alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Seizures in 65 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels." | 7.74 | Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ( Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX, 2008) |
| "Specific [3H]glutamate binding to synaptic membranes from the cerebral cortex and hippocampus of 7-, 12- and 18-day-old rats was examined, both in control animals and during seizures induced by homocysteine." | 7.69 | Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures. ( Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F, 1997) |
| "Autoimmune encephalitis (AE) associated with autoantibodies against leucine-rich glioma-inactivated protein-1 (LGI1) can present with faciobrachial dystonic seizures (FBDS) and/or limbic encephalitis (LE)." | 4.31 | Antibody Properties Associate with Clinical Phenotype in LGI1 Encephalitis. ( Bittner, D; Düzel, E; Goihl, A; Korte, M; Körtvélyessy, P; Leypoldt, F; Ludewig, S; Reinhold, D; Rohne, J; Salzburger, L; Schraven, B, 2023) |
| " Previously, we showed that α-tocopherol (α-T) reduces hippocampal neuroglial activation and neurodegeneration in the rat model of kainic acid (KA)-induced status epilepticus (SE)." | 3.88 | Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures. ( Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galati, C; Galli, F; Lattanzi, D; Minelli, A; Olivieri, F; Palma, E; Ruffolo, G; Saccomanno, S; Savelli, D; Torquato, P, 2018) |
| "Novel N3 aryl/heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7-dimethoxyquinazolin-4(3H)- ones (8a-8l) were synthesized and evaluated for their anticonvulsant activity using various models of epilepsy, such as maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and intracerebroventricular AMPA (α-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid)-induced seizures in mice." | 3.80 | Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents. ( Banerjee, AG; Das, N; Shrivastava, SK, 2014) |
| " Focal seizures in rats were induced by neocortical injections of 4-aminopyridine, an inhibitor of voltage-gated K+ channels." | 3.74 | Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. ( Rensing, N; Rothman, SM; Thio, LL; Weisenfeld, AE; Wong, M; Xu, L; Yamada, KA; Yang, XF; Zhang, HX, 2008) |
| " The evaluation is reported of their anticonvulsant effects, both in the audiogenic seizures test with DBA/2 mice and against the maximal electroshock- and pentylenetetrazole-induced seizures in Swiss mice." | 3.70 | 3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists. ( Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Libri, V; Quartarone, S; Zappalà, M, 1998) |
| "02% propylthiouracil (PTU) through mother's milk showed a high incidence of audiogenic seizures after maturation." | 3.70 | [Running fit and generalized tonic-clonic seizure are differently controlled by different subtype receptors in the brainstem]. ( Higashiyama, A; Ishida, N; Kato, N; Yasuda, S, 1998) |
