alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Status Epilepticus in 6 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Previously, we showed that α-tocopherol (α-T) reduces hippocampal neuroglial activation and neurodegeneration in the rat model of kainic acid (KA)-induced status epilepticus (SE)." | 3.88 | Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures. ( Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galati, C; Galli, F; Lattanzi, D; Minelli, A; Olivieri, F; Palma, E; Ruffolo, G; Saccomanno, S; Savelli, D; Torquato, P, 2018) |
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| "Thus, we used two different models of generalized status epilepticus, as widespread elevated neuronal activity, to study in vivo responses of the AMPA receptor mRNA expression in rat forebrain." | 1.29 | Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain. ( Belluardo, N; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Jiang, X; Mudò, G, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ambrogini, P | 1 |
| Albertini, MC | 1 |
| Betti, M | 1 |
| Galati, C | 1 |
| Lattanzi, D | 1 |
| Savelli, D | 1 |
| Di Palma, M | 1 |
| Saccomanno, S | 1 |
| Bartolini, D | 1 |
| Torquato, P | 1 |
| Ruffolo, G | 1 |
| Olivieri, F | 1 |
| Galli, F | 1 |
| Palma, E | 1 |
| Minelli, A | 1 |
| Cuppini, R | 1 |
| Joshi, S | 1 |
| Kapur, J | 1 |
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Giralt, A | 1 |
| Alberch, J | 1 |
| Collon, KW | 1 |
| Zhang, H | 1 |
| Parent, JM | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Epsztein, J | 1 |
| Represa, A | 1 |
| Jorquera, I | 1 |
| Ben-Ari, Y | 1 |
| Crépel, V | 1 |
| Condorelli, DF | 1 |
| Belluardo, N | 1 |
| Mudò, G | 1 |
| Dell'Albani, P | 1 |
| Jiang, X | 1 |
| Giuffrida-Stella, AM | 1 |
| Okazaki, MM | 1 |
| Molnár, P | 1 |
| Nadler, JV | 1 |
6 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Status Epilepticus
| Article | Year |
|---|---|
Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Tocopherol; Animals; Blood-Brain Bar | 2018 |
Mechanisms of status epilepticus: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor hypothesis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Mice, Transgenic | 2018 |
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Electric | 2005 |
Changes in gene expression of AMPA-selective glutamate receptor subunits induced by status epilepticus in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Base Sequence; Blotting, Northern | 1994 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Elect | 1999 |