Page last updated: 2024-08-21

alpha-aminopyridine and Alzheimer Disease

alpha-aminopyridine has been researched along with Alzheimer Disease in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (6.45)	18.7374
1990's	2 (3.23)	18.2507
2000's	4 (6.45)	29.6817
2010's	35 (56.45)	24.3611
2020's	17 (27.42)	2.80

Authors

Authors	Studies
Alcaro, S; Bagetta, D; Bortolami, M; Carafa, C; Chiarotto, I; Colone, M; Costi, R; De Vita, D; Di Santo, R; Feroci, M; Messore, A; Pandolfi, F; Scipione, L; Stringaro, A	1
Bard, J; Barnes, K; Chopra, R; Condon, J; Fan, K; Fobare, W; Hu, Y; Hui, Y; Johnson, M; Lovering, F; Malamas, MS; Manas, ES; Olland, A; Pangalos, MN; Reinhart, P; Robichaud, AJ; Solvibile, W; Turner, J	1
Alvarez-Pérez, M; Chioua, M; Gandía, L; García, AG; González-Lafuente, L; López, MG; Marco-Contelles, J; Ríos, Cde L; Roda, JM; Romero, A; Samadi, A; Soriano, E; Villarroya, M	1
Arahata, Y; Bundo, M; Ikenuma, H; Ito, K; Iwata, K; Kato, T; Kimura, Y; Nakamura, A; Nihashi, T; Okamura, N; Sakurai, K; Sakurai, T; Suzuki, K; Takeda, A; Washimi, Y; Yamaoka, A; Yanai, K	1
Choe, YS; Chun, MY; Jang, H; Jeong, JH; Kim, HJ; Kim, JS; Kim, YJ; Lee, J; Moon, SH; Na, DL; Oh, JS; Oh, M; Oh, SJ; Roh, JH; Seo, SW; Woo, SY	1
Akhtar, M; Hasan, N; Najmi, AK; Parvez, S; Zameer, S	1
Dennison, J; Lohse, I; Mendez, A; Szeto, A; Volmar, CH; Wahlestedt, C	1
Holtzman, DM; Hoyle, R; Long, J; Manis, M; Remolina Serrano, J; Shi, Y; Sullivan, PM; Wang, K	1
Crider, A; House, A; Sandoval, K; Umbaugh, D; Witt, K	1
Barkhausen, C; Blazhenets, G; Frings, L; Jost, WH; Meyer, PT; Rijntjes, M; Schröter, N; Weiller, C	1
Chen, W; Fu, HR; Gao, YF; Wang, H; Wang, L; Wang, XD; Xu, XY; Xu, Y; Zhang, FF; Zhang, HT; Zhang, JG	1
Choi, HD; Choi, JY; Jeong, YJ; Lee, HJ; Nam, KR; Oh, SJ; Shin, NR; Son, Y	1
Chung, SJ; Kim, JS; Lee, CS; Lee, JH; Lee, SJ; Oh, JS; Oh, M; Oh, SJ; Roh, JH	1
Bahri, MA; Balteau, E; Bastin, C; Besson, G; Cardone, P; Chylinski, D; Collette, F; Grignard, M; Lambert, C; Luxen, A; Maquet, P; Marzoli, D; Muto, V; Narbutas, J; Phillips, C; Salmon, E; Schmidt, C; Van Egroo, M; Vandeleene, N; Vandewalle, G	1
Imabayashi, E; Matsuda, H; Mukai, T; Saitoh, Y; Takahashi, Y	1
Akamatsu, G; Ito, H; Matsuda, H; Miwa, K; Sato, N; Shigemoto, Y; Wagatsuma, K; Yamao, T	1
Akhtar, M; Hasan, N; Najmi, AK; Parvez, S; Yar, MS; Zameer, S	1
Benedet, A; Bunai, T; Kang, MSP; Lussier, F; Matsudaira, T; Obi, T; Ouchi, Y; Pascoal, TA; Rosa-Neto, P; Savard, M; Terada, T; Therriault, J; Tissot, C; Tsukada, H; Wang, YT	1
Kim, JS; Kim, M; Kim, SJ; Oh, JS; Oh, M; Oh, SJ; Park, JE; Roh, JH; Seo, SW; Shim, WH; Yun, J	1
Ashour, NH; El Sayed, NS; El-Tanbouly, DM; Khattab, MM	1
Crider, A; Lodholz, E; Polina, J; Sandoval, K; Schober, J; Scott, N; Walters, F; Witt, K	1
Comley, RA; Gauthier, S; Guiot, MC; Guo, Q; Harada, R; Kang, MS; Massarweh, G; Mathotaarachchi, S; Ng, KP; Okamura, N; Pascoal, TA; Rosa-Neto, P; Shin, M; Soucy, JP; Therriault, J	1
Arai, H; Funaki, Y; Furukawa, K; Furumoto, S; Harada, R; Hiraoka, K; Ishikawa, Y; Ishiki, A; Iwata, R; Kai, H; Kitamoto, T; Kudo, Y; Nakamura, T; Okamura, N; Sasano, H; Sato, N; Tago, T; Tashiro, M; Tomita, N; Watanuki, S; Yanai, K; Yoshikawa, T	1
Cho, J; Furumoto, S; Ido, T; Jeong, HJ; Kang, H; Kang, JM; Lee, H; Lee, KM; Lee, SY; Lee, YB; Na, DL; Noh, Y; Okamura, N; Park, KH; Seo, S; Seong, JK; Shin, DH; Villemagne, VL; Woo, SH; Yanai, K; Yeon, BK	1
Hosokawa, C; Ishii, K; Saigoh, K; Shirakawa, O; Takaya, M	1
Cho, H; Choi, JY; Jagust, WJ; Jang, H; Jang, YK; Kim, HJ; Kim, JS; Lee, JS; Lyoo, CH; Moon, SH; Na, DL; Oh, M; Oh, SJ; Park, S; Rabinovici, GD; Ryu, YH; Seo, SW	1
Liu, H; Luo, D; Luo, K	1
Albay, R; Baglietto-Vargas, D; Glabe, CG; LaFerla, FM; Philipp, S; Reyes-Ruiz, JM; Sosna, J	1
Chen, J; de Leon, MJ; Li, Y; Okamura, N; Pirraglia, E; Rusinek, H	1
Almkvist, O; Arakawa, R; Chiotis, K; Ferreira, D; Halldin, C; Higuchi, M; Nordberg, A; Okamura, N; Shimada, H; Stenkrona, P; Stepanov, V; Takano, A; Varrone, A; Westman, E	1