| "We have previously shown that 1-aryl-3,5-dihydro-7, 8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) possess marked anticonvulsant properties and antagonize seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) in analogy to the structurally related 1-(4-aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2,3-benzodiazepine (1, GYKI 52466), a well-known noncompetitive AMPA/kainate receptor antagonist." | 3.70 | Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puia, G; Zappalà, M, 1999) |
| "Our purpose was to evaluate the effect of seizures on kainate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor binding in maternal rat brain and whether maternal peripheral administration of magnesium sulfate can decrease this effect." | 3.70 | Magnesium prevents seizure-induced reduction in excitatory amino acid receptor (kainate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) binding in pregnant rat brain. ( Custodio, D; Hallak, M; Hotra, JW; Kruger, ML, 2000) |
| " The new compounds were found to possess anticonvulsant effects against seizures induced both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.70 | Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones. ( Bevacqua, F; Chimirri, A; De Sarro, A; De Sarro, G; Gitto, R; Quartarone, S; Rizzo, M; Zappalà, M, 2000) |
| "The anticonvulsant activity of felbamate against sound-induced seizures was studied in the DBA/2 mouse model." | 3.69 | Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice. ( Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E, 1994) |
| " The seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice." | 3.69 | 1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists. ( Chapman, AG; Chimirri, A; Constanti, A; De Sarro, A; De Sarro, G; Gitto, R; Giusti, P; Grasso, S; Libri, V; Quartarone, S; Zappalà, M, 1997) |
| "Specific [3H]glutamate binding to synaptic membranes from the cerebral cortex and hippocampus of 7-, 12- and 18-day-old rats was examined, both in control animals and during seizures induced by homocysteine." | 3.69 | Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures. ( Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F, 1997) |
| " GYKI 52466 was also protective against seizures and lethality induced by 4-aminopyridine, kainate and AMPA, but not by NMDA, whereas NBQX was ineffective in these chemoconvulsant tests." | 3.68 | Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models. ( Donevan, SD; Rogawski, MA; Yamaguchi, S, 1993) |
| "The excitatory amino acid antagonists, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline) and GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine) that act on non-NMDA receptors, provide potent anticonvulsant protection against AMPA [RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-induced seizures in Swiss mice and against sound-induced seizures in seizure-susceptible DBA/2 mice." | 3.68 | The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. ( Chapman, AG; Meldrum, BS; Smith, SE, 1991) |
| "Bilateral inferior olive lesions, produced by systemic administration of the neurotoxin 3-acetylpyridine (3AP) produce a proconvulsant state specific for strychnine-induced seizures and myoclonus." | 3.68 | The effects of inferior olive lesion on strychnine seizure. ( Anderson, MC; Chung, EY; Van Woert, MH, 1990) |
