alpha-aminopyridine has been researched along with Acute Liver Injury, Drug-Induced in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.06) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (6.06) | 29.6817 |
| 2010's | 17 (51.52) | 24.3611 |
| 2020's | 12 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Araz, M; Artaç, M; Er, MM; Eryılmaz, MK; Hendem, E | 1 |
| Bednarski, PJ; Beirow, K; Hofstetter, RK; Jedamzik, J; Lemmerhirt, CJ; Link, A; Schulig, L; Wurm, KW | 1 |
| McCabe, C; Polson, K; Wagner, AJ; Wright, H | 1 |
| Chen, WN; Jing, ZT; Lin, X; Lin, XJ; Liu, W; Wu, SX; Xue, CR | 1 |
| Grellety, T; Meynard, L | 1 |
| Aoun, M; Assi, T; Awada, A; Farhat, F; Kanj, A; Kattan, J; Tarabaih, M | 1 |
| Kim, B; Kim, JW; Lim, CW; Qi, J; Zhou, Z | 2 |
| Donati, DM; Longhi, A; Palmerini, E; Staals, EL | 1 |
| Akakpo, S; Chalon, S; Chughlay, MF; Csermak-Renner, K; Djeriou, E; Gaur, AH; Leboulleux, D; McCarthy, J; Odedra, A; Shanks, GD; Winnips, C | 1 |
| Ardelt, M; Croner, RS; Dondorf, F; Felgendreff, P; Rauchfuss, F; Settmacher, U; Tautenhahn, HM | 1 |
| de Luna, A; Fuentes-Antrás, J; García-Sáenz, JÁ; López de Sá, A; Moreno, F; Ocaña, A | 1 |
| Björnsson, ES; Finnsdottir, S; Sverrisdottir, A | 1 |
| Baba, HA; Bauer, S; Choi, Y; Druta, M; Gelderblom, H; Healey, JH; Lewis, JH; Lin, CC; Pousa, AL; Shuster, DE; Stacchiotti, S; Tap, WD; van de Sande, M; Wagner, AJ; Wang, Q | 1 |
| Berg, T; Borlak, J; van Bömmel, F | 1 |
| Baselga, J; Bermejo, B; de la Pena, L; Denkert, C; Gombos, A; Kümmel, S; Lee, SC; Loi, S; Loibl, S; Lux, M; Michiels, S; Nekljudova, V; Piccart, MJ; Rezai, M; Steger, G; Turri, S; Untch, M; Urban, P; Von Minckwitz, G; Zardavas, D | 1 |
| Amaro, P; Ferreira, M; Perdigoto, DN; Tomé, L | 1 |
| Puljak, L | 1 |
| Andersohn, F; Bronder, E; Douros, A; Garbe, E; Klimpel, A; Kreutz, R; Orzechowski, HD; Thomae, M | 1 |
| Wörz, R | 1 |
| Kreutzkamp, B | 1 |
| Aithal, GP; Bjornsson, ES; Cascorbi, I; Coulthard, SA; Daly, AK; Floratos, A; Gundert-Remy, U; Nelson, MR; Nicoletti, P; Sawle, A; Shen, Y; Stammschulte, T; Urban, TJ; Werk, AN | 1 |
| Berg, T; Engelmann, C; Schmelzle, M; Splith, K | 1 |
| Agne, C; Borlak, J; Klein, F; Koch, M; Kreipe, HH; Manns, MP; Puls, F; Rifai, K | 1 |
| Glanemann, M; Klein, F; Neuhaus, P; Rudolph, B; Seehofer, D | 1 |
| Anderson, N; Borlak, J | 1 |
| Blot, K; Falconer, C; Marschall-Kehrel, D; Michel, MC; Radziszewski, P | 1 |
| Cnota, P; Hermann, R; Maus, J | 1 |
| Blot, K; Michel, MC | 1 |
| Locher, H | 1 |
| Dierkes-Globisch, A; Mohr, HH; Schäfer, R | 1 |
| Colohan, DP; Ghurabi, WH; Green, ED; Zimmerman, RC | 1 |
| Dent, JG; Graichen, ME; Leonard, TB; Neptun, DA; Popp, JA | 1 |
4 review(s) available for alpha-aminopyridine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Pexidartinib for the treatment of adult patients with symptomatic tenosynovial giant cell tumor: safety and efficacy.
Topics: Adult; Aminopyridines; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; Macrophage Colony-Stimulating Factor; Neoplasm Recurrence, Local; Pyrroles; Quality of Life | 2020 |
[Long-term-treatment of chronic pain patients with flupirtine--on hepatotoxicity and persistent effectiveness from 7 months to 22 years].
Topics: Adult; Aged; Aged, 80 and over; Aminopyridines; Chemical and Drug Induced Liver Injury; Chronic Pain; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Treatment Outcome | 2014 |
[Asymptomatic diclofenac-induced acute hepatitis].
Topics: Acute Disease; Aminopyridines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Diclofenac; Drug Therapy, Combination; Humans; Liver; Male; Middle Aged; Pain, Postoperative; Recurrence | 2000 |
Phenazopyridine hydrochloride toxicity: a cause of drug-induced methemoglobinemia.
Topics: Acute Kidney Injury; Adolescent; Aged; Aminopyridines; Anemia, Hemolytic; Animals; Chemical and Drug Induced Liver Injury; Child, Preschool; Dogs; Female; Humans; Infant, Newborn; Lacrimal Apparatus Diseases; Male; Methemoglobinemia; Middle Aged; Phenazopyridine; Urinary Tract Infections | 1979 |
2 trial(s) available for alpha-aminopyridine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Neoadjuvant buparlisib plus trastuzumab and paclitaxel for women with HER2+ primary breast cancer: A randomised, double-blind, placebo-controlled phase II trial (NeoPHOEBE).
Topics: Adult; Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Australia; Biomarkers, Tumor; Biopsy; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Class I Phosphatidylinositol 3-Kinases; Double-Blind Method; Early Termination of Clinical Trials; Europe; Female; Humans; Ki-67 Antigen; Lymphocytes, Tumor-Infiltrating; Middle Aged; Morpholines; Mutation; Neoadjuvant Therapy; Paclitaxel; Protein Kinase Inhibitors; Receptor, ErbB-2; Time Factors; Trastuzumab; Treatment Outcome | 2017 |
Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years.
Topics: Aged; Aminopyridines; Analgesics; Benzhydryl Compounds; Chemical and Drug Induced Liver Injury; Cresols; Double-Blind Method; Female; Humans; Liver; Male; Middle Aged; Muscarinic Antagonists; Phenylpropanolamine; Syndrome; Tolterodine Tartrate; Urinary Bladder, Overactive | 2012 |
27 other study(ies) available for alpha-aminopyridine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Ribociclib-induced hepatotoxicity.
Topics: Aged; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Protein Kinase Inhibitors; Purines | 2023 |
Structure-Activity Relationships of Flupirtine Analogues for Liver Esterase-Mediated Cleavage of the 4-Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Esterases; Humans; Structure-Activity Relationship | 2023 |
Supporting patients in the transition to the revised pexidartinib dosing regimen: perspectives from the multidisciplinary clinical and allied health professional team.
Topics: Adult; Allied Health Personnel; Aminopyridines; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; United States | 2023 |
PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury.
Topics: Aminopyridines; Animals; Antibodies; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Chemical and Drug Induced Liver Injury; Hep G2 Cells; Hepatocytes; Humans; Imidazoles; Liver; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purines; Quinazolinones; Tumor Necrosis Factor-alpha | 2019 |
CDK 4/6 inhibitor successful rechallenge after limiting hepatic toxicity.
Topics: Alanine Transaminase; Aminopyridines; Aromatase Inhibitors; Aspartate Aminotransferases; Bone Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Substitution; Drug Therapy, Combination; Female; Humans; Letrozole; Middle Aged; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines | 2020 |
Palbociclib safety and efficacy beyond Ribociclib-induced liver toxicity in metastatic hormone-receptors positive breast cancer patient.
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Letrozole; Liver; Middle Aged; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Receptors, Estrogen; Receptors, Progesterone; Zoledronic Acid | 2020 |
Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice.
Topics: Acetaminophen; Acute Lung Injury; Aminopyridines; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; I-kappa B Kinase; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protein Serine-Threonine Kinases | 2019 |
Liver Enzyme Elevations in
Topics: Acrylamides; Adamantane; Adult; Alanine Transaminase; Aminopyridines; Aminoquinolines; Antimalarials; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Erythrocyte Transfusion; Erythrocytes; Female; Ferrous Compounds; Healthy Volunteers; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Isoquinolines; Malaria, Falciparum; Male; Metallocenes; Parasitemia; Peroxides; Piperazines; Plasmodium falciparum; Primaquine; Pyrimidines; Quinolines; Spiro Compounds; Sulfones; Triazoles; Young Adult | 2020 |
Liver Transplant Due to Flupirtine-Induced Acute Liver Failure.
Topics: Adult; Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Female; Germany; Humans; Liver Failure, Acute; Liver Transplantation; Risk Factors; Time Factors; Treatment Outcome | 2020 |
Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro.
Topics: Aminopyridines; Animals; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Coculture Techniques; Cytokines; Hepatocytes; I-kappa B Kinase; Interferon Regulatory Factor-3; Kupffer Cells; Lipid Metabolism; Male; Mice, Inbred C57BL; NF-kappa B; Palmitic Acid; Protein Serine-Threonine Kinases | 2020 |
Safety and efficacy of cyclin-dependent kinase inhibitor rechallenge following ribociclib-induced limiting hypertransaminasemia.