Arancio, O; Gulisano, W; Palmeri, A; Puzzo, D; Tropea, MR	1
Nai, YH; Okamura, N; Tashiro, M; Watabe, H; Watanuki, S	1
An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T	1
Feng, H; He, B; He, W; Li, S; Wang, C; Wei, M; Wu, X; Zeng, Z	1
Ishii, K; Kubota, I; Shirakawa, O; Takaya, M	1
Banks, WA; Crider, AM; Farr, SA; Morley, JE; Sandoval, KE; Witt, KA	1
Aoki, I; Chang, Q; Furumoto, S; Higuchi, M; Ito, H; Iwata, N; Jang, MK; Ji, B; Kudo, Y; Lee, VM; Lewis, J; Maeda, J; Maruyama, M; Masamoto, K; Okamura, N; Ono, M; Sahara, N; Saido, TC; Shimada, H; Shinotoh, H; Suhara, T; Takano, H; Takashima, A; Trojanowski, JQ; Zhang, MR	1
Böö, ÉL; Eguchi, Y; Farde, L; Fujiwara, H; Fukumura, T; Higuchi, M; Hirano, S; Ikoma, Y; Ito, H; Kawamura, K; Kimura, Y; Kodaka, F; Nagashima, T; Nogami, T; Sasaki, T; Seki, C; Shimada, H; Shinotoh, H; Suhara, T; Suzuki, M; Takahata, K; Takano, H	1
Aihara, Y; Fujishiro, T; Furutsuka, K; Hashimoto, H; Hatori, A; Higuchi, M; Igarashi, N; Ito, T; Kawamura, K; Muto, M; Nemoto, K; Ono, M; Shiomi, S; Suhara, T; Takei, M; Xie, L; Yamasaki, T; Yui, J; Zhang, MR	1
Gulyás, B; Häggkvist, J; Halldin, C; Marutle, A; Ni, R; Nordberg, A; Rodriguez-Vieitez, E; Tóth, M; Voytenko, L	1
Higuchi, M; Ichise, M; Ikoma, Y; Ito, H; Kawamura, K; Kimura, Y; Kitamura, S; Sahara, N; Seki, C; Shimada, H; Shinotoh, H; Suhara, T; Takano, H; Zhang, MR	1
Ågren, H; Kuang, G; Murugan, NA; Nordberg, A; Tu, Y	1
Ashino, H; Bando, K; Chen, CJ; Farde, L; Higuchi, M; Ji, B; Kasahara, H; Minamizawa, T; Ono, M; Sano, H; Seki, C; Shiraishi, H; Suhara, T; Yamada, K; Zhang, MR	1
Gao, M; Wang, M; Xu, Z; Zheng, QH	1
Arai, H; Funaki, Y; Furukawa, K; Furumoto, S; Harada, R; Hiraoka, K; Inami, A; Ishikawa, Y; Ishiki, A; Iwata, R; Kudo, Y; Matsuda, R; Miyake, M; Okamura, N; Shidahara, M; Tago, T; Tashiro, M; Tomita, N; Watanuki, S; Yanai, K; Yoshikawa, T	1
Arai, H; Baker, SL; Furukawa, K; Furumoto, S; Harada, R; Hiraoka, K; Ishiki, A; Jagust, WJ; Kudo, Y; Lockhart, SN; Okamura, N; Tashiro, M; Tomita, N; Watanuki, S; Yanai, K	1
Halldin, C; Jia, Z; Svedberg, MM; Veldman, ER	1
Aoki, M; Arai, H; Baba, T; Ezura, M; Funaki, Y; Furukawa, K; Furumoto, S; Harada, R; Hasegawa, T; Hiraoka, K; Ishiki, A; Iwata, R; Kikuchi, A; Kobayashi, J; Kobayashi, M; Kudo, Y; Mugikura, S; Okamura, N; Oshima, R; Sugeno, N; Takeda, A; Tano, O; Tashiro, M; Watanuki, S; Yanai, K; Yoshida, S	1
Barnhart, TE; Betthauser, TJ; Christian, BT; Furumoto, S; Johnson, SC; Lao, PJ; Murali, D; Okamura, N; Stone, CK	1
Farde, L; Jeppsson, F; Johnson, AE; Juréus, A; Neelissen, JA; Norman, H; Sandell, J; Ström, P; Svensson, SP; Wensbo, D	1
Andersson, J; Cselényi, Z; Farde, L; Freund-Levi, Y; Halldin, C; Jönhagen, ME; Julin, P; Nyberg, S; Olsson, H; Svensson, S; Varnäs, K	1
Klawe, C; Maschke, M	1
Bergh, M; Jeppsson, F; Johnström, P; Juréus, A; Neelissen, J; Pyring, D; Sandell, J; Schou, M; Svensson, S; Swahn, BM	1
Chioua, M; Estrada, M; Iriepa, I; Marco-Contelles, J; Moraleda, I; Pérez, C; Rodríguez-Franco, MI; Samadi, A	1
Andersson, J; Cselényi, Z; Eriksdotter, M; Farde, L; Forsberg, A; Freund-Levi, Y; Halldin, C; Jeppsson, F; Johnström, P; Julin, P; Juréus, A; Sandell, J; Schou, M; Svensson, S; Swahn, BM; Varnäs, K	1
Agoston, S; DeWit, DJ; Havinga, H; Pasma, J; Van Dam, GB; Wesseling, H	1
Bores, GM; Brooks, KM; Camacho, F; Cunningham, DM; Davis, L; Fishkin, R; Hartman, HB; Li, M; Petko, W; Roehr, J; Rush, DK; Selk, DE; Smith, CP; Vargas, HM; Winslow, JT	1
Böhm, M; Meesters, E; Meinhardt, A; Müller, WE; Pergande, G; Perovic, S	1
Andreani, A; Leoni, A; Locatelli, A; Morigi, R; Pietra, C; Rambaldi, M; Villetti, G	1
Blass, JP; Davidson, M; Davis, KL; Horvath, TB; Mohs, RC; Powchik, P; Zemishlany, Z	1
Campbell, GA; Davis, KL; Haroutunian, V; Kanof, PD; Tsuboyama, GK	1
Davis, KL; Hollander, E; Mohs, RC	1

Reviews

2 review(s) available for alpha-aminopyridine and Alzheimer Disease

