Page last updated: 2024-08-21

alpha-aminopyridine and Aging

alpha-aminopyridine has been researched along with Aging in 19 studies

Research

Studies (19)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (42.11)	18.7374
1990's	2 (10.53)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (31.58)	24.3611
2020's	3 (15.79)	2.80

Authors

Authors	Studies
Frolkis, VV; Kobzar, AL; Tjukhtin, GM	1
Gao, X; Han, Z; Lei, P; Li, M; Li, X; Liu, M; Liu, Q; Zhang, W	1
Bian, WJ; Chen, C; Damonte, VM; de Lecea, L; Kauer, JA; Kebschull, JM; Li, SB; Mourrain, P; Pattni, R; Purmann, C; Scherrer, G; Urban, AE; Wang, GX; Yamaguchi, H	1
Choi, HD; Choi, JY; Jeong, YJ; Lee, HJ; Nam, KR; Oh, SJ; Shin, NR; Son, Y	1
Milani, H; Prickaerts, J; Santiago, A; Schepers, M; Soares, LM; Vanmierlo, T; Weffort de Oliveira, RM	1
Bennett, RE; Bryant, A; Hopp, SC; Hu, M; Hyman, BT; Robbins, AB	1
Asaka, M; Hattori, T; Iizuka, S; Muto, S; Nahata, M; Nakagawa, K; Ohnishi, S; Sadakane, C; Saegusa, Y; Takeda, H	1
Sharma, S; Wang, MH; Yao, HP; Zhang, R; Zhou, J; Zhou, YQ	1
de Mey, C; Deliyska, B; Gatchev, E; Terhaag, B	1
Abdolrasulnia, R; Blackwell, TS; Bordenstein, SR; Brucker, RM; Cheng, DS; Clark, PE; Du, RH; Gleaves, L; Han, W; Polosukhin, VV; Polosukhina, D; Richmond, BW; Zhang, Y	1
Gibson, GE; Peterson, C	2
Davis, HP; Gibson, GE; Idowu, A	1
Binah, O; Danilo, P; Legato, MJ; Rosen, MR	1
Danilo, P; Miura, DS; Reder, RF; Rosen, MR	1
Böhm, M; Meesters, E; Meinhardt, A; Müller, WE; Pergande, G; Perovic, S	1
Bowe, CM; Hildebrand, C; Kocsis, JD; Waxman, SG	1
Coraboeuf, E; Escande, D; Loisance, D; Planche, C	1
Gibson, GE; Nicholls, DG; Peterson, C	1

Trials

1 trial(s) available for alpha-aminopyridine and Aging

Article	Year
Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine. International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:3 Topics: Administration, Oral; Adult; Age Factors; Aged; Aging; Aminopyridines; Analgesics; Area Under Curve; Biomarkers; Creatinine; Delayed-Action Preparations; Drug Administration Schedule; Drug Monitoring; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Prospective Studies; Severity of Illness Index; Young Adult	2015

Article

Year

Effects of advanced age and renal dysfunction on the single- and repeated-dose pharmacokinetics of modified-release flupirtine.

International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:3

Topics: Administration, Oral; Adult; Age Factors; Aged; Aging; Aminopyridines; Analgesics; Area Under Curve; Biomarkers; Creatinine; Delayed-Action Preparations; Drug Administration Schedule; Drug Monitoring; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Prospective Studies; Severity of Illness Index; Young Adult

