alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with Acute Brain Injuries in 17 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For this purpose we conducted a dose-response study at concentrations of AMPA between 0." | 1.35 | Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain. ( Andrés, N; Batlle, M; Mahy, N; Malpesa, Y; Prats, A; Pugliese, M; Rodríguez, MJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amini, M | 1 |
| Ma, CL | 1 |
| Farazifard, R | 1 |
| Zhu, G | 1 |
| Zhang, Y | 1 |
| Vanderluit, J | 1 |
| Zoltewicz, JS | 1 |
| Hage, F | 1 |
| Savitt, JM | 1 |
| Lagace, DC | 1 |
| Slack, RS | 1 |
| Beique, JC | 1 |
| Baudry, M | 1 |
| Greer, PA | 1 |
| Bergeron, R | 1 |
| Park, DS | 1 |
| O'Hare Doig, RL | 1 |
| Fitzgerald, M | 1 |
| Klein, KU | 1 |
| Johannes, A | 1 |
| Brückner, M | 1 |
| Thomas, R | 1 |
| Matthews, S | 1 |
| Frauenknecht, K | 1 |
| Leukel, P | 1 |
| Mazur, J | 1 |
| Poplawski, A | 1 |
| Muellenbach, R | 1 |
| Sommer, CJ | 1 |
| Thal, SC | 1 |
| Engelhard, K | 1 |
| Kim, SJ | 1 |
| Lee, K | 1 |
| Rodríguez, MJ | 1 |
| Prats, A | 1 |
| Malpesa, Y | 1 |
| Andrés, N | 1 |
| Pugliese, M | 1 |
| Batlle, M | 1 |
| Mahy, N | 1 |
| Luoma, JI | 1 |
| Kelley, BG | 1 |
| Mermelstein, PG | 1 |
| Cosi, C | 1 |
| Guerin, K | 1 |
| Marien, M | 1 |
| Koek, W | 1 |
| Rollet, K | 1 |
| Fowler, JH | 1 |
| Edgar, JM | 1 |
| Pringle, A | 1 |
| McLaughlin, M | 1 |
| McCulloch, J | 1 |
| Griffiths, IR | 1 |
| Garbern, JY | 1 |
| Nave, KA | 1 |
| Dewar, D | 1 |
| Slemmer, JE | 1 |
| Haasdijk, ED | 1 |
| Engel, DC | 1 |
| Plesnila, N | 1 |
| Weber, JT | 1 |
| Palmer, AM | 1 |
| Marion, DW | 1 |
| Botscheller, ML | 1 |
| Swedlow, PE | 1 |
| Styren, SD | 1 |
| DeKosky, ST | 1 |
| Araujo, M | 1 |
| Wandosell, F | 1 |
| Regan, RF | 1 |
| Panter, SS | 1 |
| Ikonomidou, C | 3 |
| Turski, L | 3 |
| Goforth, PB | 1 |
| Ellis, EF | 1 |
| Satin, LS | 1 |
| Stefovska, V | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
1 review available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Neurodegenerative disorders: clues from glutamate and energy metabolism.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Damage, Chronic; Bra | 1996 |
16 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazol | 2013 |
Novel combinations of ion channel inhibitors for treatment of neurotrauma.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain Injuries; Calcium; Humans; Ion Chann | 2015 |
Systemic PaO2 Oscillations Cause Mild Brain Injury in a Pig Model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Gas Analysis; Brain Injurie | 2016 |
Extracts of Liriopsis tuber protect AMPA induced brain damage and improve memory with the activation of insulin receptor and ERK I/II.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Avoidance Learning; Brain Injurie | 2008 |
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Atroph | 2009 |
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2011 |
The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo.
Topics: Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzamide | 2004 |
Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Axons; Blotting, Western; Brain I | 2006 |
Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Injuries; Calbi | 2007 |
Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Brain | 1993 |
Differential cellular response after glutamate analog hippocampal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biomarkers; Brain; Br | 1996 |
Hemoglobin potentiates excitotoxic injury in cortical cell culture.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxid | 1996 |
Pharmacology of the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo-(F)-quinoxaline.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvuls | 1997 |
Enhancement of AMPA-mediated current after traumatic injury in cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anim | 1999 |
Neuronal death enhanced by N-methyl-D-aspartate antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Injuries; Cell Death; Dizoc | 2000 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |