanes; Humans; Inflammation; Isoenzymes; Mucins; Oxidative Stress; Phosphodiesterase 4 Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Circulation; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Second Messenger Systems

2010
[Roflumilast: clinical review of a new option for the treatment of inflammation in COPD].
    Archivos de bronconeumologia, 2010, Volume: 46 Suppl 9

    Topics: Aminopyridines; Anti-Inflammatory Agents; Benzamides; Bronchodilator Agents; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Gastrointestinal Diseases; Humans; Inflammation; Multicenter Studies as Topic; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Treatment Outcome; Weight Loss

2010
[A new alternative treatment in COPD: phosphodiesterase-4 inhibitors].
    Tuberkuloz ve toraks, 2011, Volume: 59, Issue:3

    Topics: Administration, Oral; Aminopyridines; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Cyclopropanes; Humans; Inflammation; Phosphodiesterase 4 Inhibitors; Practice Guidelines as Topic; Pulmonary Disease, Chronic Obstructive

2011
[New therapeutic targets in psoriatic arthritis].
    Reumatologia clinica, 2012, Volume: 8 Suppl 1

    Topics: Aminopyridines; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, CD20; Antirheumatic Agents; Arthritis, Psoriatic; Bone Remodeling; Clinical Trials, Phase III as Topic; Cyclic AMP; Cytokines; Denosumab; Disease Progression; Drug Resistance; Humans; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Janus Kinases; Lymphocyte Activation; Lymphocyte Depletion; Molecular Targeted Therapy; Morpholines; Oxazines; Phosphodiesterase 4 Inhibitors; Pyridines; Pyrimidines; T-Lymphocyte Subsets; Thalidomide; Treatment Outcome; Tumor Necrosis Factor-alpha

2012
Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease.
    Current opinion in pulmonary medicine, 2005, Volume: 11, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amides; Aminopyridines; Benzamides; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Indoles; Inflammation; Lung; Nitriles; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Disease, Chronic Obstructive

2005
AWD-12-281 (inhaled) (elbion/GlaxoSmithKline).
    Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Administration, Topical; Amides; Aminopyridines; Animals; Benzamides; Clinical Trials as Topic; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dermatitis, Atopic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Indoles; Inflammation; Lipopolysaccharides; Ovalbumin; Phosphodiesterase Inhibitors; Psoriasis; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Structure-Activity Relationship

2005

Trials

4 trial(s) available for alpha-aminopyridine and Innate Inflammatory Response

ArticleYear
    Zeitschrift fur Gesundheitswissenschaften = Journal of public health, 2022, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea

2022
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
    Nature communications, 2015, Jan-12, Volume: 6

    Topics: 3T3-L1 Cells; Adipocytes; Adult; Aged; Aminopyridines; Animals; Cyclic AMP; Female; Gene Knockdown Techniques; Gluconeogenesis; Glucose-6-Phosphatase; Humans; Inflammation; Insulin Resistance; Interleukin-6; Liver; Male; Mice; Mice, Inbred C57BL; Middle Aged; p38 Mitogen-Activated Protein Kinases; Receptors, Adrenergic, beta; Signal Transduction; STAT3 Transcription Factor; Subcutaneous Fat; Young Adult

2015
A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
    American journal of respiratory and critical care medicine, 2015, Oct-15, Volume: 192, Issue:8

    Topics: Aged; Aminopyridines; Benzamides; Bronchitis, Chronic; Cyclopropanes; Double-Blind Method; Epoxide Hydrolases; Exercise Tolerance; Female; Forced Expiratory Volume; Glycine; Humans; Inflammation; Male; Middle Aged; Neutrophils; Phosphodiesterase 4 Inhibitors; Proline; Prolyl Oligopeptidases; Pulmonary Disease, Chronic Obstructive; Quality of Life; Serine Endopeptidases; Signal Transduction; Spirometry; Sputum; Treatment Outcome; Vital Capacity

2015
Roflumilast attenuates pulmonary inflammation upon segmental endotoxin challenge in healthy subjects: a randomized placebo-controlled trial.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:4

    Topics: Administration, Oral; Adult; Aminopyridines; Anti-Inflammatory Agents; Benzamides; Bronchoalveolar Lavage; Cyclopropanes; Endotoxins; Eosinophils; Female; Humans; Inflammation; Lung; Lymphocytes; Macrophages; Male; Neutrophils; Phosphodiesterase Inhibitors; Young Adult

2008

Other Studies

83 other study(ies) available for alpha-aminopyridine and Innate Inflammatory Response

ArticleYear
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
    European journal of medicinal chemistry, 2020, Aug-15, Volume: 200

