alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Inflammation in 17 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to assess whether lifetime exposure to glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), is associated with elevated liver transaminases and metabolic syndrome among young adults." | 8.31 | Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study. ( Bradman, A; Eskenazi, B; Gunier, RB; Harley, KG; Holland, N; Kogut, K; Limbach, C; Mendez, X; Mills, PJ; Mora, AM; Perito, ER; Rauch, S, 2023) |
| "The aim of the present study was to investigate the impacts of glyphosate herbicide on the survival and proliferation of glioblastoma cells and to explore the molecular mechanisms underlying such effects." | 8.31 | Glyphosate-induced glioblastoma cell proliferation: Unraveling the interplay of oxidative, inflammatory, proliferative, and survival signaling pathways. ( Bianco, CD; Dos Santos, DC; Kviecisnki, MR; Ourique, F; Pedrosa, RC; Zamoner, A, 2023) |
| "Considerable evidence has demonstrated that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blockade has an antinociceptive effect on inflammatory pain." | 7.73 | New role for spinal Stargazin in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated pain sensitization after inflammation. ( Johns, RA; Skinner, J; Su, Q; Tao, F, 2006) |
| "We aimed to assess whether lifetime exposure to glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), is associated with elevated liver transaminases and metabolic syndrome among young adults." | 4.31 | Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study. ( Bradman, A; Eskenazi, B; Gunier, RB; Harley, KG; Holland, N; Kogut, K; Limbach, C; Mendez, X; Mills, PJ; Mora, AM; Perito, ER; Rauch, S, 2023) |
| "The aim of the present study was to investigate the impacts of glyphosate herbicide on the survival and proliferation of glioblastoma cells and to explore the molecular mechanisms underlying such effects." | 4.31 | Glyphosate-induced glioblastoma cell proliferation: Unraveling the interplay of oxidative, inflammatory, proliferative, and survival signaling pathways. ( Bianco, CD; Dos Santos, DC; Kviecisnki, MR; Ourique, F; Pedrosa, RC; Zamoner, A, 2023) |
| " Previously, we showed that α-tocopherol (α-T) reduces hippocampal neuroglial activation and neurodegeneration in the rat model of kainic acid (KA)-induced status epilepticus (SE)." | 3.88 | Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures. ( Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galati, C; Galli, F; Lattanzi, D; Minelli, A; Olivieri, F; Palma, E; Ruffolo, G; Saccomanno, S; Savelli, D; Torquato, P, 2018) |
| "Considerable evidence has demonstrated that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor blockade has an antinociceptive effect on inflammatory pain." | 3.73 | New role for spinal Stargazin in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated pain sensitization after inflammation. ( Johns, RA; Skinner, J; Su, Q; Tao, F, 2006) |
| "This study employing a rodent model of acute pain investigated the influence of carrageenan-induced inflammation on the ability of S-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activation to induce membrane currents and rises in cytosolic free calcium concentration ([Ca2+]i) in the rat substantia gelatinosa (SG) neurons using simultaneous whole-cell patch-clamp recording and fura-2 calcium imaging in spinal cord slices of L4-L5 segments." | 3.72 | Peripheral inflamation-induced increase of AMPA-mediated currents and Ca2+ transients in the presence of cyclothiazide in the rat substantia gelatinosa neurons. ( Gerber, G; Randic, M; Voitenko, N; Youn, D, 2004) |
| "Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality." | 1.91 | Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling. ( Cheng, M; Cheng, Y; Li, F; Xu, W; Zhu, L, 2023) |
| "Osteoarthritis is the single greatest cause of chronic pain, has no cure, and affects 8." | 1.56 | AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis. ( Blain, EJ; Bonnet, CS; Gilbert, SJ; Mason, DJ; Williams, AS, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 6 (35.29) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, A | 1 |
| Chang, Y | 1 |
| Wang, SJ | 1 |
| Izquierdo-Altarejos, P | 1 |
| Cabrera-Pastor, A | 1 |
| Martínez-García, M | 1 |
| Sánchez-Huertas, C | 1 |
| Hernández, A | 1 |
| Moreno-Manzano, V | 1 |
| Felipo, V | 1 |
| Eskenazi, B | 1 |
| Gunier, RB | 1 |
| Rauch, S | 1 |
| Kogut, K | 1 |
| Perito, ER | 1 |
| Mendez, X | 1 |
| Limbach, C | 1 |
| Holland, N | 1 |
| Bradman, A | 1 |
| Harley, KG | 1 |
| Mills, PJ | 1 |
| Mora, AM | 1 |
| Xu, W | 1 |
| Li, F | 1 |
| Zhu, L | 1 |
| Cheng, M | 1 |
| Cheng, Y | 1 |
| Bianco, CD | 1 |
| Ourique, F | 1 |
| Dos Santos, DC | 1 |
| Pedrosa, RC | 1 |
| Kviecisnki, MR | 1 |
