Compounds > alpha-aminopyridine
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alpha-aminopyridine and African Sleeping Sickness

alpha-aminopyridine has been researched along with African Sleeping Sickness in 7 studies

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hammarström, LG; Lundbäck, T; Rottenberg, ME; Sjöberg, B; Svensson, R; Vodnala, SK1
Bayliss, T; Brand, S; Brenk, R; Frearson, JA; Gilbert, IH; McElroy, SP; Mpamhanga, C; Norval, S; Read, KD; Robinson, DA; Smith, VC; Stojanovski, L; Torrie, LS; Wyatt, PG1
Brand, S; Brenk, R; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Hallyburton, I; Harrison, JR; McElroy, SP; Norcross, NR; Norval, S; Read, KD; Robinson, DA; Scullion, P; Simeons, FR; Smith, VC; Stojanovski, L; Thompson, S; Torrie, LS; van Aalten, D; Wyatt, PG1
Mackey, ZB; Ramsey, AC; Santos, WL; Valenciano, AL1
Cross, GA1
Brand, S; Brannigan, JA; Brenk, R; Cleghorn, LA; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Guther, ML; Hallyburton, I; Hodgkinson, M; Hui, R; McElroy, SP; Mpamhanga, CP; Price, HP; Qiu, W; Raimi, OG; Read, KD; Robinson, DA; Smid, O; Smith, DF; Stojanovski, L; Torrie, LS; van Aalten, DM; Wilkinson, AJ; Wyatt, PG1
Bayliss, T; Brand, S; Brenk, R; Cleghorn, LA; Fairlamb, AH; Ferguson, MA; Frearson, JA; Gilbert, IH; Hallyburton, I; Harrison, JR; McElroy, SP; Norcross, NR; Norval, S; Read, KD; Robinson, DA; Smith, VC; Spinks, D; Stojanovski, L; Torrie, LS; Wyatt, PG1

Other Studies

7 other study(ies) available for alpha-aminopyridine and African Sleeping Sickness

ArticleYear
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2

    Topics: Aminopyridines; Animals; Benzopyrans; Cell Line; Humans; Mice; Mice, Inbred C57BL; Piperidines; Pyrazines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African

2013
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.
    Journal of medicinal chemistry, 2017, 12-14, Volume: 60, Issue:23

    Topics: Acyltransferases; Aminopyridines; Animals; Brain; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Mice; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2017
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis.
    Journal of medicinal chemistry, 2014, Dec-11, Volume: 57, Issue:23

    Topics: Acyltransferases; Aminopyridines; Animals; Blood-Brain Barrier; Central Nervous System; Female; Humans; Inhibitory Concentration 50; Mice; Pyrazoles; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2014
Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.
    Bioorganic & medicinal chemistry, 2016, 10-01, Volume: 24, Issue:19

    Topics: Aminopyridines; Drug Discovery; Extracellular Signal-Regulated MAP Kinases; Humans; Protein Kinase Inhibitors; Pyrazoles; Recombinant Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2016
Drug discovery: Fat-free proteins kill parasites.
    Nature, 2010, Apr-01, Volume: 464, Issue:7289

    Topics: Acyltransferases; Aminopyridines; Animals; Antiparasitic Agents; Enzyme Inhibitors; Humans; Mice; Sulfonamides; Trypanosoma brucei brucei; Trypanosomiasis, African

2010
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
    Nature, 2010, Apr-01, Volume: 464, Issue:7289

    Topics: Acyltransferases; Aminopyridines; Animals; Antiparasitic Agents; Enzyme Assays; Enzyme Inhibitors; Female; Humans; Mice; Molecular Structure; Pyrazoles; Rats; Sulfonamides; Time Factors; Trypanosoma brucei brucei; Trypanosomiasis, African

2010
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Acyltransferases; Administration, Oral; Aminopyridines; Animals; Cell Line; Cell Survival; Crystallography, X-Ray; Databases, Factual; Humans; Models, Molecular; Molecular Conformation; Parasitic Sensitivity Tests; Structure-Activity Relationship; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

2012