alpha-aminopyridine has been researched along with Disease Models, Animal in 258 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.55) | 18.7374 |
| 1990's | 2 (0.78) | 18.2507 |
| 2000's | 40 (15.50) | 29.6817 |
| 2010's | 168 (65.12) | 24.3611 |
| 2020's | 44 (17.05) | 2.80 |
| Authors | Studies |
|---|---|
| Andoh, A; Araki, Y; Bamba, S; Bamba, T; Ban, H; Fujiyama, Y; Hattori, T; Kanauchi, O; Mukaisho, K; Sugihara, H | 1 |
| Geng, X; He, J; Huang, H; Jenny Lu, HA; Jia, Y; Jin, W; Li, M; Li, X; Meng, J; Qiu, Z; Shao, G; Wang, L; Wang, S; Xu, Y; Yang, B; Zhang, S; Zhou, H | 1 |
| Birnbaumer, L; Chen, Z; Duan, J; Duan, R; Feng, Q; Gu, S; He, B; Jiang, J; Lv, K; Qin, Y; Wang, Z; Yang, C; Yang, S; Yang, Y; Zhang, L; Zhao, R | 1 |
| Chen, Y; Gao, M; Guo, Y; Jiang, M; Li, T; Liu, H; Qu, Y; Sun, X; Wan, X; Wang, F; Wang, Y; Zhao, X | 1 |
| Gao, X; Han, Z; Lei, P; Li, M; Li, X; Liu, M; Liu, Q; Zhang, W | 1 |
| Chang, YC; Chen, SL; Sung, WW; Wang, SC; Wu, YC; Yu, CY | 1 |
| Akhtar, M; Hasan, N; Najmi, AK; Parvez, S; Zameer, S | 1 |
| Alotaibi, NM; Murad, HA; Shaikh-Omar, A | 1 |
| Appel, D; Hummel, R; Klein, M; Li, S; Ritter, K; Schäfer, MKE; Strehle, J; Tegeder, I; Wang, Y; Wernersbach, I | 1 |
| Cheng, W; Fang, ZM; Feng, X; He, Y; Jiang, DS; Li, R; Luo, H; Wei, X; Yi, X; Zhang, Z; Zhao, F; Zhu, XH | 1 |
| Holtzman, DM; Hoyle, R; Long, J; Manis, M; Remolina Serrano, J; Shi, Y; Sullivan, PM; Wang, K | 1 |
| Crapser, JD; Green, KN; Ochaba, J; Reidling, JC; Soni, N; Thompson, LM | 1 |
| Busquet, N; Diaz, MJ; Gonzalez, MI; Lam, PM; Laoprasert, M; Raol, YH; Sampath, D; White, AM | 1 |
| Cano, M; Gad, M; Green, KN; Leslie, FM; Linker, KE; Tawadrous, P; Wood, MA | 1 |
| Fujikawa, K; Fujikawa, M; Ikeda, F; Kanayama, S; Kitano, T; Matsumoto, T; Mori, S; Nakamura, A; Okamoto, K; Tabara, K; Tamura, R; Uratsuji, H | 1 |
| Huo, B; Jin, L; Li, H; Liu, R; Liu, S; Tang, L; Wang, Y; Yang, T; Zhang, F; Zhao, X | 1 |
| Jiang, C; Lu, Y; Zhang, S | 1 |
| Bai, Y; Chung, S; Cianciolo, RE; Clark, MA; Feng, MJHH; Jayne, LA; Kim, JY; Pabla, NS; W Christman, J | 1 |
| Cho, HJ; Jeong, BS; Kim, ES; Kim, JA; Kim, SK; Lee, H; Lee, JS; Lee, YJ; Nam, TG | 1 |
| Afshari, K; Ashraf-Ganjouei, A; Badripour, A; Bagheri, S; Dehpour, AR; Etemadi, A; Faghani, S; Golbakhsh, M; Haghighi, F; Khavandi, MM; Moradi, K; Nikbakhsh, R | 1 |
| Chen, W; Fu, HR; Gao, YF; Wang, H; Wang, L; Wang, XD; Xu, XY; Xu, Y; Zhang, FF; Zhang, HT; Zhang, JG | 1 |
| Abou Saleh, L; Aragon, IV; Boyd, A; Koloteva, A; McDonough, W; Murphy, JM; Rich, J; Richter, W | 1 |
| Choi, HD; Choi, JY; Jeong, YJ; Lee, HJ; Nam, KR; Oh, SJ; Shin, NR; Son, Y | 1 |
| He, Q; Tang, R; Wang, W; Wu, Q; Xia, X; Yao, K; Zeng, J; Zou, X | 1 |
| Chen, W; Mai, Z; Rong, Z; Su, X; Wan, C; Wu, Q; Wu, Y; Xue, Y; Yu, X; Zheng, H | 1 |
| Chancharoenthana, W; Issara-Amphorn, J; Leelahavanichkul, A; Visitchanakun, P | 1 |
| Auclair, AL; Bardin, L; Bruins Slot, LA; Depoortere, R; Newman-Tancredi, A | 1 |
| Barati, S; Kashani, IR; Madadi, S; Pasbakhsh, P; Tahmasebi, F | 1 |
| Bartolucci, M; Cancedda, L; Catelani, T; Contestabile, A; Fumagalli, A; Morelli, G; Perlini, LE; Petretto, A; Pinto, B; Rastogi, M; Savardi, A; Varea, E | 1 |
| Berve, K; Groh, J; Martini, R; West, BL | 1 |
| Alhudaithi, SS; Almuqbil, RM; Bielski, ER; Bos, PD; da Rocha, SRP; Du, W; Sunbul, FS; Zhang, H | 1 |
| Andreasen, JT; Kristensen, JL; Odland, AU | 1 |
| Akhtar, A; Bansal, Y; Bishnoi, M; Kuhad, A; Sah, SP; Saroj, P; Singh, R; Sodhi, RK | 1 |
| Boyd, MM; Collier, LS; Hagemann, TL; Litscher, SJ; Messing, A; Seitz, LL | 1 |
| Bayraktutan, Z; Bilen, A; Dincer, B; Halici, Z; Keskin, H; Kose, D; Sirin, B; Toktay, E | 1 |
| Feng, Z; Gao, Z; He, X; Hu, Y; Li, X; Min, C; Song, H; Wang, Y; Yang, Y; Zhu, Z | 1 |
| Gawalska, A; Głuch-Lutwin, M; Jamrozik, M; Kołaczkowski, M; Newman-Tancredi, A; Pytka, K; Sałaciak, K; Sniecikowska, J | 1 |
| Baettig, U; Bahra, P; Bala, K; Brocklehurst, C; Budd, E; Butler, R; Cheung, AK; Choudhury, H; Collingwood, SP; Cox, B; Danahay, H; Edwards, L; Everatt, B; Glaenzel, U; Glotin, AL; Gosling, M; Grand, DL; Groot-Kormelink, P; Hall, E; Hatto, J; Howsham, C; Hughes, G; King, A; Koehler, J; Kulkarni, S; Lightfoot, M; Nicholls, I; Page, C; Pergl-Wilson, G; Popa, MO; Robinson, R; Rowlands, D; Sandham, DA; Sharp, T; Spendiff, M; Stanley, E; Steward, O; Taylor, RJ; Tranter, P; Wagner, T; Watson, H; Williams, G; Wright, P; Young, A | 1 |
| Ashour, NH; El Sayed, NS; El-Tanbouly, DM; Khattab, MM | 1 |
| Arnes, L; Bravo, MC; Erler, JT; Horton, ER; Hwang, CI; Jackstadt, R; Jensen, ARD; Karim, SA; Laitala, A; Maltese, G; Morton, JP; Nielsen, SR; Rafaeva, M; Reuten, R; Sansom, OJ; Strøbech, JE; Tuveson, DA | 1 |
| Ren, C; Wang, Y; Xiu, J; Yang, T; Yu, Z | 1 |
| Gupta, K; Kumari, A; Pandey, S; Sen, P; Singh, G; Singh, R | 1 |
| Abe, S; Aoshiba, K; Fuchikami, JI; Kawagoe, J; Kikuchi, R; Kono, Y; Koyama, N; Maeda, Y; Nakamura, H; Takahashi, M; Tsuji, T; Yamaguchi, K | 1 |
| Barati, S; Kashani, IR; Tahmasebi, F | 1 |
| Ci, L; Dong, H; Fei, J; Huang, F; Li, Q; Liu, Z; Ma, Y; Shen, C; Shen, R; Sun, R; Wang, J; Wang, Z; Yu, M; Zhang, X | 1 |
| Chen, DD; Le Grange, JM; Zhang, JN; Zheng, XF; Zhou, LQ; Zhu, XL | 1 |
| Gao, C; Hong, T; Shen, J; Ti-Jun, D; Xin, L; Yan, C; Zhi-Xiu, M | 1 |
| Bass, CR; Meaney, DF; Morales, FN; Morrison, B; Vogel, EW | 1 |
| Aerts, JG; Bezemer, K; Dammeijer, F; Hegmans, JP; Hendriks, RW; Kaijen-Lambers, ME; Lievense, LA; van Hall, T; van Nimwegen, M | 1 |
| Abu Aboud, O; Baloglu, E; Chen, X; Chmiel, KJ; Dionne, LK; Hwang, VJ; Li, X; Mahjoub, MR; Senapedis, W; Shim, K; Trott, J; Weiss, RH; Zhou, X | 1 |
| Abbadessa, G; Chandrasekhar, V; Kontaridis, MI; Schwartz, B; Wang, J; Yu, Y | 1 |
| Raol, YH; Sampath, D; Valdez, R; White, AM | 1 |
| Kim, JW; Kim, SJ; Kim, YA; Kim, YK; Lee, HY; Lee, SH; Yeo, CD | 1 |
| Akkari, L; Huse, JT; Joyce, JA; Kowal, J; Schuhmacher, AJ; West, BL; Yan, D | 1 |
| Chen, B; Gu, X; He, Z; Li, W; Li, Y; Liu, Y; Wang, X; Williams, PR; Yu, B; Zhang, Q; Zhang, Y; Zhang, Z; Zhu, J | 1 |
| Gao, Y; Han, X; Hong, X; Koehler, RC; Lan, X; Li, Q; Luo, T; Wang, J; Yang, Q; Zhai, Y; Zhou, J | 1 |
| Baloglu, E; Chen, Y; Chien, W; Ding, LW; Gery, S; Jiang, YY; Koeffler, HP; Lill, M; Lin, DC; Madan, V; Mayakonda, A; Müschen, M; Park, E; Senapedis, W; Sudo, M; Sun, QY; Takao, S; Xu, L | 1 |
| Calkovska, A; Kolomaznik, M; Kosutova, P; Mikolka, P; Mokra, D; Rezakova, S | 1 |
| Hata, T; Iwasaki, H; Kato, T; Kobayashi, H; Matsuo, A; Matsushita, M; Ohta, T | 2 |
| Benjamin, JT; Blackwell, TS; Cheng, DS; Du, RH; Gleaves, L; Guo, M; Han, W; McKissack, A; Polosukhin, VV; Richmond, BW; van der Meer, R; Zhang, Y | 1 |
| El-Adawy, SA; El-Ashmawy, NE; El-Bahrawy, HA; Khedr, NF | 1 |
| Liu, H; Luo, D; Luo, K | 1 |
| Albay, R; Baglietto-Vargas, D; Glabe, CG; LaFerla, FM; Philipp, S; Reyes-Ruiz, JM; Sosna, J | 1 |
| Ahn, YH; Cho, HI; Jang, YK; Jin, YH; Kim, MS; Park, EJ; Yoon, HJ | 1 |
| Canton, R; Chouinard, L; Tarragó, C | 1 |
| Arañó, A; D'Aniello, F; Esquirol, LP; Lachamp, L; Tarragó, C; Zsolt, I | 1 |
| Grant, FM; Gyori, D; Hawkins, PT; Lim, EL; Okkenhaug, K; Roychoudhuri, R; Shuttleworth, SJ; Spensberger, D; Stephens, LR | 1 |
| Arancio, O; Gulisano, W; Palmeri, A; Puzzo, D; Tropea, MR | 1 |
| Milani, H; Prickaerts, J; Santiago, A; Schepers, M; Soares, LM; Vanmierlo, T; Weffort de Oliveira, RM | 1 |
| Arner, EN; Brekken, RA; Cruz, VH; Scherer, PE; Wynne, KW | 1 |
| Blosser, W; Buchanan, S; Dempsey, J; Dowless, M; Ebert, P; Flack, R; Gong, X; Gupta, S; Houghton, P; Iversen, P; Lowery, CD; Olsen, JB; Renschler, M; Shackleford, T; Stancato, L; Stephens, J; Stewart, J; VanWye, AB; Webster, Y | 1 |
| Chua, S; Iqbal, NJ; Liu, SM; Lu, Z; Schwartz, GJ; Zhu, L | 1 |
| Adewale, AT; Ashtekar, AR; Brand, JD; Harrod, KS; Lazrak, A; Matalon, S; Rowe, SM; Shei, RJ; Tipper, JL; Trombley, JE; Yu, Z | 1 |
| Griggs, JL; Mathai, ML; Sinnayah, P | 1 |
| Balkenhol, M; Beißbarth, T; Blazquez, R; Bleckmann, A; Evert, M; Hanisch, UK; Korf, U; Perera-Bel, J; Proescholdt, M; Pukrop, T; Reinz, E; Riemenschneider, MJ; Ritter, U; Salinas, G; Schatlo, B; Schildhaus, HU; Schulz, M; Seitz, S; Siam, L; Stadelmann, C; Utpatel, K; Vollmer, E; Wachter, A; Wiemann, S; Wlochowitz, D; Wolff, A | 1 |
| Finkelstein, M; Franks, T; Hirakawa, B; Hu, W; Jessen, B; Kalabat, D; Khoh-Reiter, S; Lu, S; Sacaan, A; Sung, T; Thibault, S | 1 |
| Baudry, M; Bi, X; Hao, X; Johe, K; Liu, Y; Sun, J; Wang, Y | 1 |
| Lee, BC; Li, JD; Susuki-Miyata, S; Yan, C | 1 |
| Bennett, RE; Bryant, A; Hopp, SC; Hu, M; Hyman, BT; Robbins, AB | 1 |
| Covel, J; Fierer, J; Kapoor, M; Okamoto, S; Shaw, KJ; Soltow, QA; Trzoss, M; Viriyakosol, S | 1 |
| Azimova, B; Chen, WH; Jiang, PZ; Liu, WL; Njoya, EM; Peng, T; Qiang, Z; Shi, N; Wang, F; Zhang, GL; Zhou, ZY | 1 |
| Fleck, SC; Geisslinger, G; Möller, M; Möser, CV; Niederberger, E; Thomas, D | 1 |
| Berve, K; Groh, J; Klein, D; Martini, R; West, BL | 1 |
| Anand, K; Iyer, SP; Kumar, P; Pati, D; Pingali, SR | 1 |
| Adamkov, M; Balentova, S; Calkovska, A; Kolomaznik, M; Kosutova, P; Mikolka, P; Mokra, D | 1 |
| Feng, H; He, B; He, W; Li, S; Wang, C; Wei, M; Wu, X; Zeng, Z | 1 |
| Luo, Q; Qian, Y; Qiao, S; Xu, G; Zhang, Z | 1 |
| Barati, S; Kashani, IR; Madadi, S; Mortezaee, K; Pasbakhsh, P; Tahmasebi, F | 1 |
| Chang, CL; Hsu, YT; Weng, CS; Wu, CC | 1 |
| Chang, X; Hu, LF; Li, JB; Liu, XY; Ma, XJ; Yin, J | 1 |
| Birge, RB; Calianese, D; Davra, V; De Lorenzo, MS; Geng, K; Kasikara, C; Kotenko, SV; Quigley, M; Spires, TE; Sriram, G; Suarez-Lopez, L; Wichroski, M; Yaffe, MB | 1 |
| Huang, KL; Lan, CC; Peng, CK; Tzeng, IS; Wu, CP; Wu, YK | 1 |
| Ge, XT; Guo, JX; Li, CL; Li, TY; Lv, F; Wang, XF; Wang, YJ | 1 |
| Chen, K; Gan, X; Li, S; Li, X; Pei, H; Qiu, C; Sun, X; Wang, Q; Yang, D; Yang, Y | 1 |
| Ducruet, AF; Lawton, MT; Qiu, S; Sheth, KN; Shi, E; Shi, K | 1 |
| Boussioutas, A; Brunnberg, J; Buchert, M; Dijkstra, C; Eissmann, MF; Ernst, M; Etemadi, N; Grimbaldeston, MA; Hibbs, ML; Huntington, ND; Jarnicki, A; Masson, F; O'Donoghue, RJJ; Phesse, T; Poh, AR; Thiem, S; Tsantikos, E | 1 |
| Bundschuh, DS; Eigler, A; Endres, S; Lehr, HA; Rieder, F; Siegmund, B | 1 |