Article	Year
Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. Expert opinion on pharmacotherapy, 2009, Volume: 10, Issue:9 Topics: Alzheimer Disease; Aminopyridines; Analgesics; Animals; Humans; Neuroprotective Agents	2009
Cholinergic approaches to the treatment of Alzheimer's disease. British medical bulletin, 1986, Volume: 42, Issue:1 Topics: 4-Aminopyridine; Alanine; Alzheimer Disease; Aminopyridines; Arecoline; Clinical Trials as Topic; Humans; Parasympathomimetics; Physostigmine; Piracetam; Pyrrolidines; Research Design; Succinimides; Synapses	1986

Trials

5 trial(s) available for alpha-aminopyridine and Alzheimer Disease

Article	Year
Yonsei medical journal, 2022, Volume: 63, Issue:3 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Cognition; Cognitive Dysfunction; Humans; Positron-Emission Tomography; Quinolines	2022
Combination of automated brain volumetry on MRI and quantitative tau deposition on THK-5351 PET to support diagnosis of Alzheimer's disease. Scientific reports, 2021, 05-14, Volume: 11, Issue:1 Topics: Aged; Alzheimer Disease; Aminopyridines; Brain; Cognitive Dysfunction; Diagnosis, Differential; Female; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Imaging; Positron-Emission Tomography; Prospective Studies; Quinolines; Radiopharmaceuticals; tau Proteins	2021
Effects of 4-aminopyridine in elderly patients with Alzheimer's disease. The New England journal of medicine, 1984, Apr-12, Volume: 310, Issue:15 Topics: 4-Aminopyridine; Aged; Alzheimer Disease; Aminopyridines; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Random Allocation	1984
4-Aminopyridine in the treatment of Alzheimer's disease. Biological psychiatry, 1988, Mar-01, Volume: 23, Issue:5 Topics: 4-Aminopyridine; Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Brain; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Receptors, Cholinergic	1988
Cholinergic approaches to the treatment of Alzheimer's disease. British medical bulletin, 1986, Volume: 42, Issue:1 Topics: 4-Aminopyridine; Alanine; Alzheimer Disease; Aminopyridines; Arecoline; Clinical Trials as Topic; Humans; Parasympathomimetics; Physostigmine; Piracetam; Pyrrolidines; Research Design; Succinimides; Synapses	1986

Other Studies

56 other study(ies) available for alpha-aminopyridine and Alzheimer Disease

Article	Year
New deferiprone derivatives as multi-functional cholinesterase inhibitors: design, synthesis and in vitro evaluation. European journal of medicinal chemistry, 2020, Jul-15, Volume: 198 Topics: Acetylcholinesterase; Alzheimer Disease; Amines; Amino Acid Sequence; Aminopyridines; Catalytic Domain; Cholinesterase Inhibitors; Coordination Complexes; Deferiprone; Drug Design; Humans; Iron Chelating Agents; Molecular Docking Simulation; Pyrimidines; Structure-Activity Relationship	2020
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Bioorganic & medicinal chemistry letters, 2010, Apr-01, Volume: 20, Issue:7 Topics: Alzheimer Disease; Aminopyridines; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Brain; Crystallography, X-Ray; Humans; Models, Molecular; Structure-Activity Relationship	2010
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyri Bioorganic & medicinal chemistry, 2010, Aug-15, Volume: 18, Issue:16 Topics: Acetylcholinesterase; Alzheimer Disease; Aminopyridines; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinergic Agents; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Molecular; Neurons; Neuroprotective Agents; Nitriles; Pyridines; Vascular Diseases	2010
Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer's Disease Continuum. Journal of Alzheimer's disease : JAD, 2022, Volume: 85, Issue:1 Topics: Aged; Alzheimer Disease; Aminopyridines; Amnesia; Aniline Compounds; Brain; Cognitive Dysfunction; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Severity of Illness Index; tau Proteins; Thiazoles	2022
Roflumilast Reduces Pathological Symptoms of Sporadic Alzheimer's Disease in Rats Produced by Intracerebroventricular Streptozotocin by Inhibiting NF-κB/BACE-1 Mediated Aβ Production in the Hippocampus and Activating the cAMP/BDNF Signalling Pathway. Neurotoxicity research, 2022, Volume: 40, Issue:2 Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclopropanes; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Maze Learning; Memory Disorders; NF-kappa B; Rats; Streptozocin	2022
Low-Dose Chidamide Treatment Displays Sex-Specific Differences in the 3xTg-AD Mouse. Biomolecules, 2023, 08-29, Volume: 13, Issue:9 Topics: Alzheimer Disease; Aminopyridines; Animals; Female; Glucose; Humans; Male; Mice; Sex Characteristics	2023
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. The Journal of experimental medicine, 2019, 11-04, Volume: 216, Issue:11 Topics: Alzheimer Disease; Aminopyridines; Animals; Apolipoproteins E; Brain; Dietary Supplements; Disease Models, Animal; Humans; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microglia; Neurodegenerative Diseases; Pyrroles; tau Proteins; Tauopathies	2019
Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice. Neurochemical research, 2019, Volume: 44, Issue:11 Topics: Alzheimer Disease; Aminopyridines; Animals; Brain; Catalase; Down-Regulation; Insulysin; Mice, Transgenic; Microglia; Neprilysin; Phagocytosis; Receptors, Somatostatin; RNA, Messenger; Scavenger Receptors, Class A; Sialic Acid Binding Ig-like Lectin 3; Thiourea; Up-Regulation	2019
Tau Imaging in the 4-Repeat-Tauopathies Progressive Supranuclear Palsy and Corticobasal Syndrome: A 11C-Pyridinyl-Butadienyl-Benzothiazole 3 PET Pilot Study. Clinical nuclear medicine, 2020, Volume: 45, Issue:4 Topics: Aged; Alzheimer Disease; Aminopyridines; Benzothiazoles; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Supranuclear Palsy, Progressive; tau Proteins	2020
The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer's Disease: A Preclinical Study in APP/PS1 Transgenic Mice. The international journal of neuropsychopharmacology, 2020, 12-10, Volume: 23, Issue:10 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Benzamides; Cerebral Cortex; Cyclopropanes; Depression; Disease Models, Animal; Hippocampus; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphodiesterase 4 Inhibitors; Presenilin-1; Recognition, Psychology	2020
Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. International journal of molecular sciences, 2020, Aug-03, Volume: 21, Issue:15 Topics: Aging; Alzheimer Disease; Aminopyridines; Amyloid; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Pyrroles; Receptors, Colony-Stimulating Factor; Signal Transduction	2020
Clinical Evaluation of 18F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With 18F-THK-5351. Clinical nuclear medicine, 2020, Volume: 45, Issue:11 Topics: Aged; Alzheimer Disease; Aminopyridines; Brain; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Positron-Emission Tomography; Pyridines; Quinolines; Radioactive Tracers; tau Proteins	2020
Early brainstem [18F]THK5351 uptake is linked to cortical hyperexcitability in healthy aging. JCI insight, 2021, 01-25, Volume: 6, Issue:2 Topics: Aged; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Brain Stem; Cerebral Cortex; Cross-Sectional Studies; Early Diagnosis; Electroencephalography; Female; Fluorine Radioisotopes; Functional Neuroimaging; Healthy Aging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; tau Proteins; Transcranial Magnetic Stimulation	2021
Visualization of Motor Cortex Involvement by 18F-THK5351 PET Potentially Strengthens Diagnosis of Amyotrophic Lateral Sclerosis. Clinical nuclear medicine, 2021, Mar-01, Volume: 46, Issue:3 Topics: Aged; Alzheimer Disease; Aminopyridines; Amyotrophic Lateral Sclerosis; Humans; Male; Motor Cortex; Positron-Emission Tomography; Quinolines	2021
