alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Cerebral Ischemia in 30 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| "During cerebral ischemia, elevation of TNF-α and glutamate to pathophysiological levels may induce dysregulation of normal synaptic processes, leading ultimately to cell death." | 2.47 | A role for tumor necrosis factor-α in ischemia and ischemic preconditioning. ( O'Connor, JJ; Watters, O, 2011) |
| "Transient focal cerebral ischemia was induced in male Wistar rats for 2 h using the suture occlusion technique." | 1.32 | Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra. ( Kiessling, M; Kollmar, R; Schäbitz, WR; Schwab, S; Sommer, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (63.33) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Giralt, A | 1 |
| Alberch, J | 1 |
| Collon, KW | 1 |
| Zhang, H | 1 |
| Parent, JM | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Chi, OZ | 1 |
| Hunter, C | 1 |
| Liu, X | 1 |
| Weiss, HR | 1 |
| Watters, O | 1 |
| O'Connor, JJ | 1 |
| Yang, CS | 1 |
| Tsai, PJ | 1 |
| Chen, WY | 1 |
| Kuo, JS | 1 |
| Sommer, C | 2 |
| Kollmar, R | 1 |
| Schwab, S | 1 |
| Kiessling, M | 2 |
| Schäbitz, WR | 1 |
| Pinteaux, E | 1 |
| Rothwell, NJ | 1 |
| Boutin, H | 1 |
| Gigler, G | 1 |
| Móricz, K | 1 |
| Agoston, M | 1 |
| Simó, A | 1 |
| Albert, M | 1 |
| Benedek, A | 1 |
| Kapus, G | 1 |
| Kertész, S | 1 |
| Vegh, M | 1 |
| Barkóczy, J | 1 |
| Markó, B | 1 |
| Szabó, G | 1 |
| Matucz, E | 1 |
| Gacsályi, I | 1 |
| Lévay, G | 1 |
| Hársing, LG | 1 |
| Szénási, G | 1 |
| Lecrux, C | 1 |
| Nicole, O | 1 |
| Chazalviel, L | 1 |
| Catone, C | 1 |
| Chuquet, J | 1 |
| MacKenzie, ET | 1 |
| Touzani, O | 1 |
| Nishimoto, T | 1 |
| Kihara, T | 1 |
| Akaike, A | 1 |
| Niidome, T | 1 |
| Sugimoto, H | 1 |
| Tsubokawa, H | 2 |
| Oguro, K | 2 |
| Masuzawa, T | 2 |
| Nakaima, T | 1 |
| Kawai, N | 2 |
| Puel, JL | 1 |
| Pujol, R | 1 |
| Tribillac, F | 1 |
| Ladrech, S | 1 |
| Eybalin, M | 1 |
| Hans, P | 1 |
| Bonhomme, V | 1 |
| Collette, J | 1 |
| Albert, A | 1 |
| Moonen, G | 1 |
| Gill, R | 1 |
| Robinson, HP | 1 |
| LeBlanc, MH | 1 |
| Li, XQ | 1 |
| Huang, M | 1 |
| Patel, DM | 1 |
| Smith, EE | 1 |
| Yoneda, Y | 1 |
| Desos, P | 1 |
| Lepagnol, JM | 1 |
| Morain, P | 1 |
| Lestage, P | 1 |
| Cordi, AA | 1 |
| Nurse, S | 1 |
| Corbett, D | 1 |
| Ikonomidou, C | 2 |
| Turski, L | 2 |
| McDonald, JW | 1 |
| Althomsons, SP | 1 |
| Hyrc, KL | 1 |
| Choi, DW | 1 |
| Goldberg, MP | 1 |
| Morley, P | 1 |
| Small, DL | 1 |
| Murray, CL | 1 |
| Mealing, GA | 1 |
| Poulter, MO | 1 |
| Durkin, JP | 1 |
| Stanimirovic, DB | 1 |
| Calabresi, P | 1 |
| Centonze, D | 1 |
| Pisani, A | 1 |
| Sancesario, G | 1 |
| Gubellini, P | 1 |
| Marfia, GA | 1 |
| Bernardi, G | 1 |
| Koponen, S | 1 |
| Keinänen, R | 1 |
| Roivainen, R | 1 |
| Hirvonen, T | 1 |
| Närhi, M | 1 |
| Chan, PH | 1 |
| Koistinaho, J | 1 |
| Que, M | 1 |
| Schiene, K | 1 |
| Witte, OW | 1 |
| Zilles, K | 1 |
| Fisher, M | 1 |
| Schaebitz, W | 1 |
| Fahrner, A | 1 |
| Moncada, C | 1 |
| Lekieffre, D | 1 |
| Arvin, B | 1 |
| Meldrum, B | 1 |
| Rogers, H | 1 |
| Birch, PJ | 1 |
| Hayes, AG | 1 |
| Sheardown, MJ | 1 |
| Nielsen, EO | 1 |
| Hansen, AJ | 1 |
| Jacobsen, P | 1 |
| Honoré, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Noninvasive Brain Stimulation Training to Help Recover Brain-related Symptoms[NCT03228472] | 100 participants (Anticipated) | Interventional | 2017-11-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Cerebral Ischemia
| Article | Year |
|---|---|
A role for tumor necrosis factor-α in ischemia and ischemic preconditioning.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Glutamic A | 2011 |
The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Humans; Kainic Ac | 1994 |
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Ep | 1993 |
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Bra | 1996 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; | 2000 |
25 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Cerebral Ischemia
| Article | Year |
|---|---|
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoisobutyric Acids; Animals; Blood-Brai | 2009 |
Ionotropic glutamate receptors are involved in malondialdehyde production in anesthetized rat brain cortex: a microdialysis study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Brain; Brain Ischemia | 2003 |
Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain Ische | 2003 |
Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Brain Ischemia; Cell | 2006 |
Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 2007 |
Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Brain Damage, Chr | 2007 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Ca | 2008 |
Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Electrop | 1995 |
Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; | 1994 |
Single glutamate channels in CA1 pyramidal neurones after transient ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Gerbillinae; Kain | 1995 |
AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blood Pressure; | 1995 |
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophy | 1996 |
Neuroprotection after several days of mild, drug-induced hypothermia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain; Brain Is | 1996 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Brain Ischemia; Cel | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillar | 1998 |
Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; | 1998 |
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreadin | 1999 |
Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain Ischemia; | 1999 |
[3H]muscimol binding to gamma-aminobutyric acid(A) receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia-tolerant state.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competi | 2002 |
Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Argin | 1992 |
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gam | 1990 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Ce | 1990 |