| Ahring, PK; Christophersen, P; Dalby-Brown, W; Erichsen, HK; Grunnet, M; Hougaard, C; Jacobsen, TA; Jensen, ML; Jessen, C; Jørgensen, S; Nielsen, KS; Strøbæk, D | 1 |
| Csóka, B; Eltzschig, HK; Haskó, G; Koscsó, B; Németh, ZH; Pacher, P; Trepakov, A | 1 |
| Eddy, JB; Good, MA; Humby, T; Reichelt, AC; Wilkinson, LS | 1 |
| Banks, WA; Crider, AM; Farr, SA; Morley, JE; Sandoval, KE; Witt, KA | 1 |
| Amato, RJ; Byers, FW; Conn, PJ; Daniels, JS; Emmitte, KA; Felts, AS; Jones, CK; Lindsley, CW; Morrison, RD; Niswender, CM; Rodriguez, AL; Venable, DF | 1 |
| Aoki, I; Chang, Q; Furumoto, S; Higuchi, M; Ito, H; Iwata, N; Jang, MK; Ji, B; Kudo, Y; Lee, VM; Lewis, J; Maeda, J; Maruyama, M; Masamoto, K; Okamura, N; Ono, M; Sahara, N; Saido, TC; Shimada, H; Shinotoh, H; Suhara, T; Takano, H; Takashima, A; Trojanowski, JQ; Zhang, MR | 1 |
| Bashyam, S; Charman, SA; Chibale, K; Douelle, F; González Cabrera, D; Joseph, JT; Le Manach, C; Nchinda, AT; Paquet, T; Street, LJ; Waterson, D; White, KL; Wittlin, S; Witty, MJ; Younis, Y; Zabiulla, KM | 1 |
| Wang, Q; Weisberg, E; Zhao, JJ | 1 |
| Barrett, DA; Bullock, C; Burston, JJ; Chapman, RJ; Chapman, V; Hathway, GJ; Huang, J; Kelly, S; McWilliams, DF; Okine, BN; Paton, K; Sagar, DR; Turner, J; Walsh, DA; Wong, A; Woodhams, S | 1 |
| Campos, MM; de Souza, AH; Koch, DA; Laufer, S; Leite, CE; Morrone, FB; Nicoletti, NF; Silva, RB | 1 |
| Chang, L; Chiang, SH; Leto, D; Mowers, J; Reilly, SM; Saltiel, AR; Simon, J; Uhm, M | 1 |
| Brandt, M; Cui, G; Darcy, MG; Diaz, E; Faitg, TH; Federowicz, K; Gilmartin, AG; Groy, A; Heerding, DA; Jaworski, JP; Jones, A; Kirkpatrick, RB; Kumar, R; Martens, S; McNulty, DE; Minthorn, E; Nevins, N; Peng, X; Pietrak, B; Richter, M; Schaber, M; Schwartz, B; Seefeld, MA; Sinnamon, RH; Yang, J; Zhang, H; Zhang, SY | 1 |
| Andersson, M; Berglind, F; Bielefeld, P; Deisseroth, K; Kirik, D; Kokaia, M; Ledri, M; Melis, M; Nikitidou, L; Sørensen, AT | 1 |
| Antonescu, CR; Besmer, P; Cavnar, MJ; Cohen, NA; Crawley, MH; Dematteo, RP; Green, BL; Greer, JB; Kim, TS; Ku, AT; Pillarsetty, N; Popow, R; Rossi, F; Seifert, AM; Sorenson, EC; Veach, DR; Zeng, S | 1 |
| Date, M; Fujimoto, M; Hamaguchi, Y; Hasegawa, M; Hau, KT; Kimura, H; Le Huu, D; Matsushita, T; Takehara, K | 1 |
| Bhangal, G; Cook, HT; Jackson, WD; Masuda, ES; McAdoo, SP; McDaid, JP; Pusey, CD; Reynolds, J; Smith, J; Tam, FW; Tanna, A | 1 |
| Balsas, P; Campo, E; Casserras, T; Colomer, D; Giné, E; Kalko, SG; López-Guillermo, A; Matas-Céspedes, A; Pérez-Galán, P; Rodriguez, V; Rosich, L; Roué, G; Vidal-Crespo, A; Villamor, N | 1 |
| Cao, P; Chen, Z; Shi, Y; Wang, X; Zheng, Y; Zhou, Z; Zou, X | 1 |
| Alagesan, B; Bardeesy, N; Benes, CH; Contino, G; Corcoran, RB; Deshpande, V; Engelman, J; Guimaraes, AR; Hezel, AF; Loda, M; Weissleder, R; Wojtkiewicz, GR; Wong, KK | 1 |
| Eldredge, LC; Ramsey, BW | 1 |
| Blum, S; Lamb, D; Thaler, E; Wex, E | 1 |
| Fitter, S; Gan, ZY; Martin, SK; To, LB; Zannettino, AC | 1 |
| Harrington, M | 1 |
| Hakenberg, OW; Kirschstein, T; Köhling, R; Mader, F; Porath, K; Pose, M; Protzel, C; Weller, J | 1 |
| Affolter, T; Appleman, V; Brooun, A; Charest, A; Deng, YL; Engstrom, LD; Falk, MD; Fantin, VR; Hu, W; Jiang, P; Johnson, TW; Lam, J; Lappin, PB; Li, Q; Liu, W; McDonnell, SR; McTigue, M; Nichols, T; Smeal, T; Timofeevski, S; West, M; Wong, KA; Zou, HY | 1 |
| Choi, SH; Durrance, ES; Jang, HC; Jin, H; Kim, KM; Kim, YB; Lee, GY; Lee, KS; Lim, S; Park, HS; Park, KS | 1 |
| Ahmed, N; Baldwin, ET; Burton, CR; Civiello, RL; Dubowchik, GM; Han, X; Jacutin-Porte, S; Kish, K; Krause, CM; Langley, DR; Lewis, HA; Lippy, JS; Macor, JE; Newitt, JA; Nophsker, M; Park, H; Pokross, M; Sivaprakasam, P; Szapiel, N; Xiao, H | 1 |
| Buege, M; Chen, T; Ciarimboli, G; Du, G; Gibson, AA; Hu, S; Janke, LJ; Li, L; Ong, SS; Pabla, N; Schlatter, E; Sparreboom, A; Sprowl, JA; Vasilyeva, A | 1 |
| Alexander, KA; Allen, JL; Antin, JH; Blazar, BR; Chao, NJ; Clynes, RA; Cutler, CS; Du, J; Flynn, R; Hill, GR; Koreth, J; Luznik, L; MacDonald, KP; Maillard, I; Murphy, WJ; Panoskaltsis-Mortari, A; Paz, K; Poe, JC; Ritz, J; Sarantopoulos, S; Serody, JS; Soiffer, RJ; Taylor, PA; Vulic, A | 1 |
| Fu, T; Guo, L; Huang, P; Li, C; Lu, Q; Xu, X; Yi, Z; Zhao, D | 1 |
| Arens, R; Melief, CJ; Sluijter, M; van der Burg, SH; van der Sluis, TC; van Duikeren, S; van Hall, T; West, BL | 1 |
| Bury, A; Konrad, FM; Ngamsri, KC; Reutershan, J; Schick, MA | 1 |
| Burton, EA; Chartier, S; Habets, G; Jimenez-Andrade, JM; Lin, PS; Mantyh, PW; Thompson, ML; Tsai, J; West, BL | 1 |
| Noori, HR; Spanagel, R; Vengeliene, V | 1 |
| Alfieri, RR; Ardizzoni, A; Bonelli, MA; Caffarra, C; Cavazzoni, A; Cretella, D; Falco, A; Frati, C; Fumarola, C; Galetti, M; La Monica, S; Lagrasta, CA; Madeddu, D; Petronini, PG; Quaini, F; Rossetti, P; Saccani, F; Tiseo, M | 1 |
| Chaplan, SR; Hoffmann, J; Meents, JE; Neeb, L; Reuter, U; Schuh-Hofer, S; Wickenden, A | 1 |
| Aksit, H; Ayvaz, S; Can, G; Can, H; Demirtas, S; Karaca, T; Korkmaz, U; Kurt, M; Yilmaz, B | 1 |
| Arora, RP; Green, KN; Hernandez, MX; Lee, RJ; Rice, RA; Spangenberg, EE; Tenner, AJ; West, BL; Yamate-Morgan, H | 1 |
| Girish, R; Jabaris, SS; Narayanan, S; Saravana Babu, C; Sugumar, M; Sumathy, H; Thanikachalam, M; Thanikachalam, S | 1 |
| Cortijo, J; Milara, J; Monleon, D; Morcillo, E; Tenor, H | 1 |
| Ahn, YM; Booth, RJ; Caldwell, TM; Chun, L; Clare, M; Ensinger, CL; Flynn, DL; Hood, MM; Kaufman, MD; Leary, CB; Lu, WP; Patt, TW; Patt, WC; Rutkoski, TJ; Samarakoon, T; Smith, BD; Stewart, LJ; Telikepalli, H; Turner, BA; Vogeti, L; Vogeti, S; Wise, SC; Yates, KM | 1 |
| Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN | 1 |
| Miele, L; Morello, S; Pinto, A; Porta, A; Sorrentino, C | 1 |
| Anderton, SM; Brunton, VG; Byron, A; Canel, M; Frame, MC; Gilbert, N; Gómez-Cuadrado, L; Lund, T; Maniati, E; McPherson, RC; Muir, M; Nibbs, RJ; Pachter, JA; Ring, JE; Serrels, A; Serrels, B; Sims, AH; von Kriegsheim, A | 1 |
| Dong, L; Jiang, Q; Liu, H; Pang, G; Stackman, RW; Tao, X; Wu, X; Zhang, G; Zhang, YM | 1 |
| Ahidjo, BA; Bishai, WR; Maiga, M; Maiga, MC | 1 |
| Gupta, N; Li, W; McIntyre, TM | 1 |
| Aguiar, RCT; Bhatnagar, H; Holder, KN; Kim, SW; Lin, AP; Moritz, AW; Suhasini, AN; Wang, L | 1 |
| Kim, JH; Kim, SW; Kim, TJ; Kim, YK; Kwon, SS; Lee, SY; Park, CK; Rhee, CK; Yoon, HK | 1 |
| Hong, S; Jang, HH; Kang, M; Kim, HY; Kim, S; Lee, WS | 1 |
| Han, H; Lee, JH; Park, HJ; Park, JW; Park, KH; Park, YH; Sim, da W | 1 |
| Gumus, M; Ibiloglu, I; Kapan, M; Kaplan, I; Turkoglu, A; Uslukaya, O; Yazgan, UC | 1 |
| Burgess, RW; Morelli, KH; Pinter, MJ; Seburn, KL; Sleigh, JN; Spaulding, EL | 1 |
| Abdolrasulnia, R; Blackwell, TS; Bordenstein, SR; Brucker, RM; Cheng, DS; Clark, PE; Du, RH; Gleaves, L; Han, W; Polosukhin, VV; Polosukhina, D; Richmond, BW; Zhang, Y | 1 |
| Imanishi, T; Kondo, M; Koyama, T; Ohyama, M; Yamauchi, M | 1 |
| Arendt-Nielsen, L; Harris, S; Hummel, M; Kapil, R; Knappenberger, T; Kyle, D; O'Keefe, S; Whiteside, GT | 1 |
| Beckmann, RP; Beeram, M; Chan, EM; Cronier, DM; Flaherty, KT; Frenzel, M; Fulford, AD; Gandhi, L; Goldman, JW; Hilton, JF; Kulanthaivel, P; Li, LQ; Martinez, R; Nasir, A; Nguyen, TS; Papadopoulos, KP; Patnaik, A; Rasco, DW; Rosen, LS; Schade, AE; Shapiro, GI; Tolaney, SM; Tolcher, AW; Wen, PY | 1 |
| Cobbold, M; Drayson, MT; Ellis, JD; Hampson, P; Inston, NG; Jenkinson, E; Neil, DA; Ready, AR; Shuttleworth, SJ | 1 |
| Burke, AR; DeBold, JF; Miczek, KA | 1 |
| DeNardo, DG; Hawkins, WG; Hegde, S; Herndon, JM; Jiang, H; Knolhoff, BL; Meyer, MA; Nywening, TM; Pachter, JA; Shapiro, IM; Wang-Gillam, A; Weaver, DT; Zhu, Y | 1 |
| Ghorbanalipoor, S; Hashimoto, T; Jonkman, MF; Kasprick, A; Koga, H; Ludwig, RJ; Pas, HH; Recke, A; Tenor, H; Vidarsson, G; Zillikens, D | 1 |
| Abu Aboud, O; Argueta, C; Baloglu, E; Chen, CH; Senapedis, W; Weiss, RH | 1 |
| Barker, HE; Bhide, S; Harrington, KJ; McLaughlin, M; Newbold, KL; Nutting, CM; Patel, R; Schick, U; Zaidi, S | 1 |
| Chen, Y; Tong, J; Wang, Y; Wu, Y; Xiang, R; Xu, W; Yan, H; Yu, W; Zhang, N | 1 |
| Baier, F; Bise, T; de Preux Charles, AS; Jaźwińska, A; Marro, J | 1 |
| Bozec, A; Chamorey, E; Ebran, N; Gautier, M; Marcie, S; Milano, G; Penault-Llorca, F; Radosevic-Robin, N; Yahia, HB | 1 |
| Jin, WN; Li, M; Li, Z; Liu, Q; Ren, H; Sheth, KN; Shi, FD; Wood, K | 1 |
| Asashima, H; Hirota, T; Iizuka-Koga, M; Kondo, Y; Matsui, M; Matsumoto, I; Segawa, S; Sumida, T; Tahara, M; Takahashi, H; Tsuboi, H | 1 |
| Abbadessa, G; Andrews, RK; Barazia, A; Cho, J; Gordeuk, VR; Kim, K; Li, J; Schwartz, B; Tseng, A; Youn, SW; Yu, Y | 1 |
| Bekaii-Saab, T; Bloomston, M; Che, Z; Elnaggar, O; Farren, MR; Farris, AB; Guttridge, DC; Lesinski, GB; Mace, TA; Maskarinec, JM; Rajasekera, P; Talbert, EE; Timmers, CD; Yang, J; Young, GS | 1 |
| Doh-Ura, K; Teruya, K | 1 |
| Greenwood-Van Meerveld, B; Prusator, DK | 1 |
| Li, GZ; Li, XT; Qin, Q; Yue, ZY; Zhang, H; Zhi, LT | 1 |
| Abdulrahman, AS; Habib, HS; Khabaz, MN; Murad, HA; Rafeeq, MM; Sulaiman, MI | 1 |
| Althage, A; Beyer, C; Chen, CW; Cole, SH; Distler, JH; Gergely, P; Harris, JL; Hsieh, MH; Li, C; Liu, J; Maier, C; Meeusen, S; Ng, N; Pan, S; Schett, G; Seidel, HM; Svensson, EC; Trinh-Minh, T; Xu, X | 1 |
| Borlongan, CV; Hayama, KL; Hazel, TG; Johe, K; Kaneko, Y; Lam, T; Lee, D; Quach, DM; Tajiri, N; Wu, MC; Wu, S | 1 |
| Baloglu, E; Crochiere, M; Das-Gupta, S; Landesman, Y; Minden, A; Rane, C; Senapedis, W | 1 |
| Chang, JH; Jeong, BS; Kang, Y; Nam, TG; Timilshina, M | 1 |
| Gonzales, RJ; Jin, WN; Li, M; Li, Z; Liu, Q; Shi, SX; Wood, K | 1 |
| Harada, D; Ikeda, Y; Kobayashi, K; Manabe, H; Nosaka, Y | 1 |
| Iwashita, A; Matsuoka, N; Mihara, T | 1 |
| Aberg, A; Andersson, G; Andrews, G; Arvai, AS; Cheshire, DR; Connolly, S; Crane, BR; Garcin, ED; Gensmantel, NP; Getzoff, ED; Hamley, PJ; Kroeger, MD; Mallinder, PR; Mete, A; Nicholls, DJ; Rosenfeld, RJ; St-Gallay, SA; Stuehr, DJ; Tainer, JA; Tinker, AC; Wallace, AV | 1 |
| Bhatia, DR; Bhatt, P; Bhonde, MR; Dadarkar, SD; Dagia, NM; Deore, V; Desai, NK; Gupte, RD; Jadhav, MG; Kumar, S; Sharma, S; Tannu, AA; Vishwakarma, RA; Yewalkar, N | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A; Tucker, AP | 1 |