    Topics: Aminopyridines; Binding Sites; Crystallography, X-Ray; Humans; Inflammation; Nod Signaling Adaptor Proteins; Receptor-Interacting Protein Serine-Threonine Kinase 2; Signal Transduction; Structure-Activity Relationship

2020
A European pharmacotherapeutic agent roflumilast exploring integrated preclinical and clinical evidence for SARS CoV-2 mediated inflammation to organ damage.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:8

    Topics: Aged; Aminopyridines; Benzamides; COVID-19 Drug Treatment; Cyclopropanes; Humans; Inflammation; Phosphodiesterase 4 Inhibitors; SARS-CoV-2

2022
Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration.
    Signal transduction and targeted therapy, 2022, 05-13, Volume: 7, Issue:1

    Topics: Aminopyridines; Animals; ErbB Receptors; Gefitinib; Inflammation; Mice; Morpholines; Pulmonary Fibrosis; Pyridines; Pyrimidines; Silicosis

2022
Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice.
    Brain, behavior, and immunity, 2022, Volume: 106

    Topics: Aminopyridines; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Inflammation; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred C57BL; Microglia; Oxidoreductases; Pyrroles; Receptors, Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

2022
Pexidartinib hydrochloride exposure induces developmental toxicity and immunotoxicity in zebrafish embryos via activation of Wnt signaling.
    Fish & shellfish immunology, 2023, Volume: 138

    Topics: Aminopyridines; Animals; Embryo, Nonmammalian; Inflammation; Wnt Signaling Pathway; Zebrafish

2023
Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:2

    Topics: Aminopyridines; Animals; Bile Ducts; Carbon Tetrachloride; Hepatic Stellate Cells; I-kappa B Kinase; Inflammation; Kupffer Cells; Liver Cirrhosis; Male; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; Severity of Illness Index; STAT3 Transcription Factor

2020
Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease.
    Brain : a journal of neurology, 2020, 01-01, Volume: 143, Issue:1

    Topics: Aminopyridines; Animals; Astrocytes; Chondroitin Sulfate Proteoglycans; Cytokines; Disease Models, Animal; Down-Regulation; Extracellular Matrix; Hand Strength; Humans; Huntingtin Protein; Huntington Disease; Inflammation; Mice; Mice, Transgenic; Microglia; Neostriatum; Neurites; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recognition, Psychology; RNA, Messenger; Synapses; Transcriptome

2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
    EMBO molecular medicine, 2020, 02-07, Volume: 12, Issue:2

    Topics: Aminopyridines; Animals; Breast Neoplasms; Culture Media, Conditioned; Epithelial Cells; Female; Humans; I-kappa B Kinase; Inflammation; Macrophages; Mammary Glands, Human; Mice; Obesity; Protein Serine-Threonine Kinases; Serine

2020
Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling.
    Journal of neuroinflammation, 2020, Jan-18, Volume: 17, Issue:1

    Topics: Aminopyridines; Animals; Ethanol; Hippocampus; Inflammation; Microglia; Neural Stem Cells; Organ Culture Techniques; Pyrroles; Rats; Signal Transduction; Toll-Like Receptors

2020
Anti-inflammatory effects of ozenoxacin, a topical quinolone antimicrobial agent.
    The Journal of antibiotics, 2020, Volume: 73, Issue:4

    Topics: Acne Vulgaris; Aminopyridines; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Propionibacterium acnes; Quinolones; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2020
Age-related changes to macrophages are detrimental to fracture healing in mice.
    Aging cell, 2020, Volume: 19, Issue:3

    Topics: Age Factors; Aminopyridines; Animals; Bony Callus; Cellular Senescence; Fracture Healing; Fractures, Bone; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Models, Animal; Pyrroles; RNA-Seq; Tibia; Transcriptome

2020
Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis.
    eLife, 2020, 03-02, Volume: 9

    Topics: Adult; Aminophenols; Aminopyridines; Benzodioxoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Down-Regulation; Drug Therapy, Combination; Female; Humans; Indoles; Inflammation; Interleukin-18; Interleukin-1beta; Male; Monocytes; Quinolones; Tumor Necrosis Factor-alpha; Young Adult

2020
Roflumilast, a Phosphodiesterases-4 (PDE4) Inhibitor, Alleviates Sepsis‑induced Acute Kidney Injury.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, May-25, Volume: 26

    Topics: Acute Kidney Injury; Aminopyridines; Animals; Apoptosis; Benzamides; Blood Urea Nitrogen; Creatinine; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cytokines; Female; Hepatitis A Virus Cellular Receptor 1; Inflammation; Kidney; Lipocalin-2; Mice; Mice, Inbred BALB C; NF-kappa B; Phosphodiesterase 4 Inhibitors; Sepsis

2020
Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages.
    Biochimica et biophysica acta. Molecular cell research, 2020, Volume: 1867, Issue:10

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Inflammation; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred ICR; Milrinone; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Signal Transduction; Spectrometry, Fluorescence; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2020
Reduced Intestinal Inflammation With Lumacaftor/Ivacaftor in Adolescents With Cystic Fibrosis.
    Journal of pediatric gastroenterology and nutrition, 2020, Volume: 71, Issue:6

    Topics: Adolescent; Aminophenols; Aminopyridines; Benzodioxoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Inflammation; Lung; Mutation; Quinolones

2020
Lorlatinib for the treatment of inflammatory myofibroblastic tumour with TPM4-ALK fusion following failure of entrectinib.
    Anti-cancer drugs, 2020, Volume: 31, Issue:10

    Topics: Adult; Aminopyridines; Anaplastic Lymphoma Kinase; Benzamides; Gene Fusion; Granuloma, Plasma Cell; Humans; Indazoles; Inflammation; Lactams; Lactams, Macrocyclic; Lung Neoplasms; Male; Protein Kinase Inhibitors; Pyrazoles; Treatment Failure; Tropomyosin

2020
Roflumilast prevents lymphotoxin α (TNF-β)-induced inflammation activation and degradation of type 2 collagen in chondrocytes.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020, Volume: 69, Issue:12

    Topics: Aminopyridines; Benzamides; Cell Line; Chondrocytes; Collagen Type II; Cyclopropanes; Cytokines; Extracellular Matrix; Humans; Inflammation; Lymphotoxin-alpha; Phosphodiesterase 4 Inhibitors; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction

2020
Inflammatory Myofibroblastic Tumor of the Bladder With FN1-ALK Gene Fusion: Different Response to ALK Inhibition.
    Urology, 2020, Volume: 146

    Topics: Adult; Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Crizotinib; Cystoscopy; Female; Fibronectins; Gene Fusion; Humans; Inflammation; Lactams; Myofibroblasts; Neoplasms, Muscle Tissue; Oncogene Proteins, Fusion; Protein Kinase Inhibitors; Pyrazoles; Treatment Outcome; Urinary Bladder Neoplasms

2020
Can roflumilast become steroid-sparing alternative in the treatment of COVID-19?
    Medical hypotheses, 2020, Volume: 144

    Topics: Adrenal Cortex Hormones; Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; COVID-19 Drug Treatment; Cyclopropanes; Cytokine Release Syndrome; Cytokines; Humans; Immune System; Immunity, Innate; Inflammation; Models, Theoretical; Phosphodiesterase 4 Inhibitors; Risk; Steroids; Thalidomide

2020
Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 133

    Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Anti-Inflammatory Agents; Axl Receptor Tyrosine Kinase; Focal Adhesion Kinase 1; Gene Expression Profiling; HL-60 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Protein Array Analysis; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridones; Pyrimidines; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sulfones; Time Factors; Transcriptome

2021
Roflumilast Attenuates Doxorubicin-Induced Cardiotoxicity by Targeting Inflammation and Cellular Senescence in Cardiomyocytes Mediated by SIRT1.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Aminopyridines; Animals; Benzamides; Cells, Cultured; Cellular Senescence; Cyclopropanes; Doxorubicin; Inflammation; Myocytes, Cardiac; Rats; Sirtuin 1

2021
Neuroprotective effects of roflumilast against quinolinic acid-induced rat model of Huntington's disease through inhibition of NF-κB mediated neuroinflammatory markers and activation of cAMP/CREB/BDNF signaling pathway.
    Inflammopharmacology, 2021, Volume: 29, Issue:2

    Topics: Aminopyridines; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Huntington Disease; Inflammation; Male; Neuroprotective Agents; NF-kappa B; Nitrosative Stress; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar; Signal Transduction

2021
Lumacaftor and Matrine: Possible Therapeutic Combination to Counteract the Inflammatory Process in Cystic Fibrosis.
    Biomolecules, 2021, 03-13, Volume: 11, Issue:3

    Topics: A549 Cells; Alkaloids; Aminopyridines; Benzodioxoles; Cell Death; Cell Membrane; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Drug Therapy, Combination; Humans; Inflammation; Matrines; Models, Biological; Oxidative Stress; Quinolizidines; Quinolizines; Reactive Oxygen Species; Signal Transduction

2021
Testicular adenosine acts as a pro-inflammatory molecule: role of testicular peritubular cells.
    Molecular human reproduction, 2021, 07-01, Volume: 27, Issue:7

