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alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Calcinosis

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Calcinosis in 6 studies

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.

Calcinosis: Pathologic deposition of calcium salts in tissues.

Research Excerpts

ExcerptRelevanceReference
" To investigate whether similar effects are present in the hippocampus, AMPA dose-response and calcium movement blockade were performed."1.35Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration. ( Bernal, F; Mahy, N; Petegnief, V; Pugliese, M; Rodríguez, MJ; Ursu, G, 2009)
" To gain more insight into retinal excitotoxicity, we carried out a dose-response study in adult rats using alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), a glutamate analogue."1.32Low sensitivity of retina to AMPA-induced calcification. ( Andrés, N; Mahy, N; Malpesa, Y; Rodríguez, MJ, 2003)
" Because of the lack of specificity of ibotenic acid for a glutamate receptor subtype, a dose-response study with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate was undertaken and calcified areas (identified with Alizarin Red staining) as well as astro- and microglial reactions (by autoradiography with [3H]lazabemide and [3H]Ro 5-4864) were quantified at one month post-lesion."1.30Long-term effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione in the rat basal ganglia: calcification, changes in glutamate receptors and glial reactions. ( Cummins, DJ; Dewar, D; Dragunow, M; Mahy, N; Petegnief, V; Saura, J, 1999)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernal, F3
Petegnief, V2
Rodríguez, MJ2
Ursu, G1
Pugliese, M1
Mahy, N5
Oliveira, A1
Hodges, H1
Rezaie, P1
Andrés, N2
Malpesa, Y1
Saura, J2
Dewar, D1
Cummins, DJ1
Dragunow, M1
Ojuel, J1
Samuel, D1
Kerkerian-LeGoff, L1

Other Studies

6 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Calcinosis

ArticleYear
Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration.
    Journal of neuroscience research, 2009, Volume: 87, Issue:5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anthraquino

2009
Excitotoxic lesioning of the rat basal forebrain with S-AMPA: consequent mineralization and associated glial response.
    Experimental neurology, 2003, Volume: 179, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Nucleus of Meynert; Calcino

2003
Low sensitivity of retina to AMPA-induced calcification.
    Journal of neuroscience research, 2003, May-15, Volume: 72, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcinosis; Dose-Response Relatio

2003
Long-term effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione in the rat basal ganglia: calcification, changes in glutamate receptors and glial reactions.
    Neuroscience, 1999, Volume: 94, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Autoradiography; Basa

1999
Differential vulnerability of hippocampus, basal ganglia, and prefrontal cortex to long-term NMDA excitotoxicity.
    Experimental neurology, 2000, Volume: 161, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Basal Ganglia; C

2000
Age-related resistance to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-induced hippocampal lesion.
    Hippocampus, 2000, Volume: 10, Issue:3

    Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Biom

2000