| Aihara, T; Hirao, A; Kato, T; Kurebayashi, Y; Mori, H; Ochi, Y; Ohshiro, H; Sakakibara, M; Takahashi, N; Taniguchi, Y; Tonai-Kachi, H | 1 |
| Bussel, JB; Crow, AR; Grossbard, E; Lazarus, AH; Podolanczuk, A | 1 |
| Cerdá-Nicolás, M; Cortijo, J; Hatzelmann, A; Iranzo, A; Mata, M; Milara, X; Morcillo, EJ; Ruiz-Saurí, A; Tenor, H | 1 |
| Beume, R; Braun, A; Hoymann, HG; Korolewitz, R; Krug, N; Muller, M; Wollin, L | 1 |
| Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH | 1 |
| Andree, TH; Hughes, ZA; Malberg, JE; Pulicicchio, C; Rosenzweig-Lipson, S; Schechter, LE; Stack, GP; Sukoff Rizzo, SJ | 1 |
| Gurney, AM; MacLean, MR; Morecroft, I; Murray, A; Nilsen, M | 1 |
| Adamis, AP; Knolle, J; Löffler, KU; Stragies, R; Vossmeyer, D; Wills, M; Wong, CG; Zahn, G | 1 |
| Amat, J; Christianson, JP; Fleshner, M; Greenwood, BN; Maier, SF; Paul, ED; Ragole, T; Strong, PV; Watkins, LR | 1 |
| Bhangal, G; Chawanasuntorapoj, R; Cook, HT; Masuda, ES; McDaid, JP; Pusey, CD; Smith, J; Tam, FW | 1 |
| Bahjat, FR; Deng, GM; Liu, L; Pine, PR; Tsokos, GC | 1 |
| Colgan, SP; Eckle, T; Eltzschig, HK; Hartmann, K; Macmanus, CF; Schingnitz, U; Zug, S | 1 |
| Chen, CK; Doyle, PS; Engel, JC; Hopkins, SD; Jacobson, MP; Johnston, JB; Leung, SS; McKerrow, JH; Podust, LM | 1 |
| Auclair, AL; Bardin, L; Colpaert, FC; Depoortère, R; Newman-Tancredi, A; Vacher, B | 1 |
| Duke, FD; Hamilton, EC; Neisewander, JL; Pentkowski, NS; Pockros, LA; Teer, AP; Thiel, KJ; Weber, SM | 1 |
| Bahra, P; Banner, KH; Dale, N; Freeman, MS; Hardaker, EL; Poll, C; Raza, F | 1 |
| Bennardo, S; Efremov, DG; Laurenti, L; Leone, G; Longo, PG; Perlas, E; Suljagic, M | 1 |
| Colbatzky, F; Göggel, R; Nickolaus, P; Peter, D | 1 |
| Brookes, S; Leung, G; Shi, R; Smith, D; Sun, W | 1 |
| Fujisawa, M; Hatao, F; Hori, M; Kaminishi, M; Murata, T; Ozaki, H; Seto, Y; Tsuchida, Y | 1 |
| Campbell-Dittmeyer, K; Chaplan, SR; Greenwood-Van Meerveld, B; Tyler, K; Wickenden, AD; Wiskur, BJ | 1 |
| Dalle, C; Gamper, N; Ooi, L; Robertson, B; Rose, K; Wood, IC | 1 |
| Balsam, PD; Fairhurst, S; Kandel, ER; Kellendonk, C; Lipatova, O; Richards, V; Simpson, EH; Ward, RD | 1 |
| Alvarez-Sánchez, R; Benardeau, A; Benz, J; Gubler, M; Haap, W; Hebeisen, P; Joseph, C; Kirchner, S; Kitas, E; Kuhn, B; Mohr, P; Ruf, A; Schott, B; Tozzo, E; Wessel, HP; Zutter, U | 1 |
| Boisgard, R; Da Pozzo, E; Damont, A; Dollé, F; Kassiou, M; Kuhnast, B; Lemée, F; Martini, C; Raggiri, G; Scarf, AM; Selleri, S; Tavitian, B | 1 |
| He, X; Liu, W; Liu, Y; Peng, B; Wang, H; Wang, Y; Yin, J; Yu, F | 1 |
| Cheron, G; de Kerchove d'Exaerde, A; Gall, D; Hourez, R; Millard, I; Orduz, D; Orr, HT; Pandolfo, M; Schiffmann, SN; Servais, L | 1 |
| Jiang, X; Li, Q; Luo, T; Wang, J | 1 |
| Hirano, Y; Kobayashi, M; Kobayashi, S; Kubo, S; Shimizu, Y; Takahashi, K | 1 |
| Berna, P; Bernardelli, P; Bertrand, CP; Carré, C; Chevalier, E; Coupe, M; Dassaud, M; Dupont, M; Fargeau, H; Fric, M; Lagente, V; Leduc, S; Palazzi, X; Richard, V; Vergne, F | 1 |
| Chuang, PY; Deng, Y; He, JC; Klotman, PE; Liu, R; Mallipattu, SK; Wu, Y; Zhong, Y | 1 |
| Buckley, AF; Cho, YJ; Eroshkin, A; Febbo, PG; Korshunov, A; McLendon, RE; Miller, CR; Moore, CE; Northcott, PA; Pei, Y; Pfister, SM; Read, TA; Schmitt, EM; Sun, JL; Taylor, MD; Tewari, AK; Wang, J; Wechsler-Reya, RJ; Westbrook, TF; Witt, H | 1 |
| Bryant, JW; Gibson, GW; Kolte, D; Shariat-Madar, Z; Wang, J | 1 |
| Kimura, M; Tanaka, M; Watanabe, Y; Yoshimoto, K | 1 |
| Bot, I; Bot, M; de Vries, H; Foks, AC; Ijzerman, AP; Korporaal, SJ; Kuiper, J; Ter Borg, MN; van Berkel, TJ; van Santbrink, PJ; van Veldhoven, J | 1 |
| Beume, R; Dieckmann, A; Hanauer, G; Heuser, A; Kaessner, N; Kley, HP; Knaack, D; Vollert, S; Weiss-Haljiti, C | 1 |
| Bleyer, M; Braun, A; Fieguth, HG; Förster, C; Fuchs, E; Hohlfeld, JM; Kaup, FJ; Knauf, S; Lauenstein, HD; Neuhaus, V; Pfennig, O; Schlumbohm, C; Seehase, S; Sewald, K; Switalla, S | 1 |
| Broadley, KJ; Evans, RL; Ford, WR; Kidd, EJ; Knowles, RG; Nials, AT | 1 |
| Cooke, I; Goodchild, CS; Kolosov, A; Williams, ED | 1 |
| Chang, HH; Chappeta, S; Dietrich, J; Gokhale, V; Hulme, C; Medda, F; Meuillet, EJ; Sells, E; Smith, B | 1 |
| De Carolis, L; Nencini, P; Schepisi, C | 1 |
| Christianson, JP; Drugan, RC; Flyer, JG; Maier, SF; Watkins, LR | 1 |
| Giardino, WJ; Ryabinin, AE | 1 |
| Duxon, MS; Jones, N; King, SM | 1 |
| Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Adriaensen, H; Colpaert, FC; Deseure, K; Koek, W | 1 |
| Berry, CN; Ferrari, P; Herbert, JM; Lechaire, I; Lochot, S; Lorrain, J; Lunven, C; Millet, L; O'Connor, SE; Sainte-Marie, M; Schaeffer, P; Visconte, C | 1 |
| Beume, R; Foster, PS; Herbert, C; Kumar, RK; Thomas, PS; Webb, DC; Wollin, L; Yang, M | 1 |
| Bagdy, G; Gerber, K; Graf, M; Halasz, P; Jakus, R; Juhasz, G; Levay, G | 1 |
| Altenburger, JM; Berry, CN; Bocskei, Z; Galtier, D; Herault, JP; Herbert, JM; Jetha, JC; Lassalle, GY; Lorrain, J; Lunven, C; Matrougui, M; O'Connor, SE; Schaeffer, P | 1 |
| Herbert, JM; Lorrain, J; Millet, L; O'Connor, SE; Sainte-Marie, M; Schaeffer, P; Visconte, C | 1 |
| Lambris, JD; Pappas, IS; Tsiftsoglou, AS; Vizirianakis, IS; Winters, MS | 1 |
| Cosi, C; Newman-Tancredi, A; Rollet, K; Tesori, V; Waget, A | 1 |
| Beume, R; Lucattelli, M; Lungarella, G; Martorana, PA; Wollin, L | 1 |
| Beume, R; Bundschuh, DS; Marx, D; Wohlsen, A; Wollin, L | 1 |
| Burnet, M; Guse, JH; Gutke, HJ; Khobzaoui, M; Renukappa-Gutke, T | 1 |
| Beume, R; Marx, D; Wohlsen, A; Wollin, L | 1 |
| Eckert, C; Einsiedel, HG; Fichtner, I; Henze, G; Kawan, L; Seeger, K; Witt, O | 1 |
| Inaba, T; Shishikura, T; Shito, K; Uchida, M | 1 |
| Abraham, WM; Claveau, D; Dias, R; Dubé, D; Gallant, M; Girard, Y; Goetghebeur, P; Huang, Z; Jones, T; Lacombe, P; Laliberte, F; Liu, S; Macdonald, D; Mancini, JA; Ng, K; Nicholson, DW; Otu, F; Styhler, A; Turner, MJ; Young, RN; Zhang, L | 1 |
| Banquerigo, ML; Brahn, E; Chang, B; Grossbard, EB; Lau, A; Payan, DG; Pine, PR; Schoettler, N; Wang, S; Zhao, F | 1 |
| Celly, C; Chapman, RW; House, A; Hunter, JC; Jones, H; Lamca, J; Phillips, JE; Prelusky, D; Richard, J; Ting, P | 1 |
| Foster, PS; Herbert, C; Hettiaratchi, A; Kumar, RK; Thomas, PS; Webb, DC | 1 |
| Douglas, GJ; Evans, SM; Fidock, MD; Hincks, JS; Lamb, DJ; Perros-Huguet, C; Sreckovic, S; Ulrich, K; Walsh, R; Wetterstrand, EM; Yeadon, M | 1 |
| Asaka, M; Hattori, T; Katsurada, T; Nagai, K; Ohkawara, T; Sadakane, C; Takeda, H | 1 |
| Erb, KJ; Göggel, R; Werner-Klein, M; Westhof, A | 1 |
| Chiou, GC; Miyano, K | 1 |
| Adams, PC; Azzarano, LM; Bondinell, WE; Bradbeer, J; Cousins, RD; Drake, FH; Erhard, KF; Gowen, M; Haltiwanger, RC; Hoffman, SJ; Huffman, WF; Hwang, SM; Jakas, DR; James, IE; Keenan, RM; Ku, TW; Lark, MW; Lechowska, B; Miller, WH; Newlander, KA; Rieman, DJ; Ross, ST; Stroup, GB; Vasko-Moser, JA; Zembryki, DL | 1 |
| Bradbeer, JN; Drake, FH; Erhard, KF; Gowen, M; Huffman, WF; Hwang, SM; James, IE; Lark, MW; Mathur, A; Miller, WH; Newlander, KA; Rieman, DJ; Ross, ST; Salyers, KL; Smith, BR; Stroup, GB | 1 |
| Griebel, G; Perrault, G; Rodgers, RJ; Sanger, DJ | 1 |
| Freeze, HH; Manzi, A; Panneerselvam, K; Srikrishna, G; Toomre, DK; Varki, A; Varki, NM | 1 |
| Agus, DB; Breslow, R; Butler, LM; Cordon-Cardo, C; Drobnjak, M; Higgins, B; Kutko, MC; LaQuaglia, MP; Marks, PA; Richon, VM; Rifkind, RA; Scher, HI; Tolentino, TR; Webb, Y | 1 |
| Harrison, AA; Liem, YT; Markou, A | 1 |
| Blight, AR | 1 |
| Campbell, GA; Davis, KL; Haroutunian, V; Kanof, PD; Tsuboyama, GK | 1 |
| Diamantis, W; Gordon, R; Sofia, RD | 1 |
2 review(s) available for alpha-aminopyridine and Disease Models, Animal
| Article | Year |
|---|---|
Insights from Therapeutic Studies for PrP Prion Disease.
Topics: Aminopyridines; Animals; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Doxycycline; Drug Discovery; History, 20th Century; History, 21st Century; Humans; Pentosan Sulfuric Polyester; Quinacrine; Randomized Controlled Trials as Topic; Translational Research, Biomedical | 2017 |
AWD-12-281 (inhaled) (elbion/GlaxoSmithKline).
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Administration, Topical; Amides; Aminopyridines; Animals; Benzamides; Clinical Trials as Topic; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dermatitis, Atopic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Indoles; Inflammation; Lipopolysaccharides; Ovalbumin; Phosphodiesterase Inhibitors; Psoriasis; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Structure-Activity Relationship | 2005 |
2 trial(s) available for alpha-aminopyridine and Disease Models, Animal
| Article | Year |
|---|---|
A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile.
Topics: Adolescent; Adult; Aminopyridines; Animals; Capsaicin; Celecoxib; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Double-Blind Method; Female; Healthy Volunteers; Humans; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Pressure; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Ultraviolet Rays; Young Adult | 2016 |
Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Aminopyridines; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Middle Aged; Morpholines; Oxazines; Pilot Projects; Prodrugs; Protein-Tyrosine Kinases; Purpura, Thrombocytopenic, Idiopathic; Pyridines; Pyrimidines; Syk Kinase; Treatment Outcome | 2009 |
254 other study(ies) available for alpha-aminopyridine and Disease Models, Animal
| Article | Year |
|---|---|
Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis.
Topics: Administration, Oral; Aminopyridines; Animals; Apoptosis; Caco-2 Cells; Cell Cycle Checkpoints; Cell Line, Tumor; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C | 2012 |
Inhibiting Focal Adhesion Kinase Ameliorates Cyst Development in Polycystin-1-Deficient Polycystic Kidney Disease in Animal Model.
Topics: Aminopyridines; Animals; Benzamides; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Dogs; Epithelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Polycystic Kidney, Autosomal Dominant; Pyrazines; Signal Transduction; Sulfonamides | 2021 |
Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice.
