alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Neurodegenerative Diseases in 7 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the face of these data, one therapeutic approach is to increase BDNF bioavailability in brain." | 2.82 | Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease. ( Keifer, J, 2022) |
| "As a neurodegenerative disease, Alzheimer's disease (AD) seriously affects the health of older people." | 1.72 | A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. ( Chen, J; Chen, L; Chu, H; Guo, Y; Han, Y; Liu, J; Ma, H; Wang, C; Yu, X; Zhang, C, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Keifer, J | 1 |
| Han, Y | 1 |
| Chen, L | 1 |
| Liu, J | 1 |
| Chen, J | 1 |
| Wang, C | 1 |
| Guo, Y | 1 |
| Yu, X | 1 |
| Zhang, C | 1 |
| Chu, H | 1 |
| Ma, H | 1 |
| Kandy, SK | 1 |
| Nimonkar, MM | 1 |
| Dash, SS | 1 |
| Mehta, B | 1 |
| Markandeya, YS | 1 |
| Abghari, M | 1 |
| Vu, JTCM | 1 |
| Eckberg, N | 1 |
| Aldana, BI | 1 |
| Kohlmeier, KA | 1 |
| Nunes, AF | 1 |
| Montero, M | 1 |
| Franquinho, F | 1 |
| Santos, SD | 1 |
| Malva, J | 1 |
| Zimmer, J | 1 |
| Sousa, MM | 1 |
| Hyodo, J | 1 |
| Hakuba, N | 1 |
| Hato, N | 1 |
| Takeda, S | 1 |
| Okada, M | 1 |
| Omotehara, Y | 1 |
| Gyo, K | 1 |
| Saura, CA | 1 |
| Choi, SY | 1 |
| Beglopoulos, V | 1 |
| Malkani, S | 1 |
| Zhang, D | 1 |
| Shankaranarayana Rao, BS | 1 |
| Chattarji, S | 1 |
| Kelleher, RJ | 1 |
| Kandel, ER | 1 |
| Duff, K | 1 |
| Kirkwood, A | 1 |
| Shen, J | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Brain-Derived Neu | 2022 |
6 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway.
Topics: Adaptor Proteins, Signal Transducing; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 2022 |
Astaxanthin Protection against Neuronal Excitotoxicity via Glutamate Receptor Inhibition and Improvement of Mitochondrial Function.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antioxidants; Calcium; Glutamic Acid; Huma | 2022 |
Decanoic Acid Rescues Differences in AMPA-Mediated Calcium Rises in Hippocampal CA1 Astrocytes and Neurons in the 5xFAD Mouse Model of Alzheimer's Disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Peptides; | 2023 |
Transthyretin knockout mice display decreased susceptibility to AMPA-induced neurodegeneration.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyloid beta-Peptides; Animals; Antimetabo | 2009 |
Glutamate agonist causes irreversible degeneration of inner hair cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Count; Cell Death; Dendrites | 2009 |
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Topics: Activating Transcription Factor 1; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic | 2004 |