alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Chronic Disease in 8 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Giralt, A | 1 |
| Alberch, J | 1 |
| Collon, KW | 1 |
| Zhang, H | 1 |
| Parent, JM | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Zhang, TT | 1 |
| Shen, FY | 1 |
| Ma, LQ | 1 |
| Wen, W | 1 |
| Wang, B | 1 |
| Peng, YZ | 1 |
| Wang, ZR | 1 |
| Zhao, X | 1 |
| Cabrera-Pastor, A | 1 |
| Llansola, M | 1 |
| Reznikov, V | 1 |
| Boix, J | 1 |
| Felipo, V | 1 |
| Garry, EM | 1 |
| Moss, A | 1 |
| Rosie, R | 1 |
| Delaney, A | 1 |
| Mitchell, R | 1 |
| Fleetwood-Walker, SM | 1 |
| Verkuyl, JM | 1 |
| Hemby, SE | 1 |
| Joëls, M | 1 |
| Centonze, D | 1 |
| Gubellini, P | 1 |
| Bernardi, G | 1 |
| Calabresi, P | 1 |
| Kurumaji, A | 1 |
| Ishimaru, M | 1 |
| Toru, M | 1 |
| Maddison, JE | 1 |
| Watson, WE | 1 |
| Dodd, PR | 1 |
| Johnston, GA | 1 |
8 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Chronic Disease
| Article | Year |
|---|---|
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Potentiation of synaptic transmission in Rat anterior cingulate cortex by chronic itch.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Chronic Disease | 2016 |
Differential effects of chronic hyperammonemia on modulation of the glutamate-nitric oxide-cGMP pathway by metabotropic glutamate receptor 5 and low and high affinity AMPA receptors in cerebellum in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blotting, Western; Chronic Diseas | 2012 |
Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carrier Proteins; Cell Membrane; | 2003 |
Chronic stress attenuates GABAergic inhibition and alters gene expression of parvocellular neurons in rat hypothalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2004 |
Impaired excitatory transmission in the striatum of rats chronically intoxicated with manganese.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cerebral Cortex; Chronic D | 2001 |
Alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics.
Topics: 4-Chloromercuribenzenesulfonate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Ac | 1992 |
Alterations in cortical [3H]kainate and alpha-[3H]amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding in a spontaneous canine model of chronic hepatic encephalopathy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Chronic Disease; | 1991 |