alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Brain Ischemia in 30 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Whereas MTA reduced the neuronal cell death in pilocarpine-induced status epilepticus and the size of the lesion in global but not focal ischemic brain damage, it was ineffective in preserving dopaminergic neurons of the substantia nigra in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP)-mice model." | 3.80 | Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. ( Alberch, J; Ceña, V; Collon, KW; Domercq, M; Fernández-Díez, B; Franco, R; Giralt, A; Giralt, E; Gottlieb, M; Lopez, I; Martínez-Pinilla, E; Matute, C; Moreno, B; Parent, JM; Posadas, I; Sánchez-Gómez, MV; Teixido, M; Villoslada, P; Zhang, H, 2014) |
| "During cerebral ischemia, elevation of TNF-α and glutamate to pathophysiological levels may induce dysregulation of normal synaptic processes, leading ultimately to cell death." | 2.47 | A role for tumor necrosis factor-α in ischemia and ischemic preconditioning. ( O'Connor, JJ; Watters, O, 2011) |
| "Transient focal cerebral ischemia was induced in male Wistar rats for 2 h using the suture occlusion technique." | 1.32 | Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra. ( Kiessling, M; Kollmar, R; Schäbitz, WR; Schwab, S; Sommer, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (63.33) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moreno, B | 1 |
| Lopez, I | 1 |
| Fernández-Díez, B | 1 |
| Gottlieb, M | 1 |
| Matute, C | 1 |
| Sánchez-Gómez, MV | 1 |
| Domercq, M | 1 |
| Giralt, A | 1 |
| Alberch, J | 1 |
| Collon, KW | 1 |
| Zhang, H | 1 |
| Parent, JM | 1 |
| Teixido, M | 1 |
| Giralt, E | 1 |
| Ceña, V | 1 |
| Posadas, I | 1 |
| Martínez-Pinilla, E | 1 |
| Villoslada, P | 1 |
| Franco, R | 1 |
| Chi, OZ | 1 |
| Hunter, C | 1 |
| Liu, X | 1 |
| Weiss, HR | 1 |
| Watters, O | 1 |
| O'Connor, JJ | 1 |
| Yang, CS | 1 |
| Tsai, PJ | 1 |
| Chen, WY | 1 |
| Kuo, JS | 1 |
| Sommer, C | 2 |
| Kollmar, R | 1 |
| Schwab, S | 1 |
| Kiessling, M | 2 |
| Schäbitz, WR | 1 |
| Pinteaux, E | 1 |
| Rothwell, NJ | 1 |
| Boutin, H | 1 |
| Gigler, G | 1 |
| Móricz, K | 1 |
| Agoston, M | 1 |
| Simó, A | 1 |
| Albert, M | 1 |
| Benedek, A | 1 |
| Kapus, G | 1 |
| Kertész, S | 1 |
| Vegh, M | 1 |
| Barkóczy, J | 1 |
| Markó, B | 1 |
| Szabó, G | 1 |
| Matucz, E | 1 |
| Gacsályi, I | 1 |
| Lévay, G | 1 |
| Hársing, LG | 1 |
| Szénási, G | 1 |
| Lecrux, C | 1 |
| Nicole, O | 1 |
| Chazalviel, L | 1 |
| Catone, C | 1 |
| Chuquet, J | 1 |
| MacKenzie, ET | 1 |
| Touzani, O | 1 |
| Nishimoto, T | 1 |
| Kihara, T | 1 |
| Akaike, A | 1 |
| Niidome, T | 1 |
| Sugimoto, H | 1 |
| Tsubokawa, H | 2 |
| Oguro, K | 2 |
| Masuzawa, T | 2 |
| Nakaima, T | 1 |
| Kawai, N | 2 |
| Puel, JL | 1 |
| Pujol, R | 1 |
| Tribillac, F | 1 |
| Ladrech, S | 1 |
| Eybalin, M | 1 |
| Hans, P | 1 |
| Bonhomme, V | 1 |
| Collette, J | 1 |
| Albert, A | 1 |
| Moonen, G | 1 |
| Gill, R | 1 |
| Robinson, HP | 1 |
| LeBlanc, MH | 1 |
| Li, XQ | 1 |
| Huang, M | 1 |
| Patel, DM | 1 |
| Smith, EE | 1 |
| Yoneda, Y | 1 |
| Desos, P | 1 |
| Lepagnol, JM | 1 |
| Morain, P | 1 |
| Lestage, P | 1 |
| Cordi, AA | 1 |
| Nurse, S | 1 |
| Corbett, D | 1 |
| Ikonomidou, C | 2 |
| Turski, L | 2 |
| McDonald, JW | 1 |
| Althomsons, SP | 1 |
| Hyrc, KL | 1 |
| Choi, DW | 1 |
| Goldberg, MP | 1 |
| Morley, P | 1 |
| Small, DL | 1 |
| Murray, CL | 1 |
| Mealing, GA | 1 |
| Poulter, MO | 1 |
| Durkin, JP | 1 |
| Stanimirovic, DB | 1 |
| Calabresi, P | 1 |
| Centonze, D | 1 |
| Pisani, A | 1 |
| Sancesario, G | 1 |
| Gubellini, P | 1 |
| Marfia, GA | 1 |
| Bernardi, G | 1 |
| Koponen, S | 1 |
| Keinänen, R | 1 |
| Roivainen, R | 1 |
| Hirvonen, T | 1 |
| Närhi, M | 1 |
| Chan, PH | 1 |
| Koistinaho, J | 1 |
| Que, M | 1 |
| Schiene, K | 1 |
| Witte, OW | 1 |
| Zilles, K | 1 |
| Fisher, M | 1 |
| Schaebitz, W | 1 |
| Fahrner, A | 1 |
| Moncada, C | 1 |
| Lekieffre, D | 1 |
| Arvin, B | 1 |
| Meldrum, B | 1 |
| Rogers, H | 1 |
| Birch, PJ | 1 |
| Hayes, AG | 1 |
| Sheardown, MJ | 1 |
| Nielsen, EO | 1 |
| Hansen, AJ | 1 |
| Jacobsen, P | 1 |