| " However, almost all known AMPA-R potentiators carry the risk of a narrow bell-shaped dose-response curve and a poor safety margin against seizures." | 3.01 | Role of the AMPA receptor in antidepressant effects of ketamine and potential of AMPA receptor potentiators as a novel antidepressant. ( Hara, H; Kimura, H; Suzuki, A, 2023) |
| "Epileptic seizures and LGI1 hypo-functions have been found in both ADLTE, a genetic epileptogenic syndrome and LGI1 limbic encephalitis (LE), an autoimmune disease." | 1.72 | Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies. ( Fels, E; Honnorat, J; Malleval, C; Mayeur, ME; Pascual, O; Vincent, C; Wayere, E, 2022) |
| "Induction of an early life seizure by kainic acid (KA) in immature rats on post-natal day (P) 7 results in behavioral changes in the adult rat that reflect social and intellectual deficits without overt cellular damage." | 1.56 | Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid. ( Benke, TA; Castano, A; O'Leary, H; Saba, LM; Southard, L; Vanderlinden, L, 2020) |
| "Generalized seizures were precipitated by the intraperitoneal injection of 4-aminopyridine." | 1.48 | Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats. ( Krisztin-Péva, B; Mátyás, A; Mihály, A; Tóth, Z, 2018) |
| "However, the impact of ZDHHC8 on seizures remains unclear." | 1.48 | ZDHHC8 critically regulates seizure susceptibility in epilepsy. ( Chen, G; Gao, X; He, M; Hu, Y; Li, Y; Ma, Y; Tian, X; Wang, Q; Wang, W; Wang, X; Xu, D; Yang, Q; Yang, Y; Zheng, F; Zhou, R, 2018) |
| "When performing kainic acid-induced seizures in vivo, we showed that elevated seizure susceptibility in Nedd4-2andi mice was normalized when GluA1 is genetically reduced." | 1.46 | Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. ( Chung, HJ; Jewett, KA; Lee, KY; Man, HY; Tsai, NP; Zhu, J, 2017) |
| "They show, in two rodent seizure models, that leptin administered directly to the brain or nasal epithelium suppresses seizures via direct effects on glutamate neurotransmission in the hippocampus." | 1.35 | Anticonvulsant effects of leptin in epilepsy. ( Diano, S; Horvath, TL, 2008) |
| "Increased seizure duration [3,522 +/- 660 sec (SEM) vs." | 1.33 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. ( Allan, SM; Davies, RE; Heenan, LE; Patel, HC; Ross, FM; Rothwell, NJ, 2006) |
| "Compound 21 also effectively suppresses seizures induced in Swiss mice by maximal electroshock (MES) and pentylenetetrazole (PTZ)." | 1.31 | Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones. ( Baraldi, M; De Micheli, C; De Sarro, A; De Sarro, G; Grasso, S; Micale, N; Puja, G; Zappalà, M, 2000) |
| "There was a commensurate reduction in seizure-related neuronal loss in the limbic regions of the brain." | 1.31 | In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466. ( Lees, GJ; Leong, W, 2001) |
| "Furthermore, SPD 502 increased the seizure threshold for electroshock-induced tonic seizures in mice at i." | 1.30 | SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity. ( Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F, 1999) |
| "I." | 1.29 | Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity. ( Arnt, J; Krogsgaard-Larsen, P; Lenz, SM; Madsen, U; Sánchez, C, 1995) |
