alpha-aminopyridine has been researched along with Cancer of Liver in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (26.83) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 1 (2.44) | 29.6817 |
| 2010's | 18 (43.90) | 24.3611 |
| 2020's | 10 (24.39) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, J; Jiang, S; Shen, Z; Zhou, D | 1 |
| Fang, JC; Liu, J; Zhong, L | 1 |
| Chow, EK; Hooi, L; Lim, JJ; Rashid, MBMA; Toh, TB | 1 |
| Cong, L; Dong, J; Ke, M; Li, Y; Lv, Y; Wang, X; Zhang, Z; Zhao, S; Zhu, Y | 1 |
| Cheng, W; Fang, S; Gong, YF; Guan, XY; Hu, L; Jiang, LX; Kong, FE; Li, HL; Li, L; Li, MM; Li, Y; Lin, G; Liu, M; Loong, JH; Ma, NF; Ma, S; Mo, JQ; Nam, Y; Ouyang, Q; Sun, Y; Tang, YQ; Wang, JG; Yan, Q; Yang, XD; Yuan, YF; Zhang, Y | 1 |
| Gao, J; Jiang, X; Liu, F; Qian, Y; Wang, Y; Wu, X | 1 |
| Huynh, H; Le, TBU; Prawira, A; Vu, TC | 1 |
| Decaens, T; Lerat, H; Macek Jílková, Z; Marche, PN; Mroweh, M; Roth, G | 1 |
| Chen, X; Duan, Y; Huang, H; Jiang, Y; Jin, Z; Li, C; Wang, Q; Wu, D; Xu, T; Zhu, Q | 1 |
| Ajioka, I; Harada, K; Horike, SI; Inoue, H; Kitajima, S; Kohno, S; Kumar, S; Linn, P; Matsuda, F; Nagatani, N; Okada, N; Okahashi, N; Sheng, J; Shimizu, H; Takahashi, C; Teranishi, K; Yamamura, M; Yano, S | 1 |
| He, X; Ji, X; Jiang, C; Shen, Z; Yin, L; Zhou, H; Zhu, X | 1 |
| Feng, S; Huang, H; Ling, Q; Rui, T; Sun, J; Tu, Z; Zhang, C; Zhang, X; Zheng, S | 1 |
| Alisi, A; Artuso, S; Balsano, C; Carcarino, E; Ceccarelli, S; Chierici, M; Crudele, A; D'Oria, V; De Stefanis, C; Ferrari, K; Furlanello, C; Giorda, E; Gnani, D; Leonetti, C; Locatelli, F; Miele, L; Nobili, V; Panera, N; Pasini, D; Porru, M; Romito, I; Rota, R; Villa, E | 1 |
| Ao, JY; Cai, H; Chai, ZT; Kong, LQ; Ma, DN; Sun, HC; Ye, BG; Zhang, KZ; Zhang, N; Zhang, YY; Zhu, XD | 1 |
| Arteaga, CL; Blackwell, KL; Burris, HA; Cameron, DA; Campone, M; Conte, P; Elmeliegy, M; Germa, C; Hortobagyi, GN; Janni, W; Miller, M; Mondal, S; O'Shaughnessy, J; Paluch-Shimon, S; Petrakova, K; Sonke, GS; Stemmer, SM; Su, F; Verma, S; Winer, EP; Yap, YS | 1 |
| Fang, D; Hou, JZ; Li, W; Liang, C; Niu, J; Sun, H; Wang, X; Xi, ZQ; Xie, SQ | 1 |
| Dong, QZ; Gao, XM; Hsu, JL; Hung, MC; Jia, HL; Li, CW; Li, JH; Lim, SO; Lu, L; Luo, Q; Qin, LX; Sheng, YY; Xu, D; Yang, J; Zhang, Y; Zhang, Z; Zhao, Y; Zheng, Y; Zhu, Y | 1 |
| Cheng, Y; Cristofanilli, M; Cui, S; Feng, J; Gao, J; Geng, C; Gu, K; Hu, X; Jiang, Z; Li, W; Liu, T; Lu, X; Ning, Z; Ouyang, Q; Ouyang, T; Pan, Y; Sun, T; Sun, Y; Tong, Z; Wang, H; Wang, S; Wang, X; Yin, Y; Zhang, Q | 1 |
| De Toni, EN; Denk, G; Gerbes, AL; Hohenester, S; Itzel, T; Mayerle, J; Munker, S; Ofner, A; Reiter, FP; Schiergens, TS; Spampatti, M; Teufel, A; Wimmer, R; Ye, L; Ziesch, A | 1 |
