alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Aging in 52 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Specific [3H]glutamate binding to synaptic membranes from the cerebral cortex and hippocampus of 7-, 12- and 18-day-old rats was examined, both in control animals and during seizures induced by homocysteine." | 7.69 | Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures. ( Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F, 1997) |
| "Specific [3H]glutamate binding to synaptic membranes from the cerebral cortex and hippocampus of 7-, 12- and 18-day-old rats was examined, both in control animals and during seizures induced by homocysteine." | 3.69 | Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures. ( Folbergrová, J; Haugvicová, R; Lisý, V; Stastný, F, 1997) |
| "In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area but not in dentate gyrus (DG)." | 1.42 | Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease. ( Borsello, T; Calabresi, P; Costa, C; de Iure, A; Di Filippo, M; Ghiglieri, V; Sclip, A; Tantucci, M; Tozzi, A, 2015) |
| "Hypoxic encephalopathy is the most common cause of neonatal seizures and can lead to chronic epilepsy." | 1.31 | Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures. ( Corfas, G; Jensen, FE; Koh, S; Lamperti, ED; Rio, C; Sanchez, RM; Sharma, D; Wang, C, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.92) | 18.7374 |
| 1990's | 32 (61.54) | 18.2507 |
| 2000's | 12 (23.08) | 29.6817 |
| 2010's | 7 (13.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, T | 1 |
| Jiang, CY | 1 |
| Fujita, T | 1 |
| Luo, SW | 1 |
| Kumamoto, E | 1 |
| Wang, Y | 1 |
| Mattson, MP | 1 |
| Tozzi, A | 1 |
| Sclip, A | 1 |
| Tantucci, M | 1 |
| de Iure, A | 1 |
| Ghiglieri, V | 1 |
| Costa, C | 1 |
| Di Filippo, M | 1 |
| Borsello, T | 1 |
| Calabresi, P | 1 |
| Darvish-Ghane, S | 1 |
| Yamanaka, M | 1 |
| Zhuo, M | 2 |
| Abrahamsson, T | 1 |
| Gustafsson, B | 1 |
| Hanse, E | 1 |
| Zhao, MG | 1 |
| Toyoda, H | 1 |
| Wang, YK | 1 |
| Him, A | 1 |
| Guneser, R | 1 |
| Cengiz, N | 1 |
| Oztürk, G | 1 |
| Walz, C | 1 |
| Elssner-Beyer, B | 1 |
| Schubert, D | 1 |
| Gottmann, K | 1 |
| Molina, DP | 1 |
| Ariwodola, OJ | 1 |
| Linville, C | 1 |
| Sonntag, WE | 1 |
| Weiner, JL | 1 |
| Brunso-Bechtold, JK | 1 |
| Adams, MM | 1 |
| Segovia, G | 1 |
| Mora, F | 1 |
| Oray, S | 1 |
| Majewska, A | 1 |
| Sur, M | 1 |
| van de Bovenkamp-Janssen, MC | 1 |
| van der Kloet, JC | 1 |
| van Luijtelaar, G | 1 |
| Roubos, EW | 1 |
| Topic, B | 1 |
| Willuhn, I | 1 |
| Palomero-Gallagher, N | 1 |
| Zilles, K | 1 |
| Huston, JP | 1 |
| Hasenöhrl, RU | 1 |
| Billard, JM | 1 |
| Rouaud, E | 1 |
| Saransaari, P | 2 |
| Oja, SS | 2 |
| Nicoletti, VG | 1 |
| Condorelli, DF | 1 |
| Dell'Albani, P | 1 |
| Ragusa, N | 1 |
| Giuffrida Stella, AM | 1 |
| Nabekura, J | 1 |
| Kawamoto, I | 1 |
| Horimoto, N | 1 |
| Ogawa, T | 1 |
| Callaway, EM | 1 |
| Katz, LC | 1 |
| Kriegler, S | 1 |
| Chiu, SY | 1 |
| Izumi, Y | 1 |
| Benz, AM | 1 |
| Kurby, CO | 1 |
| Labruyere, J | 1 |
| Zorumski, CF | 1 |
| Price, MT | 1 |
| Olney, JW | 1 |
| Zuo, Z | 1 |
| Mahesh, VB | 1 |
| Zamorano, PL | 1 |
| Brann, DW | 1 |
| Wenk, GL | 1 |
| Mobley, SL | 1 |
| Le Jeune, H | 1 |
| Cécyre, D | 1 |
| Rowe, W | 1 |
| Meaney, MJ | 1 |
| Quirion, R | 2 |
| Granger, R | 1 |
| Deadwyler, S | 1 |
| Davis, M | 1 |
| Moskovitz, B | 1 |
| Kessler, M | 1 |
| Rogers, G | 1 |
| Lynch, G | 1 |
| Fleischer-Lambropoulos, E | 1 |
| Kazazoglou, T | 1 |
| Geladopoulos, T | 1 |
| Kentroti, S | 1 |
| Stefanis, C | 1 |
| Vernadakis, A | 1 |
| Nicolle, MM | 1 |
| Bizon, JL | 1 |
| Gallagher, M | 1 |