2015

Other Studies

18 other study(ies) available for alpha-aminopyridine and Aging

Article	Year
Plasmic membranes of hepatocytes and adrenocorticocytes in rats of different ages: effect of testosterone. Mechanisms of ageing and development, 1992, Volume: 66, Issue:2 Topics: Adrenal Cortex; Aging; Aminopyridines; Animals; Cell Membrane; Cycloheximide; Cytosol; Dactinomycin; Enzyme Activation; In Vitro Techniques; Liver; Male; Membrane Potentials; Ouabain; Potassium Channel Blockers; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Testosterone	1992
Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage. Cell death & disease, 2022, 01-10, Volume: 13, Issue:1 Topics: Aging; Aminopyridines; Animals; Blood-Brain Barrier; Brain; Brain Injuries; Cell Death; Cerebral Hemorrhage; Chemotaxis, Leukocyte; Disease Models, Animal; Mice; Microglia; Neuroinflammatory Diseases; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor	2022
Hyperexcitable arousal circuits drive sleep instability during aging. Science (New York, N.Y.), 2022, 02-25, Volume: 375, Issue:6583 Topics: Aging; Aminopyridines; Animals; CRISPR-Cas Systems; Electroencephalography; Electromyography; Female; Hypothalamic Area, Lateral; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Narcolepsy; Nerve Tissue Proteins; Neural Pathways; Neurons; Optogenetics; Orexins; Patch-Clamp Techniques; RNA-Seq; Sleep; Sleep Deprivation; Sleep Quality; Wakefulness	2022
Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. International journal of molecular sciences, 2020, Aug-03, Volume: 21, Issue:15 Topics: Aging; Alzheimer Disease; Aminopyridines; Amyloid; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Hippocampus; Humans; Macrophage Colony-Stimulating Factor; Mice; Mice, Transgenic; Pyrroles; Receptors, Colony-Stimulating Factor; Signal Transduction	2020
Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. Neuropharmacology, 2018, Volume: 138 Topics: Aging; Aminopyridines; Animals; Arginase; Benzamides; Brain Ischemia; Chronic Disease; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Male; Maze Learning; Memory Disorders; Microglia; Neurodegenerative Diseases; Neuroprotective Agents; Nootropic Agents; Optic Tract; Random Allocation; Rats, Wistar; White Matter	2018
Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation, 2018, Nov-09, Volume: 15, Issue:1 Topics: Aging; Aminopyridines; Animals; Blood Vessels; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytokines; Disease Models, Animal; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microglia; Mutation; Pyrroles; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; RNA, Messenger; tau Proteins; Tauopathies	2018
Serotonin 2C receptor antagonism ameliorates novelty-induced hypophagia in aged mice. Psychoneuroendocrinology, 2013, Volume: 38, Issue:10 Topics: Aging; Aminopyridines; Animals; CHO Cells; Cricetinae; Cricetulus; Eating; Exploratory Behavior; Feeding Behavior; HEK293 Cells; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT2 Receptor Antagonists; Stress, Psychological	2013
Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics. Molecular oncology, 2014, Volume: 8, Issue:3 Topics: Aging; Aminopyridines; Breast; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Morpholines; Polyploidy; Protein Kinase Inhibitors; Pyridones; Signal Transduction; TOR Serine-Threonine Kinases	2014
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nature communications, 2016, Apr-05, Volume: 7 Topics: Aging; Airway Remodeling; Aminopyridines; Animals; Benzamides; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Disease Models, Animal; Gene Expression Regulation; Host-Pathogen Interactions; Humans; Immunity, Innate; Immunoglobulin A, Secretory; Leukocyte Elastase; Lung; Matrix Metalloproteinase 12; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; NF-kappa B; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Receptors, Polymeric Immunoglobulin; Respiratory Mucosa	2016
Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake. The Journal of biological chemistry, 1983, Oct-10, Volume: 258, Issue:19 Topics: 4-Aminopyridine; Aging; Aminopyridines; Animals; Biological Transport, Active; Brain; Calcium; Kinetics; Potassium; Rats; Rats, Inbred F344; Synaptosomes	1983
Improvement of 8-arm maze performance in aged Fischer 344 rats with 3,4-diaminopyridine. Experimental aging research, 1983,Fall, Volume: 9, Issue:3 Topics: 4-Aminopyridine; Aging; Amifampridine; Aminopyridines; Animals; Male; Memory, Short-Term; Rats	1983
Developmental changes in the cardiac effects of amrinone in the dog. Circulation research, 1983, Volume: 52, Issue:6 Topics: Aging; Aminopyridines; Amrinone; Animals; Animals, Newborn; Dogs; Female; Heart Conduction System; Male; Muscle Contraction; Muscle Development; Myocardial Contraction; Papillary Muscles; Purkinje Fibers	1983
Amelioration of age-related neurochemical and behavioral deficits by 3,4-diaminopyridine. Neurobiology of aging, 1983,Spring, Volume: 4, Issue:1 Topics: 4-Aminopyridine; Acetylcholine; Aging; Amifampridine; Aminopyridines; Animals; Behavior, Animal; Male; Mice; Mice, Inbred BALB C; Nervous System	1983
The electrophysiological properties of normal neonatal and adult canine cardiac Purkinje fibers. Circulation research, 1981, Volume: 48, Issue:5 Topics: Action Potentials; Aging; Aminopyridines; Animals; Animals, Newborn; Dogs; Electric Stimulation; Electrodes; Electrophysiology; Female; Heart Conduction System; Male; Membrane Potentials; Perfusion; Potassium; Purkinje Fibers; Temperature; Tetrodotoxin; Time Factors; Verapamil	1981
Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases. Mechanisms of ageing and development, 1998, Mar-16, Volume: 101, Issue:1-2 Topics: Aging; Alzheimer Disease; Amino Acid Sequence; Aminopyridines; Amyloid beta-Peptides; Animals; Apoptosis; Calcium; Cell Survival; Cells, Cultured; Glutamates; Molecular Sequence Data; Neurons; Neuroprotective Agents; Peptide Fragments; Prion Diseases; Prions; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Time Factors	1998
Physiological properties of regenerated rat sciatic nerve following lesions at different postnatal ages. Brain research, 1987, Volume: 431, Issue:1 Topics: 4-Aminopyridine; Aging; Aminopyridines; Animals; Ion Channels; Myelin Sheath; Nerve Regeneration; Peripheral Nerve Injuries; Peripheral Nerves; Potassium; Rats; Rats, Inbred Strains; Sciatic Nerve	1987
Age-related changes of action potential plateau shape in isolated human atrial fibers. The American journal of physiology, 1985, Volume: 249, Issue:4 Pt 2 Topics: 4-Aminopyridine; Action Potentials; Adult; Aged; Aging; Aminopyridines; Atrial Function; Caffeine; Heart Atria; Humans; Infant; Middle Aged	1985
Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment. Neurobiology of aging, 1985,Winter, Volume: 6, Issue:4 Topics: 4-Aminopyridine; Aging; Amifampridine; Aminopyridines; Animals; Brain; Calcium; Digitonin; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mitochondria; Onium Compounds; Organophosphorus Compounds; Potassium; Synaptosomes	1985