| Coleman, N; Popat, S; Wotherspoon, A; Yousaf, N | 1 |
| Higo, H; Hotta, K; Ichihara, E; Kano, H; Kayatani, H; Kiura, K; Kubo, T; Maeda, Y; Makimoto, G; Matsubara, T; Ninomiya, K; Ninomiya, T; Nishii, K; Ohashi, K; Rai, K; Sato, A; Tabata, M; Takata, M; Tomida, S; Toyooka, S; Watanabe, H | 1 |
| de Gramont, A; Dos Santos, C; Faivre, S; Raymond, E; Riveiro, ME; Serova, M; Slimane, K; Tijeras-Raballand, A | 1 |
| Boukouris, AE; Buitrago-Molina, LE; Hegermann, J; Kirstein, MM; Kühnel, F; Manns, MP; Marhenke, S; Orlik, J; Pothiraju, D; Schütt, J; Vogel, A | 1 |
| Huang, YH; Lin, HC | 1 |
| Cheng, AL; Cheng, JC; Gao, M; Hsu, FM; Liu, WL; Tsai, CL; Tzen, KY | 1 |
| Dou, H; Feng, K; Jiang, X; Li, Z; Wang, T; Zhang, Y; Zhou, F | 1 |
| Choi, JH; Chung, YY; Jung, IH; Lim, GL; Park, SW; Park, YN | 1 |
| Bergqvist, S; Brooun, A; Burke, BJ; Dardaei, L; Deng, YL; Engelman, JA; Frias, RL; Friboulet, L; Gainor, JF; Getz, G; Iafrate, AJ; James, LP; Johnson, TW; Katayama, R; Le, L; Leshchiner, I; Liu, W; Logan, J; McTigue, M; Schultz, KR; Shaw, AT; Smeal, T; Timofeevski, S | 1 |
| Fu, M; Guo, Y; Liang, X; Lin, C; Qian, H; Wang, H; Wang, R; Zhang, X | 1 |
| Gao, CX; Hayashi, N; Honke, K; Hori, M; Ihara, H; Kasahara, A; Miyoshi, E; Nakahara, S; Noda, K; Sasaki, Y; Taniguchi, N; Yanagidani, S | 1 |
| Altmannsberger, M; Fischer, G; Katz, N; Schauer, A | 1 |
| Casciano, DA; Schol, HM | 1 |
| Lijinsky, W | 1 |
| Brennan, LM; Creasia, DA; Ohshima, M; Ward, JM | 1 |
| Furuya, K; Williams, GM | 1 |
| Brennan, LM; Creasia, DA | 1 |
| Lijinsky, W; Reznik-Schüller, HM | 1 |
| Kovatch, RM; Lijinsky, W | 1 |
| Katyal, SL; Perera, MI; Shinozuka, H | 1 |
| Kammerer, RC; Kloc, K; Lampe, MA; Schmitz, DA | 1 |
| Eisenbrand, G; Habs, M; Shubik, P | 1 |
2 review(s) available for alpha-aminopyridine and Cancer of Liver
| Article | Year |
|---|---|
Effective treatment with programmed cell death protein-1 antibody, chidamide and conventional chemotherapy for hepatosplenic γδ T-cell lymphoma: A case report and literature review.
Topics: Aminopyridines; Apoptosis Regulatory Proteins; Benzamides; Humans; Liver Neoplasms; Lymphoma, T-Cell; Receptors, Antigen, T-Cell, gamma-delta | 2022 |
Targeting Akt in Hepatocellular Carcinoma and Its Tumor Microenvironment.
Topics: Aminopyridines; Carcinoma, Hepatocellular; Drug Delivery Systems; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Liver Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Tumor Microenvironment | 2021 |
3 trial(s) available for alpha-aminopyridine and Cancer of Liver
| Article | Year |
|---|---|
Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.