| "Kainic acid-induced seizure activity in adult rats produces an impairment of long-term potentiation induction in hippocampal slices." | 1.28 | Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices. ( Baudry, M; Fitzpatrick, JS; Shahi, K, 1992) |
| ", allowing for better dosage control." | 1.28 | 4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action. ( Arnold, MB; Elzey, T; Leander, JD; Lodge, D; Ornstein, PL; Paschal, JW; Schoepp, DD, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.54) | 18.7374 |
| 1990's | 28 (43.08) | 18.2507 |
| 2000's | 19 (29.23) | 29.6817 |
| 2010's | 10 (15.38) | 24.3611 |
| 2020's | 7 (10.77) | 2.80 |
| Authors | Studies |
|---|---|
| Fels, E | 1 |
| Mayeur, ME | 1 |
| Wayere, E | 1 |
| Vincent, C | 1 |
| Malleval, C | 1 |
| Honnorat, J | 2 |
| Pascual, O | 1 |
| Chang, A | 1 |
| Chang, Y | 1 |
| Wang, SJ | 1 |
| Rajasekaran, K | 1 |
| Ma, Q | 1 |
| Good, LB | 1 |
| Kathote, G | 1 |
| Jakkamsetti, V | 1 |
| Liu, P | 1 |
| Avila, A | 1 |
| Primeaux, S | 1 |
| Enciso Alva, J | 1 |
| Markussen, KH | 1 |
| Marin-Valencia, I | 1 |
| Sirsi, D | 1 |
| Hacker, PMS | 1 |
| Gentry, MS | 1 |
| Su, J | 1 |
| Lu, H | 1 |
| Pascual, JM | 1 |
| Suzuki, A | 1 |
| Hara, H | 1 |
| Kimura, H | 1 |
| Ludewig, S | 1 |
| Salzburger, L | 1 |
| Goihl, A | 1 |
| Rohne, J | 1 |
| Leypoldt, F | 1 |
| Bittner, D | 1 |
| Düzel, E | 1 |
| Schraven, B | 1 |
| Reinhold, D | 1 |
| Korte, M | 1 |
| Körtvélyessy, P | 1 |
| O'Leary, H | 1 |
| Vanderlinden, L | 1 |
| Southard, L | 1 |
| Castano, A | 1 |
| Saba, LM | 1 |
| Benke, TA | 1 |
| Abulkhair, HS | 1 |
| Elmeligie, S | 1 |
| Ghiaty, A | 1 |
| El-Morsy, A | 1 |
| Bayoumi, AH | 1 |
| Ahmed, HEA | 1 |
| El-Adl, K | 1 |
| Zayed, MF | 1 |
| Hassan, MH | 1 |
| Akl, EN | 1 |
| El-Zoghbi, MS | 1 |
| Ambrogini, P | 1 |
| Albertini, MC | 1 |
| Betti, M | 1 |
| Galati, C | 1 |
| Lattanzi, D | 1 |
| Savelli, D | 1 |
| Di Palma, M | 1 |
| Saccomanno, S | 1 |
| Bartolini, D | 1 |
| Torquato, P | 1 |
| Ruffolo, G | 1 |
| Olivieri, F | 1 |
| Galli, F | 1 |
| Palma, E | 1 |
| Minelli, A | 1 |
| Cuppini, R | 1 |
| Tóth, Z | 1 |
| Mihály, A | 1 |
| Mátyás, A | 1 |
| Krisztin-Péva, B | 1 |
| Yang, Q | 1 |
| Zheng, F | 1 |
| Hu, Y | 1 |
| Yang, Y | 1 |
| Li, Y | 1 |
| Chen, G | 1 |
| Wang, W | 1 |
| He, M | 1 |
| Zhou, R | 1 |
| Ma, Y | 1 |
| Xu, D | 1 |
| Tian, X | 1 |
| Gao, X | 1 |
| Wang, Q | 1 |
| Wang, X | 1 |
| Malik, S | 1 |
| Bahare, RS | 1 |
| Khan, SA | 1 |
| Das, N | 1 |
| Banerjee, AG | 1 |
| Shrivastava, SK | 1 |
| Joubert, B | 1 |
| Kerschen, P | 1 |
| Zekeridou, A | 1 |
| Desestret, V | 1 |
| Rogemond, V | 1 |
| Chaffois, MO | 1 |
| Ducray, F | 1 |
| Larrue, V | 1 |
| Daubail, B | 1 |
| Idbaih, A | 1 |
| Psimaras, D | 1 |
| Antoine, JC | 1 |
| Delattre, JY | 1 |
| Zhu, J | 1 |
| Lee, KY | 1 |
| Jewett, KA | 1 |
| Man, HY | 1 |
| Chung, HJ | 1 |
| Tsai, NP | 1 |
| Rawls, SM | 1 |
| Thomas, T | 1 |
| Adeola, M | 1 |
| Patil, T | 1 |
| Raymondi, N | 1 |
| Poles, A | 1 |
| Loo, M | 1 |
| Raffa, RB | 1 |
| Traub, RD | 1 |
| Duncan, R | 1 |
| Russell, AJ | 1 |
| Baldeweg, T | 1 |
| Tu, Y | 1 |
| Cunningham, MO | 1 |
| Whittington, MA | 1 |
| Lee, RH | 1 |
