alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Calcification, Pathologic in 6 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To investigate whether similar effects are present in the hippocampus, AMPA dose-response and calcium movement blockade were performed." | 1.35 | Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration. ( Bernal, F; Mahy, N; Petegnief, V; Pugliese, M; Rodríguez, MJ; Ursu, G, 2009) |
| " To gain more insight into retinal excitotoxicity, we carried out a dose-response study in adult rats using alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), a glutamate analogue." | 1.32 | Low sensitivity of retina to AMPA-induced calcification. ( Andrés, N; Mahy, N; Malpesa, Y; Rodríguez, MJ, 2003) |
| " Because of the lack of specificity of ibotenic acid for a glutamate receptor subtype, a dose-response study with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate was undertaken and calcified areas (identified with Alizarin Red staining) as well as astro- and microglial reactions (by autoradiography with [3H]lazabemide and [3H]Ro 5-4864) were quantified at one month post-lesion." | 1.30 | Long-term effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione in the rat basal ganglia: calcification, changes in glutamate receptors and glial reactions. ( Cummins, DJ; Dewar, D; Dragunow, M; Mahy, N; Petegnief, V; Saura, J, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bernal, F | 3 |
| Petegnief, V | 2 |
| Rodríguez, MJ | 2 |
| Ursu, G | 1 |
| Pugliese, M | 1 |
| Mahy, N | 5 |
| Oliveira, A | 1 |
| Hodges, H | 1 |
| Rezaie, P | 1 |
| Andrés, N | 2 |
| Malpesa, Y | 1 |
| Saura, J | 2 |
| Dewar, D | 1 |
| Cummins, DJ | 1 |
| Dragunow, M | 1 |
| Ojuel, J | 1 |
| Samuel, D | 1 |
| Kerkerian-LeGoff, L | 1 |
6 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Calcification, Pathologic
| Article | Year |
|---|---|
Nimodipine inhibits TMB-8 potentiation of AMPA-induced hippocampal neurodegeneration.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anthraquino | 2009 |
Excitotoxic lesioning of the rat basal forebrain with S-AMPA: consequent mineralization and associated glial response.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Nucleus of Meynert; Calcino | 2003 |
Low sensitivity of retina to AMPA-induced calcification.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcinosis; Dose-Response Relatio | 2003 |
Long-term effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate and 6-nitro-7-sulphamoylbenzo(f)quinoxaline-2,3-dione in the rat basal ganglia: calcification, changes in glutamate receptors and glial reactions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Autoradiography; Basa | 1999 |
Differential vulnerability of hippocampus, basal ganglia, and prefrontal cortex to long-term NMDA excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Basal Ganglia; C | 2000 |
Age-related resistance to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-induced hippocampal lesion.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Biom | 2000 |