Topics: Aminopyridines; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Substitution; Female; Humans; Middle Aged; Piperazines; Protein Kinase Inhibitors; Purines; Pyridines; Receptors, Estrogen; Receptors, Progesterone; Retrospective Studies; Transaminases; Treatment Outcome | 2020 |
Hepatotoxicity associated with ribociclib among breast cancer patients.
Topics: Aminopyridines; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Female; Humans; Purines | 2021 |
Pexidartinib Long-Term Hepatic Safety Profile in Patients with Tenosynovial Giant Cell Tumors.
Topics: Aminopyridines; Chemical and Drug Induced Liver Injury; Giant Cell Tumor of Tendon Sheath; Humans; Liver; Pyrroles | 2021 |
N-acetylcysteine and prednisolone treatment improved serum biochemistries in suspected flupirtine cases of severe idiosyncratic liver injury.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminopyridines; Analgesics; Antidotes; Biomarkers; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Therapy, Combination; Female; Glucocorticoids; Glutathione; Hepatocytes; Humans; Infusions, Intravenous; Liver; Liver Transplantation; Male; Middle Aged; Prednisolone; Recovery of Function; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2018 |
Flupirtine drug-induced liver injury in a patient developing acute liver failure.
Topics: Adult; Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drug Interactions; Fatal Outcome; Female; Hepatic Encephalopathy; Humans; Hypericum; Liver Failure, Acute; Shock, Septic | 2018 |
Flupirtine, an Effective Analgesic, but Hepatotoxicity Should Limit Its Use.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Pain | 2018 |
Flupirtine-induced liver injury--seven cases from the Berlin Case-control Surveillance Study and review of the German spontaneous adverse drug reaction reporting database.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aminopyridines; Analgesics; Berlin; Case-Control Studies; Chemical and Drug Induced Liver Injury; Female; Germany; Humans; Male; Middle Aged | 2014 |
[Flupirtine helps - but pay attention to the liver!].
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Myalgia | 2015 |
HLA-DRB1*16: 01-DQB1*05: 02 is a novel genetic risk factor for flupirtine-induced liver injury.
Topics: Adult; Aged; Aminopyridines; Chemical and Drug Induced Liver Injury; Female; Genome-Wide Association Study; HLA-DQ beta-Chains; HLA-DRB1 Chains; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide | 2016 |
Effects of granulocyte-colony stimulating factor (G-CSF) on stem cell mobilization in patients with liver failure.
Topics: Acute-On-Chronic Liver Failure; Aminopyridines; Analgesics; Bacterial Infections; Bilirubin; Cell Count; Chemical and Drug Induced Liver Injury; Filgrastim; Granulocyte Colony-Stimulating Factor; Hematologic Agents; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Hepatitis E; Hepatitis, Alcoholic; Humans; Prothrombin Time | 2016 |
Pathology of flupirtine-induced liver injury: a histological and clinical study of six cases.
Topics: Aged; Alanine Transaminase; Aminopyridines; Analgesics; Aspartate Aminotransferases; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Lymphocytes; Macrophages; Male; Middle Aged | 2011 |
Flupirtine-induced hepatic failure requiring orthotopic liver transplant.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Graft Rejection; Humans; Immunosuppressive Agents; Liver Failure; Liver Transplantation; Male; Middle Aged; Pulse Therapy, Drug; Steroids; Treatment Outcome | 2011 |
Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous ADR reporting.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aminopyridines; Analgesics; Bile Duct Diseases; Causality; Chemical and Drug Induced Liver Injury; Female; Germany; Humans; Liver; Liver Diseases; Liver Function Tests; Male; Middle Aged; Pharmacovigilance; Virus Diseases; World Health Organization | 2011 |
Minimum quality criteria are needed in the assessment and communication of unexpected drug safety findings of marketed products from randomized controlled trials.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Urinary Bladder, Overactive | 2012 |
Authors' response to Hermann et al. Minimum quality criteria are needed in the assessment and communication of unexpected drug safety findings of marketed products from RCTs.
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Male; Urinary Bladder, Overactive | 2012 |
[Drugs for back pain: caution, liver damage!].
Topics: Aminopyridines; Analgesics; Chemical and Drug Induced Liver Injury; Humans; Low Back Pain | 2000 |
Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology.
Topics: Alanine Transaminase; Aminopyridines; Animals; Bile Acids and Salts; Bile Ducts; Chemical and Drug Induced Liver Injury; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver Diseases; Liver Function Tests; Male; Methapyrilene; Microsomes, Liver; Mixed Function Oxygenases; Necrosis; Rats; Rats, Inbred F344 | 1985 |