alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate has been researched along with Seizures in 6 studies
alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate: a glutamate agonist
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Furthermore, it antagonized in vivo seizures induced by icv administration of AMPA or kainate (KA)." | 1.31 | Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters. ( De Micheli, C; De Sarro, A; De Sarro, G; Ferreri, G; Grasso, S; Micale, N; Puja, G; Toma, L; Zappalà, M, 2002) |
| "Compound 21 also effectively suppresses seizures induced in Swiss mice by maximal electroshock (MES) and pentylenetetrazole (PTZ)." | 1.31 | Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M, 2000) |
| "Using this novel method of seizure threshold determination, it was found that systemically administered diphenylhydantoin and carbamazepine elevated the threshold for ATPA and had negligible effects on the threshold for kainate and NMDA." | 1.29 | Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants. ( Steppuhn, KG; Turski, L, 1993) |
| "I." | 1.29 | Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity. ( Arnt, J; Krogsgaard-Larsen, P; Lenz, SM; Madsen, U; Sánchez, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fritsch, B | 1 |
| Reis, J | 1 |
| Gasior, M | 1 |
| Kaminski, RM | 1 |
| Rogawski, MA | 1 |
| Micale, N | 2 |
| Zappalà, M | 2 |
| Grasso, S | 2 |
| Puja, G | 2 |
| De Sarro, G | 2 |
| Ferreri, G | 1 |
| De Sarro, A | 2 |
| Toma, L | 1 |
| De Micheli, C | 2 |
| Steppuhn, KG | 1 |
| Turski, L | 1 |
| Arnt, J | 1 |
| Sánchez, C | 1 |
| Lenz, SM | 1 |
| Madsen, U | 1 |
| Krogsgaard-Larsen, P | 1 |
| Baraldi, M | 1 |
| Khalilov, I | 1 |
| Hirsch, J | 1 |
| Cossart, R | 1 |
| Ben-Ari, Y | 1 |
6 other studies available for alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate and Seizures
| Article | Year |
|---|---|
Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis.
Topics: Amygdala; Animals; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Is | 2014 |
Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cerebellum; Dioxoles; Excitatory Amino Acid Antagoni | 2002 |
Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and chemoconvulsants.
Topics: Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Drug Administration Routes; Isoxazoles; Kain | 1993 |
Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Convulsants; Cue | 1995 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2000 |
Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors.
Topics: Animals; Animals, Newborn; Anticonvulsants; Hippocampus; Interneurons; Isoxazoles; Neural Inhibition | 2002 |