Topics: Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Double-Blind Method; Female; Follow-Up Studies; Humans; Letrozole; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Neoplasm Recurrence, Local; Prognosis; Purines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Survival Rate | 2018 |
Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Aminopyridines; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Neoplasms; Breast Neoplasms; Double-Blind Method; Female; Follow-Up Studies; Humans; Liver Neoplasms; Lung Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Postmenopause; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Salvage Therapy; Survival Rate; Treatment Outcome | 2019 |
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Binding Sites; Carcinoma, Non-Small-Cell Lung; Crizotinib; Drug Resistance, Neoplasm; Female; Humans; Lactams; Lactams, Macrocyclic; Liver Failure; Liver Neoplasms; Lung Neoplasms; Middle Aged; Molecular Structure; Mutation; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Sulfones | 2016 |
36 other study(ies) available for alpha-aminopyridine and Cancer of Liver
| Article | Year |
|---|---|
Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface beta-1,4-galactosyltransferase.
Topics: Aminopyridines; Carbohydrate Conformation; Carbohydrate Sequence; Carcinoma, Hepatocellular; Cell Differentiation; Cell Division; Cell Line; Cell Membrane; Humans; Kinetics; Liver Neoplasms; Molecular Sequence Data; N-Acetyllactosamine Synthase; Oligosaccharides; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1996 |
Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinoma.
Topics: Aminopyridines; Animals; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Dimethyl Sulfoxide; Female; Humans; Hyaluronan Receptors; Janus Kinases; Liver Neoplasms; Male; Mice; Mice, Transgenic; Neoplastic Stem Cells; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Signal Transduction; STAT Transcription Factors; Sulfonamides; Transfection; Transplantation, Homologous; Tumor Burden | 2020 |
MicroRNA-148b-colony-stimulating factor-1 signaling-induced tumor-associated macrophage infiltration promotes hepatocellular carcinoma metastasis.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice; Mice, Nude; MicroRNAs; Neoplasm Metastasis; Neoplasms, Experimental; Pyrroles; Signal Transduction | 2019 |
A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.
Topics: Aminopyridines; Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cohort Studies; Disease-Free Survival; E2F1 Transcription Factor; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Hepatectomy; Hepatocytes; Human Embryonic Stem Cells; Humans; Hydroxyquinolines; Isoquinolines; Kaplan-Meier Estimate; Liver; Liver Neoplasms; Male; Mice; Middle Aged; Prognosis; Pyridines; Pyrroles; Signal Transduction; Smad3 Protein; Xenograft Model Antitumor Assays | 2020 |
PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Liver Neoplasms; Mice; Mice, Nude; Neoplastic Stem Cells; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Random Allocation; Transfection; Triazines; Xenograft Model Antitumor Assays | 2020 |
Ribociclib enhances infigratinib-induced cancer cell differentiation and delays resistance in FGFR-driven hepatocellular carcinoma.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Male; Mice; Mice, SCID; Phenylurea Compounds; Purines; Pyrimidines; Xenograft Model Antitumor Assays | 2021 |
Clinical features and treatment outcomes of 14 patients with hepatosplenic γ δ T-cell lymphoma.
Topics: Adolescent; Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bortezomib; Cyclophosphamide; Doxorubicin; Hematopoietic Stem Cell Transplantation; Humans; Intraepithelial Lymphocytes; Liver Neoplasms; Lymphoma, T-Cell, Peripheral; Middle Aged; Prednisolone; Retrospective Studies; Splenic Neoplasms; Treatment Outcome; Vincristine; Young Adult | 2021 |
Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy.
Topics: Aminopyridines; Animals; Benzimidazoles; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Hep G2 Cells; Humans; In Vitro Techniques; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Neoplasm Transplantation; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Retinoblastoma Protein; Tumor Suppressor Protein p53; Xenopus Proteins | 2021 |
Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aurora Kinase A; Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; Hep G2 Cells; Humans; Indazoles; Kaplan-Meier Estimate; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Pyrazoles; RNA Interference; Xenograft Model Antitumor Assays | 2021 |
Sarcomatoid hepatocellular carcinoma: From clinical features to cancer genome.