| Mills, EA | 1 |
| Schwartz, N | 1 |
| Bell, MR | 1 |
| Deeg, KE | 1 |
| Ruthazer, ES | 1 |
| Marsh-Armstrong, N | 1 |
| Aizenman, CD | 1 |
| Sawant, PM | 1 |
| Tyndall, JD | 1 |
| Holland, PT | 1 |
| Peake, BM | 1 |
| Mountfort, DO | 1 |
| Kerr, DS | 1 |
| Lubisch, W | 1 |
| Behl, B | 1 |
| Henn, C | 1 |
| Hofmann, HP | 1 |
| Reeb, J | 1 |
| Regner, F | 1 |
| Vierling, M | 1 |
| Cordi, AA | 1 |
| Desos, P | 1 |
| Ruano, E | 1 |
| Al-Badri, H | 1 |
| Fugier, C | 1 |
| Chapman, AG | 3 |
| Meldrum, BS | 2 |
| Thomas, JY | 1 |
| Roger, A | 1 |
| Lestage, P | 1 |
| Cheung, EC | 1 |
| Melanson-Drapeau, L | 1 |
| Cregan, SP | 1 |
| Vanderluit, JL | 1 |
| Ferguson, KL | 1 |
| McIntosh, WC | 1 |
| Park, DS | 1 |
| Bennett, SA | 1 |
| Slack, RS | 1 |
| Patel, HC | 1 |
| Ross, FM | 1 |
| Heenan, LE | 1 |
| Davies, RE | 1 |
| Rothwell, NJ | 1 |
| Allan, SM | 1 |
| Hendricson, AW | 1 |
| Maldve, RE | 1 |
| Salinas, AG | 1 |
| Theile, JW | 1 |
| Zhang, TA | 1 |
| Diaz, LM | 1 |
| Morrisett, RA | 1 |
| Gigler, G | 1 |
| Móricz, K | 1 |
| Agoston, M | 1 |
| Simó, A | 1 |
| Albert, M | 1 |
| Benedek, A | 1 |
| Kapus, G | 2 |
| Kertész, S | 1 |
| Vegh, M | 1 |
| Barkóczy, J | 1 |
| Markó, B | 1 |
| Szabó, G | 1 |
| Matucz, E | 1 |
| Gacsályi, I | 1 |
| Lévay, G | 1 |
| Hársing, LG | 2 |
| Szénási, G | 1 |
| Xu, L | 1 |
| Rensing, N | 1 |
| Yang, XF | 1 |
| Zhang, HX | 1 |
| Thio, LL | 1 |
| Rothman, SM | 1 |
| Weisenfeld, AE | 1 |
| Wong, M | 1 |
| Yamada, KA | 1 |
| Diano, S | 1 |
| Horvath, TL | 1 |
| Laudrup, P | 2 |
| Klitgaard, H | 2 |
| Lee, S | 1 |
| Miskovsky, J | 1 |
| Williamson, J | 1 |
| Howells, R | 1 |
| Devinsky, O | 1 |
| Lothman, E | 1 |
| Christakos, S | 1 |
| De Sarro, G | 7 |
| Ongini, E | 1 |
| Bertorelli, R | 1 |
| Aguglia, U | 1 |
| De Sarro, A | 7 |
| Lees, GJ | 2 |
| Leong, W | 2 |
| Nakamura, M | 1 |
| Abe, S | 1 |
| Akazawa, K | 1 |
| Shukla, VK | 1 |
| Lemaire, S | 1 |
| Fischer, S | 1 |
| Wolf, G | 1 |
| Keilhoff, G | 1 |
| Hass, P | 1 |
| Yamaguchi, S | 1 |
| Donevan, SD | 1 |
| Rogawski, MA | 1 |
| Zarnowski, T | 1 |
| Kleinrok, Z | 1 |
| Turski, WA | 1 |
| Czuczwar, SJ | 1 |
| Arnt, J | 1 |
| Sánchez, C | 1 |
| Lenz, SM | 1 |
| Madsen, U | 1 |
| Krogsgaard-Larsen, P | 1 |
| Ornstein, PL | 3 |
| Arnold, MB | 2 |
| Allen, NK | 1 |
| Bleisch, T | 1 |
| Borromeo, PS | 1 |
| Lugar, CW | 1 |
| Leander, JD | 3 |
| Lodge, D | 3 |
| Schoepp, DD | 3 |
| Salhoff, CR | 1 |
| Fuson, KS | 1 |
| Sacaan, AI | 1 |
| Tizzano, JP | 1 |
| May, PC | 1 |
| Chimirri, A | 3 |
| Gitto, R | 4 |
| Grasso, S | 4 |
| Quartarone, S | 4 |
| Zappalà, M | 6 |
| Giusti, P | 1 |
| Libri, V | 2 |
| Constanti, A | 2 |
| Folbergrová, J | 1 |
| Lisý, V | 1 |
| Haugvicová, R | 1 |
| Stastný, F | 1 |
| Ikonomidou, C | 1 |
| Turski, L | 1 |
| Yasuda, S | 2 |
| Ishida, N | 2 |
| Higashiyama, A | 2 |
| Kato, N | 2 |
| Micale, N | 3 |
| Nielsen, EO | 1 |
| Varming, T | 1 |
| Mathiesen, C | 1 |
| Jensen, LH | 1 |
| Moller, A | 1 |
| Gouliaev, AH | 1 |
| Wätjen, F | 1 |
| Drejer, J | 1 |
| Anderson, BA | 1 |
| Harn, NK | 1 |
| Hansen, MM | 1 |
| Harkness, AR | 1 |
| Puia, G | 1 |
| Baraldi, M | 2 |
| De Micheli, C | 2 |
| Isokawa, M | 1 |
