alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Neuroblastoma in 4 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Process extension was induced in cells of the N18-RE-105 neuroblastoma-retinal hybrid line by toxic agents, including glutamate and the p53-inducing anticancer agents adriamycin and etoposide." | 3.70 | N18-RE-105 cells: differentiation and activation of p53 in response to glutamate and adriamycin is blocked by SV40 large T antigen tsA58. ( Conejero, C; Dillon-Carter, O; Freed, WJ; Poltorak, M; Tornatore, C, 1998) |
| " The cotransporter activity in human neuroblastoma SH-SY5Y cells was assessed by bumetanide-sensitive K+ influx, and protein expression was evaluated by Western blot analysis." | 3.70 | Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate. ( Murali, SG; Sun, D, 1998) |
| "As a neurodegenerative disease, Alzheimer's disease (AD) seriously affects the health of older people." | 1.72 | A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway. ( Chen, J; Chen, L; Chu, H; Guo, Y; Han, Y; Liu, J; Ma, H; Wang, C; Yu, X; Zhang, C, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, Y | 1 |
| Chen, L | 1 |
| Liu, J | 1 |
| Chen, J | 1 |
| Wang, C | 1 |
| Guo, Y | 1 |
| Yu, X | 1 |
| Zhang, C | 1 |
| Chu, H | 1 |
| Ma, H | 1 |
| Voss, OP | 1 |
| Milne, S | 1 |
| Sharkey, J | 1 |
| O'Neill, MJ | 1 |
| McCulloch, J | 1 |
| Dillon-Carter, O | 1 |
| Conejero, C | 1 |
| Tornatore, C | 1 |
| Poltorak, M | 1 |
| Freed, WJ | 1 |
| Sun, D | 1 |
| Murali, SG | 1 |
4 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Neuroblastoma
| Article | Year |
|---|---|
A Class I HDAC Inhibitor Rescues Synaptic Damage and Neuron Loss in APP-Transfected Cells and APP/PS1 Mice through the GRIP1/AMPA Pathway.
Topics: Adaptor Proteins, Signal Transducing; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 2022 |
Molecular mechanisms of neurite growth with AMPA receptor potentiation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti | 2007 |
N18-RE-105 cells: differentiation and activation of p53 in response to glutamate and adriamycin is blocked by SV40 large T antigen tsA58.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antigens, Polyomavirus Transformi | 1998 |
Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bumetanide; Carrier Proteins; Cycloleucine | 1998 |