Topics: Aged; Aminopyridines; Benzimidazoles; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Cyclin-Dependent Kinase Inhibitor p16; Disease-Free Survival; DNA Helicases; Female; Follow-Up Studies; Hepatectomy; Humans; Liver; Liver Neoplasms; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mutation Rate; Neoplasm Recurrence, Local; Prognosis; Receptor, EphA5; Risk Factors; Tumor Burden | 2021 |
Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.
Topics: Aminopyridines; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; E2F2 Transcription Factor; E2F3 Transcription Factor; Enhancer of Zeste Homolog 2 Protein; Focal Adhesion Kinase 1; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Receptor, Notch2; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Protein p53 | 2017 |
Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma.
Topics: Aminopyridines; Animals; Biomarkers, Tumor; Bone Marrow Cells; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Humans; Liver Neoplasms; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Monocytes; Phenotype; Pyrroles; Receptor, Macrophage Colony-Stimulating Factor; Tumor Microenvironment | 2017 |
Inhibition of PIKfyve using YM201636 suppresses the growth of liver cancer via the induction of autophagy.
Topics: Adult; Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Heterocyclic Compounds, 3-Ring; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Xenograft Model Antitumor Assays | 2019 |
Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; B7-H1 Antigen; Biomarkers, Tumor; Carcinoma, Hepatocellular; Chemotaxis; Cytokines; Gene Deletion; Humans; Liver Neoplasms; Lymphocytes, Tumor-Infiltrating; Macrophage Colony-Stimulating Factor; Macrophages; Male; Mice, Knockout; Molecular Targeted Therapy; Osteopontin; Prognosis; Pyrroles; Tumor Cells, Cultured; Tumor Escape; Tumor Microenvironment | 2019 |
Predictors of ribociclib-mediated antitumour effects in native and sorafenib-resistant human hepatocellular carcinoma cells.
Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Drug Resistance, Neoplasm; G1 Phase Cell Cycle Checkpoints; Hepatocytes; Humans; Liver Neoplasms; Purines; Retinoblastoma Protein; RNA, Small Interfering; Sorafenib | 2019 |
Transformation to neuroendocrine carcinoma as a resistance mechanism to lorlatinib.
Topics: Adult; Aminopyridines; Anaplastic Lymphoma Kinase; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Gene Rearrangement; Humans; Lactams; Lactams, Macrocyclic; Liver Neoplasms; Lung Neoplasms; Male; Molecular Targeted Therapy; Mutation; Neoplasm Metastasis; Neoplasm Staging; Pyrazoles; Tomography, X-Ray Computed | 2019 |
Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.
Topics: Aminopyridines; Anaplastic Lymphoma Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazoles; Cell Line, Tumor; Crizotinib; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Kidney Neoplasms; Lactams; Lactams, Macrocyclic; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred NOD; Middle Aged; Mutation; Piperidines; Pyrazoles; Xenograft Model Antitumor Assays | 2019 |
Benchmarking effects of mTOR, PI3K, and dual PI3K/mTOR inhibitors in hepatocellular and renal cell carcinoma models developing resistance to sunitinib and sorafenib.
Topics: Aminopyridines; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Everolimus; Humans; Imidazoles; Indoles; Kidney Neoplasms; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Niacinamide; Phenylurea Compounds; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Pyrroles; Quinolines; Signal Transduction; Sirolimus; Sorafenib; Sunitinib; TOR Serine-Threonine Kinases | 2013 |
Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.
Topics: Aminopyridines; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Camptothecin; Carcinoma, Hepatocellular; Cell Cycle; Cell Line; Cell Respiration; Cisplatin; Doxorubicin; Everolimus; Humans; Imidazoles; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Irinotecan; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
The role of mTOR inhibitors in the treatment of hepatocellular carcinoma.
Topics: Aminopyridines; Carcinoma, Hepatocellular; Humans; Imidazoles; Liver Neoplasms; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma.
Topics: Aminopyridines; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Random Allocation | 2014 |
Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma.
Topics: Aminopyridines; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzoxazoles; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Liver Neoplasms; Mice; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Real-Time Polymerase Chain Reaction; Sorafenib; Transfection; Xenograft Model Antitumor Assays | 2015 |
Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis.