Centiloid scale analysis for Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2021, Volume: 82 Topics: Alzheimer Disease; Aminopyridines; Humans; Positron-Emission Tomography; Quinolines	2021
Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway. Pharmacological reports : PR, 2021, Volume: 73, Issue:5 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic GMP; Cyclopropanes; Cytokines; Gene Expression Regulation; Hippocampus; Male; Memory Disorders; Morris Water Maze Test; Oxidative Stress; Peptide Fragments; Random Allocation; Rats; Rats, Wistar; Tadalafil; Vasodilator Agents	2021
Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease. Molecular neurodegeneration, 2021, 04-26, Volume: 16, Issue:1 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Aniline Compounds; Benzothiazoles; Brain Chemistry; Carbon Radioisotopes; Electron Transport Complex I; Entorhinal Cortex; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Middle Aged; Neuroimaging; Positron-Emission Tomography; Pyridazines; Pyridines; Radiopharmaceuticals; Severity of Illness Index; Symptom Assessment; tau Proteins; Thiazoles	2021
Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89. Progress in neuro-psychopharmacology & biological psychiatry, 2021, 12-20, Volume: 111 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cognitive Dysfunction; Cyclopropanes; Disease Models, Animal; Hippocampus; Isoquinolines; Male; Mice; Nitric Oxide; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Streptozocin; Sulfonamides; Tauopathies	2021
NNC 26-9100 increases Aβ1-42 phagocytosis, inhibits nitric oxide production and decreases calcium in BV2 microglia cells. PloS one, 2021, Volume: 16, Issue:7 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Calcium; Cell Line; Inflammation; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Peptide Fragments; Phagocytosis; Thiourea	2021
Monoamine oxidase B inhibitor, selegiline, reduces Alzheimer's research & therapy, 2017, Mar-31, Volume: 9, Issue:1 Topics: Aged; Alzheimer Disease; Aminopyridines; Autoradiography; Binding, Competitive; Brain; Cognitive Dysfunction; Drug Interactions; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Selegiline; Supranuclear Palsy, Progressive; tau Proteins	2017
Correlations of Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018, Volume: 59, Issue:4 Topics: Aged, 80 and over; Alzheimer Disease; Aminopyridines; Gliosis; Humans; Male; Positron-Emission Tomography; Postmortem Changes; Quinolines; tau Proteins	2018
Tau positron emission tomography using [ Neurobiology of aging, 2017, Volume: 59 Topics: Aged; Alzheimer Disease; Aminopyridines; Amnesia; Brain; Cognitive Dysfunction; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Severity of Illness Index; tau Proteins	2017
Tau accumulation in two patients with frontotemporal lobe degeneration showing different types of aphasia using 18F-THK-5351 positron emission tomography: a case report. International psychogeriatrics, 2018, Volume: 30, Issue:5 Topics: Aged; Alzheimer Disease; Aminopyridines; Aphasia, Primary Progressive; Brain; Female; Frontotemporal Lobar Degeneration; Humans; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Quinolines; Radioactive Tracers; tau Proteins	2018
Head to head comparison of [ European journal of nuclear medicine and molecular imaging, 2018, Volume: 45, Issue:3 Topics: Aged; Alzheimer Disease; Aminopyridines; Biological Transport; Carbolines; Female; Frontotemporal Dementia; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Quinolines; tau Proteins	2018
Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease. Scientific reports, 2018, 02-09, Volume: 8, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzodioxoles; C-Reactive Protein; Databases, Genetic; Disease Models, Animal; Enzyme Inhibitors; Glycogen Synthase Kinase 3 beta; GMP Reductase; Mice; Molecular Targeted Therapy; Nerve Tissue Proteins; Phosphorylation; Proto-Oncogene Proteins c-met; Repressor Proteins; tau Proteins; Wnt Signaling Pathway	2018
