alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Motor Neuron Disease in 8 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neurolathyrism, konzo, and amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS-PDC) have attracted researchers to study the pathology of motor neuron (MN) diseases such as ALS." | 2.61 | [Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism]. ( Kusama-Eguchi, K, 2019) |
| "Because motoneuron degeneration is the main pathological hallmark in motoneuron diseases, and excitotoxicity is an important mechanism of neuronal death in this type of disorders, in this work we tested whether the tetanus toxin C-fragment is able to protect MN in the spinal cord in vivo." | 1.48 | Tetanus toxin C-fragment protects against excitotoxic spinal motoneuron degeneration in vivo. ( Netzahualcoyotzi, C; Tapia, R, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Netzahualcoyotzi, C | 1 |
| Tapia, R | 3 |
| Kusama-Eguchi, K | 1 |
| Santa-Cruz, LD | 1 |
| Guerrero-Castillo, S | 1 |
| Uribe-Carvajal, S | 1 |
| Ramírez-Jarquín, UN | 1 |
| Kieran, D | 1 |
| Greensmith, L | 1 |
| Willis, CL | 1 |
| Meldrum, BS | 1 |
| Nunn, PB | 1 |
| Anderton, BH | 1 |
| Leigh, PN | 1 |
| Kruman, II | 1 |
| Pedersen, WA | 1 |
| Springer, JE | 1 |
| Mattson, MP | 1 |
| Urushitani, M | 1 |
| Nakamizo, T | 1 |
| Inoue, R | 1 |
| Sawada, H | 1 |
| Kihara, T | 1 |
| Honda, K | 1 |
| Akaike, A | 1 |
| Shimohama, S | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Motor Neuron Disease
| Article | Year |
|---|---|
[Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; beta-Alanine; Cell Death; Disease | 2019 |
7 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Motor Neuron Disease
| Article | Year |
|---|---|
Tetanus toxin C-fragment protects against excitotoxic spinal motoneuron degeneration in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Injection | 2018 |
Mitochondrial Dysfunction during the Early Stages of Excitotoxic Spinal Motor Neuron Degeneration in Vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Excitator | 2016 |
Neuropathological characterization of spinal motor neuron degeneration processes induced by acute and chronic excitotoxic stimulus in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Astrocytes; Caspase 3; | 2016 |
Inhibition of calpains, by treatment with leupeptin, improves motoneuron survival and muscle function in models of motoneuron degeneration.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calpain; Cell C | 2004 |
Neuroprotective effect of free radical scavengers on beta-N-oxalylamino-L-alanine (BOAA)-induced neuronal damage in rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response Relationship, Drug; | 1994 |
ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 1999 |
N-methyl-D-aspartate receptor-mediated mitochondrial Ca(2+) overload in acute excitotoxic motor neuron death: a mechanism distinct from chronic neurotoxicity after Ca(2+) influx.
Topics: 2,4-Dinitrophenol; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolep | 2001 |