Topics: Aminopyridines; Animals; Benzimidazoles; Biopsy; Coenzyme A Ligases; Diet, High-Fat; Disease Models, Animal; Fatty Acids; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver; Mice; Mice, Knockout; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction | 2022 |
Myosin 1f-mediated activation of microglia contributes to the photoreceptor degeneration in a mouse model of retinal detachment.
Topics: Aminopyridines; Animals; Calcium-Binding Proteins; Cell Death; Cell Line; Disease Models, Animal; Gene Expression Profiling; Light; MAP Kinase Signaling System; Mice, Knockout; Microfilament Proteins; Microglia; Models, Biological; Myosin Type I; Myosins; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins c-akt; Pyrroles; Retinal Degeneration; Retinal Detachment; Up-Regulation | 2021 |
Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage.
Topics: Aging; Aminopyridines; Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cell Death; Cerebral Hemorrhage; Chemotaxis, Leukocyte; Disease Models, Animal; Mice; Microglia; Neuroinflammatory Diseases; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2022 |
Chidamide and mitomycin C exert synergistic cytotoxic effects against bladder cancer cells in vitro and suppress tumor growth in a rat bladder cancer model.
Topics: Administration, Intravesical; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; BCG Vaccine; Benzamides; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Mitomycin; Neoplasm Recurrence, Local; Rats; Urinary Bladder; Urinary Bladder Neoplasms | 2022 |
Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer's Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclopropanes; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Maze Learning; Memory Disorders; NF-kappa B; Rats; Streptozocin | 2022 |
Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats.
Topics: Aminopyridines; Animals; Benzamides; Colitis; Cyclopropanes; Disease Models, Animal; Mice; Peroxidase; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice.
Topics: Aminopyridines; Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Inflammation; Macrophage Colony-Stimulating Factor; Male; Mice; Mice, Inbred C57BL; Microglia; Oxidoreductases; Pyrroles; Receptors, Colony-Stimulating Factor; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2022 |
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells.
Topics: Aminopyridines; Animals; Cell Movement; Cell Proliferation; Disease Models, Animal; DNA Methylation; Histone Demethylases; Histones; Hydrazones; Mice; Muscle, Smooth, Vascular; Neointima; Phenotype | 2022 |
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.
Topics: Alzheimer Disease; Aminopyridines; Animals; Apolipoproteins E; Brain; Dietary Supplements; Disease Models, Animal; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Pyrroles; tau Proteins; Tauopathies | 2019 |
Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease.
Topics: Aminopyridines; Animals; Astrocytes; Chondroitin Sulfate Proteoglycans; Cytokines; Disease Models, Animal; Down-Regulation; Extracellular Matrix; Hand Strength; Humans; Huntingtin Protein; Huntington Disease; Inflammation; Mice; Mice, Transgenic; Microglia; Neostriatum; Neurites; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Recognition, Psychology; RNA, Messenger; Synapses; Transcriptome | 2020 |
Effects of a potassium channel opener on brain injury and neurologic outcomes in an animal model of neonatal hypoxic-ischemic injury.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Injuries; Carotid Arteries; Cognition; Disease Models, Animal; Hand Strength; Hypoxia; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Skills; Nervous System Diseases; Neuroprotection; Neuroprotective Agents; Potassium Channels; Quality of Life; Rats; Seizures | 2020 |
Microglial activation increases cocaine self-administration following adolescent nicotine exposure.
Topics: Aminopyridines; Animals; Chemokine CX3CL1; Cocaine; Disease Models, Animal; Drug-Seeking Behavior; Electronic Nicotine Delivery Systems; Female; Gene Expression Regulation; Male; Microglia; Minocycline; Nicotine; Phenotype; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reinforcement, Psychology; Reward; Self Administration; Synaptophysin | 2020 |
Anti-inflammatory effects of ozenoxacin, a topical quinolone antimicrobial agent.
Topics: Acne Vulgaris; Aminopyridines; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Inflammation; Interleukin-6; Interleukin-8; Male; Propionibacterium acnes; Quinolones; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2020 |
Antinociceptive Efficacy of Retigabine and Flupirtine for Gout Arthritis Pain.
Topics: Aminopyridines; Analgesics; Animals; Arthritis, Experimental; Arthritis, Gouty; Behavior, Animal; Carbamates; Disease Models, Animal; Hyperalgesia; KCNQ Potassium Channels; Male; Pain; Phenylenediamines; Rats; Rats, Sprague-Dawley; Uric Acid | 2020 |
Inhibition of histone demethylase JMJD1C attenuates cardiac hypertrophy and fibrosis induced by angiotensin II.
Topics: Aminopyridines; Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart; Humans; Hydrazones; Jumonji Domain-Containing Histone Demethylases; Myocardium; Myocytes, Cardiac; Oxidoreductases, N-Demethylating; Rats; RNA, Small Interfering; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1 | 2020 |
Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms.
Topics: Acute Kidney Injury; Aminopyridines; Animals; Cell Cycle Checkpoints; Cells, Cultured; Cisplatin; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cytoprotection; Disease Models, Animal; DNA Damage; Epithelial Cells; Gene Knockdown Techniques; Kidney Tubules; Male; Mice; Mice, Knockout; Phosphorylation; Protective Agents; Purines; Retinoblastoma Binding Proteins; Signal Transduction | 2020 |
Antioxidant Analogue 6-Amino-2,4,5-Trimethylpyridin-3-ol Ameliorates Experimental Colitis in Mice.
Topics: Aminopyridines; Aniline Compounds; Animals; Antioxidants; Caco-2 Cells; Colitis; Cytokines; Disease Models, Animal; Humans; Intestinal Mucosa; Mice; Oxidative Stress; Permeability; Protective Agents; Severity of Illness Index; Treatment Outcome | 2021 |
Inhibition of phosphodiesterase IV enzyme improves locomotor and sensory complications of spinal cord injury via altering microglial activity: Introduction of Roflumilast as an alternative therapy.
Topics: Agnosia; Aminopyridines; Animals; Benzamides; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Humans; Male; Microglia; Neurogenic Inflammation; Phosphodiesterase 4 Inhibitors; Rats; Spinal Cord; Spinal Cord Injuries; Tabes Dorsalis | 2020 |
The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer's Disease: A Preclinical Study in APP/PS1 Transgenic Mice.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Benzamides; Cerebral Cortex; Cyclopropanes; Depression; Disease Models, Animal; Hippocampus; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphodiesterase 4 Inhibitors; Presenilin-1; Recognition, Psychology | 2020 |
PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.
Topics: Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Female; Gastroparesis; Mice; Mice, Nude; Phosphodiesterase 4 Inhibitors; Pyridines; Pyrimidinones; Rolipram | 2020 |
Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice.
Topics: Aging; Alzheimer Disease; Aminopyridines; Amyloid; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Pyrroles; Receptors, Colony-Stimulating Factor; Signal Transduction | 2020 |
Long-term subcutaneous injection of lipopolysaccharides and high-fat diet induced non-alcoholic fatty liver disease through IKKε/ NF-κB signaling.
Topics: Aminopyridines; Animals; Diet, High-Fat; Disease Models, Animal; Gene Expression; I-kappa B Kinase; Injections, Subcutaneous; Lipid Metabolism; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Protein Kinase Inhibitors; Signal Transduction | 2020 |
Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection.
Topics: Aminopyridines; Animals; Chlamydia Infections; Chlamydia trachomatis; Chlorocebus aethiops; Disease Models, Animal; Female; Gene Knockdown Techniques; HeLa Cells; Host-Pathogen Interactions; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyrroles; Ribosomal Protein S6 Kinases, 90-kDa; Vero Cells | 2021 |
Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis.
Topics: Aminopyridines; Animals; Cells, Cultured; Coinfection; Disease Models, Animal; Humans; Inflammation Mediators; Lipopolysaccharides; Lupus Erythematosus, Systemic; Lupus Nephritis; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Oxazines; Pyridines; Pyrimidines; Receptors, IgG; Sepsis; Signal Transduction; Syk Kinase | 2020 |
Marble Burying in NMRI Male Mice Is Preferentially Sensitive to Pre- Versus Postsynaptic 5-HT1A Receptor Biased Agonists.
Topics: Aminopyridines; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Mice, Inbred Strains; Obsessive-Compulsive Disorder; Piperazines; Piperidines; Pyridines; Pyrimidines; Receptor, Serotonin, 5-HT1A; Receptors, Presynaptic; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Synapses | 2021 |
The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model.
Topics: Aminopyridines; Animals; Behavior, Animal; Biomarkers; Calcium-Binding Proteins; Chemokine CX3CL1; Corpus Callosum; Cuprizone; CX3C Chemokine Receptor 1; Demyelinating Diseases; Disease Models, Animal; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Myelin Sheath; Pyrroles | 2021 |
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Topics: Adult; Age Factors; Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cognition; Disease Models, Animal; Down Syndrome; Female; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles | 2020 |
Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.
Topics: Aminopyridines; Animals; Brain; Disease Models, Animal; Female; Macrophages; Male; Mice; Microglia; Nerve Degeneration; Neuronal Ceroid-Lipofuscinoses; Neurons; Pyrroles; Retina; Sex Factors; T-Lymphocytes; Tomography, Optical Coherence | 2020 |
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
Topics: Administration, Inhalation; Administration, Intravenous; Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Lung Neoplasms; Mice; Paclitaxel; Phosphorylation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment; Tumor-Associated Macrophages | 2020 |
Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice.
Topics: Aminopyridines; Amphetamines; Animals; Behavior, Animal; Citalopram; Compulsive Behavior; Disease Models, Animal; Female; Fluorobenzenes; Indoles; Mice; Piperidines; Psilocybin; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists | 2021 |
Neuroprotective effects of roflumilast against quinolinic acid-induced rat model of Huntington's disease through inhibition of NF-κB mediated neuroinflammatory markers and activation of cAMP/CREB/BDNF signaling pathway.
Topics: Aminopyridines; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Huntington Disease; Inflammation; Male; Neuroprotective Agents; NF-kappa B; Nitrosative Stress; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar; Signal Transduction | 2021 |
Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.
Topics: Alexander Disease; Aminopyridines; Animals; Disease Models, Animal; Glial Fibrillary Acidic Protein; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Pyrroles | 2021 |
Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury.
Topics: Aminopyridines; Animals; Benzamides; Cecum; Cyclopropanes; Disease Models, Animal; Ligation; Lung; Lung Injury; NF-kappa B; Punctures; Rats; Sepsis | 2022 |
Chemogenetic stimulation of proprioceptors remodels lumbar interneuron excitability and promotes motor recovery after SCI.
Topics: Aminopyridines; Animals; Combined Modality Therapy; Dependovirus; Disease Models, Animal; Female; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Mice; Motor Neurons; Neural Conduction; Proprioception; Recovery of Function; Spinal Cord Injuries | 2021 |
The selective 5-HT
Topics: Aminopyridines; Animals; Antidepressive Agents; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Mice; Piperidines; Pyrimidines; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Single-Blind Method; Stress, Psychological | 2021 |
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Topics: Administration, Oral; Aminopyridines; Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Deletion; Half-Life; Humans; Protein Binding; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Solubility; Structure-Activity Relationship | 2021 |
Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cognitive Dysfunction; Cyclopropanes; Disease Models, Animal; Hippocampus; Isoquinolines; Male; Mice; Nitric Oxide; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Streptozocin; Sulfonamides; Tauopathies | 2021 |
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Female; Humans; Immune Checkpoint Inhibitors; Lactams; Lactams, Macrocyclic; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Male; Mice; Mice, Transgenic; Neutrophils; Pancreatic Neoplasms; Programmed Cell Death 1 Receptor; Pyrazoles; Tumor Microenvironment | 2021 |
HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression.
Topics: Aminopyridines; Animals; Blotting, Western; Cell Count; Cell Line; Cell Movement; Cell Proliferation; Disease Models, Animal; Endometriosis; Female; Gene Knockdown Techniques; Glucose; Glycolysis; Heat Shock Transcription Factors; Humans; Indazoles; Lactic Acid; Mice; Phosphofructokinase-2; Real-Time Polymerase Chain Reaction; Up-Regulation | 2021 |
Roflumilast improves resolution of sepsis-induced acute kidney injury by retarding late phase renal interstitial immune cells infiltration and leakage in urinary sediments.
Topics: Acute Kidney Injury; Aminopyridines; Animals; Benzamides; Cyclopropanes; Disease Models, Animal; Kidney; Rats; Sepsis | 2022 |
Differential effects of dexamethasone and roflumilast on asthma in mice with or without short cigarette smoke exposure.
Topics: Aminopyridines; Animals; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Cyclopropanes; Dexamethasone; Disease Models, Animal; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Smoking | 2021 |
Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model.
Topics: Aminopyridines; Animals; Cuprizone; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Neuroglia; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Remyelination | 2021 |
Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aminopyridines; Animals; Behavior, Animal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Inflammation Mediators; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microglia; MPTP Poisoning; Neuroprotective Agents; Pyrroles; Receptors, Immunologic | 2021 |
Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Cyclopropanes; Disease Models, Animal; Histone Deacetylase 2; Interleukin-8; Lung; Male; Mice, Inbred C57BL; Nicotiana; Pentoxifylline; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species; Smoke; Smoking; Theophylline; Tumor Necrosis Factor-alpha | 2021 |
5-HT1A Receptors Mediate Analgesia Induced by Emulsified Sevoflurane in Thermal Nociception but Have Little Effect on Chemical Nociception.
Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Injections, Spinal; Male; Methyl Ethers; Mice; Nociception; Pain; Pain Threshold; Piperazines; Receptor, Serotonin, 5-HT1A; Sevoflurane; Spinal Cord | 2017 |
Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast.
Topics: Aminopyridines; Animals; Animals, Newborn; Benzamides; Blast Injuries; Cell Death; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Disks Large Homolog 4 Protein; Gene Expression Regulation; Glycine; Guanylate Kinases; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Membrane Proteins; Papaverine; Phosphodiesterase 4 Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Time Factors | 2017 |
Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy.
Topics: Aminopyridines; Animals; Antigens, Neoplasm; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Macrophages; Mesothelioma; Mesothelioma, Malignant; Neoplasm Invasiveness; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor | 2017 |
Anticystogenic activity of a small molecule PAK4 inhibitor may be a novel treatment for autosomal dominant polycystic kidney disease.
Topics: Acrylamides; Aminopyridines; Animals; Apoptosis; beta Catenin; Cell Proliferation; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial Cells; Female; Humans; Kidney; Male; Mice; Mice, Transgenic; NAD; Nicotinamide Phosphoribosyltransferase; Organ Culture Techniques; p21-Activated Kinases; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Receptors, Cell Surface; Signal Transduction; TRPP Cation Channels | 2017 |
In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy.
Topics: Alleles; Aminopyridines; Animals; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Disease Models, Animal; Echocardiography; Gene Expression Regulation; Humans; Imidazoles; LEOPARD Syndrome; Male; Mice; Mice, Transgenic; Mutation; Myocytes, Cardiac; Phosphoproteins; Protein Domains; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2017 |
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease Progression; Electrocorticography; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Phenobarbital; Random Allocation; Rats, Sprague-Dawley; Seizures; Time Factors | 2017 |
Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model.
Topics: Aminopyridines; Animals; Benzamides; Benzo(a)pyrene; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Neovascularization, Pathologic | 2017 |
Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.
Topics: Aminopyridines; Animals; Becaplermin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Resistance, Neoplasm; Glioma; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Tumor Microenvironment | 2017 |
A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.
Topics: Age Factors; Aminopyridines; Animals; Axotomy; Disease Models, Animal; Functional Laterality; Hindlimb; Insulin-Like Growth Factor I; Mice; Movement Disorders; Neurons; Osteopontin; Psychomotor Performance; Pyramidal Tracts; Recovery of Function; Reflex; Serotonin; Spinal Cord Injuries; Stroke; Time Factors | 2017 |
Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia.
Topics: Adenosine A2 Receptor Agonists; Aminopyridines; Animals; Blood-Brain Barrier; Brain Ischemia; Cerebral Hemorrhage; Disease Models, Animal; Fibrinolytic Agents; Male; Matrix Metalloproteinase 9; Microvessels; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Stroke; Tissue Inhibitor of Metalloproteinase-1; Tissue Plasminogen Activator | 2017 |
Targeting the vulnerability to NAD
Topics: Acrylamides; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokines; Disease Models, Animal; Female; Humans; Male; Mice; NAD; Nicotinamide Phosphoribosyltransferase; p21-Activated Kinases; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Effects of roflumilast, a phosphodiesterase-4 inhibitor, on the lung functions in a saline lavage-induced model of acute lung injury.
Topics: Acute Lung Injury; Administration, Intravenous; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Female; Lung; Male; Phosphodiesterase 4 Inhibitors; Rabbits; Sodium Chloride; Treatment Outcome | 2017 |
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo.
Topics: Aminopyridines; Animals; Arthritis, Experimental; Autoimmune Diseases; Autoimmunity; Cells, Cultured; Disease Models, Animal; Female; Humans; Immunoglobulin G; Male; Mast Cells; Monocytes; Passive Cutaneous Anaphylaxis; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Syk Kinase; Thiazoles | 2017 |
Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease.
Topics: Airway Remodeling; Aminopyridines; Animals; Bacillus; Benzamides; Cyclopropanes; Disease Models, Animal; Mice, Inbred C57BL; Mice, Mutant Strains; Neutrophils; Pneumonia, Bacterial; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Receptors, Cell Surface | 2018 |
Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Colitis, Ulcerative; Colon; Cyclic AMP; Cyclopropanes; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Humans; Male; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats.
Topics: Airway Obstruction; Aminopyridines; Animals; Antigens; Cytokines; Disease Models, Animal; Hypersensitivity; Male; Mast Cells; Nasal Mucosa; Protein-Tyrosine Kinases; Rats; Rats, Inbred BN; Respiratory Hypersensitivity; Sneezing; Spleen; Thiazoles | 2018 |
Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzodioxoles; C-Reactive Protein; Databases, Genetic; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3 beta; GMP Reductase; Mice; Molecular Targeted Therapy; Nerve Tissue Proteins; Phosphorylation; Proto-Oncogene Proteins c-met; Repressor Proteins; tau Proteins; Wnt Signaling Pathway | 2018 |
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Animals; Brain; Disease Models, Animal; Mice; Mice, Transgenic; Microglia; Neurons; Plaque, Amyloid; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2018 |
JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.
Topics: Aminopyridines; Animals; Biomarkers; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Self Renewal; Colorectal Neoplasms; Disease Models, Animal; Gene Expression; Histone Demethylases; Humans; Hydrazones; Mice; Neoplastic Stem Cells; Tumor Cells, Cultured; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2018 |
A review of the antibacterial activity of ozenoxacin.
Topics: Aminopyridines; Animals; Anti-Bacterial Agents; Child; Disease Models, Animal; Dogs; Humans; Impetigo; Quinolones; Rats; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes | 2018 |
Therapeutic efficacy of ozenoxacin in animal models of dermal infection with Staphylococcus aureus.
Topics: Administration, Topical; Aminopyridines; Animals; Animals, Outbred Strains; Anti-Bacterial Agents; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Humans; Impetigo; Mice; Mupirocin; Ointments; Quinolones; Skin Cream; Staphylococcus aureus; Treatment Outcome; Wound Infection | 2018 |
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
Topics: Aminopyridines; Animals; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Diphtheria Toxin; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Forkhead Transcription Factors; Gene Knockout Techniques; Humans; Lymphocyte Depletion; Macrophages; Male; Mice; Mice, Transgenic; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Purines; Pyrroles; Quinazolinones; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; T-Lymphocytes, Regulatory; Tumor Microenvironment | 2018 |
Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Protein Precursor; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclopropanes; Disease Models, Animal; Female; Humans; Male; Memory; Mice, Transgenic; Nootropic Agents; Phosphodiesterase Inhibitors; Random Allocation; Vardenafil Dihydrochloride | 2018 |
Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion.
Topics: Aging; Aminopyridines; Animals; Arginase; Benzamides; Brain Ischemia; Chronic Disease; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Male; Maze Learning; Memory Disorders; Microglia; Neurodegenerative Diseases; Neuroprotective Agents; Nootropic Agents; Optic Tract; Random Allocation; Rats, Wistar; White Matter | 2018 |
Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction.
Topics: Aminopyridines; Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Fatty Liver; I-kappa B Kinase; Insulin; Insulin Resistance; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Weight Loss | 2018 |
Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.
Topics: Aminopyridines; Animals; Benzimidazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Interferons; Mice; Sarcoma, Ewing; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity.
Topics: Aminopyridines; Animals; Benzimidazoles; Cyclin-Dependent Kinase 4; Diet, High-Fat; Disease Models, Animal; Drug Approval; Energy Metabolism; Hypothalamus; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Obesity; Phosphorylation; Retinoblastoma Protein; United States; United States Food and Drug Administration | 2018 |
Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis.
Topics: Aminopyridines; Animals; Benzodioxoles; Bronchi; Cells, Cultured; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dogs; Epithelial Cells; Epithelial Sodium Channels; Female; Humans; Influenza A virus; Influenza, Human; Madin Darby Canine Kidney Cells; Male; Mice; Primary Cell Culture; Pulmonary Edema; Respiratory Distress Syndrome; Respiratory Mucosa; Sodium-Potassium-Exchanging ATPase; Water-Electrolyte Balance | 2018 |
Caralluma fimbriata extract activity involves the 5-HT2c receptor in PWS Snord116 deletion mouse model.
Topics: Aminopyridines; Animals; Apocynaceae; Appetite Depressants; Chromosome Deletion; Disease Models, Animal; Eating; Female; Gene Deletion; Humans; Hypothalamus; Indoles; Male; Mice, Inbred C57BL; Phenotype; Phytotherapy; Plant Extracts; Prader-Willi Syndrome; Random Allocation; Receptor, Serotonin, 5-HT2C; RNA, Small Nucleolar; Serotonin 5-HT2 Receptor Antagonists | 2018 |
PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.
Topics: Adult; Aged; Aminopyridines; Animals; Brain Neoplasms; Breast Neoplasms; Calcium-Binding Proteins; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Humans; Macrophages; Mice; Mice, Inbred BALB C; Microfilament Proteins; Microglia; Middle Aged; Morpholines; Phosphatidylinositol 3-Kinases; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary Pharmacology.
Topics: Aminopyridines; Animals; Benzimidazoles; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Diarrhea; Disease Models, Animal; Gene Expression Regulation; Male; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Rats; Rats, Sprague-Dawley | 2019 |
Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189.
Topics: Aminopyridines; Angelman Syndrome; Animals; Central Nervous System Agents; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Long-Term Potentiation; Male; Mice, Transgenic; Motor Activity; Piperazines; Tissue Culture Techniques | 2019 |
Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi.
Topics: Aminopyridines; Animals; Benzamides; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dexamethasone; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Bacterial; Haemophilus influenzae; Humans; Inflammation; Lung; Pulmonary Disease, Chronic Obstructive | 2018 |
Partial reduction of microglia does not affect tau pathology in aged mice.
Topics: Aging; Aminopyridines; Animals; Blood Vessels; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Mutation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; tau Proteins; Tauopathies | 2018 |
APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental
Topics: Aminopyridines; Amphotericin B; Animals; Antifungal Agents; Coccidioides; Disease Models, Animal; Female; Fluconazole; Isoxazoles; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia; Prodrugs; Triazoles | 2019 |
Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D.
Topics: Aminopyridines; Animals; Antiviral Agents; Benzamides; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclooxygenase 2; Cyclopropanes; Disease Models, Animal; Drug Synergism; Enzyme Activation; Female; HEK293 Cells; Humans; Interferon-alpha; MAP Kinase Kinase Kinases; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Proto-Oncogene Proteins; Urinary Bladder Neoplasms | 2018 |
Inhibition of the protein kinase IKKepsilon attenuates neuropathic pain in mice.
Topics: Aminopyridines; Animals; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; I-kappa B Kinase; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Neuralgia; NF-kappa B; Peripheral Nerve Injuries; Protein Serine-Threonine Kinases; Sciatic Nerve; Signal Transduction; Spinal Cord | 2019 |
Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Central Nervous System Diseases; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Microscopy, Electron, Transmission; Mutation; Myelin Proteolipid Protein; Neurons; Pyrroles; T-Lymphocytes; Tomography, Optical Coherence | 2019 |
Acute myeloid leukemia with eosinophilia after cyclin-dependent kinases 4/6 inhibitor treatment due to underlying clonal hematopoiesis of indeterminate potential.
Topics: Adult; Aminopyridines; Animals; Antigens, Nuclear; Antineoplastic Agents; Cell Cycle Proteins; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Disease Models, Animal; DNA-Binding Proteins; Eosinophilia; Female; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Mice; Mutation; Nuclear Proteins; Phosphoproteins; Protein Kinase Inhibitors; Purines | 2019 |
Reduction of lung inflammation, oxidative stress and apoptosis by the PDE4 inhibitor roflumilast in experimental model of acute lung injury.
Topics: Acute Lung Injury; Aminopyridines; Animals; Apoptosis; Benzamides; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Female; Male; Oxidative Stress; Phosphodiesterase 4 Inhibitors; Pneumonia; Rabbits | 2018 |
Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cyclic AMP; Cyclopropanes; Disease Models, Animal; Male; Memory; Mice, Transgenic; Nootropic Agents; Phosphodiesterase 4 Inhibitors | 2019 |
Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging.
Topics: Aminopyridines; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; CX3C Chemokine Receptor 1; Disease Models, Animal; Functional Laterality; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Intravital Microscopy; Macrophages; Matrix Metalloproteinase 3; Melanoma; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Pyrroles; Time Factors; Zonula Occludens-1 Protein | 2019 |
Effect of the CSF1R inhibitor PLX3397 on remyelination of corpus callosum in a cuprizone-induced demyelination mouse model.
Topics: Aminopyridines; Animals; Corpus Callosum; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Gene Expression Regulation; Indoles; Macrophage Colony-Stimulating Factor; Male; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Multiple Sclerosis; Myelin Sheath; Pyrroles; Real-Time Polymerase Chain Reaction; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Rotarod Performance Test | 2019 |
Antitumor effects of BMS-777607 on ovarian cancer cells with constitutively activated c-MET.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Aurora Kinase B; Blotting, Western; Cell Proliferation; Disease Models, Animal; Female; Humans; Mice; Molecular Targeted Therapy; Ovarian Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-met; Pyridones; Signal Transduction | 2019 |
Influence of roflumilast on sepsis mice through the JAK/STAT signaling pathway.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Female; Janus Kinases; Lung; Male; Mice; Phosphodiesterase 4 Inhibitors; Sepsis; Signal Transduction; STAT3 Transcription Factor | 2019 |
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer.
Topics: Aminopyridines; Animals; Antibodies, Monoclonal; Cell Line, Tumor; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Protein-Tyrosine Kinases; Pyridones; Triple Negative Breast Neoplasms; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.
Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Capillary Permeability; Cyclopropanes; Cytokines; Disease Models, Animal; Embolism, Air; Humans; Lung; Male; NF-kappa B; Perfusion; Phosphodiesterase 4 Inhibitors; Rats; Signal Transduction | 2019 |
Colony-stimulating factor 1 receptor inhibition prevents against lipopolysaccharide -induced osteoporosis by inhibiting osteoclast formation.
Topics: Aminopyridines; Animals; Biomechanical Phenomena; Bone Density; Bone Resorption; Cancellous Bone; Disease Models, Animal; Lipopolysaccharides; Male; Osteoclasts; Osteoporosis; Pyrroles; Rats, Sprague-Dawley; Receptor, Macrophage Colony-Stimulating Factor; Tibia | 2019 |
Wild-type p53-induced phosphatase 1 promotes vascular smooth muscle cell proliferation and neointima hyperplasia after vascular injury via p-adenosine 5'-monophosphate-activated protein kinase/mammalian target of rapamycin complex 1 pathway.
Topics: Aminopyridines; AMP-Activated Protein Kinases; Animals; Becaplermin; Carotid Artery, Common; Cell Proliferation; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Hyperplasia; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Protein Phosphatase 2C; Tumor Suppressor Protein p53; Vascular System Injuries | 2019 |
Chronic inflammation, cognitive impairment, and distal brain region alteration following intracerebral hemorrhage.
Topics: Aminopyridines; Animals; Brain; Cerebral Hemorrhage; Cognition; Cognitive Dysfunction; Disease Models, Animal; Fingolimod Hydrochloride; Flow Cytometry; Hippocampus; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Neuronal Plasticity; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2019 |
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.
Topics: Aminopyridines; Animals; Cell Degranulation; Cromolyn Sodium; Disease Models, Animal; Epithelium; Female; Gastric Mucosa; Humans; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Macrophages; Male; Mast Cells; Mice; Mice, Transgenic; Pyrroles; Signal Transduction; Stomach Neoplasms; Tissue Array Analysis; Tumor Microenvironment | 2019 |
The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.
Topics: Aminopyridines; Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Benzamides; Colitis; Colon; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Dextran Sulfate; Disease Models, Animal; Female; Interferon-gamma; Intestinal Mucosa; Lectins, C-Type; Mice; Naphthyridines; Phosphodiesterase 3 Inhibitors; Phosphodiesterase 4 Inhibitors; Spleen; Tumor Necrosis Factor-alpha | 2013 |
Characterization of a novel high-potency positive modulator of K(v)7 channels.
Topics: Aminopyridines; Animals; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzeneacetamides; Bipolar Disorder; CA1 Region, Hippocampal; Disease Models, Animal; Dopaminergic Neurons; Epilepsies, Partial; Female; GABAergic Neurons; HEK293 Cells; Humans; In Vitro Techniques; KCNQ1 Potassium Channel; Male; Membrane Transport Modulators; Mice; Nerve Tissue Proteins; Psychotic Disorders; Rats; Recombinant Proteins; Substantia Nigra | 2013 |
Stimulation of A2B adenosine receptors protects against trauma-hemorrhagic shock-induced lung injury.
Topics: Acute Lung Injury; Aminopyridines; Animals; Blotting, Western; Disease Models, Animal; Inflammation; Male; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Shock, Hemorrhagic; Wounds and Injuries | 2013 |
A novel translational assay of response inhibition and impulsivity: effects of prefrontal cortex lesions, drugs used in ADHD, and serotonin 2C receptor antagonism.
Topics: Aminopyridines; Animals; Atomoxetine Hydrochloride; Disease Models, Animal; Impulsive Behavior; Indoles; Inhibition, Psychological; Male; Methylphenidate; Mice; Prefrontal Cortex; Propylamines; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists | 2013 |
Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Maze Learning; Metalloproteases; Mice; Mice, Transgenic; Receptors, Somatostatin; Thiourea | 2013 |
Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.
Topics: Allosteric Regulation; Aminopyridines; Animals; Brain; Cocaine-Related Disorders; Disease Models, Animal; Liver; Phenylurea Compounds; Rats; Receptor, Metabotropic Glutamate 5; Structure-Activity Relationship; Urea | 2013 |
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.
Topics: Age Factors; Aged; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Brain Mapping; Calcium-Binding Proteins; Carbon Isotopes; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Middle Aged; Mutation; Positron-Emission Tomography; Protein Structure, Secondary; tau Proteins; Tauopathies; Thiazoles | 2013 |
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity.
Topics: Administration, Oral; Aminopyridines; Animals; Antimalarials; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Rats; Structure-Activity Relationship | 2013 |
The gene dosage of class Ia PI3K dictates the development of PTEN hamartoma tumor syndrome.