    Topics: 5'-Nucleotidase; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Adult; Aminopyridines; Animals; Apyrase; Cells, Cultured; Cytokines; GPI-Linked Proteins; Humans; Infertility, Male; Inflammation; Male; Mice; Mice, Inbred C57BL; Middle Aged; Receptor, Adenosine A2B; Receptors, Purinergic P1; RNA Interference; RNA, Small Interfering; Testis

2021
Inhibitory effect of roflumilast on experimental periodontitis.
    Journal of periodontology, 2022, Volume: 93, Issue:3

    Topics: Alveolar Bone Loss; Aminopyridines; Animals; Benzamides; Cyclopropanes; Gingiva; Inflammation; Interleukin-1beta; Interleukin-6; NF-kappa B; Periodontitis; Rats; Rats, Wistar; RNA, Messenger; Tumor Necrosis Factor-alpha; X-Ray Microtomography

2022
NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells.
    PloS one, 2021, Volume: 16, Issue:7

    Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Calcium; Cell Line; Inflammation; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Peptide Fragments; Phagocytosis; Thiourea

2021
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
    Journal of medicinal chemistry, 2021, 08-26, Volume: 64, Issue:16

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Class Ib Phosphatidylinositol 3-Kinase; Female; Humans; Inflammation; Molecular Structure; No-Observed-Adverse-Effect Level; Protein Kinase Inhibitors; Pyrazines; Rats, Sprague-Dawley; Structure-Activity Relationship

2021
Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage.
    Inflammation, 2017, Volume: 40, Issue:4

    Topics: Aminopyridines; Animals; Apoptosis; Benzamides; Blood-Brain Barrier; Brain; Brain Edema; Cyclopropanes; Inflammation; Inflammation Mediators; Permeability; Phosphodiesterase 4 Inhibitors; Rats; Subarachnoid Hemorrhage

2017
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
    Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Discovery; Humans; Imidazoles; Inflammation; Mitogen-Activated Protein Kinase 14; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha

2017
Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice.
    Laboratory investigation; a journal of technical methods and pathology, 2017, Volume: 97, Issue:9

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Bacterial Load; Benzamides; Cyclopropanes; Cytokines; Inflammation; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Sepsis; STAT3 Transcription Factor; Survival Analysis

2017
Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves cystic fibrosis transmembrane conductance regulator correctors efficacy.
    Hepatology (Baltimore, Md.), 2018, Volume: 67, Issue:3

    Topics: Aminophenols; Aminopyridines; Animals; Benzodioxoles; Biliary Tract; Cell Culture Techniques; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Cytokines; Cytoskeleton; Epithelial Cells; Fluorescent Antibody Technique; Humans; Induced Pluripotent Stem Cells; Inflammation; Mice; Microscopy, Confocal; Pyrimidines; Quinolones; Signal Transduction; src-Family Kinases

2018
Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.
    Nature neuroscience, 2018, Volume: 21, Issue:3

    Topics: Aminopyridines; Amyotrophic Lateral Sclerosis; Animals; Gene Expression Profiling; Gliosis; Humans; Inflammation; Mice; Mice, Transgenic; Motor Neurons; Muscle, Skeletal; Mutation; Myeloid Cells; Pyrroles; Recovery of Function; Spinal Cord; Superoxide Dismutase-1; TDP-43 Proteinopathies

2018
Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:1

    Topics: Aminopyridines; Animals; Aorta; Biological Availability; Enzyme Inhibitors; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Peroxidase; Rats; Rats, Sprague-Dawley

2018
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK
    Molecular pharmacology, 2018, Volume: 94, Issue:4

    Topics: 3T3-L1 Cells; Adipocytes; Aminopyridines; Animals; Carboxylic Acids; Cell Line; Diabetes Mellitus, Type 2; Energy Metabolism; Humans; I-kappa B Kinase; Inflammation; Mice; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Structure-Activity Relationship

2018
Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives.
    Bioorganic & medicinal chemistry letters, 2018, 11-01, Volume: 28, Issue:20

    Topics: Administration, Oral; Aminopyridines; Anemia; Animals; Binding Sites; Cell Line, Tumor; Drug Design; Hepcidins; Humans; Inflammation; Interleukin-6; Iron; Male; Mice, Inbred C57BL; Molecular Structure; Quinazolines; Structure-Activity Relationship

2018
The cystic fibrosis airway milieu enhances rescue of F508del in a pre-clinical model.
    The European respiratory journal, 2018, Volume: 52, Issue:6

    Topics: Aminophenols; Aminopyridines; Benzodioxoles; Bronchi; Cell Line; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Humans; Inflammation; Mutation; Quinolones; Respiratory System

2018
Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi.
    International journal of molecular sciences, 2018, Nov-08, Volume: 19, Issue:11

    Topics: Aminopyridines; Animals; Benzamides; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dexamethasone; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Bacterial; Haemophilus influenzae; Humans; Inflammation; Lung; Pulmonary Disease, Chronic Obstructive

2018
The phosphodiesterase type 4 inhibitor roflumilast suppresses inflammation to improve diabetic bladder dysfunction rats.
    International urology and nephrology, 2019, Volume: 51, Issue:2

    Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Cystitis; Diabetes Complications; Diabetes Mellitus, Experimental; Female; Inflammation; Interleukin-1beta; Interleukin-6; NF-kappa B; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Treatment Outcome; Tumor Necrosis Factor-alpha; Urodynamics

2019
Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.
    Glia, 2019, Volume: 67, Issue:2

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Central Nervous System Diseases; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Mutation; Myelin Proteolipid Protein; Neurons; Pyrroles; T-Lymphocytes; Tomography, Optical Coherence

2019
Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:8

    Topics: Aminopyridines; Animals; Brain; Cerebral Hemorrhage; Cognition; Cognitive Dysfunction; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Neuronal Plasticity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

2019
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Apr-02, Volume: 110, Issue:14

    Topics: Aminopyridines; Animals; Cell Survival; Chromatography, Affinity; Crystallization; Escherichia coli; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Inflammation; Macrophages; Mast Cells; Models, Molecular; Molecular Structure; Mutation, Missense; Neoplasm Metastasis; Oncogene Protein gp140(v-fms); Osteoclasts; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrroles; Sf9 Cells; Spodoptera

2013
Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury.
    Purinergic signalling, 2013, Volume: 9, Issue:3

    Topics: Acute Lung Injury; Aminopyridines; Animals; Blotting, Western; Disease Models, Animal; Inflammation; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Shock, Hemorrhagic; Wounds and Injuries

2013
Concurrent agonism of adenosine A2B and glucocorticoid receptors in human airway epithelial cells cooperatively induces genes with anti-inflammatory potential: a novel approach to treat chronic obstructive pulmonary disease.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 346, Issue:3

    Topics: Adenosine; Adenosine A2 Receptor Agonists; Algorithms; Aminopyridines; Calcium; Cell Line; Cyclic AMP; Cyclic AMP Response Element Modulator; Cytosol; Dexamethasone; Epithelial Cells; Humans; Inflammation; Phenethylamines; Pulmonary Disease, Chronic Obstructive; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A2B; Receptors, Glucocorticoid; Respiratory Mucosa; RNA, Messenger; Transfection

2013
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.
    eLife, 2013, Dec-24, Volume: 2

    Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; Adrenergic beta-3 Receptor Agonists; Aminopyridines; Animals; Catecholamines; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dioxoles; Disease Models, Animal; Energy Metabolism; Enzyme Activation; HEK293 Cells; Humans; I-kappa B Kinase; Inflammation; Ion Channels; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Phosphorylation; Poly I-C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Sterol Esterase; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Uncoupling Protein 1

2013
GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 350, Issue:1

    Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Callithrix; Cerebral Cortex; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Evaluation, Preclinical; Ferrets; Inflammation; Isoenzymes; Macaca fascicularis; Male; Nootropic Agents; Oxadiazoles; Phosphodiesterase 4 Inhibitors; Pica; Rats; Rolipram; Thiazoles

2014
Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Apr-07, Volume: 112, Issue:14

    Topics: Aminopyridines; Animals; Benzamides; Catalytic Domain; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Haemophilus influenzae; Humans; Inflammation; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Binding; Pulmonary Disease, Chronic Obstructive; RNA, Small Interfering; Transcription Factor RelA; Up-Regulation

2015
Protective effect of a novel Rho kinase inhibitor WAR-5 in experimental autoimmune encephalomyelitis by modulating inflammatory response and neurotrophic factors.
    Experimental and molecular pathology, 2015, Volume: 99, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Aminopyridines; Animals; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Immunoenzyme Techniques; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Microglia; Nerve Growth Factors; Piperidines; Protein Kinase Inhibitors; Pyridines; rho-Associated Kinases; T-Lymphocytes, Regulatory

2015
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
    Neoplasia (New York, N.Y.), 2015, Volume: 17, Issue:7

    Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides; Disease Models, Animal; Enzyme Activation; Humans; Inflammation; Interleukin-6; Janus Kinases; Liver; Liver Neoplasms; Morpholines; Niclosamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; STAT3 Transcription Factor; Zebrafish; Zebrafish Proteins