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Molecular neurodegeneration, 2018, 03-01, Volume: 13, Issue:1 Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Animals; Brain; Disease Models, Animal; Mice; Mice, Transgenic; Microglia; Neurons; Plaque, Amyloid; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2018
Quantitative evaluation of tau PET tracers European journal of nuclear medicine and molecular imaging, 2018, Volume: 45, Issue:9 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Brain; Carbolines; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Quinolines	2018
Dual tracer tau PET imaging reveals different molecular targets for European journal of nuclear medicine and molecular imaging, 2018, Volume: 45, Issue:9 Topics: Aged; Alzheimer Disease; Aminopyridines; Brain; Carbon Radioisotopes; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Quinolines; Sweden; tau Proteins	2018
Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease. Neuropharmacology, 2018, Volume: 138 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Protein Precursor; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclopropanes; Disease Models, Animal; Female; Humans; Male; Memory; Mice, Transgenic; Nootropic Agents; Phosphodiesterase Inhibitors; Random Allocation; Vardenafil Dihydrochloride	2018
Investigation of the quantitative accuracy of low-dose amyloid and tau PET imaging. Radiological physics and technology, 2018, Volume: 11, Issue:4 Topics: Aged; Algorithms; Alzheimer Disease; Aminopyridines; Amyloid; Aniline Compounds; Artifacts; Benzothiazoles; Brain; Case-Control Studies; Female; Humans; Image Processing, Computer-Assisted; Male; Movement; Positron-Emission Tomography; Quinolines; Radiation Dosage; tau Proteins; Thiazoles; Young Adult	2018
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease. European journal of medicinal chemistry, 2019, Feb-01, Volume: 163 Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram	2019
Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects. Metabolic brain disease, 2019, Volume: 34, Issue:2 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cyclic AMP; Cyclopropanes; Disease Models, Animal; Male; Memory; Mice, Transgenic; Nootropic Agents; Phosphodiesterase 4 Inhibitors	2019
Progression of logopenic aphasia to frontotemporal dementia in an amyloid β-negative and Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2019, Volume: 19, Issue:4 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aphasia; Brain; Disease Progression; Female; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Humans; Middle Aged; Positron-Emission Tomography; Quinolines; Radioactive Tracers; tau Proteins	2019
Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ(42) oligomers via a metalloproteinase-dependent mechanism. Brain research, 2013, Jul-03, Volume: 1520 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Blotting, Western; Cerebral Cortex; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Male; Maze Learning; Metalloproteases; Mice; Mice, Transgenic; Receptors, Somatostatin; Thiourea	2013
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron, 2013, Sep-18, Volume: 79, Issue:6 Topics: Age Factors; Aged; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Brain Mapping; Calcium-Binding Proteins; Carbon Isotopes; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Middle Aged; Mutation; Positron-Emission Tomography; Protein Structure, Secondary; tau Proteins; Tauopathies; Thiazoles	2013
Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer ¹¹C-AZD2184. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Amyloid; Arteries; Benzothiazoles; Female; Humans; Kinetics; Male; Middle Aged; Models, Biological; Positron-Emission Tomography	2014