| Ikonomidou, C | 1 |
| Turski, L | 1 |
| Huang, W | 1 |
| Smith, SE | 1 |
| Chesler, M | 1 |
| Folbergrová, J | 1 |
| Lisý, V | 1 |
| Haugvicová, R | 1 |
| Stastný, F | 1 |
| Brennan, EM | 1 |
| Martin, LJ | 1 |
| Johnston, MV | 2 |
| Blue, ME | 1 |
| Akaike, N | 1 |
| Rhee, JS | 1 |
| Binns, KE | 1 |
| Salt, TE | 1 |
| White, SA | 1 |
| Livingston, FS | 1 |
| Mooney, R | 1 |
| Anderson, KJ | 1 |
| Mason, KL | 1 |
| McGraw, TS | 1 |
| Theophilopoulos, DT | 1 |
| Sapper, MS | 1 |
| Burchfield, DJ | 1 |
| Bernal, F | 1 |
| Andrés, N | 1 |
| Samuel, D | 1 |
| Kerkerian-LeGoff, L | 1 |
| Mahy, N | 1 |
| Follett, PL | 1 |
| Rosenberg, PA | 1 |
| Volpe, JJ | 1 |
| Jensen, FE | 2 |
| Barnes, CA | 3 |
| Rao, G | 3 |
| Orr, G | 1 |
| Ossowska, K | 1 |
| Wolfarth, S | 1 |
| Schulze, G | 1 |
| Wardas, J | 1 |
| Pietraszek, M | 1 |
| Lorenc-Koci, E | 1 |
| Smiałowska, M | 1 |
| Coper, H | 1 |
| Sanchez, RM | 1 |
| Koh, S | 1 |
| Rio, C | 1 |
| Wang, C | 1 |
| Lamperti, ED | 1 |
| Sharma, D | 1 |
| Corfas, G | 1 |
| Foster, TC | 2 |
| McNaughton, BL | 2 |
| Martin, D | 1 |
| McNamara, JO | 1 |
| Nadler, JV | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Baudry, M | 1 |
| Massicotte, G | 1 |
| Hauge, S | 1 |
| Miyoshi, R | 1 |
| Kito, S | 1 |
| Doudou, N | 1 |
| Nomoto, T | 1 |
| Chaudieu, I | 1 |
| Mount, H | 1 |
| Boksa, P | 1 |
| Kato, N | 1 |
| Artola, A | 1 |
| Singer, W | 1 |
| Insel, TR | 1 |
| Miller, LP | 1 |
| Gelhard, RE | 1 |
| Patel, AJ | 1 |
| Sanfeliu, C | 1 |
| Hunt, A | 1 |
| Erdö, SL | 2 |
| Wolff, JR | 2 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Aging
| Article | Year |
|---|---|
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Bra | 1996 |
51 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Aging
| Article | Year |
|---|---|
Enhancement by interleukin-1β of AMPA and NMDA receptor-mediated currents in adult rat spinal superficial dorsal horn neurons.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Humans; In Vitro | 2013 |
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Pep | 2014 |
Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Pro | 2015 |
Dopaminergic Modulation of Excitatory Transmission in the Anterior Cingulate Cortex of Adult Mice.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzazepines; Dopamine; Ex | 2016 |
AMPA silencing is a prerequisite for developmental long-term potentiation in the hippocampal CA1 region.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Animals, Newb | 2008 |
Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Gyrus Cinguli; Long-Term P | 2009 |
Glutamate responsiveness of medial vestibular nucleus neurons in aged rats.
Topics: Action Potentials; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutami | 2010 |
Properties of glutamatergic synapses in immature layer Vb pyramidal neurons: coupling of pre- and postsynaptic maturational states.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Excitatory Postsy | 2010 |
Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Bicu | 2012 |
Dopamine and GABA increases produced by activation of glutamate receptors in the nucleus accumbens are decreased during aging.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Ana | 2005 |
Effects of synaptic activity on dendritic spine motility of developing cortical layer v pyramidal neurons.
Topics: Actins; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals | 2006 |
NMDA-NR1 and AMPA-GluR4 receptor subunit immunoreactivities in the absence epileptic WAG/Rij rat.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anterior Thalamic Nuclei; | 2006 |
Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus.
