alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Schizophrenia in 13 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Soltani, M | 1 |
| Beshkar, P | 1 |
| Mokhtarian, K | 1 |
| Anjomshoa, M | 1 |
| Mohammad-Rezaei, M | 1 |
| Azadegan-Dehkordi, F | 1 |
| Mirzaei, Y | 1 |
| Majidi, J | 1 |
| Bagheri, N | 1 |
| Lin, KH | 1 |
| Hu, TM | 1 |
| Hsu, SH | 1 |
| Tsai, HY | 1 |
| Cheng, MC | 1 |
| Gulchina, Y | 1 |
| Xu, SJ | 1 |
| Snyder, MA | 1 |
| Elefant, F | 1 |
| Gao, WJ | 1 |
| Kusi, M | 1 |
| Brooks, G | 1 |
| Noakes, J | 1 |
| Hasekiu, E | 1 |
| Ingle Gonzalez, JE | 1 |
| Wang, Q | 1 |
| Man Wu, H | 1 |
| Yue, W | 1 |
| Yan, H | 1 |
| Zhang, Y | 1 |
| Tan, L | 1 |
| Deng, W | 1 |
| Chen, Q | 1 |
| Yang, G | 1 |
| Lu, T | 1 |
| Wang, L | 1 |
| Zhang, F | 1 |
| Yang, J | 1 |
| Li, K | 1 |
| Lv, L | 1 |
| Tan, Q | 1 |
| Zhang, H | 1 |
| Ma, X | 2 |
| Yang, F | 1 |
| Li, L | 1 |
| Wang, C | 1 |
| Zhao, L | 1 |
| Ren, H | 1 |
| Yu, H | 1 |
| Wang, Y | 1 |
| Hu, X | 1 |
| Zhang, D | 1 |
| Sham, P | 1 |
| Li, T | 1 |
| Siekmeier, PJ | 1 |
| vanMaanen, DP | 1 |
| Ninan, I | 1 |
| Jardemark, KE | 1 |
| Wang, RY | 1 |
| Scarr, E | 1 |
| Beneyto, M | 1 |
| Meador-Woodruff, JH | 1 |
| Dean, B | 1 |
| Newell, KA | 1 |
| Zavitsanou, K | 1 |
| Huang, XF | 1 |
| Tseng, KY | 1 |
| Lewis, BL | 1 |
| Lipska, BK | 1 |
| O'Donnell, P | 1 |
| Amargós-Bosch, M | 1 |
| Adell, A | 1 |
| Artigas, F | 1 |
| Freed, WJ | 1 |
| Dillon-Carter, O | 1 |
| Kleinman, JE | 1 |
| Kurumaji, A | 1 |
| Ishimaru, M | 1 |
| Toru, M | 1 |
1 trial available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Schizophrenia
| Article | Year |
|---|---|
Effect of Damaging Rare Mutations in Synapse-Related Gene Sets on Response to Short-term Antipsychotic Medication in Chinese Patients With Schizophrenia: A Randomized Clinical Trial.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antipsychotic Agents; China; Exome | 2018 |
12 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Schizophrenia
| Article | Year |
|---|---|
A Study of Autoantibodies against Some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aquaporins; Autoantibodies; Butyric Acid; | 2022 |
Identification of rare missense mutations in the glutamate ionotropic receptor AMPA type subunit genes in schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Exons; Glutamic Acid; Humans; Mutation, Mi | 2023 |
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cognition Disor | 2017 |
Modeling Schizophrenia's Abnormal Cortical Neural Synchrony in Monkeys.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Haplorhini; Humans; Ketamine; N-M | 2018 |
Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antipsychotic Agents; Computer Simulation; | 2013 |
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazep | 2003 |
Cortical glutamatergic markers in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; | 2005 |
Ionotropic glutamate receptor binding in the posterior cingulate cortex in schizophrenia patients.
Topics: Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Varia | 2005 |
Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazo | 2007 |
Antipsychotic drugs reverse the AMPA receptor-stimulated release of 5-HT in the medial prefrontal cortex.
Topics: Adrenergic alpha-1 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; A | 2007 |
Properties of [3H]AMPA binding in postmortem human brain from psychotic subjects and controls: increases in caudate nucleus associated with suicide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Cadaver; Caudate Nucleus; Female; F | 1993 |
Alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics.
Topics: 4-Chloromercuribenzenesulfonate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Ac | 1992 |