alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Brain Injuries in 17 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For this purpose we conducted a dose-response study at concentrations of AMPA between 0." | 1.35 | Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain. ( Andrés, N; Batlle, M; Mahy, N; Malpesa, Y; Prats, A; Pugliese, M; Rodríguez, MJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amini, M | 1 |
| Ma, CL | 1 |
| Farazifard, R | 1 |
| Zhu, G | 1 |
| Zhang, Y | 1 |
| Vanderluit, J | 1 |
| Zoltewicz, JS | 1 |
| Hage, F | 1 |
| Savitt, JM | 1 |
| Lagace, DC | 1 |
| Slack, RS | 1 |
| Beique, JC | 1 |
| Baudry, M | 1 |
| Greer, PA | 1 |
| Bergeron, R | 1 |
| Park, DS | 1 |
| O'Hare Doig, RL | 1 |
| Fitzgerald, M | 1 |
| Klein, KU | 1 |
| Johannes, A | 1 |
| Brückner, M | 1 |
| Thomas, R | 1 |
| Matthews, S | 1 |
| Frauenknecht, K | 1 |
| Leukel, P | 1 |
| Mazur, J | 1 |
| Poplawski, A | 1 |
| Muellenbach, R | 1 |
| Sommer, CJ | 1 |
| Thal, SC | 1 |
| Engelhard, K | 1 |
| Kim, SJ | 1 |
| Lee, K | 1 |
| Rodríguez, MJ | 1 |
| Prats, A | 1 |
| Malpesa, Y | 1 |
| Andrés, N | 1 |
| Pugliese, M | 1 |
| Batlle, M | 1 |
| Mahy, N | 1 |
| Luoma, JI | 1 |
| Kelley, BG | 1 |
| Mermelstein, PG | 1 |
| Cosi, C | 1 |
| Guerin, K | 1 |
| Marien, M | 1 |
| Koek, W | 1 |
| Rollet, K | 1 |
| Fowler, JH | 1 |
| Edgar, JM | 1 |
| Pringle, A | 1 |
| McLaughlin, M | 1 |
| McCulloch, J | 1 |
| Griffiths, IR | 1 |
| Garbern, JY | 1 |
| Nave, KA | 1 |
| Dewar, D | 1 |
| Slemmer, JE | 1 |
| Haasdijk, ED | 1 |
| Engel, DC | 1 |
| Plesnila, N | 1 |
| Weber, JT | 1 |
| Palmer, AM | 1 |
| Marion, DW | 1 |
| Botscheller, ML | 1 |
| Swedlow, PE | 1 |
| Styren, SD | 1 |
| DeKosky, ST | 1 |
| Araujo, M | 1 |
| Wandosell, F | 1 |
| Regan, RF | 1 |
| Panter, SS | 1 |
| Ikonomidou, C | 3 |
| Turski, L | 3 |
| Goforth, PB | 1 |
| Ellis, EF | 1 |
| Satin, LS | 1 |
| Stefovska, V | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Brain Injuries
| Article | Year |
|---|---|
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Bra | 1996 |
16 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Brain Injuries
| Article | Year |
|---|---|
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazol | 2013 |
Novel combinations of ion channel inhibitors for treatment of neurotrauma.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Injuries; Calcium; Humans; Ion Chann | 2015 |
Systemic PaO2 Oscillations Cause Mild Brain Injury in a Pig Model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Gas Analysis; Brain Injurie | 2016 |
Extracts of Liriopsis tuber protect AMPA induced brain damage and improve memory with the activation of insulin receptor and ERK I/II.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Avoidance Learning; Brain Injurie | 2008 |
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Atroph | 2009 |
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2011 |
The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzamide | 2004 |
Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Blotting, Western; Brain I | 2006 |
Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Injuries; Calbi | 2007 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain | 1993 |
Differential cellular response after glutamate analog hippocampal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biomarkers; Brain; Br | 1996 |
Hemoglobin potentiates excitotoxic injury in cortical cell culture.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxid | 1996 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Enhancement of AMPA-mediated current after traumatic injury in cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anim | 1999 |
Neuronal death enhanced by N-methyl-D-aspartate antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizoc | 2000 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |