alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid has been researched along with ALS - Amyotrophic Lateral Sclerosis in 13 studies
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mutations in the hypoxia-inducible factor angiogenin (ANG) have been identified in Amyotrophic Lateral Sclerosis (ALS) patients, but the potential role of ANG in ALS pathogenesis was undetermined." | 3.74 | Control of motoneuron survival by angiogenin. ( Concannon, CG; Connaughton, D; Fenner, B; Greenway, MJ; Hardiman, O; Kieran, D; King, MA; Prehn, JH; Sebastia, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Widagdo, J | 1 |
| Udagedara, S | 1 |
| Bhembre, N | 1 |
| Tan, JZA | 1 |
| Neureiter, L | 1 |
| Huang, J | 1 |
| Anggono, V | 1 |
| Lee, M | 1 |
| Ramirez-Jarquin, UN | 1 |
| Lopez-Huerta, VG | 1 |
| Tapia, R | 3 |
| Prior-González, M | 1 |
| Lazo-Gómez, R | 1 |
| Kieran, D | 1 |
| Sebastia, J | 1 |
| Greenway, MJ | 1 |
| King, MA | 1 |
| Connaughton, D | 1 |
| Concannon, CG | 1 |
| Fenner, B | 1 |
| Hardiman, O | 1 |
| Prehn, JH | 1 |
| Lai, C | 2 |
| Xie, C | 2 |
| Shim, H | 2 |
| Chandran, J | 2 |
| Howell, BW | 1 |
| Cai, H | 2 |
| Platania, P | 1 |
| Seminara, G | 1 |
| Aronica, E | 1 |
| Troost, D | 1 |
| Vincenza Catania, M | 1 |
| Angela Sortino, M | 1 |
| McCormack, SG | 1 |
| Chiang, HC | 1 |
| Michalak, MK | 1 |
| Lin, X | 1 |
| Shimoji, M | 1 |
| Cookson, MR | 1 |
| Huganir, RL | 1 |
| Rothstein, JD | 1 |
| Price, DL | 1 |
| Wong, PC | 1 |
| Martin, LJ | 1 |
| Zhu, JJ | 1 |
| Van Damme, P | 1 |
| Bogaert, E | 1 |
| Dewil, M | 1 |
| Hersmus, N | 1 |
| Kiraly, D | 1 |
| Scheveneels, W | 1 |
| Bockx, I | 1 |
| Braeken, D | 1 |
| Verpoorten, N | 1 |
| Verhoeven, K | 1 |
| Timmerman, V | 1 |
| Herijgers, P | 1 |
| Callewaert, G | 1 |
| Carmeliet, P | 1 |
| Van Den Bosch, L | 1 |
| Robberecht, W | 2 |
| Corona, JC | 1 |
| Mennini, T | 2 |
| Cagnotto, A | 1 |
| Carvelli, L | 1 |
| Comoletti, D | 2 |
| Manzoni, C | 1 |
| Muzio, V | 2 |
| Rizzi, M | 1 |
| Vezzani, A | 1 |
| Vartiainen, N | 1 |
| Tikka, T | 1 |
| Keinänen, R | 1 |
| Chan, PH | 1 |
| Koistinaho, J | 1 |
| Vandenberghe, W | 1 |
| Brorson, JR | 1 |
| Capobianco, A | 1 |
| Ravizza, T | 1 |
13 other studies available for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Familial ALS-associated
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Glutamine; | 2022 |
Characterization of Mitochondria Degeneration in Spinal Motor Neurons Triggered by Chronic Over-activation of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors in the Rat Spinal Cord in Vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Ca | 2023 |
Sodium butyrate does not protect spinal motor neurons from AMPA-induced excitotoxic degeneration in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Bu | 2023 |
Control of motoneuron survival by angiogenin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Androstadie | 2008 |
Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; En | 2009 |
17beta-estradiol rescues spinal motoneurons from AMPA-induced toxicity: a role for glial cells.
Topics: Adult; Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophi | 2005 |
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Topics: Adaptor Proteins, Signal Transducing; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyo | 2006 |
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; As | 2007 |
Calpain inhibition protects spinal motoneurons from the excitotoxic effects of AMPA in vivo.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Ca | 2008 |
Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic L | 1999 |
Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyo | 1999 |
AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; Ca | 2000 |
Nitric oxide produced by non-motoneuron cells enhances rat embryonic motoneuron sensitivity to excitotoxins: comparison in mixed neuron/glia or purified cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic Lateral Sclerosis; Animals; An | 2001 |