alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Aura in 32 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, knowledge about the typical adverse events (AEs) for ASMs and other coadministered drugs (CDs) is essential for practitioners and patients." | 1.91 | Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy. ( Knake, S; Kovac, S; Rosenow, F; Strzelczyk, A; van der Goten, M; von Podewils, F; Willems, LM; Zöllner, JP, 2023) |
| "Epileptic seizures and LGI1 hypo-functions have been found in both ADLTE, a genetic epileptogenic syndrome and LGI1 limbic encephalitis (LE), an autoimmune disease." | 1.72 | Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies. ( Fels, E; Honnorat, J; Malleval, C; Mayeur, ME; Pascual, O; Vincent, C; Wayere, E, 2022) |
| "Epilepsy is one of the most prevalent and drug-refractory neurological disorders." | 1.48 | ZDHHC8 critically regulates seizure susceptibility in epilepsy. ( Chen, G; Gao, X; He, M; Hu, Y; Li, Y; Ma, Y; Tian, X; Wang, Q; Wang, W; Wang, X; Xu, D; Yang, Q; Yang, Y; Zheng, F; Zhou, R, 2018) |
| "When performing kainic acid-induced seizures in vivo, we showed that elevated seizure susceptibility in Nedd4-2andi mice was normalized when GluA1 is genetically reduced." | 1.46 | Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. ( Chung, HJ; Jewett, KA; Lee, KY; Man, HY; Tsai, NP; Zhu, J, 2017) |
| " injections at 1-h intervals, the first dosage was given shortly after the intrastriatal injection of (S)-alpha-amino-3-hydroxy-5,7-methylisoxazole-4-propionic acid (AMPA) (2." | 1.31 | Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats. ( Banczerowski-Pelyhe, I; Gulyás-Kovács, A; Takács, J; Tarnawa, I; Világi, I, 2002) |
| "There was a commensurate reduction in seizure-related neuronal loss in the limbic regions of the brain." | 1.31 | In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466. ( Lees, GJ; Leong, W, 2001) |
| "Hypoxic encephalopathy is the most common cause of neonatal seizures and can lead to chronic epilepsy." | 1.31 | Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. ( Corfas, G; Jensen, FE; Koh, S; Lamperti, ED; Rio, C; Sanchez, RM; Sharma, D; Wang, C, 2001) |
| "Pregnancy is associated with a significant alteration of NMDA and non-NMDA receptor binding in rats." | 1.30 | N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats. ( Standley, CA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 12 (37.50) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Fels, E | 1 |
| Mayeur, ME | 1 |
| Wayere, E | 1 |
| Vincent, C | 1 |
| Malleval, C | 1 |
| Honnorat, J | 1 |
| Pascual, O | 1 |
| Willems, LM | 1 |
| van der Goten, M | 1 |
| von Podewils, F | 1 |
| Knake, S | 1 |
| Kovac, S | 1 |
| Zöllner, JP | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Fukuyama, K | 1 |
| Fukuzawa, M | 1 |
| Shiroyama, T | 1 |
| Okada, M | 1 |
| Yang, Q | 1 |
| Zheng, F | 1 |
| Hu, Y | 1 |
| Yang, Y | 2 |
| Li, Y | 1 |
| Chen, G | 1 |
| Wang, W | 1 |
| He, M | 1 |
| Zhou, R | 1 |
| Ma, Y | 1 |
| Xu, D | 1 |
| Tian, X | 1 |
| Gao, X | 1 |
| Wang, Q | 1 |
| Wang, X | 1 |
| Rotstein, HG | 1 |
| Morelli, E | 1 |
| Ghiglieri, V | 1 |
| Pendolino, V | 1 |
| Bagetta, V | 1 |
| Pignataro, A | 1 |
| Fejtova, A | 1 |
| Costa, C | 1 |
| Ammassari-Teule, M | 1 |
| Gundelfinger, ED | 1 |
| Picconi, B | 1 |
| Calabresi, P | 1 |
| Muthukumaraswamy, SD | 1 |
| Routley, B | 1 |
| Droog, W | 1 |
| Singh, KD | 1 |
| Hamandi, K | 1 |
| Madeo, M | 1 |
| Stewart, M | 1 |
| Sun, Y | 1 |
| Sahir, N | 1 |
| Wiethoff, S | 1 |
| Chandrasekar, I | 1 |
| Yarrow, A | 1 |
| Rosenfeld, JA | 1 |
| Cordeiro, D | 1 |
| McCormick, EM | 1 |
| Muraresku, CC | 1 |
| Jepperson, TN | 1 |
| McBeth, LJ | 1 |
| Seidahmed, MZ | 1 |
| El Khashab, HY | 1 |
| Hamad, M | 1 |
| Azzedine, H | 1 |
| Clark, K | 1 |
| Corrochano, S | 1 |
| Wells, S | 1 |
| Elting, MW | 1 |
| Weiss, MM | 1 |
| Burn, S | 1 |
| Myers, A | 1 |
| Landsverk, M | 1 |
| Crotwell, PL | 1 |
| Waisfisz, Q | 1 |
| Wolf, NI | 1 |
| Nolan, PM | 1 |
| Padilla-Lopez, S | 1 |
| Houlden, H | 1 |
| Lifton, R | 1 |
| Mane, S | 1 |
| Singh, BB | 1 |
| Falk, MJ | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Bilguvar, K | 1 |
| Salih, MA | 1 |
| Acevedo-Arozena, A | 1 |
| Kruer, MC | 1 |
| Zhu, J | 1 |
| Lee, KY | 1 |
| Jewett, KA | 1 |
| Man, HY | 1 |
| Chung, HJ | 1 |
| Tsai, NP | 1 |
| Yan, B | 1 |
| Li, P | 1 |
| Kaneko, S | 1 |
| Yoshida, S | 1 |
| Világi, I | 1 |
| Takács, J | 1 |
| Gulyás-Kovács, A | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Tarnawa, I | 1 |
| Gitto, R | 1 |
| Orlando, V | 1 |
| Quartarone, S | 1 |
| De Sarro, G | 1 |
| De Sarro, A | 1 |
| Russo, E | 1 |
| Ferreri, G | 1 |
| Chimirri, A | 1 |
| Verleye, M | 1 |
| André, N | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| Epsztein, J | 1 |
| Represa, A | 1 |
| Jorquera, I | 1 |
| Ben-Ari, Y | 1 |
| Crépel, V | 1 |
| Addae, JI | 1 |
| Ali, N | 1 |
| Youssef, FF | 1 |
| Stone, TW | 1 |
| Lee, CY | 1 |
| Fu, WM | 1 |
| Chen, CC | 1 |
| Su, MJ | 1 |
| Liou, HH | 1 |
| Robichaud, LJ | 1 |
| Boxer, PA | 1 |
| Yoneda, Y | 1 |
| Fedele, E | 1 |
| Varnier, G | 1 |
| Raiteri, M | 1 |
| Potschka, H | 1 |
| Löscher, W | 1 |
| Wlaź, P | 1 |
| Behl, B | 1 |
| Hofmann, HP | 1 |
| Treiber, HJ | 1 |
| Szabo, L | 1 |
| Standley, CA | 1 |
| Zilles, K | 1 |
| Qü, MS | 1 |
| Köhling, R | 1 |
| Speckmann, EJ | 1 |
| Pierzchała, K | 1 |
| Kapustecki, J | 1 |
| Lees, GJ | 1 |
| Leong, W | 1 |
| Madsen, U | 1 |
| Stensbøl, TB | 1 |
| Krogsgaard-Larsen, P | 1 |
| Sanchez, RM | 1 |
| Koh, S | 1 |
| Rio, C | 1 |
| Wang, C | 1 |
| Lamperti, ED | 1 |
| Sharma, D | 1 |
| Corfas, G | 1 |
| Jensen, FE | 1 |
| Raol, YH | 1 |
| Lynch, DR | 1 |
| Brooks-Kayal, AR | 1 |
| Traub, RD | 1 |
| Draguhn, A | 1 |
| Whittington, MA | 1 |
| Baldeweg, T | 1 |
| Bibbig, A | 1 |
| Buhl, EH | 1 |
| Schmitz, D | 1 |
| Gale, K | 1 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Hosford, DA | 1 |
| Crain, BJ | 1 |
| Cao, Z | 1 |
| Bonhaus, DW | 1 |
| Friedman, AH | 1 |
| Okazaki, MM | 1 |
| Nadler, JV | 1 |
| McNamara, JO | 1 |
| Pedder, SC | 1 |
| Wilcox, RI | 1 |
| Tuchek, JM | 1 |
| Johnson, DD | 1 |
| Crawford, RD | 1 |
5 reviews available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Aura
| Article | Year |
|---|---|
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Ep | 1993 |
[Stimulating amino acids in epilepsy: possibilities of treatment].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Asparagine; Epilepsy; Fem | 2000 |
Inhibitors of AMPA and kainate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Epilepsy; Humans | 2001 |
Role of excitatory amino acids in developmental epilepsies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Epilepsy; Excitatory Amino Acids; Glutamic | 2001 |
Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Calcium; Carbenoxolone; Ep | 2002 |
1 trial available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Aura
| Article | Year |
|---|---|
The effects of AMPA blockade on the spectral profile of human early visual cortex recordings studied with non-invasive MEG.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cross-Over Studies; Electr | 2016 |
26 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Aura
| Article | Year |
|---|---|
Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoantibodies; Epilepsy; Hippoca | 2022 |
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Epilepsy; Humans; | 2023 |
Pathomechanism of nocturnal paroxysmal dystonia in autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor.
Topics: Alleles; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Substitution; Animals; | 2020 |
ZDHHC8 critically regulates seizure susceptibility in epilepsy.
Topics: Acyltransferases; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anima | 2018 |
Abrupt and gradual transitions between low and hyperexcited firing frequencies in neuronal models with fast synaptic excitation: a comparative study.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Epilepsy; Female; Humans; Male; Models, Ne | 2013 |
Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Ne | 2014 |
Loss-of-Function Mutations in FRRS1L Lead to an Epileptic-Dyskinetic Encephalopathy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Diseases; Electrophysiology; Epileps | 2016 |
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.
Topics: 14-3-3 Proteins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Anim | 2017 |
An integrative view of mechanisms underlying generalized spike-and-wave epileptic seizures and its implication on optimal therapeutic treatments.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Comput | 2011 |
[Selection of proper antiepileptic drugs].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Drug Therapy, Combination | 2010 |
Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Anti-Anxiety Ag | 2002 |
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; | 2003 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, N | 2004 |
Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal; Electric | 2005 |
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2007 |
Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dentate Gyrus; D | 2008 |
Polyamine modulation of excitatory amino acid responses in the rat cortical wedge.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Biogenic Polyamines; | 1993 |
In vivo microdialysis study of GABA(A) and GABA(B) receptors modulating the glutamate receptor/NO/cyclic GMP pathway in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Epi | 1997 |
LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, | 1998 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Conv | 1999 |
Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Binding Sites; Dizocilpin | 1999 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 2001 |
Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; | 2001 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus.
Topics: Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding Sites; Cell Sur | 1991 |
Quisqualate receptors in epileptic fowl: the absence of coupling between quisqualate and N-methyl-D-aspartate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Chickens; | 1990 |