alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Optic Atrophy, Hereditary, Leber in 1 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Optic Atrophy, Hereditary, Leber: A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4." | 1.51 | Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells. ( Chen, SJ; Chen, WS; Chien, CS; Chiou, GY; Chiou, SH; Hsu, CC; Hwang, DK; Lin, TC; Lin, TW; Nguyen, PNN; Peng, CH; Tsai, CY; Yang, YP; Yarmishyn, AA, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, YP | 1 |
| Nguyen, PNN | 1 |
| Lin, TC | 1 |
| Yarmishyn, AA | 1 |
| Chen, WS | 1 |
| Hwang, DK | 1 |
| Chiou, GY | 1 |
| Lin, TW | 1 |
| Chien, CS | 1 |
| Tsai, CY | 1 |
| Chiou, SH | 1 |
| Chen, SJ | 1 |
| Peng, CH | 1 |
| Hsu, CC | 1 |
1 other study available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Optic Atrophy, Hereditary, Leber
| Article | Year |
|---|---|
Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber's Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Base Sequence; Cell Differentiation; Down- | 2019 |