| Honoré, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Noninvasive Brain Stimulation Training to Help Recover Brain-related Symptoms[NCT03228472] | 100 participants (Anticipated) | Interventional | 2017-11-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Brain Ischemia
| Article | Year |
|---|---|
A role for tumor necrosis factor-α in ischemia and ischemic preconditioning.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Glutamic A | 2011 |
The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Humans; Kainic Ac | 1994 |
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Ep | 1993 |
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Bra | 1996 |
An overview of acute stroke therapy: past, present, and future.
Topics: Acute Disease; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antibodies; Brain Ischemia; | 2000 |
25 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Brain Ischemia
| Article | Year |
|---|---|
Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine.
Topics: Acute Disease; Adrenergic Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ani | 2014 |
Effects of exogenous excitatory amino acid neurotransmitters on blood-brain barrier disruption in focal cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoisobutyric Acids; Animals; Blood-Brai | 2009 |
Ionotropic glutamate receptors are involved in malondialdehyde production in anesthetized rat brain cortex: a microdialysis study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Brain; Brain Ischemia | 2003 |
Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain Ische | 2003 |
Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Brain Ischemia; Cell | 2006 |
Neuroprotective and anticonvulsant effects of EGIS-8332, a non-competitive AMPA receptor antagonist, in a range of animal models.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 2007 |
Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Brain Damage, Chr | 2007 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Ca | 2008 |
Effects of a spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Electrop | 1995 |
Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; | 1994 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; | 1994 |
Single glutamate channels in CA1 pyramidal neurones after transient ischaemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Gerbillinae; Kain | 1995 |
AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blood Pressure; | 1995 |
Structure-activity relationships in a series of 2(1H)-quinolones bearing different acidic function in the 3-position: 6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid, a new potent and selective AMPA/kainate antagonist with neuroprotective properties.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Ischemia; Electrophy | 1996 |
Neuroprotection after several days of mild, drug-induced hypothermia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain; Brain Is | 1996 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antioxidants; Brain Ischemia; Cel | 1998 |
Evidence that functional glutamate receptors are not expressed on rat or human cerebromicrovascular endothelial cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Calcium; Capillar | 1998 |
Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: implications for ischemia and Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; | 1998 |
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreadin | 1999 |
Widespread up-regulation of N-methyl-D-aspartate receptors after focal photothrombotic lesion in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain Ischemia; | 1999 |
[3H]muscimol binding to gamma-aminobutyric acid(A) receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia-tolerant state.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competi | 2002 |
Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Argin | 1992 |
Effects of hypoxia and hypoglycaemia on DC potentials recorded from the gerbil hippocampus in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cell Hypoxia; gam | 1990 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Ce | 1990 |