Topics: Alleles; Aminopyridines; Animals; Breast Neoplasms; Class Ia Phosphatidylinositol 3-Kinase; Disease Models, Animal; Female; Gene Dosage; Genotype; Hamartoma Syndrome, Multiple; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Skin Neoplasms | 2013 |
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Aged; Aminopyridines; Animals; Arthralgia; Behavior, Animal; Body Temperature; Chromatography, Liquid; Disease Models, Animal; Humans; Injections, Intra-Articular; Middle Aged; Nociceptive Pain; Osteoarthritis; Piperazines; Rats, Sprague-Dawley; Synovial Membrane; Tandem Mass Spectrometry; TRPV Cation Channels | 2015 |
Efficacy and gastrointestinal tolerability of ML3403, a selective inhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats.
Topics: Aminopyridines; Animals; Arthritis, Experimental; Biopsy; Cytokines; Disease Models, Animal; Freund's Adjuvant; Gastrointestinal Tract; Imidazoles; Liver; Male; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Treatment Outcome | 2014 |
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, White; Adrenergic beta-3 Receptor Agonists; Aminopyridines; Animals; Catecholamines; Chlorocebus aethiops; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dioxoles; Disease Models, Animal; Energy Metabolism; Enzyme Activation; HEK293 Cells; Humans; I-kappa B Kinase; Inflammation; Ion Channels; Lipolysis; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Obesity; Phosphorylation; Poly I-C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptors, Adrenergic, beta; Signal Transduction; Sterol Esterase; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Uncoupling Protein 1 | 2013 |
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.
Topics: Administration, Oral; Allosteric Regulation; Amino Acid Motifs; Aminopyridines; Animals; Antineoplastic Agents; Catalytic Domain; Cell Line, Tumor; Dipeptides; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Inhibitors; Female; Heterografts; Humans; Mice; Mice, SCID; Models, Biological; Neoplasms; Phosphoprotein Phosphatases; Protein Phosphatase 2C | 2014 |
Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.
Topics: Action Potentials; Aminopyridines; Analysis of Variance; Animals; Bacterial Proteins; Disease Models, Animal; Excitatory Amino Acid Agonists; Female; GABA Agents; GABA Antagonists; Halorhodopsins; In Vitro Techniques; Kainic Acid; Luminescent Proteins; Membrane Potentials; Mice; Neurons; Optogenetics; Patch-Clamp Techniques; Picrotoxin; Status Epilepticus; Transduction, Genetic | 2014 |
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzamides; Biopsy; Cell Survival; Disease Models, Animal; Drug Evaluation, Preclinical; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Inhibitory Concentration 50; Mice, Knockout; Molecular Targeted Therapy; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Burden | 2014 |
Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease.
Topics: Aminopyridines; Animals; B-Lymphocytes; Bone Marrow Transplantation; Chemokines; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Graft vs Host Disease; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred BALB C; Monocytes; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Receptors, CXCR4; Scleroderma, Systemic; Syk Kinase; T-Lymphocytes | 2014 |
Spleen tyrosine kinase inhibition attenuates autoantibody production and reverses experimental autoimmune GN.
Topics: Aminopyridines; Animals; Anti-Glomerular Basement Membrane Disease; Antibody Formation; Autoantibodies; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Intracellular Signaling Peptides and Proteins; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats, Inbred WKY; Spleen; Syk Kinase | 2014 |
Disruption of follicular dendritic cells-follicular lymphoma cross-talk by the pan-PI3K inhibitor BKM120 (Buparlisib).
Topics: Aminopyridines; Animals; Cell Adhesion; Cell Communication; Cell Line, Tumor; Cell Movement; Cell Survival; Chemokine CXCL12; Cluster Analysis; Dendritic Cells, Follicular; Disease Models, Animal; Extracellular Matrix; Gene Expression Profiling; Humans; Lymphoma, Follicular; Mice; Morpholines; Neovascularization, Pathologic; Phosphoinositide-3 Kinase Inhibitors; Receptors, CXCR4; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
[Role of new K(+) channel blocker 4-AP-3-MeOH in acute spinal cord compression injury in rats].
Topics: Aminopyridines; Animals; Disease Models, Animal; Male; Neural Conduction; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Compression | 2014 |
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzimidazoles; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Erlotinib Hydrochloride; Humans; MAP Kinase Kinase Kinases; Mice, Transgenic; Morpholines; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines | 2015 |
Remarkable progress toward new treatments for cystic fibrosis.
Topics: Aminophenols; Aminopyridines; Animals; Benzodioxoles; Clinical Trials, Phase III as Topic; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Forced Expiratory Volume; Humans; Mutation; Quinolones | 2014 |
A novel model of IgE-mediated passive pulmonary anaphylaxis in rats.
Topics: Aminopyridines; Anaphylaxis; Animals; Anti-Asthmatic Agents; Bronchoalveolar Lavage; Bronchoconstriction; Cell Degranulation; Cromolyn Sodium; Dinitrophenols; Disease Models, Animal; Histamine H1 Antagonists, Non-Sedating; Immunoglobulin E; Intracellular Signaling Peptides and Proteins; Loratadine; Lung; Mast Cells; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Wistar; Serum Albumin, Bovine; Syk Kinase | 2014 |
The effect of the PI3K inhibitor BKM120 on tumour growth and osteolytic bone disease in multiple myeloma.
Topics: Aminopyridines; Animals; Apoptosis; Blotting, Western; Bone Diseases; Cell Cycle; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Mice, Inbred C57BL; Morpholines; Multiple Myeloma; Osteoclasts; Osteolysis; Phosphoinositide-3 Kinase Inhibitors; Tumor Burden; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Mouse model to clarify ovarian clear-cell carcinoma.
Topics: Aminopyridines; Animals; Carcinoma; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; DNA-Binding Proteins; Female; Humans; Mice; Morpholines; Nuclear Proteins; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Transcription Factors | 2015 |
Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation.
Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine Triphosphate; Age Factors; Aged; Aminopyridines; Animals; Disease Models, Animal; Down-Regulation; Female; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Rats; Receptor, Adenosine A2B; Urinary Bladder, Overactive | 2015 |
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Topics: Aminopyridines; Animals; Carcinogenesis; Cell Proliferation; Crizotinib; Crystallography, X-Ray; Disease Models, Animal; Drug Resistance, Neoplasm; Glioma; Humans; Lactams; Lactams, Macrocyclic; Mice; Models, Molecular; Mutation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrazoles; Pyridines; Signal Transduction | 2015 |
Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3β inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance.
Topics: Aminopyridines; Animals; Carboxylic Acids; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose; Glucose Tolerance Test; Glycogen Synthase Kinase 3; Hypoglycemic Agents; Imidazoles; Insulin Resistance; Mice; Mice, Obese; Rats; Rats, Inbred OLETF; Receptors, Leptin | 2015 |
Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Topics: Aminopyridines; Animals; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Glycogen Synthase Kinase 3; Humans; Mice; Mice, Transgenic; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Pyridones; Pyrroles; Structure-Activity Relationship | 2015 |
Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.
Topics: Acute Kidney Injury; Aminopyridines; Animals; Cell Cycle Checkpoints; Cisplatin; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Disease Models, Animal; Enzyme Activation; HEK293 Cells; HeLa Cells; Humans; Kidney Tubules; Mice; Organic Cation Transport Proteins; Organic Cation Transporter 2; Piperazines; Protective Agents; Purines; Pyridines; Small Molecule Libraries | 2015 |
Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.
Topics: Aminopyridines; Animals; B-Lymphocytes; Disease Models, Animal; Enzyme Inhibitors; Female; Flow Cytometry; Fluorescent Antibody Technique; Graft vs Host Disease; Humans; Intracellular Signaling Peptides and Proteins; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Syk Kinase | 2015 |
Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.
Topics: Aminopyridines; Animals; Apoptosis; Chronic Disease; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Hippocampus; Male; Maze Learning; Mice; Neurons; Neuroprotective Agents; Nootropic Agents; Random Allocation; Restraint, Physical; Spatial Memory; Stress, Psychological | 2015 |
Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.
Topics: Aminopyridines; Animals; Cancer Vaccines; CD8-Positive T-Lymphocytes; Cell Movement; Chemokines; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating; Macrophages; Mice, Inbred C57BL; Myeloid Cells; Ovarian Neoplasms; Protein-Tyrosine Kinases; Pyrroles; Vaccines, Subunit | 2015 |
The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.
Topics: Aminopyridines; Animals; Benzamides; Capillary Permeability; Chemokines; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Cytoskeleton; Disease Models, Animal; Enzyme Activation; Epithelial Cells; Gene Expression; Male; Mice; Neutrophil Infiltration; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Protein Transport; Rolipram; Time Factors | 2015 |
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.
Topics: Aminopyridines; Analgesics; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone and Bones; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Dogs; Formaldehyde; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pain; Pain Measurement; Prostatic Neoplasms; Protein Kinases; Pyrroles; Rats; Rats, Sprague-Dawley | 2015 |
Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption.
Topics: Acetamides; Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Aminopyridines; Animals; Choice Behavior; Circadian Rhythm; Disease Models, Animal; Indoles; Male; Melatonin; Motor Activity; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Recurrence; Serotonin 5-HT2 Receptor Antagonists | 2015 |
Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations.
Topics: Aminopyridines; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Epithelial-Mesenchymal Transition; Humans; Imidazoles; Lung Neoplasms; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2015 |
Two TRPV1 receptor antagonists are effective in two different experimental models of migraine.
Topics: Aminopyridines; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Genes, fos; Male; Migraine Disorders; Piperazines; Rats; Rats, Sprague-Dawley; Treatment Outcome; TRPV Cation Channels; Up-Regulation | 2015 |
The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis.
Topics: Acetic Acid; Aminopyridines; Animals; Colitis; Disease Models, Animal; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Syk Kinase | 2015 |
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.
Topics: Aminopyridines; Animals; Behavioral Symptoms; Blood-Brain Barrier; Brain Injuries; Cognition Disorders; Dendritic Spines; Disease Models, Animal; Doxycycline; Female; Hippocampus; Male; Maze Learning; Mice; Mice, Transgenic; Microglia; Neurons; Phosphopyruvate Hydratase; Pyrroles; Recovery of Function; Synaptophysin | 2015 |
Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Topics: Adrenergic alpha-2 Receptor Agonists; Aminopyridines; Animals; Antihypertensive Agents; Benzamides; Brain-Derived Neurotrophic Factor; Clonidine; Cognition Disorders; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclopropanes; Desoxycorticosterone Acetate; Disease Models, Animal; Hippocampus; Hypertension; Male; Memory; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Rats; Rats, Wistar; Rolipram | 2015 |
Roflumilast Prevents the Metabolic Effects of Bleomycin-Induced Fibrosis in a Murine Model.
Topics: Aminopyridines; Animals; Benzamides; Bleomycin; Cyclopropanes; Disease Models, Animal; Lung; Magnetic Resonance Spectroscopy; Male; Metabolome; Mice; Mice, Inbred C57BL; Pulmonary Fibrosis | 2015 |
Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Topics: Aminopyridines; Anilides; Animals; Antineoplastic Agents; Bevacizumab; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Drug Design; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Hepatocyte Growth Factor; Humans; Inhibitory Concentration 50; Melanoma, Experimental; Mice; Models, Molecular; Molecular Conformation; Monocytes; Neovascularization, Pathologic; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-met; Receptor, TIE-2; Recombinant Proteins; Stromal Cells; Tumor Microenvironment; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2015 |
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides; Disease Models, Animal; Enzyme Activation; Humans; Inflammation; Interleukin-6; Janus Kinases; Liver; Liver Neoplasms; Morpholines; Niclosamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; STAT3 Transcription Factor; Zebrafish; Zebrafish Proteins | 2015 |
Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model.
Topics: Aminopyridines; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Antigens, Ly; CD11b Antigen; Disease Models, Animal; Female; Flow Cytometry; Melanoma; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Myeloid Cells; Neovascularization, Pathologic; Receptor, Adenosine A2B; Skin Neoplasms; T-Lymphocytes; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2015 |
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
Topics: Aminopyridines; Animals; Carcinoma, Squamous Cell; Chemokine CCL5; Disease Models, Animal; Focal Adhesion Protein-Tyrosine Kinases; Humans; Keratinocytes; Mice; Mice, Nude; Skin Neoplasms; T-Lymphocytes, Regulatory; Transcription, Genetic; Tumor Escape | 2015 |
Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
Topics: Aminopyridines; Analgesics, Opioid; Animals; Benzazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Indoles; Locomotion; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Reaction Time; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Substance Withdrawal Syndrome; Time Factors | 2016 |
Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.
Topics: Aminopyridines; Animals; Antitubercular Agents; Benzamides; Cyclopropanes; Disease Models, Animal; Female; Interferon-gamma; Interleukin-1beta; Isoniazid; Lung; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Phosphodiesterase 4 Inhibitors; Survival Analysis; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha | 2015 |
Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.
Topics: Aminopyridines; Animals; Benzoates; Blood Platelets; Chlorides; Disease Models, Animal; Enzyme Inhibitors; Ferric Compounds; Furans; Humans; Mice, Inbred C57BL; Microfluidic Analytical Techniques; Microscopy, Interference; Piperidones; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Proteasome Endopeptidase Complex; Pyrazoles; Receptors, Collagen; Receptors, Thrombin; Signal Transduction; Thiocyanates; Thrombosis; Ubiquitin Thiolesterase; Ubiquitin-Specific Proteases; Ubiquitination | 2015 |
A phosphodiesterase 4B-dependent interplay between tumor cells and the microenvironment regulates angiogenesis in B-cell lymphoma.
Topics: Aminopyridines; Animals; B-Lymphocytes; Benzamides; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Transgenic; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphodiesterase 4 Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Microenvironment; Vascular Endothelial Growth Factor A | 2016 |
Effect of roflumilast on airway remodelling in a murine model of chronic asthma.
Topics: Airway Remodeling; Allergens; Aminopyridines; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Chronic Disease; Cyclopropanes; Cytokines; Disease Models, Animal; Female; Goblet Cells; Humans; Hydroxyproline; Immunoglobulin E; Lung; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; Respiratory Hypersensitivity; T-Lymphocyte Subsets | 2016 |
Targeting the PI3K signaling pathway in KRAS mutant colon cancer.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cetuximab; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; Humans; Male; MAP Kinase Signaling System; Molecular Targeted Therapy; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; ras Proteins; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Roflumilast Ameliorates Airway Hyperresponsiveness Caused by Diet-Induced Obesity in a Murine Model.
Topics: Adiponectin; Aminopyridines; Animals; Benzamides; Cell Proliferation; Cyclopropanes; Cytokines; Diet; Disease Models, Animal; Leptin; Mice, Inbred C57BL; Models, Biological; Obesity; Ovalbumin; Pulmonary Fibrosis; Reactive Oxygen Species; Respiratory Hypersensitivity; T-Lymphocytes | 2016 |
The effects of roflumilast on the pancreas and remote organs in a cerulein-induced experimental acute pancreatitis model in rats.
Topics: Acute Disease; Aminopyridines; Amylases; Animals; Benzamides; Ceruletide; Cyclopropanes; Disease Models, Animal; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Lung; Male; Oxidative Stress; Pancreas; Pancreatitis; Rats, Wistar; Tumor Necrosis Factor-alpha | 2016 |
Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d.
Topics: Age Factors; Aminopyridines; Animals; Charcot-Marie-Tooth Disease; Disease Models, Animal; Electric Stimulation; Glycine-tRNA Ligase; Imaging, Three-Dimensional; Mice; Mice, Transgenic; Motor Endplate; Muscle Strength; Muscle, Skeletal; Mutation; Nerve Tissue Proteins; Neuromuscular Junction; Patch-Clamp Techniques; Receptors, Cholinergic; Synaptic Potentials; Synaptic Transmission; Synaptic Vesicles | 2016 |
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Topics: Aging; Airway Remodeling; Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunity, Innate; Immunoglobulin A, Secretory; Leukocyte Elastase; Lung; Matrix Metalloproteinase 12; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; NF-kappa B; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Receptors, Polymeric Immunoglobulin; Respiratory Mucosa | 2016 |
Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model.
Topics: Aminopyridines; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Benzodiazepines; Buspirone; Clozapine; Conditioning, Classical; Dibenzocycloheptenes; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Fear; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Indoles; Male; Olanzapine; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Stress, Psychological | 2016 |
Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Disease Models, Animal; Drug Monitoring; Female; Humans; Lung Neoplasms; Male; Mice; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Staging; Neoplasms; Tomography, X-Ray Computed; Treatment Outcome; Xenograft Model Antitumor Assays | 2016 |
Inhibition of Histone Deacetylase 6 Reveals a Potent Immunosuppressant Effect in Models of Transplantation.
Topics: Aminopyridines; Animals; Cell Proliferation; Cells, Cultured; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Graft Rejection; Graft Survival; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunosuppressive Agents; Interferon-gamma; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Targeted Therapy; Signal Transduction; Skin; Skin Transplantation; T-Lymphocytes, Regulatory; Time Factors; Transplantation, Homologous; Vorinostat | 2016 |
CRF type 1 receptor antagonism in ventral tegmental area of adolescent rats during social defeat: prevention of escalated cocaine self-administration in adulthood and behavioral adaptations during adolescence.
Topics: Adaptation, Psychological; Aminopyridines; Animals; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Corticotropin-Releasing Hormone; Disease Models, Animal; Locomotion; Male; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Reinforcement, Psychology; Self Administration; Social Behavior; Stress, Psychological; Ventral Tegmental Area | 2016 |
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
Topics: Aminopyridines; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; CD8-Positive T-Lymphocytes; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Disease Progression; Fibrosis; Focal Adhesion Protein-Tyrosine Kinases; Gemcitabine; Humans; Immunoblotting; Immunohistochemistry; Immunotherapy; Immunotherapy, Adoptive; Mice; Pancreatic Neoplasms; Programmed Cell Death 1 Receptor; Reverse Transcriptase Polymerase Chain Reaction; Tumor Escape; Tumor Microenvironment | 2016 |
PDE4 Inhibition as Potential Treatment of Epidermolysis Bullosa Acquisita.
Topics: Aminopyridines; Animals; Antigen-Antibody Complex; Autoantibodies; Autoantigens; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Epidermis; Epidermolysis Bullosa Acquisita; Humans; Mice; Mice, Inbred C57BL; Neutrophils; Phosphodiesterase 4 Inhibitors | 2016 |
Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.
Topics: Acrylamides; Aminopyridines; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; beta Catenin; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Humans; Kidney Neoplasms; Male; Mice; Molecular Targeted Therapy; NAD; Nicotinamide Phosphoribosyltransferase; p21-Activated Kinases; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
CHK1 Inhibition Radiosensitizes Head and Neck Cancers to Paclitaxel-Based Chemoradiotherapy.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; Chemoradiotherapy; Combined Modality Therapy; Disease Models, Animal; Female; Head and Neck Neoplasms; Humans; Mice; Mitosis; Neoplastic Stem Cells; Paclitaxel; Protein Kinase Inhibitors; Pyrimidines; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Xenograft Model Antitumor Assays | 2016 |
Novel phosphatidylinositol 3-kinase inhibitor BKM120 enhances the sensitivity of multiple myeloma to bortezomib and overcomes resistance.
Topics: Aminopyridines; Animals; Apoptosis; Bortezomib; Cell Cycle; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Inhibitory Concentration 50; Mice; Morpholines; Multiple Myeloma; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2017 |
Distinct effects of inflammation on preconditioning and regeneration of the adult zebrafish heart.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Cell Cycle; Cell Proliferation; Cryopreservation; Disease Models, Animal; Heart; Inflammation; Ischemic Preconditioning, Myocardial; Leukocytes; Myocardial Infarction; Myocytes, Cardiac; Pyrroles; Regeneration; Thoracotomy; Zebrafish | 2016 |
Combination of phosphotidylinositol-3-kinase targeting with cetuximab and irradiation: A preclinical study on an orthotopic xenograft model of head and neck cancer.
Topics: Aminopyridines; Animals; Antineoplastic Agents, Immunological; Carcinoma, Squamous Cell; Cetuximab; Combined Modality Therapy; Disease Models, Animal; Female; Head and Neck Neoplasms; Mice; Mice, Nude; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays | 2017 |
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage.
Topics: Aminopyridines; Animals; Brain; Brain Edema; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Microglia; Neuroimaging; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Species Specificity | 2017 |
RORγt antagonist suppresses M3 muscarinic acetylcholine receptor-induced Sjögren's syndrome-like sialadenitis.
Topics: Adoptive Transfer; Aminopyridines; Animals; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Peptide Fragments; Receptor, Muscarinic M3; Sialadenitis; Sjogren's Syndrome; Sulfonamides; Th1 Cells; Th17 Cells | 2017 |
ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease.
Topics: Administration, Oral; Adult; Aminopyridines; Anemia, Sickle Cell; Animals; Biomarkers; Blood Platelets; Cell Adhesion; Cell Communication; Disease Models, Animal; Female; Humans; Hydroxyurea; Imidazoles; Male; Mice, Knockout; Middle Aged; Neutrophil Activation; Neutrophils; Nitric Oxide; Oxidation-Reduction; Phosphorylation; Platelet Activation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Transendothelial and Transepithelial Migration; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzimidazoles; Biomarkers; Body Weight; Cachexia; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Humans; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Skeletal; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Amygdala-mediated mechanisms regulate visceral hypersensitivity in adult females following early life stress: importance of the glucocorticoid receptor and corticotropin-releasing factor.
Topics: Aminopyridines; Amygdala; Analysis of Variance; Animals; Animals, Newborn; Conditioning, Classical; Corticotropin-Releasing Hormone; Disease Models, Animal; Female; Male; Maze Learning; Odorants; Oligodeoxyribonucleotides, Antisense; Rats; Rats, Long-Evans; Receptors, Glucocorticoid; RNA, Messenger; Sex Characteristics; Stress, Psychological; Up-Regulation; Visceral Pain | 2017 |
Effects of LRRK2 Inhibitors on Nigrostriatal Dopaminergic Neurotransmission.
Topics: Aminopyridines; Animals; Benzamides; Benzodiazepinones; Biophysical Phenomena; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Mice; Mice, Transgenic; Morpholines; Mutation; Parkinson Disease; Patch-Clamp Techniques; Pyrimidines; Substantia Nigra | 2017 |
Co-inhalation of roflumilast, rather than formoterol, with fluticasone more effectively improves asthma in asthmatic mice.
Topics: Administration, Inhalation; Aminopyridines; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Female; Fluticasone; Formoterol Fumarate; Immunoglobulin E; Interleukin-4; Interleukin-5; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2017 |
Pharmacological inhibition of porcupine induces regression of experimental skin fibrosis by targeting Wnt signalling.
Topics: Acyltransferases; Aminopyridines; Animals; Bleomycin; Disease Models, Animal; Disease Progression; Female; Fibrosis; Graft vs Host Disease; Membrane Proteins; Mice, Inbred BALB C; Piperazines; Protein Serine-Threonine Kinases; Pulmonary Fibrosis; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Scleroderma, Localized; Scleroderma, Systemic; Skin; Transforming Growth Factor beta; Wnt Signaling Pathway | 2017 |
NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats.
Topics: Aminopyridines; Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Infarction, Middle Cerebral Artery; Ki-67 Antigen; Male; Microtubule-Associated Proteins; Motor Activity; Neurogenesis; Neuronal Outgrowth; Neurons; Neuroprotective Agents; Piperazines; Rats, Sprague-Dawley; Recovery of Function; Time Factors | 2017 |
A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.
Topics: Acrylamides; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Humans; Mice; p21-Activated Kinases; Phosphorylation; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis.
Topics: Aminopyridines; Aniline Compounds; Animals; Apoptosis; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Flow Cytometry; Lymph Nodes; Mice, Inbred C57BL; Reproducibility of Results; Spleen; Th1 Cells; Th17 Cells | 2017 |
Depletion of microglia exacerbates postischemic inflammation and brain injury.
Topics: Aminopyridines; Animals; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Inflammation Mediators; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Microglia; Neurons; Primary Cell Culture; Proto-Oncogene Proteins c-kit; Pyrroles; Reactive Oxygen Species; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | 2017 |
Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model.
Topics: Aminopyridines; Animals; Benzamides; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Dermatitis; Dermatitis, Contact; Disease Models, Animal; Eosinophil Peroxidase; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Nitriles; Peroxidase; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Picryl Chloride; Rolipram | 2008 |
A novel adenosine A(1) and A(2A) receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: comparison with existing anti-Parkinson's disease drugs.
Topics: Aminopyridines; Analysis of Variance; Animals; Antiparkinson Agents; Callithrix; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Movement Disorders; MPTP Poisoning; Piperazines; Purinergic Antagonists; Time Factors | 2008 |
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Topics: Amino Acid Sequence; Aminopyridines; Animals; Cattle; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Gene Expression; Humans; Inflammation; Isoenzymes; Male; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Nitric Oxide Synthase; Quinazolines; Rats | 2008 |
A novel mTOR inhibitor is efficacious in a murine model of colitis.
Topics: Aminopyridines; Anilides; Animals; Carrier Proteins; Cell Line, Tumor; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Interferon-gamma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2008 |
Combination therapy with flupirtine and opioid: studies in rat pain models.
Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Male; Morphine; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Treatment Outcome | 2008 |
N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.
Topics: Aminopyridines; Animals; Anti-Ulcer Agents; Benzopyrans; Disease Models, Animal; Dogs; Enzyme Inhibitors; Gastroesophageal Reflux; Humans; Omeprazole; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Stomach; Swine | 2009 |
Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury.
Topics: Aminopyridines; Animals; Benzamides; Bleomycin; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Fibrosis; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Effects of the phosphodiesterase type 4 inhibitor roflumilast on early and late allergic response and airway hyperresponsiveness in Aspergillus-fumigatus-sensitized mice.
Topics: Aminopyridines; Animals; Antigens, Fungal; Aspergillus fumigatus; Asthma; Benzamides; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Eosinophils; Female; Leukocyte Count; Lymphocytes; Methacholine Chloride; Mice; Mice, Inbred BALB C; Neutrophils; Phosphodiesterase 4 Inhibitors; Pneumonia; Respiratory Hypersensitivity; Respiratory Mechanics | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors | 2009 |
5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.
Topics: Aminopyridines; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior; Female; Fluoxetine; Male; Olfactory Bulb; Ovariectomy; Piperazines; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Sexual Dysfunction, Physiological; Time Factors | 2009 |
Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension.
Topics: Aminopyridines; Animals; Disease Models, Animal; Female; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels, Voltage-Gated; Pulmonary Artery; Serotonin Plasma Membrane Transport Proteins | 2009 |
Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.
Topics: Aminopyridines; Angiogenesis Inhibitors; Animals; beta-Alanine; Choroidal Neovascularization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electroretinography; Female; Fibroblast Growth Factor 2; Fluorescein Angiography; Injections; Integrin alpha5beta1; Macaca fascicularis; Male; Rabbits; Vascular Endothelial Growth Factor A; Vitreous Body | 2009 |
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Amygdala; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Disease Models, Animal; Electroshock; Indoles; Microdialysis; Rats; Receptor, Serotonin, 5-HT2C; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress Disorders, Traumatic | 2010 |
A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis.
Topics: Aminopyridines; Animals; Cells, Cultured; Chemokine CCL2; Disease Models, Animal; Glomerulonephritis; Interleukin-1beta; Intracellular Signaling Peptides and Proteins; Macrophages; Mesangial Cells; Morpholines; Oxazines; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Inbred WKY; Severity of Illness Index; Signal Transduction; Syk Kinase | 2010 |
Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice.
Topics: Aminopyridines; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymph Nodes; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Morpholines; Oxazines; Prodrugs; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Skin Diseases | 2010 |
Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury.
Topics: Acetamides; Acute Lung Injury; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Administration, Inhalation; Aminopyridines; Animals; Bone Marrow Transplantation; Cell Line; Cell Line, Tumor; Disease Models, Animal; Humans; Inflammation Mediators; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Purines; Receptor, Adenosine A2B; Sepsis; Signal Transduction | 2010 |
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
Topics: Aminopyridines; Animals; Antiprotozoal Agents; Catalytic Domain; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Indoles; Mice; Mice, Inbred C3H; Microscopy, Electron, Transmission; Models, Molecular; Protozoan Proteins; Recombinant Proteins; Sterols; Trypanosoma cruzi | 2010 |
F15599, a preferential post-synaptic 5-HT1A receptor agonist: activity in models of cognition in comparison with reference 5-HT1A receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Cognition; Disease Models, Animal; Enzyme Inhibitors; Male; Memory, Short-Term; Phencyclidine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Reflex, Startle; Serotonin 5-HT1 Receptor Agonists; Signal Transduction | 2010 |
Stimulation of medial prefrontal cortex serotonin 2C (5-HT(2C)) receptors attenuates cocaine-seeking behavior.
Topics: Aminopyridines; Animals; Cocaine-Related Disorders; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Extinction, Psychological; Indoles; Male; Prefrontal Cortex; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Self Administration; Serotonin Antagonists; Serotonin Receptor Agonists | 2010 |
Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung.
Topics: Adrenal Cortex Hormones; Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Bronchoalveolar Lavage Fluid; Budesonide; Cyclopropanes; Disease Models, Animal; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mucus; Neutrophil Infiltration; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pneumonia; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Time Factors; Tobacco Smoke Pollution | 2010 |
The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.
Topics: Adoptive Transfer; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Separation; Disease Models, Animal; Flow Cytometry; Immunophenotyping; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Transgenic; Morpholines; Oxazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction; Syk Kinase | 2010 |
Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.
Topics: Acute Lung Injury; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cyclopropanes; Diclofenac; Disease Models, Animal; Humans; Inflammation; Lipopolysaccharides; Male; Neutrophil Infiltration; Phosphodiesterase 4 Inhibitors; Pyrazoles; Rats; Rats, Wistar | 2011 |
Potassium channel blocker, 4-aminopyridine-3-methanol, restores axonal conduction in spinal cord of an animal model of multiple sclerosis.
Topics: Action Potentials; Aminopyridines; Animals; Axons; Disease Models, Animal; Glycoproteins; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Myelin-Oligodendrocyte Glycoprotein; Neural Conduction; Neurofilament Proteins; Peptide Fragments; Potassium Channel Blockers; Reaction Time; Spinal Cord | 2011 |
Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Aminopyridines; Animals; Benzamides; Cholinergic Fibers; Disease Models, Animal; Drug Evaluation, Preclinical; Gastrointestinal Transit; Ileum; Ileus; Imidazoles; Inflammation Mediators; Macrophages; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neutrophil Infiltration; Postoperative Complications; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Tissue Culture Techniques | 2011 |
A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats.
Topics: Acetic Acid; Administration, Oral; Aminopyridines; Animals; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Irritable Bowel Syndrome; Male; Piperazines; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2010 |
Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury.
Topics: Aminopyridines; Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Chronic Disease; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glycoproteins; Hyperalgesia; Indoles; KCNQ2 Potassium Channel; Lectins; Lidocaine; Male; Membrane Potentials; Neurofilament Proteins; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Sciatic Neuropathy; TRPV Cation Channels; Versicans | 2011 |
Pharmacologic rescue of motivational deficit in an animal model of the negative symptoms of schizophrenia.
Topics: Affective Symptoms; Aminopyridines; Analysis of Variance; Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Gene Expression; Indoles; Mice; Mice, Transgenic; Motivation; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Reward; Schizophrenia; Serotonin 5-HT2 Receptor Antagonists; Up-Regulation | 2011 |
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Topics: Administration, Oral; Allosteric Site; Aminopyridines; Animals; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fructose-Bisphosphatase; Humans; Inhibitory Concentration 50; Liver; Mice; Molecular Structure | 2011 |
Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminopyridines; Animals; Corpus Striatum; Disease Models, Animal; Fluorine Radioisotopes; Ligands; Molecular Imaging; Molecular Structure; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, GABA; Stereoisomerism | 2011 |
Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Female; Fever; KCNQ Potassium Channels; Male; Maze Learning; Memory; Nerve Degeneration; Neuroprotective Agents; Phenobarbital; Rats; Rats, Sprague-Dawley; Risk Factors; Secondary Prevention; Seizures, Febrile | 2011 |
Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
Topics: Action Potentials; Aminopyridines; Animals; Conditioning, Eyelid; Disease Models, Animal; Mice; Mice, Transgenic; Motor Skills Disorders; Nerve Degeneration; Neuroprotective Agents; Spinocerebellar Ataxias; Time Factors | 2011 |
Anxiolytic effects of 5-HT₁A receptors and anxiogenic effects of 5-HT₂C receptors in the amygdala of mice.