| Mathern, GW | 1 |
| Morinobu, S | 1 |
| Puja, G | 1 |
| Abrahám, G | 1 |
| Sólyom, S | 1 |
| Csuzdi, E | 1 |
| Berzsenyi, P | 1 |
| Ling, I | 1 |
| Tarnawa, I | 1 |
| Hámori, T | 1 |
| Pallagi, I | 1 |
| Horváth, K | 1 |
| Andrási, F | 1 |
| Király, I | 1 |
| Patthy, M | 1 |
| Horváth, G | 1 |
| Hallak, M | 1 |
| Hotra, JW | 1 |
| Custodio, D | 1 |
| Kruger, ML | 1 |
| Bevacqua, F | 1 |
| Rizzo, M | 1 |
| Pratt, J | 2 |
| Jimonet, P | 2 |
| Bohme, GA | 2 |
| Boireau, A | 2 |
| Damour, D | 2 |
| Debono, MW | 2 |
| Genevois-Borella, A | 2 |
| Randle, JC | 2 |
| Ribeill, Y | 2 |
| Stutzmann, JM | 2 |
| Vuilhorgne, M | 2 |
| Mignani, S | 2 |
| Bouquerel, J | 1 |
| Hardy, JC | 1 |
| Hubert, P | 1 |
| Manfré, F | 1 |
| Nemecek, P | 1 |
| Manjarrez, J | 1 |
| Alvarado, R | 1 |
| Camacho-Arroyo, I | 1 |
| Motles, E | 1 |
| Cartier, L | 1 |
| Infante, C | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
| Fitzpatrick, JS | 1 |
| Shahi, K | 1 |
| Baudry, M | 1 |
| Smith, SE | 1 |
| Paschal, JW | 1 |
| Elzey, T | 1 |
| Anderson, MC | 1 |
| Chung, EY | 1 |
| Van Woert, MH | 1 |
| Frandsen, A | 1 |
| Belhage, B | 1 |
| Schousboe, A | 1 |
2 reviews available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Seizures
| Article | Year |
|---|---|
Role of the AMPA receptor in antidepressant effects of ketamine and potential of AMPA receptor potentiators as a novel antidepressant.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents; Humans; Ketamine; R | 2023 |
Clinical Spectrum of Encephalitis Associated With Antibodies Against the α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor: Case Series and Review of the Literature.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoantibodies; Autoimmune Diseases; | 2015 |
63 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Seizures
| Article | Year |
|---|---|
Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoantibodies; Epilepsy; Hippoca | 2022 |
Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems; Animals; Ant | 2022 |
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Glucose; Carbohydrate Metab | 2022 |
Antibody Properties Associate with Clinical Phenotype in LGI1 Encephalitis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoantibodies; Encephalitis; Int | 2023 |
Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Gene Expression Profiling; Hippoc | 2020 |
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dose-Response Re | 2021 |
Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Tocopherol; Animals; Blood-Brain Bar | 2018 |
Non-competitive antagonists of NMDA and AMPA receptors decrease seizure-induced c-fos protein expression in the cerebellum and protect against seizure symptoms in adult rats.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Exci | 2018 |
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Topics: Acyltransferases; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anima | 2018 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 2013 |
Design, synthesis and pharmacological evaluation of N3 aryl/ heteroaryl substituted 2-((benzyloxy and phenylthio) methyl) 6,7- dimethoxyquinazolin-4(3H)-ones as potential anticonvulsant agents.