2015
CFTR-regulated MAPK/NF-κB signaling in pulmonary inflammation in thermal inhalation injury.
    Scientific reports, 2015, Oct-30, Volume: 5

    Topics: Aminopyridines; Animals; Benzodioxoles; Cell Line; Curcumin; Cyclooxygenase 2; Cystic Fibrosis Transmembrane Conductance Regulator; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Hot Temperature; Inflammation; Inhalation; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lung Diseases; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; NF-kappa B; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Up-Regulation

2015
Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.
    Nature communications, 2015, Dec-21, Volume: 6

    Topics: Aminopyridines; Animals; Apolipoproteins E; Atherosclerosis; Endothelial Cells; Gene Expression Regulation; Inflammation; Macrophages; Male; Mice; Mice, Knockout; NF-kappa B; NF-kappaB-Inducing Kinase; Protein Serine-Threonine Kinases; Receptors, LDL; Vascular Diseases

2015
Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:2

    Topics: Adrenergic beta-2 Receptor Agonists; Aminopyridines; Animals; Asthma; Benzamides; Bronchial Hyperreactivity; Cyclopropanes; Drug Therapy, Combination; Eosinophils; Formoterol Fumarate; Inflammation; Lung; Mice; Mice, Knockout; Mucus; Phenotype; Phenylethanolamine N-Methyltransferase; Phosphodiesterase 4 Inhibitors

2016
Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart.
    Open biology, 2016, Volume: 6, Issue:7

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Cell Cycle; Cell Proliferation; Cryopreservation; Disease Models, Animal; Heart; Inflammation; Ischemic Preconditioning, Myocardial; Leukocytes; Myocardial Infarction; Myocytes, Cardiac; Pyrroles; Regeneration; Thoracotomy; Zebrafish

2016
Targeting Kv7 channels in pain pathways.
    Oncotarget, 2017, Feb-21, Volume: 8, Issue:8

    Topics: Aminopyridines; Animals; Carbamates; Deafness; Epilepsy; Humans; Inflammation; KCNQ Potassium Channels; Long QT Syndrome; Mutation; Neurons; Pain; Pain Management; Phenylenediamines; Protein Conformation

2017
The reno-vascular A2B adenosine receptor protects the kidney from ischemia.
    PLoS medicine, 2008, Jun-24, Volume: 5, Issue:6

    Topics: Adenosine; Adenosine A2 Receptor Antagonists; Aminopyridines; Animals; Blood Vessels; Cytoprotection; Extracellular Fluid; Female; Inflammation; Ischemia; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Receptor, Adenosine A2B; Signal Transduction; Xanthines

2008
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis.
    The American journal of pathology, 2008, Volume: 173, Issue:5

    Topics: Aminopyridines; Animals; Autoimmune Diseases; Cell Survival; Cells, Cultured; Cytoprotection; Disease Progression; Drug Therapy, Combination; Evoked Potentials, Visual; Female; Inflammation; Interferon-beta; Ion Channel Gating; Neuroprotective Agents; Optic Nerve; Optic Neuritis; Potassium Channels, Inwardly Rectifying; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred BN; Rats, Wistar; Retinal Ganglion Cells

2008
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
    Nature chemical biology, 2008, Volume: 4, Issue:11

    Topics: Amino Acid Sequence; Aminopyridines; Animals; Cattle; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Isoenzymes; Male; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Nitric Oxide Synthase; Quinazolines; Rats

2008
Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.
    Journal of immunology (Baltimore, Md. : 1950), 2009, Apr-01, Volume: 182, Issue:7

    Topics: Aminopyridines; Animals; Blotting, Western; Gene Expression Profiling; Inflammation; Intestinal Mucosa; Intestines; Mice; Mice, Knockout; Receptor, Adenosine A2B; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction

2009
Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.
    British journal of pharmacology, 2011, Volume: 162, Issue:2

    Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopropanes; Diclofenac; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Male; Neutrophil Infiltration; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Wistar

2011
Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor.
    British journal of pharmacology, 2011, Volume: 162, Issue:7

    Topics: Aminobenzoates; Aminopyridines; Animals; Bradykinin; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Epoprostenol; Humans; Inflammation; Kinetics; Kininogen, High-Molecular-Weight; Lipopolysaccharides; Muscle Contraction; Nitric Oxide; Phenylephrine; Plasma Kallikrein; Rats; Signal Transduction; Substrate Specificity

2011
Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model.
    Neurochemical research, 2011, Volume: 36, Issue:10