Radiosynthesis, photoisomerization, biodistribution, and metabolite analysis of 11C-PBB3 as a clinically useful PET probe for imaging of tau pathology. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:9 Topics: Alzheimer Disease; Aminopyridines; Animals; Benzothiazoles; Brain; Carbon Radioisotopes; Humans; Mice; Positron-Emission Tomography; Quality Control; Radiochemistry; Radiopharmaceuticals; tau Proteins; Tissue Distribution	2014
Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study. European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:7 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Carbon Radioisotopes; Female; Gliosis; Male; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals	2015
PET Quantification of Tau Pathology in Human Brain with 11C-PBB3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:9 Topics: Aged; Algorithms; Alzheimer Disease; Aminopyridines; Benzothiazoles; Brain; Computer Simulation; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Male; Models, Biological; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; tau Proteins	2015
Investigation of the Binding Profiles of AZD2184 and Thioflavin T with Amyloid-β(1-42) Fibril by Molecular Docking and Molecular Dynamics Methods. The journal of physical chemistry. B, 2015, Sep-03, Volume: 119, Issue:35 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Elasticity; Fluorescent Dyes; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Peptide Fragments; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Static Electricity; Thiazoles	2015
Distinct binding of amyloid imaging ligands to unique amyloid-β deposited in the presubiculum of Alzheimer's disease. Journal of neurochemistry, 2015, Volume: 135, Issue:5 Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Aniline Compounds; Autoradiography; Benzothiazoles; Humans; Imidazoles; In Vitro Techniques; Parahippocampal Gyrus; Plaque, Amyloid; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptors, GABA; Thiazoles; Tomography, Emission-Computed, Single-Photon	2015
Synthesis of a PET tau tracer [(11)C]PBB3 for imaging of Alzheimer's disease. Bioorganic & medicinal chemistry letters, 2015, Oct-15, Volume: 25, Issue:20 Topics: Alzheimer Disease; Aminopyridines; Benzothiazoles; Carbon Radioisotopes; Humans; Molecular Imaging; Molecular Structure; Positron-Emission Tomography; tau Proteins	2015
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:2 Topics: Alzheimer Disease; Aminopyridines; Animals; Autoradiography; Biotransformation; Brain; Hippocampus; Magnetic Resonance Imaging; Mice; Mice, Inbred ICR; Neurofibrillary Tangles; Positron-Emission Tomography; Quinolines; Radiation Dosage; Radiopharmaceuticals; tau Proteins; Tissue Distribution; White Matter	2016
Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351. PloS one, 2016, Volume: 11, Issue:6 Topics: Aged; Alzheimer Disease; Aminopyridines; Biomarkers; Brain; Brain Mapping; Case-Control Studies; Cognition; Fluorine Radioisotopes; Frontal Lobe; Humans; Positron-Emission Tomography; Quinolines; tau Proteins; Temporal Lobe; Time Factors	2016
Amyloid binding properties of curcumin analogues in Alzheimer's disease postmortem brain tissue. Neuroscience letters, 2016, Sep-06, Volume: 630 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Autoradiography; Benzothiazoles; Curcumin; Diarylheptanoids; Female; Humans; Inhibitory Concentration 50; Male; Temporal Lobe	2016
In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET. Neurology, 2016, Nov-29, Volume: 87, Issue:22 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Autoradiography; Basal Ganglia Diseases; Biomarkers; Brain; Brain Mapping; Diagnosis, Differential; Female; Humans; Male; Mental Status Schedule; Middle Aged; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; tau Proteins	2016