| Zamoner, A | 1 |
| Bonnet, CS | 1 |
| Gilbert, SJ | 1 |
| Blain, EJ | 1 |
| Williams, AS | 1 |
| Mason, DJ | 1 |
| Ambrogini, P | 1 |
| Albertini, MC | 1 |
| Betti, M | 1 |
| Galati, C | 1 |
| Lattanzi, D | 1 |
| Savelli, D | 1 |
| Di Palma, M | 1 |
| Saccomanno, S | 1 |
| Bartolini, D | 1 |
| Torquato, P | 1 |
| Ruffolo, G | 1 |
| Olivieri, F | 1 |
| Galli, F | 1 |
| Palma, E | 1 |
| Minelli, A | 1 |
| Cuppini, R | 1 |
| Callaghan, PD | 1 |
| Wimberley, CA | 1 |
| Rahardjo, GL | 1 |
| Berghofer, PJ | 1 |
| Pham, TQ | 1 |
| Jackson, T | 1 |
| Zahra, D | 1 |
| Bourdier, T | 1 |
| Wyatt, N | 1 |
| Greguric, I | 1 |
| Howell, NR | 1 |
| Siegele, R | 1 |
| Pastuovic, Z | 1 |
| Mattner, F | 1 |
| Loc'h, C | 1 |
| Gregoire, MC | 2 |
| Katsifis, A | 1 |
| Zhang, YH | 1 |
| Wang, XM | 1 |
| Ennis, M | 1 |
| Kopach, O | 1 |
| Kao, SC | 1 |
| Petralia, RS | 1 |
| Belan, P | 1 |
| Tao, YX | 1 |
| Voitenko, N | 2 |
| Gerber, G | 1 |
| Youn, D | 1 |
| Randic, M | 1 |
| Tao, F | 1 |
| Skinner, J | 1 |
| Su, Q | 1 |
| Johns, RA | 1 |
| Bolton, C | 1 |
| Paul, C | 1 |
| Boutin, H | 1 |
| Chauveau, F | 1 |
| Thominiaux, C | 1 |
| James, ML | 1 |
| Trebossen, R | 1 |
| Hantraye, P | 1 |
| Dollé, F | 1 |
| Tavitian, B | 1 |
| Kassiou, M | 1 |
| Andrianov, GN | 1 |
| Nozdrachev, AD | 1 |
| Ryzhova, IV | 1 |
| Neugebauer, V | 1 |
| Lücke, T | 1 |
| Schaible, HG | 2 |
| Vasquez, E | 1 |
| Bär, KJ | 1 |
| Ebersberger, A | 1 |
| Klein, B | 1 |
| Vanegas, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of [11C]DPA-713 in Temporal Lobe Epilepsy[NCT01793532] | 38 participants (Actual) | Observational | 2013-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Inflammation
| Article | Year |
|---|---|
Glutamate receptors in neuroinflammatory demyelinating disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Demyelinating Diseases; Encephalo | 2006 |
16 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Inflammation
| Article | Year |
|---|---|
Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport Systems; Animals; Ant | 2022 |
Extracellular vesicles from mesenchymal stem cells reduce neuroinflammation in hippocampus and restore cognitive function in hyperammonemic rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cognition; Extracellular Vesicles | 2023 |
Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study.
Topics: Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Case-Control Studies; C | 2023 |
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cigarette Smoking; Humans; Inflammation; M | 2023 |
Glyphosate-induced glioblastoma cell proliferation: Unraveling the interplay of oxidative, inflammatory, proliferative, and survival signaling pathways.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cell Proliferation; Glioblastoma; Glyphosa | 2023 |
AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis.
Topics: Adolescent; Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anima | 2020 |
Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Tocopherol; Animals; Blood-Brain Bar | 2018 |
Comparison of in vivo binding properties of the 18-kDa translocator protein (TSPO) ligands [(18)F]PBR102 and [ (18)F]PBR111 in a model of excitotoxin-induced neuroinflammation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Carrier Proteins; Imidazol | 2015 |
Effects of neonatal inflammation on descending modulation from the rostroventromedial medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Ne | 2010 |
Inflammation alters trafficking of extrasynaptic AMPA receptors in tonically firing lamina II neurons of the rat spinal dorsal horn.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biotinylation; | 2011 |
Peripheral inflamation-induced increase of AMPA-mediated currents and Ca2+ transients in the presence of cyclothiazide in the rat substantia gelatinosa neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antihypertensive Agents; Benzothi | 2004 |
New role for spinal Stargazin in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated pain sensitization after inflammation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anal | 2006 |
11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation.
Topics: Acetamides; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood-Brain Barrier; | 2007 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-De | 2007 |
Requirement of metabotropic glutamate receptors for the generation of inflammation-evoked hyperexcitability in rat spinal cord neurons.
Topics: Acute Disease; Afferent Pathways; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; | 1994 |
Spinal prostaglandins are involved in the development but not the maintenance of inflammation-induced spinal hyperexcitability.
Topics: Action Potentials; Administration, Topical; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 2001 |