alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Epilepsy in 32 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, knowledge about the typical adverse events (AEs) for ASMs and other coadministered drugs (CDs) is essential for practitioners and patients." | 1.91 | Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy. ( Knake, S; Kovac, S; Rosenow, F; Strzelczyk, A; van der Goten, M; von Podewils, F; Willems, LM; Zöllner, JP, 2023) |
| "Epileptic seizures and LGI1 hypo-functions have been found in both ADLTE, a genetic epileptogenic syndrome and LGI1 limbic encephalitis (LE), an autoimmune disease." | 1.72 | Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies. ( Fels, E; Honnorat, J; Malleval, C; Mayeur, ME; Pascual, O; Vincent, C; Wayere, E, 2022) |
| "Epilepsy is one of the most prevalent and drug-refractory neurological disorders." | 1.48 | ZDHHC8 critically regulates seizure susceptibility in epilepsy. ( Chen, G; Gao, X; He, M; Hu, Y; Li, Y; Ma, Y; Tian, X; Wang, Q; Wang, W; Wang, X; Xu, D; Yang, Q; Yang, Y; Zheng, F; Zhou, R, 2018) |
| "When performing kainic acid-induced seizures in vivo, we showed that elevated seizure susceptibility in Nedd4-2andi mice was normalized when GluA1 is genetically reduced." | 1.46 | Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. ( Chung, HJ; Jewett, KA; Lee, KY; Man, HY; Tsai, NP; Zhu, J, 2017) |
| " injections at 1-h intervals, the first dosage was given shortly after the intrastriatal injection of (S)-alpha-amino-3-hydroxy-5,7-methylisoxazole-4-propionic acid (AMPA) (2." | 1.31 | Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats. ( Banczerowski-Pelyhe, I; Gulyás-Kovács, A; Takács, J; Tarnawa, I; Világi, I, 2002) |
| "There was a commensurate reduction in seizure-related neuronal loss in the limbic regions of the brain." | 1.31 | In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466. ( Lees, GJ; Leong, W, 2001) |
| "Hypoxic encephalopathy is the most common cause of neonatal seizures and can lead to chronic epilepsy." | 1.31 | Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. ( Corfas, G; Jensen, FE; Koh, S; Lamperti, ED; Rio, C; Sanchez, RM; Sharma, D; Wang, C, 2001) |
| "Pregnancy is associated with a significant alteration of NMDA and non-NMDA receptor binding in rats." | 1.30 | N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats. ( Standley, CA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 12 (37.50) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Fels, E | 1 |
| Mayeur, ME | 1 |
| Wayere, E | 1 |
| Vincent, C | 1 |
| Malleval, C | 1 |
| Honnorat, J | 1 |
| Pascual, O | 1 |
| Willems, LM | 1 |
| van der Goten, M | 1 |
| von Podewils, F | 1 |
| Knake, S | 1 |
| Kovac, S | 1 |
| Zöllner, JP | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Fukuyama, K | 1 |
| Fukuzawa, M | 1 |
| Shiroyama, T | 1 |
| Okada, M | 1 |
| Yang, Q | 1 |
| Zheng, F | 1 |
| Hu, Y | 1 |
| Yang, Y | 2 |
| Li, Y | 1 |
| Chen, G | 1 |
| Wang, W | 1 |
| He, M | 1 |
| Zhou, R | 1 |
| Ma, Y | 1 |
| Xu, D | 1 |
| Tian, X | 1 |
| Gao, X | 1 |
| Wang, Q | 1 |
| Wang, X | 1 |
| Rotstein, HG | 1 |
| Morelli, E | 1 |
| Ghiglieri, V | 1 |
| Pendolino, V | 1 |
| Bagetta, V | 1 |
| Pignataro, A | 1 |
| Fejtova, A | 1 |
| Costa, C | 1 |
| Ammassari-Teule, M | 1 |
| Gundelfinger, ED | 1 |
| Picconi, B | 1 |
| Calabresi, P | 1 |
| Muthukumaraswamy, SD | 1 |
| Routley, B | 1 |
| Droog, W | 1 |
| Singh, KD | 1 |
| Hamandi, K | 1 |
| Madeo, M | 1 |
| Stewart, M | 1 |
| Sun, Y | 1 |
| Sahir, N | 1 |
| Wiethoff, S | 1 |
| Chandrasekar, I | 1 |
| Yarrow, A | 1 |
| Rosenfeld, JA | 1 |
| Cordeiro, D | 1 |
| McCormick, EM | 1 |
| Muraresku, CC | 1 |
| Jepperson, TN | 1 |
| McBeth, LJ | 1 |
| Seidahmed, MZ | 1 |
| El Khashab, HY | 1 |
| Hamad, M | 1 |
| Azzedine, H | 1 |
| Clark, K | 1 |
| Corrochano, S | 1 |
| Wells, S | 1 |
| Elting, MW | 1 |
| Weiss, MM | 1 |
| Burn, S | 1 |
| Myers, A | 1 |
| Landsverk, M | 1 |
| Crotwell, PL | 1 |
| Waisfisz, Q | 1 |
| Wolf, NI | 1 |
| Nolan, PM | 1 |
| Padilla-Lopez, S | 1 |
| Houlden, H | 1 |
| Lifton, R | 1 |
| Mane, S | 1 |
| Singh, BB | 1 |
| Falk, MJ | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Bilguvar, K | 1 |
| Salih, MA | 1 |
| Acevedo-Arozena, A | 1 |
| Kruer, MC | 1 |
| Zhu, J | 1 |
| Lee, KY | 1 |
| Jewett, KA | 1 |
| Man, HY | 1 |
| Chung, HJ | 1 |
| Tsai, NP | 1 |
| Yan, B | 1 |
| Li, P | 1 |
| Kaneko, S | 1 |
| Yoshida, S | 1 |
| Világi, I | 1 |
| Takács, J | 1 |
| Gulyás-Kovács, A | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Tarnawa, I | 1 |
| Gitto, R | 1 |
| Orlando, V | 1 |
| Quartarone, S | 1 |
| De Sarro, G | 1 |
| De Sarro, A | 1 |
| Russo, E | 1 |
| Ferreri, G | 1 |
| Chimirri, A | 1 |
| Verleye, M | 1 |
| André, N | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| Epsztein, J | 1 |
| Represa, A | 1 |
| Jorquera, I | 1 |
| Ben-Ari, Y | 1 |
| Crépel, V | 1 |
| Addae, JI | 1 |
| Ali, N | 1 |
| Youssef, FF | 1 |
| Stone, TW | 1 |
| Lee, CY | 1 |
| Fu, WM | 1 |
| Chen, CC | 1 |
| Su, MJ | 1 |
| Liou, HH | 1 |
| Robichaud, LJ | 1 |
| Boxer, PA | 1 |
| Yoneda, Y | 1 |
| Fedele, E | 1 |
| Varnier, G | 1 |
| Raiteri, M | 1 |
| Potschka, H | 1 |
| Löscher, W | 1 |
| Wlaź, P | 1 |
| Behl, B | 1 |
| Hofmann, HP | 1 |
| Treiber, HJ | 1 |
| Szabo, L | 1 |
| Standley, CA | 1 |
| Zilles, K | 1 |
| Qü, MS | 1 |
| Köhling, R | 1 |
| Speckmann, EJ | 1 |
| Pierzchała, K | 1 |
| Kapustecki, J | 1 |
| Lees, GJ | 1 |
| Leong, W | 1 |
| Madsen, U | 1 |
| Stensbøl, TB | 1 |
| Krogsgaard-Larsen, P | 1 |
| Sanchez, RM | 1 |
| Koh, S | 1 |
| Rio, C | 1 |
| Wang, C | 1 |
| Lamperti, ED | 1 |
| Sharma, D | 1 |
| Corfas, G | 1 |
| Jensen, FE | 1 |
| Raol, YH | 1 |
| Lynch, DR | 1 |
| Brooks-Kayal, AR | 1 |
| Traub, RD | 1 |
| Draguhn, A | 1 |
| Whittington, MA | 1 |
| Baldeweg, T | 1 |
| Bibbig, A | 1 |
| Buhl, EH | 1 |
| Schmitz, D | 1 |
| Gale, K | 1 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Hosford, DA | 1 |
| Crain, BJ | 1 |
| Cao, Z | 1 |
| Bonhaus, DW | 1 |
| Friedman, AH | 1 |
| Okazaki, MM | 1 |
| Nadler, JV | 1 |
| McNamara, JO | 1 |
| Pedder, SC | 1 |
| Wilcox, RI | 1 |
| Tuchek, JM | 1 |
| Johnson, DD | 1 |
| Crawford, RD | 1 |
5 reviews available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Epilepsy
| Article | Year |
|---|---|
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Ep | 1993 |
[Stimulating amino acids in epilepsy: possibilities of treatment].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Asparagine; Epilepsy; Fem | 2000 |
Inhibitors of AMPA and kainate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Epilepsy; Humans | 2001 |
Role of excitatory amino acids in developmental epilepsies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Epilepsy; Excitatory Amino Acids; Glutamic | 2001 |
Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Calcium; Carbenoxolone; Ep | 2002 |
1 trial available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Epilepsy
| Article | Year |
|---|---|
The effects of AMPA blockade on the spectral profile of human early visual cortex recordings studied with non-invasive MEG.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cross-Over Studies; Electr | 2016 |
26 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Epilepsy
| Article | Year |
|---|---|
Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoantibodies; Epilepsy; Hippoca | 2022 |
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Epilepsy; Humans; | 2023 |
Pathomechanism of nocturnal paroxysmal dystonia in autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor.
Topics: Alleles; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Substitution; Animals; | 2020 |
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Topics: Acyltransferases; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anima | 2018 |
Abrupt and gradual transitions between low and hyperexcited firing frequencies in neuronal models with fast synaptic excitation: a comparative study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Epilepsy; Female; Humans; Male; Models, Ne | 2013 |
Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Ne | 2014 |
Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Diseases; Electrophysiology; Epileps | 2016 |
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.
Topics: 14-3-3 Proteins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Anim | 2017 |
An integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Comput | 2011 |
[Selection of proper antiepileptic drugs].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Drug Therapy, Combination | 2010 |
Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Anti-Anxiety Ag | 2002 |
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 2003 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, N | 2004 |
Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Electric | 2005 |
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2007 |
Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dentate Gyrus; D | 2008 |
Polyamine modulation of excitatory amino acid responses in the rat cortical wedge.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Biogenic Polyamines; | 1993 |
In vivo microdialysis study of GABA(A) and GABA(B) receptors modulating the glutamate receptor/NO/cyclic GMP pathway in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Epi | 1997 |
LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 1998 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Conv | 1999 |
Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Binding Sites; Dizocilpin | 1999 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 2001 |
Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; | 2001 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus.
Topics: Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding Sites; Cell Sur | 1991 |
Quisqualate receptors in epileptic fowl: the absence of coupling between quisqualate and N-methyl-D-aspartate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Chickens; | 1990 |