Topics: Adenoviridae; Aminopyridines; Amphetamines; Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Iodine Radioisotopes; Maze Learning; Mice; Mice, Inbred C57BL; Oligodeoxyribonucleotides, Antisense; Piperazines; Protein Binding; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2012 |
Anti-asthmatic effect of ASP3258, a novel phosphodiesterase 4 inhibitor.
Topics: Aminopyridines; Animals; Anti-Asthmatic Agents; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Eosinophils; Female; Guinea Pigs; In Vitro Techniques; Lung; Male; Naphthyridines; Nitriles; Ovalbumin; Phosphodiesterase 4 Inhibitors; Rats; Trachea | 2012 |
Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma.
Topics: Aminopyridines; Animals; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 7; Cyclopropanes; Cytokines; Disease Models, Animal; Female; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout | 2012 |
Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure.
Topics: AIDS-Associated Nephropathy; Aminopyridines; Animals; Benzamides; Benzoates; Cell Differentiation; CREB-Binding Protein; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Cytoprotection; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Kidney Tubules; Male; Mice; Mice, Transgenic; Phosphodiesterase 4 Inhibitors; Phosphorylation; Proteinuria; Receptors, Retinoic Acid; Renal Insufficiency; Retinoic Acid Receptor alpha; Signal Transduction; Tetrahydronaphthalenes; Time Factors | 2012 |
An animal model of MYC-driven medulloblastoma.
Topics: Aminopyridines; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cerebellar Neoplasms; Cerebellum; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genes, p53; Imidazoles; Medulloblastoma; Mice; Morpholines; Neural Stem Cells; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-myc; Quinolines; TOR Serine-Threonine Kinases | 2012 |
PF-04886847 (an inhibitor of plasma kallikrein) attenuates inflammatory mediators and activation of blood coagulation in rat model of lipopolysaccharide (LPS)-induced sepsis.
Topics: Aminobenzoates; Aminopyridines; Animals; Blood Coagulation; Disease Models, Animal; Disseminated Intravascular Coagulation; Dose-Response Relationship, Drug; Inflammation Mediators; Lipopolysaccharides; Male; Plasma Kallikrein; Rabbits; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Thrombosis | 2012 |
Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior.
Topics: Alcohol Drinking; Aminopyridines; Analysis of Variance; Animals; Biogenic Monoamines; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Disease Models, Animal; Ethanol; Gene Expression Regulation; Indoles; Male; Mice; Mice, Inbred C57BL; Microdialysis; Microinjections; Nucleus Accumbens; Piperidines; Raphe Nuclei; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine; RNA, Messenger; Serotonin Agents; Sulfonamides | 2012 |
Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice.
Topics: Adenosine A2 Receptor Agonists; Aminopyridines; Animals; Apolipoproteins E; Cardiovascular Agents; Carotid Artery Injuries; Carotid Artery, Common; Carotid Stenosis; Cell Adhesion; Cell Proliferation; CHO Cells; Collagen; Cricetinae; Cricetulus; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; HEK293 Cells; Humans; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Neutrophil Activation; Neutrophils; Platelet Activation; Receptor, Adenosine A2B; Time Factors; Transfection | 2012 |
The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice.
Topics: Administration, Oral; Aminopyridines; Animals; Benzamides; Blood Glucose; Cyclopropanes; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Female; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Mice; Mice, Mutant Strains; Phosphodiesterase 4 Inhibitors | 2012 |
LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing.
Topics: Aged; Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Bronchoalveolar Lavage Fluid; Callithrix; Cyclopropanes; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Lung Diseases; Male; Middle Aged; Phosphodiesterase 4 Inhibitors; Tumor Necrosis Factor-alpha | 2012 |
A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged guinea-pig models of asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Aminopyridines; Androstadienes; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchial Hyperreactivity; Chronic Disease; Cyclopropanes; Disease Models, Animal; Fluticasone; Guinea Pigs; Histamine; Inflammation; Male; Ovalbumin; Sulfides; Time Factors | 2012 |
Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis.
Topics: Aminopyridines; Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Hyperalgesia; Male; Morphine; Pain; Prostatic Neoplasms; Rats; Rats, Wistar | 2012 |
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Dinoprostone; Disease Models, Animal; Enzyme Activation; Gene Expression Regulation; Humans; Mice; Molecular Structure; Phthalazines; Transplantation, Heterologous | 2013 |
Effects of the 5HT2C antagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behavior.
Topics: Aminopyridines; Animals; Benzothiazoles; Compulsive Behavior; Disease Models, Animal; Dopamine Agonists; Drinking; Indoles; Male; Pramipexole; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D3; Reinforcement Schedule; Serotonin 5-HT2 Receptor Antagonists; Treatment Outcome | 2013 |
Anxiogenic effects of brief swim stress are sensitive to stress history.
Topics: Aminopyridines; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Escape Reaction; Exploratory Behavior; Immobility Response, Tonic; Indoles; Male; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Stress, Physiological; Stress, Psychological; Swimming; Time Factors | 2013 |
CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption.
Topics: Alcohol Drinking; Aminopyridines; Aniline Compounds; Animals; Binge Drinking; Darkness; Disease Models, Animal; Drinking; Eating; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrimidines; Receptors, Corticotropin-Releasing Hormone; Signal Transduction | 2013 |
5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze.
Topics: Aminopyridines; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reaction; Exploratory Behavior; Fear; Indoles; Male; Maze Learning; Motor Activity; Piperazines; Random Allocation; Rats; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Synergism; Female; Fentanyl; Gabapentin; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Imipramine; Ketamine; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Time Factors; Transfection | 2002 |
The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain.
Topics: Aminopyridines; Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morphine; Muscle Relaxants, Central; Narcotics; Pain; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stress, Mechanical; Trigeminal Neuralgia | 2002 |
Antithrombotic properties of SSR182289A, a new, orally active thrombin inhibitor.
Topics: Administration, Oral; Aminopyridines; Animals; Bleeding Time; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Rabbits; Rats; Rats, Sprague-Dawley; Sulfonamides; Thrombin; Thrombosis | 2003 |
Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma.
Topics: Aminopyridines; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchi; Cyclopropanes; Dexamethasone; Disease Models, Animal; Immunohistochemistry; Inflammation; Mice; Mice, Inbred BALB C | 2003 |
5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.
Topics: Action Potentials; Aminopyridines; Animals; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Absence; Fluoxetine; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
SSR182289A, a selective and potent orally active thrombin inhibitor.
Topics: Administration, Oral; Aminopyridines; Animals; Azetidines; Benzylamines; Blood Coagulation; Crystallography, X-Ray; Disease Models, Animal; Humans; Hydrogen Bonding; Male; Models, Molecular; Molecular Structure; Platelet Aggregation; Rats; Structure-Activity Relationship; Sulfonamides; Thrombin; Thrombosis | 2004 |
SSR182289A enhances thrombolysis induced by fibrinolytic agents in rabbit models of venous and arterial thrombosis.
Topics: Aminopyridines; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Femoral Artery; Fibrinolytic Agents; Jugular Veins; Male; Rabbits; Streptokinase; Sulfonamides; Thrombolytic Therapy; Thrombosis; Tissue Plasminogen Activator | 2004 |
Mechanisms of action of differentiation inducers: detection of inducer binding protein(s) in murine erythroleukemia cells.
Topics: Aminopyridines; Animals; Binding Sites; Cell Differentiation; Cytosol; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Kinetics; Leukemia, Erythroblastic, Acute; Ligands; Mice; Multiprotein Complexes; Neuroectodermal Tumors; p38 Mitogen-Activated Protein Kinases | 2005 |
Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Quinolones; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Thiazoles | 2005 |
Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke.
Topics: Administration, Oral; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Goblet Cells; Hyperplasia; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Pulmonary Emphysema; Smoking | 2005 |
Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Aminopyridines; Animals; Benzamides; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Immunization; Male; Neutrophils; Nitriles; Ovalbumin; Phosphodiesterase Inhibitors; Pneumonia; Pyridines; Rats; Respiratory Hypersensitivity; Rolipram; Serotonin; Treatment Outcome; Tumor Necrosis Factor-alpha | 2006 |
Roflumilast inhibition of pulmonary leukotriene production and bronchoconstriction in ovalbumin-sensitized and -challenged Guinea pigs.
Topics: Allergens; Aminopyridines; Animals; Benzamides; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cyclopropanes; Cysteine; Disease Models, Animal; Guinea Pigs; Leukotriene B4; Leukotrienes; Male; Ovalbumin; Phosphodiesterase Inhibitors; SRS-A | 2005 |
Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Transplantation, Heterologous | 2006 |
A late cutaneous response in actively sensitized rats: a new method for evaluating the efficacy of antiallergic drugs.
Topics: Aminopyridines; Animals; Anti-Allergic Agents; Antigens; Cromolyn Sodium; Cyclosporine; Dinitrobenzenes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Edema; Haptens; Hindlimb; Hypersensitivity, Delayed; Male; ortho-Aminobenzoates; Ovalbumin; Passive Cutaneous Anaphylaxis; Promethazine; Pyridines; Pyrimidinones; Quinolones; Rats; Rats, Wistar | 2006 |
L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Animals; Apoenzymes; Ascaris suum; Asthma; Benzamides; Bronchoconstriction; Carboxylic Acids; Cognition Disorders; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Humans; Inhibitory Concentration 50; Injections, Intraperitoneal; Interferon-gamma; Male; Molecular Structure; Nitriles; Ovalbumin; Polymerase Chain Reaction; Quinolines; Rats; Sensitivity and Specificity; Sheep | 2007 |
Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor.
Topics: Aminopyridines; Animals; Arthritis, Rheumatoid; Arthus Reaction; Bone Resorption; Collagen Type II; Disease Models, Animal; Female; Immunoglobulin G; Inflammation; Intracellular Signaling Peptides and Proteins; Morpholines; Oxazines; Prodrugs; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, IgG; Signal Transduction; Syk Kinase; Synovial Fluid; Synovitis | 2007 |
Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Aminopyridines; Animals; Anti-Allergic Agents; Benzamides; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Lung; Ovalbumin; Peak Expiratory Flow Rate; Phosphodiesterase Inhibitors; Pulmonary Edema; Rats; Rats, Inbred BN; Respiratory Hypersensitivity; Time Factors; Vital Capacity | 2007 |
Suppression of cytokine expression by roflumilast and dexamethasone in a model of chronic asthma.
Topics: Aminopyridines; Animals; Anti-Asthmatic Agents; Asthma; Benzamides; Bronchi; Chronic Disease; Cyclopropanes; Cytokines; Dexamethasone; Disease Models, Animal; Female; Humans; Inflammation; Mice; Mice, Inbred BALB C; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Specific Pathogen-Free Organisms | 2008 |
Anti-inflammatory modulation of chronic airway inflammation in the murine house dust mite model.
Topics: Aminopyridines; Androstadienes; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchoalveolar Lavage; Cyclopropanes; Dermatophagoides pteronyssinus; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluticasone; Glucocorticoids; Inflammation; Mice; Mice, Inbred BALB C; Phosphodiesterase Inhibitors; Prednisolone | 2008 |
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
Topics: Acylation; Aminopyridines; Animals; Anorexia; Antineoplastic Agents; Body Weight; Chalcones; Cisplatin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Eating; Flavones; Gastric Mucosa; Gastrointestinal Agents; Ghrelin; Hesperidin; Indoles; Male; Oligopeptides; Piperazines; Protein Binding; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Ghrelin; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Stomach; Thiophenes; Vagotomy | 2008 |
Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.
Topics: Alum Compounds; Aminopyridines; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchoalveolar Lavage Fluid; Budesonide; Cyclopropanes; Dibenzazepines; Disease Models, Animal; Eosinophils; Histamine H1 Antagonists; Imidazoles; Ketotifen; Lung; Mice; Mice, Inbred BALB C; Ovalbumin; Phosphodiesterase Inhibitors; Prednisolone; Rats; Rats, Inbred BN | 2008 |
Pharmacological prevention of ocular inflammation induced by lens proteins.
Topics: Aminopyridines; Animals; Catechols; Cimetidine; Crystallins; Disease Models, Animal; Drug Therapy, Combination; Endophthalmitis; Female; Indomethacin; Masoprocol; Pyrilamine; Rabbits | 1984 |
Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model.
Topics: Acetates; Administration, Oral; Aminopyridines; Animals; Benzodiazepinones; Biological Availability; Disease Models, Animal; Kinetics; Osteoporosis; Rats; Receptors, Vitronectin; Time Factors | 1999 |
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis.
Topics: Acetates; Administration, Oral; Aminopyridines; Animals; Bone Resorption; Cell Adhesion; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Infusions, Intravenous; Integrins; Osteoporosis; Ovariectomy; Parathyroidectomy; Platelet Aggregation; Protein Binding; Rats; Receptors, Vitronectin; Thyroidectomy; Time Factors | 1999 |
The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety.
Topics: Aminopyridines; Animals; Anxiety; Cyclohexane Monoterpenes; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Isoquinolines; Male; Maze Learning; Motor Activity; Pindolol; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Succinimides | 2000 |
A novel anionic modification of N-glycans on mammalian endothelial cells is recognized by activated neutrophils and modulates acute inflammatory responses.
Topics: Acute Disease; Adjuvants, Immunologic; Amidohydrolases; Aminopyridines; Animals; Anions; Antibodies, Monoclonal; Antibody Specificity; Antigen-Antibody Reactions; Binding Sites, Antibody; Biotin; Carboxylic Acids; Cattle; Cell Movement; Cells, Cultured; Disease Models, Animal; Endothelium, Vascular; Epitopes; Female; Humans; Injections, Intravenous; Mice; Mice, Inbred BALB C; Monocytes; Neutrophil Activation; Neutrophils; Oligosaccharides; Organ Specificity; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Peritonitis | 2001 |
Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.
Topics: Acetylation; Aminopyridines; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line, Transformed; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostate-Specific Antigen; Prostatic Neoplasms; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats.
Topics: Aminopyridines; Amphetamine; Amphetamine-Related Disorders; Animals; Body Weight; Brain; Depression; Disease Models, Animal; Drug Combinations; Electric Stimulation; Fluoxetine; Male; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Piperazines; Rats; Rats, Wistar; Reaction Time; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reward; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome; Synaptic Transmission; Tobacco Use Disorder | 2001 |
Effect of 4-aminopyridine on axonal conduction-block in chronic spinal cord injury.
Topics: 4-Aminopyridine; Action Potentials; Aminopyridines; Animals; Cats; Disease Models, Animal; Female; Neural Conduction; Spinal Cord Injuries; Temperature | 1989 |
Animal models of Alzheimer's disease: behavior, pharmacology, transplants.
Topics: 4-Aminopyridine; Alzheimer Disease; Aminopyridines; Animals; Behavior, Animal; Brain; Disease Models, Animal; Fetus; Growth Substances; Humans; Nerve Growth Factors; Nerve Tissue; Nerve Tissue Proteins; Nervous System Diseases; Norepinephrine; Parasympathetic Nervous System; Physostigmine; Somatostatin | 1986 |
Abuse potential and physical dependence liability studies with flupirtine maleate in laboratory animals.
Topics: Aminopyridines; Analgesics; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Macaca mulatta; Mice; Mice, Inbred Strains; Rats; Substance-Related Disorders | 1987 |