alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Amyotrophic Lateral Sclerosis in 13 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mutations in the hypoxia-inducible factor angiogenin (ANG) have been identified in Amyotrophic Lateral Sclerosis (ALS) patients, but the potential role of ANG in ALS pathogenesis was undetermined." | 3.74 | Control of motoneuron survival by angiogenin. ( Concannon, CG; Connaughton, D; Fenner, B; Greenway, MJ; Hardiman, O; Kieran, D; King, MA; Prehn, JH; Sebastia, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Widagdo, J | 1 |
| Udagedara, S | 1 |
| Bhembre, N | 1 |
| Tan, JZA | 1 |
| Neureiter, L | 1 |
| Huang, J | 1 |
| Anggono, V | 1 |
| Lee, M | 1 |
| Ramirez-Jarquin, UN | 1 |
| Lopez-Huerta, VG | 1 |
| Tapia, R | 3 |
| Prior-González, M | 1 |
| Lazo-Gómez, R | 1 |
| Kieran, D | 1 |
| Sebastia, J | 1 |
| Greenway, MJ | 1 |
| King, MA | 1 |
| Connaughton, D | 1 |
| Concannon, CG | 1 |
| Fenner, B | 1 |
| Hardiman, O | 1 |
| Prehn, JH | 1 |
| Lai, C | 2 |
| Xie, C | 2 |
| Shim, H | 2 |
| Chandran, J | 2 |
| Howell, BW | 1 |
| Cai, H | 2 |
| Platania, P | 1 |
| Seminara, G | 1 |
| Aronica, E | 1 |
| Troost, D | 1 |
| Vincenza Catania, M | 1 |
| Angela Sortino, M | 1 |
| McCormack, SG | 1 |
| Chiang, HC | 1 |
| Michalak, MK | 1 |
| Lin, X | 1 |
| Shimoji, M | 1 |
| Cookson, MR | 1 |
| Huganir, RL | 1 |
| Rothstein, JD | 1 |
| Price, DL | 1 |
| Wong, PC | 1 |
| Martin, LJ | 1 |
| Zhu, JJ | 1 |
| Van Damme, P | 1 |
| Bogaert, E | 1 |
| Dewil, M | 1 |
| Hersmus, N | 1 |
| Kiraly, D | 1 |
| Scheveneels, W | 1 |
| Bockx, I | 1 |
| Braeken, D | 1 |
| Verpoorten, N | 1 |
| Verhoeven, K | 1 |
| Timmerman, V | 1 |
| Herijgers, P | 1 |
| Callewaert, G | 1 |
| Carmeliet, P | 1 |
| Van Den Bosch, L | 1 |
| Robberecht, W | 2 |
| Corona, JC | 1 |
| Mennini, T | 2 |
| Cagnotto, A | 1 |
| Carvelli, L | 1 |
| Comoletti, D | 2 |
| Manzoni, C | 1 |
| Muzio, V | 2 |
| Rizzi, M | 1 |
| Vezzani, A | 1 |
| Vartiainen, N | 1 |
| Tikka, T | 1 |
| Keinänen, R | 1 |
| Chan, PH | 1 |
| Koistinaho, J | 1 |
| Vandenberghe, W | 1 |
| Brorson, JR | 1 |
| Capobianco, A | 1 |
| Ravizza, T | 1 |
13 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Familial ALS-associated
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Glutamine; | 2022 |
Characterization of Mitochondria Degeneration in Spinal Motor Neurons Triggered by Chronic Over-activation of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors in the Rat Spinal Cord in Vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Ca | 2023 |
Sodium butyrate does not protect spinal motor neurons from AMPA-induced excitotoxic degeneration in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Bu | 2023 |
Control of motoneuron survival by angiogenin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Androstadie | 2008 |
Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; En | 2009 |
17beta-estradiol rescues spinal motoneurons from AMPA-induced toxicity: a role for glial cells.
Topics: Adult; Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophi | 2005 |
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Topics: Adaptor Proteins, Signal Transducing; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyo | 2006 |
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; As | 2007 |
Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Ca | 2008 |
Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic L | 1999 |
Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyo | 1999 |
AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Ca | 2000 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; An | 2001 |