Topics: Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2014 |
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.
Topics: 14-3-3 Proteins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Anim | 2017 |
Topiramate antagonizes NMDA- and AMPA-induced seizure-like activity in planarians.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Dizocilpine Mal | 2009 |
Spatiotemporal patterns of electrocorticographic very fast oscillations (> 80 Hz) consistent with a network model based on electrical coupling between principal neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auto | 2010 |
Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Avoidance Learning; Behavior, Ani | 2010 |
In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Binding, Co | 2010 |
Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Dose-Response Rela | 2002 |
Novel quinolinone-phosphonic acid AMPA antagonists devoid of nephrotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anticonvuls | 2002 |
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Apoptosis Inducing Fac | 2005 |
Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anticonvuls | 2006 |
Aberrant synaptic activation of N-methyl-D-aspartate receptors underlies ethanol withdrawal hyperexcitability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blotting, Western; Central Nervou | 2007 |
Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 2007 |
Leptin inhibits 4-aminopyridine- and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2008 |
Anticonvulsant effects of leptin in epilepsy.
Topics: 4-Aminopyridine; Administration, Intranasal; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2008 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; D | 1993 |
Metabotropic excitatory amino acid receptor agonists selectively potentiate behavioral effects induced by ionotropic excitatory amino acid receptor agonists in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; D | 1993 |
Changes in glutamate receptor and proenkephalin gene expression after kindled seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amygdala; Animals; Blotting, Northern; Bra | 1994 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1994 |
NBQX prevents contralateral but not ipsilateral seizure-induced cytotoxicity of kainate but not AMPA-reversal at high doses of NBQX.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Dose-Response Relatio | 1994 |
AMPA-, but not NMDA-, receptor blocker, NBQX, prevents seizure induction in magnesium-deficient rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Magnesium Deficiency; Male; Quino | 1995 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicu | 1993 |
Mg2+ antagonizes alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced brain damage and convulsions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Ibotenic Acid; Ma | 1993 |
Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBOX in maximal electroshock and chemoconvulsant seizure models.
Topics: 4-Aminopyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Age | 1993 |
2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline enhances the protective activity of common antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Ataxia; Avoidanc | 1993 |
Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Convulsants; Cue | 1995 |
Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carboxylic Acids; Cerebral Cortex | 1996 |
Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino | 1996 |
1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Bind | 1997 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1998 |
[Running fit and generalized tonic-clonic seizure are differently controlled by different subtype receptors in the brainstem].
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1998 |
7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiet | 1998 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competiti | 1999 |
Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazephine AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 1999 |
Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cells, Cultured; | 1999 |
Developmental changes in NMDA-induced intrinsic optical signals in the hippocampal dentate gyrus of children with medically intractable seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cell Survival; | 1999 |
Characterization of audiogenic-like seizures in naive rats evoked by activation of AMPA and NMDA receptors in the inferior colliculus.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Su | 2000 |
Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 2000 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsa | 2000 |
Magnesium prevents seizure-induced reduction in excitatory amino acid receptor (kainate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) binding in pregnant rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Female; K | 2000 |
Synthesis and evaluation of pharmacological and pharmacokinetic properties of 11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones.
Topics: Acoustic Stimulation; Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2000 |
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Cell Memb | 2000 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 2001 |
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Ch | 2001 |
Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizo | 2001 |
Induction and blockade of epileptic foci by intracerebral injection of glutamatergic agonists and antagonists in frerly moving cats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyg | 2002 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Glycoproteins; Hip | 1992 |
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiet | 1991 |
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Ibotenic Acid; I | 1991 |
The effects of inferior olive lesion on strychnine seizure.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dizocilpine Male | 1990 |
Differences between seizure-prone and non-seizure-prone mice with regard to glutamate and GABA receptor binding in the hippocampus and other regions of the brain.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cerebral | 1987 |