Topics: Aminopyridines; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic S-Oxides; Disease Models, Animal; Enzyme Activation; Humans; Inflammation; Interleukin-6; Janus Kinases; Liver; Liver Neoplasms; Morpholines; Niclosamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; STAT3 Transcription Factor; Zebrafish; Zebrafish Proteins | 2015 |
Antitumor activity of Chidamide in hepatocellular carcinoma cell lines.
Topics: Aminopyridines; Antineoplastic Agents; Apoptosis; Benzamides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms; Pyridines; Up-Regulation | 2012 |
An enzymatic method of analysis for GDP-L-fucose in biological samples, involving high-performance liquid chromatography.
Topics: Aminopyridines; Animals; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Colonic Neoplasms; Fluorescent Dyes; Fucosyltransferases; Guanosine Diphosphate Fucose; Humans; Liver; Liver Neoplasms; Microsomes; Molecular Sequence Data; Oligosaccharides; Rats; Spectrometry, Fluorescence; Time Factors; Tumor Cells, Cultured | 2002 |
Early stages of chemically induced liver carcinogenesis by oral administration of the antihistaminic methapyrilene hydrochloride.
Topics: Adenosine Triphosphatases; Administration, Oral; Aminopyridines; Animals; Female; gamma-Glutamyltransferase; Liver Neoplasms; Methapyrilene; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains | 1983 |
Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay.
Topics: Aminopyridines; Animals; Cricetinae; Cricetulus; Female; Hypoxanthine Phosphoribosyltransferase; Liver Neoplasms; Male; Methapyrilene; Mutagenicity Tests; Mutagens; Ovary; Rats; Rats, Inbred Strains | 1984 |
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.
Topics: Aminopyridines; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Male; Methapyrilene; Pyrilamine; Rats; Rats, Inbred F344; Structure-Activity Relationship; Time Factors | 1984 |
A sequential study of methapyrilene hydrochloride-induced liver carcinogenesis in male F344 rats.
Topics: Aminopyridines; Animals; Body Weight; Carcinogens; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methapyrilene; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1984 |
Neoplastic conversion in rat liver by the antihistamine methapyrilene demonstrated by a sequential syncarcinogenic effect with N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Diethylnitrosamine; DNA; Drug Synergism; Liver Neoplasms; Male; Methapyrilene; Rats; Rats, Inbred F344 | 1984 |
The effects of methapyrilene hydrochloride on hepatocarcinogenicity and pentobarbital-induced sleeping time in rats and mice.
Topics: Aminopyridines; Animals; Enzyme Induction; Female; Liver; Liver Neoplasms; Male; Methapyrilene; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pentobarbital; Rats; Rats, Inbred F344; Sleep | 1982 |
Morphology of early changes in liver carcinogenesis induced by methapyrilene.
Topics: Aminopyridines; Animals; Female; Liver; Liver Neoplasms; Methapyrilene; Microscopy, Electron; Rats; Rats, Inbred F344; Subcellular Fractions | 1981 |
Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats.
Topics: Aminopyridines; Animals; Female; Histamine H1 Antagonists; Liver Neoplasms; Male; Methapyrilene; Pyridines; Pyrilamine; Rats; Rats, Inbred F344; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Choline deficient diet enhances the initiating and promoting effects of methapyrilene hydrochloride in rat liver as assayed by the induction of gamma-glutamyltranspeptidase-positive hepatocyte foci.
Topics: Aminopyridines; Animals; Choline Deficiency; Enzyme Activation; gamma-Glutamyltransferase; Lipid Peroxides; Liver; Liver Neoplasms; Male; Membrane Lipids; Methapyrilene; Microsomes, Liver; Rats; Rats, Inbred Strains | 1987 |
The in vivo metabolism of methapyrilene, a hepatocarcinogen, in the rat.
Topics: Aminopyridines; Animals; Deuterium; Gas Chromatography-Mass Spectrometry; Liver Neoplasms; Male; Methapyrilene; Molecular Structure; Rats; Rats, Inbred Strains | 1988 |
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Methapyrilene; Neoplasms, Experimental; Pyridines; Pyrilamine; Rats; Structure-Activity Relationship; Tripelennamine | 1986 |