In Vivo Comparison of Tau Radioligands Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017, Volume: 58, Issue:6 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Aniline Compounds; Biomarkers; Brain; Female; Humans; Isotope Labeling; Male; Metabolic Clearance Rate; Middle Aged; Molecular Imaging; Positron-Emission Tomography; Protein Binding; Quinolines; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; tau Proteins; Tissue Distribution	2017
AZD2184: a radioligand for sensitive detection of beta-amyloid deposits. Journal of neurochemistry, 2009, Volume: 108, Issue:5 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Carbon Radioisotopes; Competitive Bidding; Humans; Male; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Positron-Emission Tomography; Presenilin-1; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Thiazoles; Tritium	2009
Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:11 Topics: Adult; Aged; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Benzothiazoles; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Young Adult	2009
Synthesis and evaluation of pyridylbenzofuran, pyridylbenzothiazole and pyridylbenzoxazole derivatives as ¹⁸F-PET imaging agents for β-amyloid plaques. Bioorganic & medicinal chemistry letters, 2012, Jul-01, Volume: 22, Issue:13 Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Animals; Benzofurans; Benzothiazoles; Benzoxazoles; Brain; Contrast Media; Fluorine Radioisotopes; Humans; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Structure-Activity Relationship	2012
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling. European journal of medicinal chemistry, 2012, Volume: 57 Topics: Acetylcholinesterase; Alzheimer Disease; Aminopyridines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Enzyme Assays; Humans; Indans; Models, Biological; Models, Molecular; Nitriles; Permeability; Piperidines; Protein Binding; Pyridines; Structure-Activity Relationship	2012
Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients. European journal of nuclear medicine and molecular imaging, 2013, Volume: 40, Issue:4 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Benzoxazoles; Binding Sites; Brain; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Middle Aged; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Sensitivity and Specificity; Thiazoles	2013
Pharmacological activity and safety profile of P10358, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Acetylcholinesterase; Administration, Oral; Alzheimer Disease; Aminopyridines; Animals; Avoidance Learning; Brain; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Corpus Striatum; Dopamine; Female; Humans; Hypothermia, Induced; Kinetics; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; Ovariectomy; Prosencephalon; Rats; Rats, Wistar; Scopolamine; Social Behavior; Space Perception; Time Factors	1997
Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases. Mechanisms of ageing and development, 1998, Mar-16, Volume: 101, Issue:1-2 Topics: Aging; Alzheimer Disease; Amino Acid Sequence; Aminopyridines; Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cell Survival; Cells, Cultured; Glutamates; Molecular Sequence Data; Neurons; Neuroprotective Agents; Peptide Fragments; Prion Diseases; Prions; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Time Factors	1998
4-Aminopyridine derivatives with antiamnesic activity. European journal of medicinal chemistry, 2000, Volume: 35, Issue:1 Topics: 4-Aminopyridine; Alzheimer Disease; Aminopyridines; Amnesia; Animals; Avoidance Learning; Carbon Dioxide; Indoles; Male; Mice; Nootropic Agents; Piracetam	2000
Animal models of Alzheimer's disease: behavior, pharmacology, transplants. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1986, Volume: 13, Issue:4 Suppl Topics: 4-Aminopyridine; Alzheimer Disease; Aminopyridines; Animals; Behavior, Animal; Brain; Disease Models, Animal; Fetus; Growth Substances; Humans; Nerve Growth Factors; Nerve Tissue; Nerve Tissue Proteins; Nervous System Diseases; Norepinephrine; Parasympathetic Nervous System; Physostigmine; Somatostatin	1986