alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Multiple Sclerosis

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Multiple Sclerosis in 3 studies

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.

Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Research

Studies (3)

Authors

Reviews

1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Multiple Sclerosis

Other Studies

2 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Multiple Sclerosis