alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Substance-Related Disorders in 5 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Substance-Related Disorders: Disorders related to substance use or abuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Learning and memory and drug addiction are modulated by the same neurotrophic factors, share certain intracellular signaling cascades, and depend on activation of the transcription factor CREB." | 1.31 | Common molecular and cellular substrates of addiction and memory. ( Nestler, EJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Papathanou, M | 1 |
| Creed, M | 1 |
| Dorst, MC | 1 |
| Bimpisidis, Z | 1 |
| Dumas, S | 1 |
| Pettersson, H | 1 |
| Bellone, C | 1 |
| Silberberg, G | 1 |
| Lüscher, C | 1 |
| Wallén-Mackenzie, Å | 1 |
| McNair, LF | 1 |
| Kohlmeier, KA | 1 |
| Korpi, ER | 1 |
| den Hollander, B | 1 |
| Farooq, U | 1 |
| Vashchinkina, E | 1 |
| Rajkumar, R | 1 |
| Nutt, DJ | 1 |
| Hyytiä, P | 1 |
| Dawe, GS | 1 |
| Nestler, EJ | 1 |
| Carr, D | 1 |
| Kalivas, PW | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Substance-Related Disorders
| Article | Year |
|---|---|
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse.
Topics: Alcoholism; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamines; Animals; Behavio | 2015 |
4 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Substance-Related Disorders
| Article | Year |
|---|---|
Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amphetamine; Animals; Behavior, Animal; Co | 2018 |
Prenatal nicotine is associated with reduced AMPA and NMDA receptor-mediated rises in calcium within the laterodorsal tegmentum: a pontine nucleus involved in addiction processes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Female; Glutamic Acid; H | 2015 |
Common molecular and cellular substrates of addiction and memory.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Corpus Striatum; Cyclic AMP Respons | 2002 |
Orexin: a gatekeeper of addiction.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Intracellular Signaling Peptides | 2006 |