Compounds > alpha-aminopyridine
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alpha-aminopyridine and Carcinoma, Pancreatic Ductal

alpha-aminopyridine has been researched along with Carcinoma, Pancreatic Ductal in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (44.44)24.3611
2020's5 (55.56)2.80

Authors

AuthorsStudies
Hiramoto, M; Hirota, A; Kazama, H; Miyazaki, M; Miyazawa, K; Ogawa, M; Ota, K; Suzuki, S; Takano, N1
Al-Ali, R; Ameziane, N; Bauer, P; Junghanss, C; Kong, W; Krake, S; Lerch, MM; Ma, Y; Murua Escobar, H; Parveen, A; Radefeldt, M; Sekora, A; Sender, S; Weiss, FU; Zechner, D1
Amen, A; Bronsert, P; Brunner, TB; Follo, M; Grosu, AL; Mekawy, M; Mohamed, AA; Mostafa, H; Thomsen, A; Zamboglou, C1
Arnes, L; Bravo, MC; Erler, JT; Horton, ER; Hwang, CI; Jackstadt, R; Jensen, ARD; Karim, SA; Laitala, A; Maltese, G; Morton, JP; Nielsen, SR; Rafaeva, M; Reuten, R; Sansom, OJ; Strøbech, JE; Tuveson, DA1
Aboukameel, A; Azmi, AS; Baloglu, E; Landesman, Y; Li, Y; Mohammad, RM; Muqbil, I; Philip, PA; Senapedis, W1
DeNardo, DG; Fields, RC; Hegde, S; Jiang, H; Knolhoff, BL; Lee, KB; Lim, KH; Liu, X; Pachter, JA1
Alagesan, B; Bardeesy, N; Benes, CH; Contino, G; Corcoran, RB; Deshpande, V; Engelman, J; Guimaraes, AR; Hezel, AF; Loda, M; Weissleder, R; Wojtkiewicz, GR; Wong, KK1
He, DH; Hochwald, SN; Zajac-Kaye, M; Zhang, J1
DeNardo, DG; Hawkins, WG; Hegde, S; Herndon, JM; Jiang, H; Knolhoff, BL; Meyer, MA; Nywening, TM; Pachter, JA; Shapiro, IM; Wang-Gillam, A; Weaver, DT; Zhu, Y1

Other Studies

9 other study(ies) available for alpha-aminopyridine and Carcinoma, Pancreatic Ductal

ArticleYear
Lysosome‑targeted drug combination induces multiple organelle dysfunctions and non‑canonical death in pancreatic cancer cells.
    Oncology reports, 2022, Volume: 47, Issue:2

    Topics: Aminopyridines; Antineoplastic Agents; Benzimidazoles; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Drug Synergism; Endoplasmic Reticulum Stress; Fingolimod Hydrochloride; Humans; Hydroxychloroquine; Lapatinib; Lysosomes; Pancreatic Neoplasms; Sphingosine 1 Phosphate Receptor Modulators

2022
The Inhibitory Response to PI3K/AKT Pathway Inhibitors MK-2206 and Buparlisib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines.
    International journal of molecular sciences, 2022, Apr-13, Volume: 23, Issue:8

    Topics: Aminopyridines; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Heterocyclic Compounds, 3-Ring; Humans; Morpholines; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Signal Transduction

2022
FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2021, Volume: 197, Issue:1

    Topics: Aminopyridines; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Line, Tumor; Coculture Techniques; Collagen; Extracellular Matrix Proteins; Focal Adhesion Kinase 1; Histones; Humans; Kaplan-Meier Estimate; Neoplasm Proteins; Pancreatic Neoplasms; Pancreatic Stellate Cells; Progression-Free Survival; Protein Kinase Inhibitors; Radiation Tolerance; Radiation-Sensitizing Agents; RNA Interference; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Spheroids, Cellular; Stromal Cells; Tumor Stem Cell Assay

2021
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
    Nature communications, 2021, 06-07, Volume: 12, Issue:1

    Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Disease Models, Animal; Drug Synergism; Female; Humans; Immune Checkpoint Inhibitors; Lactams; Lactams, Macrocyclic; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Male; Mice; Mice, Transgenic; Neutrophils; Pancreatic Neoplasms; Programmed Cell Death 1 Receptor; Pyrazoles; Tumor Microenvironment

2021
Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.
    Small GTPases, 2019, Volume: 10, Issue:5

    Topics: Acrylamides; Aminopyridines; bcl-Associated Death Protein; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cytokines; Drug Resistance, Neoplasm; Enzyme Activation; Humans; MicroRNAs; Nicotinamide Phosphoribosyltransferase; p21-Activated Kinases; Pancreatic Neoplasms; RNA, Neoplasm

2019
Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion.
    Gut, 2020, Volume: 69, Issue:1

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Collagen; Down-Regulation; Drug Resistance, Neoplasm; Female; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Mice, Inbred Strains; Pancreatic Neoplasms; Signal Transduction; Smad3 Protein; STAT3 Transcription Factor; Stromal Cells; Transforming Growth Factor beta; Xenograft Model Antitumor Assays

2020
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jan-15, Volume: 21, Issue:2

    Topics: Aminopyridines; Animals; Antineoplastic Agents; Benzimidazoles; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Erlotinib Hydrochloride; Humans; MAP Kinase Kinase Kinases; Mice, Transgenic; Morpholines; Pancreatic Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines

2015
A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells.
    Cell cycle (Georgetown, Tex.), 2014, Volume: 13, Issue:19

    Topics: Adenocarcinoma; Aminopyridines; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Hydroxamic Acids; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt

2014
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.
    Nature medicine, 2016, Volume: 22, Issue:8

    Topics: Aminopyridines; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; CD8-Positive T-Lymphocytes; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Disease Progression; Fibrosis; Focal Adhesion Protein-Tyrosine Kinases; Gemcitabine; Humans; Immunoblotting; Immunohistochemistry; Immunotherapy; Immunotherapy, Adoptive; Mice; Pancreatic Neoplasms; Programmed Cell Death 1 Receptor; Reverse Transcriptase Polymerase Chain Reaction; Tumor Escape; Tumor Microenvironment

2016