    Topics: 5,6-Dihydroxytryptamine; Aminopyridines; Animals; Behavior, Animal; Creatinine; Electroacupuncture; Hyperalgesia; Indoles; Inflammation; Male; Pain; Piperazines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonergic Neurons; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Spinal Cord

2011
The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:9

    Topics: Administration, Oral; Aminopyridines; Animals; Atherosclerosis; Cell Differentiation; Cell Movement; Cholesterol, Dietary; Inflammation; Intracellular Signaling Peptides and Proteins; Macrophages; Mice; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Receptors, LDL; Syk Kinase

2011
M channel enhancers and physiological M channel block.
    The Journal of physiology, 2012, Feb-15, Volume: 590, Issue:4

    Topics: Aminopyridines; Animals; Bradykinin; Calcium; Carbamates; CHO Cells; Cricetinae; Cricetulus; Ganglia, Spinal; Hydrogen Peroxide; Inflammation; KCNQ Potassium Channels; Organometallic Compounds; Pain; Phenylenediamines; Phosphatidylinositol 4,5-Diphosphate; Pyridines; Rats; Rats, Wistar; Sensory Receptor Cells; Type C Phospholipases

2012
Additive anti-inflammatory effects of beta 2 adrenoceptor agonists or glucocorticosteroid with roflumilast in human peripheral blood mononuclear cells.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:2

    Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Aminopyridines; Anti-Inflammatory Agents; Benzamides; Cyclopropanes; Dexamethasone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ethanolamines; Formoterol Fumarate; Glucocorticoids; Humans; Inflammation; Inhibitory Concentration 50; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Phosphodiesterase 4 Inhibitors; Salmeterol Xinafoate; Tumor Necrosis Factor-alpha

2012
Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts.
    Respiratory research, 2012, Mar-27, Volume: 13

    Topics: Actins; Adrenergic beta-2 Receptor Agonists; Aminopyridines; Benzamides; Cells, Cultured; Chemokine CCL5; Chemokine CXCL10; Connective Tissue Growth Factor; Cyclopropanes; Endothelin-1; Fibroblasts; Fibronectins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Indans; Inflammation; Lung; Phosphodiesterase 4 Inhibitors; Pulmonary Fibrosis; Quinolones; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2012
Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation.
    The Journal of physiology, 2012, Jun-01, Volume: 590, Issue:11

    Topics: Aminopyridines; Animals; Benzamides; Capillaries; Capillary Permeability; Cyclic AMP; Cyclopropanes; Endothelium, Vascular; Inflammation; Lipopolysaccharides; Male; Microcirculation; Phosphodiesterase 4 Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Vascular Diseases

2012
Alternatives to indicating roflumilast and the chronic obstructive pulmonary disease classification.
    Archivos de bronconeumologia, 2012, Volume: 48, Issue:9

    Topics: Aminopyridines; Autoimmunity; Benzamides; Bronchodilator Agents; Cholinergic Antagonists; Comorbidity; Cyclopropanes; Drug Synergism; Humans; Immunocompromised Host; Infection Control; Inflammation; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Smoking; Tumor Necrosis Factor-alpha

2012
The A2b adenosine receptor modulates glucose homeostasis and obesity.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Adenosine A2 Receptor Agonists; Adult; Aminopyridines; Animals; Cholesterol; Diabetes Mellitus, Type 2; Dietary Fats; Female; Gene Expression Regulation; Glucose; Homeostasis; Humans; Inflammation; Insulin; Insulin Receptor Substrate Proteins; Male; Mice; Mice, Knockout; Middle Aged; Obesity; Receptor, Adenosine A2B; Sterol Regulatory Element Binding Protein 1

2012
LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Aged; Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Bronchoalveolar Lavage Fluid; Callithrix; Cyclopropanes; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Lung Diseases; Male; Middle Aged; Phosphodiesterase 4 Inhibitors; Tumor Necrosis Factor-alpha

2012
Altered response to hydrogen sulphide during experimental colitis in rats.
    Journal of animal physiology and animal nutrition, 2013, Volume: 97, Issue:5

    Topics: Aminopyridines; Analgesics; Animals; Colitis; Diet; Female; Hydrogen Sulfide; Inflammation; Intestines; Male; Rats; Rats, Wistar; Sulfur; Trinitrobenzenesulfonic Acid

2013
A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma.
    Pulmonary pharmacology & therapeutics, 2012, Volume: 25, Issue:6

    Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Aminopyridines; Androstadienes; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchial Hyperreactivity; Chronic Disease; Cyclopropanes; Disease Models, Animal; Fluticasone; Guinea Pigs; Histamine; Inflammation; Male; Ovalbumin; Sulfides; Time Factors

