alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Anoxia, Brain in 10 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypoxic encephalopathy is the most common cause of neonatal seizures and can lead to chronic epilepsy." | 1.31 | Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. ( Corfas, G; Jensen, FE; Koh, S; Lamperti, ED; Rio, C; Sanchez, RM; Sharma, D; Wang, C, 2001) |
| " KA and AMPA were found to be more toxic than either N-methyl-D-aspartate (NMDA), quinolinate, or glutamate, both under normal conditions and under states of energy deprivation." | 1.29 | Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation. ( Rigor, BM; Schurr, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Raveh, L | 1 |
| Weissman, BA | 1 |
| Cohen, G | 1 |
| Alkalay, D | 1 |
| Rabinovitz, I | 1 |
| Sonego, H | 1 |
| Brandeis, R | 1 |
| Russell, JC | 1 |
| Blue, ME | 1 |
| Johnston, MV | 1 |
| Naidu, S | 1 |
| Hossain, MA | 1 |
| Schurr, A | 2 |
| Payne, RS | 1 |
| Rigor, BM | 2 |
| LeBlanc, MH | 1 |
| Li, XQ | 1 |
| Huang, M | 1 |
| Patel, DM | 1 |
| Smith, EE | 1 |
| Khazipov, R | 1 |
| Congar, P | 1 |
| Ben-Ari, Y | 1 |
| Banno, T | 1 |
| Kohno, K | 1 |
| Sinor, AD | 1 |
| Greenberg, DA | 1 |
| Barenberg, P | 1 |
| Strahlendorf, H | 1 |
| Strahlendorf, J | 1 |
| Sanchez, RM | 1 |
| Koh, S | 1 |
| Rio, C | 1 |
| Wang, C | 1 |
| Lamperti, ED | 1 |
| Sharma, D | 1 |
| Corfas, G | 1 |
| Jensen, FE | 1 |
1 trial available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Anoxia, Brain
| Article | Year |
|---|---|
Caramiphen and scopolamine prevent soman-induced brain damage and cognitive dysfunction.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cognition Disorders; Cyclopentane | 2002 |
9 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Anoxia, Brain
| Article | Year |
|---|---|
Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Caspase 3; Cell Hypoxi | 2007 |
Protection by MK-801 against hypoxia-, excitotoxin-, and depolarization-induced neuronal damage in vitro.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anti-Anxiety | 1995 |
AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blood Pressure; | 1995 |
Kainate toxicity in energy-compromised rat hippocampal slices: differences between oxygen and glucose deprivation.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calc | 1993 |
Hippocampal CA1 lacunosum-moleculare interneurons: comparison of effects of anoxia on excitatory and inhibitory postsynaptic currents.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evoked Pote | 1995 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calc | 1998 |
Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Culture Techniqu | 2000 |
Hypoxia induces an excitotoxic-type of dark cell degeneration in cerebellar Purkinje neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Death; Chromatin; DNA Fragme | 2001 |
Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; | 2001 |