alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Epilepsy, Temporal Lobe in 7 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epilepsy is one of the most prevalent and drug-refractory neurological disorders." | 1.48 | ZDHHC8 critically regulates seizure susceptibility in epilepsy. ( Chen, G; Gao, X; He, M; Hu, Y; Li, Y; Ma, Y; Tian, X; Wang, Q; Wang, W; Wang, X; Xu, D; Yang, Q; Yang, Y; Zheng, F; Zhou, R, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Q | 1 |
| Zheng, F | 1 |
| Hu, Y | 1 |
| Yang, Y | 1 |
| Li, Y | 1 |
| Chen, G | 1 |
| Wang, W | 1 |
| He, M | 1 |
| Zhou, R | 1 |
| Ma, Y | 1 |
| Xu, D | 1 |
| Tian, X | 1 |
| Gao, X | 1 |
| Wang, Q | 1 |
| Wang, X | 1 |
| Soman, S | 1 |
| Anju, TR | 1 |
| Jayanarayanan, S | 1 |
| Antony, S | 1 |
| Paulose, CS | 1 |
| Huneau, C | 1 |
| Demont-Guignard, S | 1 |
| Benquet, P | 1 |
| Martin, B | 1 |
| Wendling, F | 1 |
| Palma, E | 1 |
| Esposito, V | 1 |
| Mileo, AM | 1 |
| Di Gennaro, G | 1 |
| Quarato, P | 1 |
| Giangaspero, F | 1 |
| Scoppetta, C | 1 |
| Onorati, P | 1 |
| Trettel, F | 1 |
| Miledi, R | 1 |
| Eusebi, F | 1 |
| Blümcke, I | 1 |
| Beck, H | 1 |
| Scheffler, B | 1 |
| Hof, PR | 1 |
| Morrison, JH | 1 |
| Wolf, HK | 1 |
| Schramm, J | 1 |
| Elger, CE | 1 |
| Wiestler, OD | 1 |
| Okazaki, MM | 1 |
| Molnár, P | 1 |
| Nadler, JV | 1 |
| Isokawa, M | 1 |
7 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Topics: Acyltransferases; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anima | 2018 |
Impaired motor learning attributed to altered AMPA receptor function in the cerebellum of rats with temporal lobe epilepsy: ameliorating effects of Withania somnifera and withanolide A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Carbamazepine; C | 2013 |
Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Co | 2010 |
Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolep | 2002 |
Altered distribution of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-D-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy.
Topics: Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cadaver; Cell Count; Ep | 1996 |
Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicuculline; Dentate Gyrus; Elect | 1999 |
Altered pattern of light transmittance and resistance to AMPA-induced swelling in the dentate gyrus of the epileptic hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 2000 |