Topics: Adrenergic Agents; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavio | 2007 |
Deficit of NMDA receptor activation in CA1 hippocampal area of aged rats is rescued by D-cycloserine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloserine; Excitatory Am | 2007 |
Glycine release from hippocampal slices in developing and ageing mice: modulation by glutamatergic receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1994 |
AMPA-selective glutamate receptor subunits in the rat hippocampus during aging.
Topics: Age Factors; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiograp | 1995 |
Developmental change of the potentiation of NMDA response by spermine.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Drug Synergism; Electrophy | 1995 |
Photostimulation using caged glutamate reveals functional circuitry in living brain slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1993 |
Calcium signaling of glial cells along mammalian axons.
Topics: Action Potentials; Adenosine; Adenosine Triphosphate; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxaz | 1993 |
An ex vivo rat retinal preparation for excitotoxicity studies.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chick Embryo; Excitatory A | 1995 |
Decreased gonadotropin-releasing hormone neurosecretory response to glutamate agonists in middle-aged female rats on proestrus afternoon: a possible role in reproductive aging?
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate Nucleus of Hypotha | 1996 |
Choline acetyltransferase activity and vesamicol binding in Rett syndrome and in rats with nucleus basalis lesions.
Topics: Acetylcholine; Adolescent; Adult; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; A | 1996 |
Ionotropic glutamate receptor subtypes in the aged memory-impaired and unimpaired Long-Evans rat.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Behavior, | 1996 |
Facilitation of glutamate receptors reverses an age-associated memory impairment in rats.
Topics: Age Factors; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dose-Response | 1996 |
Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1996 |
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus St | 1996 |
Addition of carbonic anhydrase augments extracellular pH buffering in rat cerebral cortex.
Topics: Aging; Alkalies; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn | 1995 |
Specific [3H]glutamate binding in the cerebral cortex and hippocampus of rats during development: effect of homocysteine-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Bind | 1997 |
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: II. Alpha-AMPA and kainate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Autoradi | 1997 |
Age-related functional changes of the glutamate receptor channels in rat Meynert neurones.
Topics: Acetylcholinesterase; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calc | 1997 |
Taurine release from the developing and ageing hippocampus: stimulation by agonists of ionotropic glutamate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agon | 1997 |
Experience-dependent changes in the importance of N-methyl-D-aspartate (NMDA) receptors for visual transmission in superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animal | 1998 |
Androgens modulate NMDA receptor-mediated EPSCs in the zebra finch song system.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androgens; Animals; Brain; Dendrite | 1999 |
The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic | 1999 |
Age-related resistance to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-induced hippocampal lesion.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Biom | 2000 |
NBQX attenuates excitotoxic injury in developing white matter.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agon | 2000 |
Age-related decrease in the Schaffer collateral-evoked EPSP in awake, freely behaving rats.
Topics: Afferent Pathways; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; | 2000 |
Decline in motor functions in aging is related to the loss of NMDA receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ankle Joint; Biomarkers; B | 2001 |
Decreased glutamate receptor 2 expression and enhanced epileptogenesis in immature rat hippocampus after perinatal hypoxia-induced seizures.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; | 2001 |
Region-specific age effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electric Stimulation; Evok | 1992 |
Kindling enhances sensitivity of CA3 hippocampal pyramidal cells to NMDA.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glutamates; Glutamic Acid; | 1992 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
Opposite effects of phospholipase A2 on [3H]AMPA binding in adult and neonatal membranes.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Ibotenic | 1991 |
Effect of age on alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) binding sites in the rat brain studied by in vitro autoradiography.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Ce | 1991 |
Transient postnatal increases in excitatory amino acid binding sites in rat ventral mesencephalon.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Corpus Stri | 1991 |
Developmental changes in the susceptibility to long-term potentiation of neurones in rat visual cortex slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-me | 1991 |
Specificity of functional changes during normal brain aging.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Hippocampus; Ibotenic Acid | 1991 |
The ontogeny of excitatory amino acid receptors in rat forebrain--I. N-methyl-D-aspartate and quisqualate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Frontal Lobe; Glutamates; | 1990 |
Development and regulation of excitatory amino acid receptors involved in the release of arachidonic acid in cultured hippocampal neural cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1990 |
Postnatal development of the excitatory amino acid system in visual cortex of the rat. Changes in ligand binding to NMDA, quisqualate and kainate receptors.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Ibotenic Acid; Male; Piper | 1990 |
Transient increase in ligand binding to quisqualate and kainate sites in cerebral cortex of immature rats.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cerebral | 1989 |