alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Nervous System Diseases in 8 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nifedipine response was reproduced by isradipine and by verapamil with IC50 values of 9 and 100 nM, respectively." | 1.28 | Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity. ( Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Higashi, S | 1 |
| Hioki, K | 1 |
| Kurotani, T | 1 |
| Kasim, N | 1 |
| Molnár, Z | 1 |
| Moncada, CR | 1 |
| Arvin, B | 1 |
| Meldrum, BS | 1 |
| Weiss, JH | 1 |
| Hartley, DM | 1 |
| Koh, JY | 1 |
| Choi, DW | 1 |
| Caner, H | 1 |
| Collins, JL | 1 |
| Harris, SM | 1 |
| Kassell, NF | 1 |
| Lee, KS | 1 |
| Ikonomidou, C | 1 |
| Turski, L | 1 |
| Pizzi, M | 1 |
| Ribola, M | 1 |
| Valerio, A | 1 |
| Memo, M | 1 |
| Spano, P | 1 |
| Berg, M | 1 |
| Bruhn, T | 1 |
| Johansen, FF | 1 |
| Krogsgaard-Larsen, P | 2 |
| Diemer, NH | 1 |
| Madsen, U | 1 |
| Ferkany, JW | 1 |
| Jones, BE | 1 |
| Ebert, B | 1 |
| Johansen, TN | 1 |
| Holm, T | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Nervous System Diseases
| Article | Year |
|---|---|
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Bra | 1996 |
7 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Nervous System Diseases
| Article | Year |
|---|---|
Functional thalamocortical synapse reorganization from subplate to layer IV during postnatal development in the reeler-like mutant rat (shaking rat Kawasaki).
Topics: Action Potentials; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; A | 2005 |
The pyrimidine derivative BW 1003C87 protects against excitotoxic lesions induced by kainate in the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Hippocampus; Kai | 1994 |
AMPA receptor activation potentiates zinc neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, | 1993 |
Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Calpain; Cer | 1993 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Kainic acid neurotoxicity: in vivo test of two new non-N-methyl-D-aspartate receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Corpus Striatum | 1991 |
NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Choline O-Acetyl | 1990 |