alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Brain Disorders in 12 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the face of these data, one therapeutic approach is to increase BDNF bioavailability in brain." | 2.82 | Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease. ( Keifer, J, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Keifer, J | 1 |
| Madeo, M | 1 |
| Stewart, M | 1 |
| Sun, Y | 1 |
| Sahir, N | 1 |
| Wiethoff, S | 1 |
| Chandrasekar, I | 1 |
| Yarrow, A | 1 |
| Rosenfeld, JA | 1 |
| Yang, Y | 1 |
| Cordeiro, D | 1 |
| McCormick, EM | 1 |
| Muraresku, CC | 1 |
| Jepperson, TN | 1 |
| McBeth, LJ | 1 |
| Seidahmed, MZ | 1 |
| El Khashab, HY | 1 |
| Hamad, M | 1 |
| Azzedine, H | 1 |
| Clark, K | 1 |
| Corrochano, S | 1 |
| Wells, S | 1 |
| Elting, MW | 1 |
| Weiss, MM | 1 |
| Burn, S | 1 |
| Myers, A | 1 |
| Landsverk, M | 1 |
| Crotwell, PL | 1 |
| Waisfisz, Q | 1 |
| Wolf, NI | 1 |
| Nolan, PM | 1 |
| Padilla-Lopez, S | 1 |
| Houlden, H | 1 |
| Lifton, R | 1 |
| Mane, S | 1 |
| Singh, BB | 1 |
| Falk, MJ | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Bilguvar, K | 1 |
| Salih, MA | 1 |
| Acevedo-Arozena, A | 1 |
| Kruer, MC | 1 |
| Szárics, E | 1 |
| LaszTóczi, B | 1 |
| Nyikos, L | 1 |
| Barabás, P | 1 |
| Kovács, I | 1 |
| Skuban, N | 1 |
| Nagy, PI | 1 |
| Kökösi, J | 1 |
| Takácsné, NK | 1 |
| Kardos, J | 1 |
| Han, Y | 1 |
| Kwon, EH | 1 |
| Kim, SJ | 1 |
| Munirathinam, S | 1 |
| Bahr, BA | 1 |
| Wolf, G | 2 |
| Henschke, G | 1 |
| Würdig, S | 1 |
| Greene, JG | 2 |
| Greenamyre, JT | 2 |
| Fischer, S | 1 |
| Keilhoff, G | 1 |
| Hass, P | 1 |
| Lehmann, JC | 1 |
| Procureur, D | 1 |
| Wood, PL | 1 |
| Li, H | 1 |
| Buchan, AM | 1 |
| Ballard, TM | 1 |
| Hunter, AJ | 1 |
| Bennett, GW | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Brain Disorders
| Article | Year |
|---|---|
Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Brain-Derived Neu | 2022 |
11 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Brain Disorders
| Article | Year |
|---|---|
Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Diseases; Electrophysiology; Epileps | 2016 |
[EFfect of quinazolone-alkyl-carboxylic acid derivatives on the transmembrane Ca2+ ion flux mediated by AMPA receptors].
Topics: Alkylation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Diseases; Calcium; Carbo | 2002 |
Protection of brain cells against AMPA-induced damage by Asiasari Radix extracts.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Asarum; Brain Diseases; Cerebral | 2003 |
Repeated contact with subtoxic soman leads to synaptic vulnerability in hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blotting, Weste | 2004 |
Glutamate agonist-induced hippocampal lesion and nitric oxide synthase/NADPH-diaphorase: a light and electron microscopical study in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Benzo | 1993 |
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain Diseases; | 1995 |
Exacerbation of NMDA, AMPA, and L-glutamate excitotoxicity by the succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Brain Diseases; Dizocilpin | 1995 |
Mg2+ antagonizes alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced brain damage and convulsions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Ibotenic Acid; Ma | 1993 |
7-Chlorokynurenate prevents NMDA-induced and kainate-induced striatal lesions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Choline O-Acetylt | 1993 |
Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 1993 |
Effect of a thyrotrophin-releasing hormone analogue, RX77368, on AMPA-induced septal-hippocampal lesioned rats in an operant delayed non-matching to position test.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Hippocampus; Male | 1996 |