aloxistatin has been researched along with Acute Confusional Senile Dementia in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hook, G; Hook, V; Kindy, M; Toneff, T; Yu, J | 1 |
| Arancio, O; Fa', M; Hidalgo, A; Liu, S; Mathews, PM; Nixon, RA; Schmidt, SD; Trinchese, F; Yamaguchi, H; Yoshii, N; Zhang, H | 1 |
| Hook, G; Hook, V; Kindy, M | 2 |
| Hook, G; Hook, VY; Kindy, M | 1 |
5 other study(ies) available for aloxistatin and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cattle; Cells, Cultured; Chromaffin Cells; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Leucine; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2014 |
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Calpain; Cells, Cultured; Disease Models, Animal; Glycoproteins; Hippocampus; Homozygote; Immunohistochemistry; Leucine; Memory; Mice; Mice, Transgenic; Models, Neurological; Synaptic Transmission | 2008 |
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cysteine Proteinase Inhibitors; Disease Models, Animal; Guinea Pigs; Leucine; Memory; Mice; Mice, Transgenic | 2011 |
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cathepsin B; Cysteine Endopeptidases; Dipeptides; Guinea Pigs; Leucine; Molecular Weight; Protease Inhibitors; Synaptosomes | 2007 |
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cathepsin B; Cattle; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Humans; Leucine; Maze Learning; Memory; Mice; Mice, Transgenic | 2008 |