2012
Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Apoptosis; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Hyperplasia; Imidazoles; Inflammation; Macrophages; Mice; Neoplasms, Experimental; Plant Extracts; Reishi

2012
Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Nov-01, Volume: 169, Issue:9

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Migration Inhibition; Chemotaxis, Leukocyte; Cytokines; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Imidazoles; Inflammation; Intubation, Gastrointestinal; Lipopolysaccharides; Lung; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Neutrophil Infiltration; Neutrophils; p38 Mitogen-Activated Protein Kinases

2002
Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:1

    Topics: Aminopyridines; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchi; Cyclopropanes; Dexamethasone; Disease Models, Animal; Immunohistochemistry; Inflammation; Mice; Mice, Inbred BALB C

2003
2,3-diaminopyridine bradykinin B1 receptor antagonists.
    Journal of medicinal chemistry, 2004, Dec-16, Volume: 47, Issue:26

    Topics: Aminopyridines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin B1 Receptor Antagonists; Dogs; Half-Life; Inflammation; Pain Measurement; Rabbits; Rats; Species Specificity; Structure-Activity Relationship

2004
Roflumilast for chronic obstructive pulmonary disease.
    Lancet (London, England), 2005, Nov-26, Volume: 366, Issue:9500

    Topics: Aminopyridines; Benzamides; Bronchodilator Agents; Cyclopropanes; Forced Expiratory Flow Rates; Humans; Inflammation; Pulmonary Disease, Chronic Obstructive; Smoking

2005
Phosphodiesterase type 4 inhibitors cause proinflammatory effects in vivo.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cytokines; Humans; Inflammation; Interleukin-8; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Pyridines

2006
Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.
    Mediators of inflammation, 2006, Volume: 2006, Issue:1

    Topics: Aminopyridines; Cell Culture Techniques; Cell Movement; Dibenzoxepins; Gene Expression Regulation; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Inflammation; Ketotifen; Monocytes; Olopatadine Hydrochloride; Receptors, Histamine H1; S100 Proteins; S100A12 Protein

2006
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor.
    Clinical immunology (Orlando, Fla.), 2007, Volume: 124, Issue:3

    Topics: Aminopyridines; Animals; Arthritis, Rheumatoid; Arthus Reaction; Bone Resorption; Collagen Type II; Disease Models, Animal; Female; Immunoglobulin G; Inflammation; Intracellular Signaling Peptides and Proteins; Morpholines; Oxazines; Prodrugs; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, IgG; Signal Transduction; Syk Kinase; Synovial Fluid; Synovitis

2007
Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Volume: 38, Issue:5

    Topics: Aminopyridines; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchi; Chronic Disease; Cyclopropanes; Cytokines; Dexamethasone; Disease Models, Animal; Female; Humans; Inflammation; Mice; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Specific Pathogen-Free Organisms

2008
Anti-inflammatory modulation of chronic airway inflammation in the murine house dust mite model.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:4

    Topics: Aminopyridines; Androstadienes; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchoalveolar Lavage; Cyclopropanes; Dermatophagoides pteronyssinus; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluticasone; Glucocorticoids; Inflammation; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Prednisolone

2008
CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes.
    Journal of immunology (Baltimore, Md. : 1950), 2008, May-01, Volume: 180, Issue:9

    Topics: 5'-Nucleotidase; Adenosine; Adenosine A2 Receptor Agonists; Adenosine Monophosphate; Aminopyridines; Animals; Cell Movement; Dendritic Cells; Endothelium, Vascular; Inflammation; L-Selectin; Lipopolysaccharides; Lymph Nodes; Mice; Mice, Knockout; Receptor, Adenosine A2B; T-Lymphocytes; Tumor Necrosis Factor-alpha; Up-Regulation; Venules

2008
The selective MMP-12 inhibitor, AS111793 reduces airway inflammation in mice exposed to cigarette smoke.
    British journal of pharmacology, 2008, Volume: 154, Issue:6

    Topics: Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Chemokine CXCL1; Cyclopropanes; Inflammation; Interleukin-6; Lipopolysaccharides; Male; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protease Inhibitors; Respiratory System; Smoking

2008
Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Feb-15, Volume: 164, Issue:4

    Topics: Aminopyridines; Animals; Bronchoalveolar Lavage Fluid; Calcium-Calmodulin-Dependent Protein Kinases; Chemotaxis, Leukocyte; Cytokines; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Imidazoles; Inflammation; Intubation, Intratracheal; Leukocyte Count; Lipopolysaccharides; Lung; Macrophages, Alveolar; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases

2000